scholarly journals Мінеральний склад коренеплодів та плодів пастернаку посівного (PASTINACA SATIVA L.) сорту “Петрик”

2017 ◽  
Author(s):  
J. E. Shimorova ◽  
V. S. Kyslychenko ◽  
V. Yu. Kuznietsova
Keyword(s):  
Human Health ◽  
Experimental Studies ◽  
Living Organism ◽  
Atomic Emission ◽  
The Body ◽  
New Drugs ◽  
Quantitative Composition ◽  
Pastinaca Sativa ◽  
National Academy Of Sciences ◽  
Mineral Substances

Introduction. Human health preserving in an environment of eco-depending pathologies is the most important issue of modern medicine and pharmacy. The presence of certain mineral substances in the body in an appropriate quantity is one of the conditions for maintaining and preserving human health. Despite the fact that minerals do not have energy value, like proteins, fats and carbohydrates, many enzymatic processes in the body are impossible without their participation. Thus, the most important functions of a living organism are the realization of genetic information, the formation of subcellular structures, metabolic processes of energy production, the functioning of all organs and systems, depend on the quantitative and qualitative content of mineral substances in the body.The aim of the study – to determine macro- and microelement composition of parsnip`s roots and fruits of "Petrik" variety.Research Methods. Determination of the qualitative and quantitative composition of macro- and microelements of dried parsnip`s roots and fruits – Pastinaca sativa L. "Petrik" variety was carried out by atomic-emission spectroscopy with photographic registration in the State scientific institution "Institute for single crystals" of National Academy of Sciences of Ukraine.Results and Discussion. 19 elements were detected as a result of experimental studies. The roots predominantly contains potassium (2010.00 mg of /100 g), calcium (435.00 mg/100g), magnesium (300.00 mg/100g), sodium (270.00 mg /100 g), phosphorus (235.00 mg/100g); in fruits – