Assessment of Serum Spexin Levels In Obese Adolescents with Metabolic Syndrome Antecedents: Preliminary Results

2021 ◽  
Author(s):  
Nida Gulderen Kalay Senturk ◽  
Aydilek Dagdeviren Cakir ◽  
Zeynep Yildiz Yildirmak ◽  
Ahmet Ucar
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
International Diabetes Federation ◽  
Obese Patients ◽  
Pressure Measurements ◽  
Lower Serum ◽  
Blood Samples ◽  
Obese Adolescents ◽  
Laboratory Variables ◽  
Clinical Blood Pressure

Objective: Spexin (SPX) is a novel peptide implicated in food intake and satiety. Spexin levels are reduced in obese patients. Aim: To compare serum SPX levels in obese adolescents versus healthy controls and to assess the associations of metabolic syndrome (metS) antecedents with serum SPX levels. Methods: Eighty consecutive obese adolescents aged 10-18 years and 80 healthy peers were enrolled. Anthropometric measurements, pubertal examinations and clinical blood pressure measurements were performed. Fasting blood samples were drawn for glucose, insulin, lipids, uric acid, alanine aminotransferase (ALT) and SPX. Metabolic syndrome (metS) was diagnosed using International Diabetes Federation criteria. Associations of serum SPX with clinical and laboratory variables were assessed. Results: Obese adolescents had lower serum SPX levels than healthy peers (50 pg/mL [25%-75% IQR: 25-98 pg/mL] and 67.0 pg/mL [25%-75% IQR:32.5-126.0 pg/mL; respectively], p =0.035). Twenty (25 %) obese adolescents were diagnosed as having metS. Obese adolescents with metS had lower SPX than those without metS (24.5 pg/mL [25%-75% IQR: 15.3-49.5 pg/mL] and 69.0 pg/mL [25%-75% IQR: 42.0-142.0 pg/mL]; respectively p<0.0001). The frequencies of hyperuricemia, IR and elevated ALT were similar in obese adolescents with metS and those without metS (p > 0.05 for all). Serum uric acid levels were correlated significantly with serum SPX after correcting for BMI and HOMA-IR (r =-0.41, p<0.05). A serum SPX level at a cut -off level of 49.5 pg/mL predicted the presence of metS in obese adolecents with 75 % sensitivity and 71 % specifity. Conclusions: Obese adolescents have reduced SPX levels, and this reduction is more pronounced in those with metS. Further research is needed to verify the utility of SPX as a biomarker in the diagnosis of metS in obese adolescents.

scholarly journals Relation of uric acid with components of metabolic syndrome before and after Roux-en-Y gastric bypass in morbidly obese subjects

2011 ◽  
Vol 55 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Ary Serpa Neto ◽  
Felipe Martin Bianco Rossi ◽  
Leonardo Guedes Moreira Valle ◽  
Gabriel Kushiyama Teixeira ◽  
Marçal Rossi
Keyword(s):  
Metabolic Syndrome ◽  
Gastric Bypass ◽  
Uric Acid ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Metabolic Abnormalities ◽  
Blood Samples ◽  
Glucose Levels ◽  
Before And After ◽  
Obese Subjects

OBJECTIVE: The purpose of the study was to investigate the prevalence of hyperuricemia in morbidly obese subjects before and after Roux-en-Y gastric bypass (RYGBP) and its relationship with metabolic syndrome abnormalities. SUBJECTS AND METHOD: We evaluated 420 morbidly obese patients. Pre and postoperative (8 months after RYGBP) blood samples were drawn. Obese patients underwent laparoscopic RYGBP and after eight months all the tests were repeated. RESULTS: The overall prevalence of hyperuricemia was 34.28%. Hyperuricemia was more common in men than in women (51.72 vs. 29.72%; p = 0.0002). Men with hyperuricemia were more likely to have diabetes (p = 0.034) and more elevated fasting plasma glucose levels (p = 0.027). Women with hyperuricemia were more likely to have hypertension (p = 0.003), metabolic syndrome (p = 0.001), elevated triglycerides (p = 0.001) and GGT (p = 0.009), and decreased HDL (p = 0.011). After surgery, uric acid levels decreased from 5.60 ± 1.28 to 4.23 ± 1.20 (p < 0.0001). The prevalence of hyperuricemia decreased from 33.6% to 6.4% (p < 0.0001), in men from 48.3% to 17.2% (p < 0.0001) and in women from 29.7% to 3.6% (p < 0.0001). CONCLUSION: Concentrations of uric acid were associated with the prevalence of metabolic abnormalities in this sample of morbidly obese patients. Also, weight loss after RYGBP can reduce uric acid levels and the prevalence of hyperuricemia.

scholarly journals Diet dan Sindrom Metabolik pada Remaja Obesitas

2020 ◽  
Vol 4 (3) ◽  
pp. 191
Author(s):  
Rendi Aji Prihaningtyas ◽  
Nur Aisiyah Widjaja ◽  
Meta Herdiana Hanindita ◽  
Roedi Irawan
Keyword(s):  
Metabolic Syndrome ◽  
Food Consumption ◽  
Fruits And Vegetables ◽  
International Diabetes Federation ◽  
Hdl Cholesterol ◽  
Dietary Factors ◽  
Chi Square ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Significant Difference

ABSTRACTBackground : The prevalence of obesity in adolescents is increasing and causes metabolic syndrome at a young age. Metabolic syndrome results from the interaction of environmental, genetic, and dietary factors. The purpose of this study was to determine the diet profile of obese adolescents suffering from metabolic syndrome.Methods: This study was a cross-sectional study of obese adolescents who visited the Pediatric Nutrition and Metabolic Disease in Dr. Soetomo General Hospital, Surabaya. The anthropometry examination (weight, height and waist circumference), blood pressure, and blood tests (HDL cholesterol, triglycerides and blood glucose levels) were measured. The diagnosis of metabolic syndrome was based on the International Diabetes Federation. Food consumption data was obtained through direct interviews using data collection sheets. Analysis of dietary differences in obese adolescents suffering from metabolic syndrome was performed by chi square using SPSS.Results and Discussions: A total of 59 obese adolescents aged 13-16 years were involved in this study. A total of 27 subjects (45.8%) suffered from metabolic syndrome and 32 subjects (54.2%) did not suffer from metabolic syndrome. The level of the consumption of fish, vegetables, and fruit in obese adolescents were still low. There was no significant difference in the diet profile between obese adolescents who suffer from metabolic syndrome or not.Conclusion: Prevention strategies through food consumption patterns are needed in obese adolescents to control metabolic stress processes and prevent metabolic syndrome in the future. Diet knowledge in obese adolescents needs to be given early to prevent further complications. Increasing foods that contain anti-oxidants, such as fruits and vegetables, is one of the strategies to prevent metabolic syndrome in obese adolescents.ABSTRAKLatar Belakang : Prevalensi obesitas pada remaja semakin meningkat dan menyebabkan sindrom metabolik di usia muda. Sindrom metabolik terjadi akibat interaksi faktor lingkungan, genetik, dan diet. Tujuan dari penelitian ini adalah mengetahui profil diet pada remaja obesitas yang menderita sindrom metabolik.Metode : Penelitian ini merupakan penelitian potong lintang pada remaja obesitas yang berkunjung di Poli Nutrisi dan Penyakit Metabolik Anak di RSUD Dr. Soetomo, Surabaya. Pada subyek dilakukan pemeriksaan antropometri (berat badan, tinggi badan, dan lingkar pinggang), pemeriksaan tekanan darah, dan pemeriksaan darah (kolesterol HDL, trigliserida, dan kadar glukosa darah). Diagnosis sindrom metabolik ditegakkan berdasarkan International Diabetes Federation. Data konsumsi makanan didapatkan melalui wawancara langsung dengan menggunakan lembar pengumpul data. Analisis perbedaan diet pada remaja obesitas yang menderita sindrom metabolik dilakukan dengan chi square menggunakan SPSS.Hasil dan Pembahasan : Sebanyak 59 remaja obesitas yang berusia 13-16 tahun terlibat dalam penelitian ini. Sebanyak 27 subyek (45,8%) menderita sindrom metabolik dan sebanyak 32 subyek (54,2%) tidak menderita sindrom metabolik. Tingkat konsumsi ikan, sayur, dan buah pada remaja obesitas masih rendah. Tidak ada perbedaan yang bermakna pada profil diet antara remaja obesitas yang menderita sindrom metabolik maupun tidak.Kesimpulan : Strategi pencegahan melalui pola konsumsi makanan diperlukan pada remaja obesitas untuk mengontrol proses stres metabolik sehingga dapat mencegah sindrom metabolik di masa datang. Pengetahuan diet pada remaja obesitas perlu diberikan sejak dini untuk mencegah komplikasi lebih lanjut. Memperbanyak makanan yang mengandung anti-oksidan, seperti buah dan sayur merupakan salah satu strategi mencegah sindrom metabolik pada remaja obesitas.

scholarly journals A Longitudinal Study of the Antioxidant Barrier and Oxidative Stress in Morbidly Obese Patients after Bariatric Surgery. Does the Metabolic Syndrome Affect the Redox Homeostasis of Obese People?

2020 ◽  
Vol 9 (4) ◽  
pp. 976 ◽  
Author(s):  
Barbara Choromańska ◽  
Piotr Myśliwiec ◽  
Magdalena Łuba ◽  
Piotr Wojskowicz ◽  
Jacek Dadan ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Metabolic Syndrome ◽  
Superoxide Dismutase ◽  
Uric Acid ◽  
Oxidative Damage ◽  
Redox Homeostasis ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Obese People ◽  
Oxidative Damage To Proteins

This is the first study to evaluate both the antioxidant barrier, glutathione metabolism, and oxidative damage to proteins and lipids in morbidly obese patients undergoing bariatric treatment. The study included 65 patients with class 3 obesity divided into two subgroups: morbidly obese patients without metabolic syndrome (OB) and obese patients with metabolic syndrome (OB + MS). Blood samples were collected before surgery as well as one, three, six, and twelve months after the bariatric treatment. Superoxide dismutase and reduced glutathione (GSH) were significantly decreased, whereas glutathione reductase and uric acid were enhanced in morbidly obese patients before bariatric surgery as compared to lean control. Moreover, in the OB group, we observed the increase of superoxide dismutase (SOD) and the decrease of uric acid (UA) after the bariatric treatment; however, these changes were not observed in the OB + MS group. The oxidative damage to proteins (advanced glycation end products, AGE; advanced oxidation protein products, AOPP) and lipids (8-isoprostanes, 8-isop; 4-hydroxynoneal) was higher in OB as well as OB + MS patients. We noticed that AGE and AOPP levels diminished after the bariatric treatment, whereas redox status (ratio of GSH to oxidized glutathione) was still reduced in the OB + MS group. Summarizing, morbid obesity is associated with disturbances in the antioxidant barrier and enhanced oxidative damage to proteins and lipids. Although bariatric surgery improves redox homeostasis in obese patients, those with metabolic syndrome show a continuous decrease in the antioxidant status. In patients undergoing bariatric treatment, antioxidant supplementation may be considered.

scholarly journals Impact of Weight Loss on the Total Antioxidant/Oxidant Potential in Patients with Morbid Obesity—A Longitudinal Study

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 376 ◽  
Author(s):  
Barbara Choromańska ◽  
Piotr Myśliwiec ◽  
Magdalena Łuba ◽  
Piotr Wojskowicz ◽  
Hanna Myśliwiec ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Insulin ◽  
Diagnostic Value ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Antioxidant Power ◽  
Total Antioxidant ◽  
Ferric Reducing Antioxidant Power ◽  
Oxidant Status

The assessment of total antioxidant activity seems to have a higher diagnostic value than the evaluation of individual antioxidants separately. Therefore, this is the first study to assess the total antioxidant/oxidant status in morbidly obese patients undergoing bariatric surgery. The study involved 60 patients with Class 3 obesity (BMI > 40 kg/m2) divided into two equal subgroups: morbidly obese patients without and with metabolic syndrome. The analyses were performed in plasma samples collected before surgery as well as 1, 3, 6, and 12 months after a laparoscopic sleeve gastrectomy. Total antioxidant capacity (TAC), ferric-reducing antioxidant power (FRAP), DPPH (2,2′-diphenyl-1-picrylhydrazyl) radical assay, and total oxidant status (TOS) were significantly higher before surgery (as compared to the healthy controls, n = 60) and generally decreased after bariatric treatment. Interestingly, all assessed biomarkers correlated positively with uric acid content. However, the total antioxidant/oxidant potential did not differ between obese patients without metabolic syndrome and those with both obesity and metabolic syndrome. Only DPPH differentiated the two subgroups (p < 0.0001; AUC 0.8) with 73% sensitivity and 77% specificity. Plasma TAC correlated positively with body mass index, waist–hip ratio, serum insulin, and uric acid. Therefore, TAC seems to be the best biomarker to assess the antioxidant status of obese patients.

scholarly journals Increased Aldehyde Formation as a Key Component of the Metabolic Syndrome in Adolescents: A Machine Learning Study

2020 ◽  
Author(s):  
Kamila Bonifacio ◽  
Michael Maes ◽  
Carine de Farias ◽  
Andressa Matsumoto ◽  
Crisieli Tomereli ◽  
...  
Keyword(s):  
Machine Learning ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Task Force ◽  
International Diabetes Federation ◽  
Density Lipoprotein ◽  
Support Vector ◽  
Lipid Hydroperoxides ◽  
Radical Trapping ◽  
The Metabolic Syndrome

Purpose: To investigate the alterations in nitro-oxidative stress (OS) and antioxidant status in adolescents with metabolic syndrome (MetS) and whether these alterations occur independently from effects of overweight or obesity.Methods: Blood was collected in 47 adolescents with MetS and 94 adolescents without MetS as assessed with the International Diabetes Federation criteria. The International Obesity Task Force (IOTF) criteria were used to classify the subjects into those with overweight or obesity. We measured nitro-oxidative biomarkers including nitric oxide metabolites (NOx), lipid hydroperoxides (LOOH), and malondialdehyde (MDA), and antioxidant biomarkers, i.e. total radical-trapping antioxidant parameter (TRAP), paraoxonase (PON)-1 activity, thiol (SH-) groups, as well as tumor necrosis factor-&alpha;, glucose, insulin, triglycerides, uric acid and high-density lipoprotein cholesterol (HDL-C).Results: Logistic regression analysis showed that increased MDA and NOx and a lowered TRAP/uric acid ratio were associated with MetS. Machine learning including soft independent modeling of class analogy (SIMCA) showed that the top-3 most important features of MetS were increased glucose and MDA and lowered HDL-C. Support vector machine using MDA, glucose, insulin, HDL-C, triglycerides and body mass index as input variables yielded a 10-fold cross-validated accuracy of 89.8% when discriminating MetS from controls. The association between MetS and increased MDA was independent from the effects of overweight-obesity. glucose, insulin, triglycerides and HDL-C.Conclusion: In adolescents, increased MDA formation is a key component of MetS, indicating that increased production of reactive oxygen species with consequent lipid peroxidation and aldehyde formation participate in the development of MetS.

scholarly journals Anthropometric characteristics of adolescents with signs of metabolic syndrome

2021 ◽  
pp. 35-40
Author(s):  
L.A. Strashok ◽  
◽  
O.V. Buznytska ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
International Diabetes Federation ◽  
Resistance Index ◽  
Atherogenic Dyslipidemia ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Healthy Children ◽  
Growth Ratio ◽  
Obese Adolescents

An analysis of recent global research on the prevalence of obesity and its consequences, including metabolic syndrome, among adolescents is a matter of considerable concern. The same unfavorable tendencies are observed in Ukraine among modern youth. Therefore, an effective strategy for the detection and follow-up of adolescents is urgently needed for the timely treatment of obesity and the prevention of threatening complications. Purpose — to analyze and generalize anthropometrical indicators in adolescents with signs of metabolic syndrome to improve the management of this category of patients. Materials and methods. 200 obese adolescents (aged 16 years: 100 boys and 100 girls) were examined in the clinic of the Institute of Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine. The control group consisted of 30 healthy children of the same age category. The criteria for the diagnosis of metabolic syndrome (MS) in children, proposed by the International Diabetes Federation [IDF, 2007], were used, which allowed to divide patients into two groups: 1 — with signs of MS (50.0%) and 2 — without signs of MS (50.0%), each of which included 100 patients. Patients underwent an anthropometric examination with the calculation of the following indicators: body mass index (BMI), the waist;to;growth ratio (WC/height) and waist circumference to hip circumference ratio (WC/HC). Blood lipid profile as a marker of atherogenesis, carbohydrate metabolism (fasting serum glucose, the level of immunoreactive insulin with the calculation of insulin resistance index HOMA) were also studied in detail. Results. The anthropometric analysis showed that in adolescents with MS the main indicators (BMI, WC/height, WC/HC), the degree of abdominal obesity were statistically significantly higher (p<0.05). When comparing the results by gender, probable differences were found between boys and girls: indicators of body weight, waist circumference, WC/HC, which were statistically significantly higher in boys (p<0.05). Characterization of lipid metabolism in the patients showed signs of atherogenic dyslipidemia (increased cholesterol levels, low and very low density lipoproteins, atherogenic factor, triglycerides, β-lipoproteins levels and tendencies to lower the levels of high density lipoproteins) with a significant predominance among those surveyed with MS (p<0.05). Conclusions. Promising careful anthropometric monitoring of obese adolescents will identify and predict trends in the disease, the risk of complications, which will increase the effectiveness of preventive measures for metabolic syndrome. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: adolescents, metabolic syndrome, anthropometry, diagnostics, dyslipidemia.

scholarly journals Az elhízás anyagcsere-szövődményei serdülőkorban, különös tekintettel az emelkedett húgysavszintek előfordulására

2015 ◽  
Vol 156 (22) ◽  
pp. 888-895 ◽  
Author(s):  
László Ságodi ◽  
Viktória Fehér ◽  
Emőke Kiss-Tóth ◽  
Andrea Almási ◽  
László Barkai
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Cross Sectional Study ◽  
Control Group ◽  
High Concentration ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Paediatric Endocrinology

Introduction: Obesity is a social problem worldwide that leads to several diseases, including metabolic syndrome, hypertension and cardiovascular diseases. It is known that hyperuricemia in adults may be associated with these disorders. Aim: The aim of the authors was to investigate the frequency of metabolic syndrome and hyperuricemia and their relationship among obese adolescents. Method: This was a cross-sectional study. The authors analysed the data of 162 overweight or obese adolescents (100 boys and 62 girls) who were previously investigated in a paediatric endocrinology consultation. Anthropometric and metabolic parameters were evaluated in all subjects. Healthy, age-matched, non obese girls (n = 20) and boys (n = 26) were used as controls. The age of overweight or obese boys was: 12±2.1 and overweight or obese girls was 11±2.5 years. In the control group the age of boys was 12.9±2.5 years and the age of girls was 13.2±1.6 years. Linear regression was used to evaluate associations between uric acid and clinical and laboratory findings associated with metabolic syndrome. Results: Obese or overweight subjects had greater BMI SDS (boys, 3.4±1.3 vs 0.05±0.4 in controls, p<0.0001; girls, 3.75±1.4 vs 0.72±0.9 in controls, p = 0.0001), waist circumference (boys, 90.1±9.2 vs 82.3±6.4 cm in controls; girls, 90.2±8.6 vs 78.1±7.2 cm in controls, p<0.001), higher systolic blood pressure (boys, 125±14.3 vs 118.2±10.8 mmHg in controls, p = 0.02; girls, 125.8±11.8 vs 119.8±8.8 mmHg in controls, p<0.01), diastolic blood pressure (boys, 78.4±9.1 vs 71.2±8.0 mmHg in controls, p = 0.0003; girls, 76.45±7.2 vs 73.2±6.3 mmHg in controls, p = 0.0453). The prevalence of metabolic syndrome was 45/162 (27.8%) and the prevalence of hyperuricemia was 62/162 (38.3%). Of the 45 subjects with metabolic syndrome, 30 (66.7%) had hyperuricemia. Conclusions: It can be concluded that hyperuricemia is strongly associated with metabolic syndrome. The high concentration of uric acid predicts cardiovascular risk in adulthood. It is important for paediatricians to determine and assess uric acid levels in overweight or obese adolescents. Orv. Hetil., 2015, 156(22), 888–895.

Prevalence of metabolic syndrome and its associated factors in overweight and obese adolescents

2020 ◽  
Vol 33 (2) ◽  
pp. 233-239 ◽  
Author(s):  
Rosemeire A.S. Dejavitte ◽  
Carla C. Enes ◽  
Luciana B. Nucci
Keyword(s):  
Metabolic Syndrome ◽  
Associated Factors ◽  
Protective Factor ◽  
Adult Life ◽  
International Diabetes Federation ◽  
Density Lipoprotein ◽  
Cardiovascular Complications ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Obese Adolescents

AbstractBackgroundMetabolic syndrome (MetS) is not only a problem of adulthood but is already present in children and adolescents. The aim of this study was to estimate the prevalence of MetS in adolescents and to identify the associated factors.MethodsThis was a cross-sectional study with 354 overweight and obese school-aged adolescents (10–19 years). Sociodemographic, anthropometric, clinical, biochemical and lifestyle variables were collected. MetS was identified according to the criteria proposed by the International Diabetes Federation (IDF). Multivariate logistic regression models were used to examine the associations between risk variables and MetS.ResultsThe prevalence of MetS was 9.6%. Among adolescents with MetS, all of them had low high-density lipoprotein cholesterol (HDL-c), while 76.5% had hyperglycemia and 38.2% had hypertriglyceridemia. Only 12.1% did not present any component of MetS, while 40% had at least two components. Multivariate analysis showed that being a girl was a protective factor (odds ratio [OR] = 0.29, confidence interval [CI] = 0.13–0.65) for the presence of MetS, while obesity (OR = 3.63, CI = 1.62–8.17) and being insufficiently active (OR = 4.60, CI = 1.01–20.96) were the risk factors for MetS.ConclusionsObese and insufficiently active male adolescents are more likely to have MetS. Early identification of MetS components, especially among obese adolescents, is an important tool for the prevention of cardiovascular complications in adult life.

scholarly journals SLEEP DURATION AND METABOLIC SYNDROME IN OBESE ADOLESCENTS

2021 ◽  
Vol 16 (1) ◽  
pp. 33
Author(s):  
Nur Aisiyah Widjaja ◽  
Rendi Aji Prihaningtyas ◽  
Roedi Irawan ◽  
Meta Herdiana Hanindita
Keyword(s):  
Metabolic Syndrome ◽  
Sleep Duration ◽  
Fasting Blood Glucose ◽  
International Diabetes Federation ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Glucose Levels

Shorter sleep duration is a risk factor for obesity and metabolic syndrome. Previous studies conducted on diff erent races showed inconsistent results. The purpose of this study was to analyze the diff erences in sleep duration in obese adolescents who suff er from metabolic syndrome compared with obese adolescents who do not suff er from metabolic syndrome. A cross sectional study was carried out on 59 obese adolescents who visited the Pediatric Nutrition and Metabolic Disease Clinic in Dr. Soetomo General Academic Hospital, Surabaya. Subjects were selected using total sampling techniques who met the inclusion and exclusion criteria in August-November 2018. Anthropometry (weight, height and waist circumference), blood pressure, and blood tests (HDL cholesterol levels, triglycerides, and fasting blood glucose levels) were held to determine obesity according to CDC 2000 and metabolic syndrome according to International Diabetes Federation. The diff erence in sleep duration in obese adolescents suff ering from metabolic syndrome and without metabolic syndrome analyzed using Chi square test. A total of 27 subjects (45.8%) suff ered from metabolic syndrome. Most obese adolescents (57,6%) have suffi cient sleep duration (≥ 8 hours/day). There was no sleep duration diff erences in obese adolescents suff ering and not suff ering from metabolic syndrome (p> 0.05).

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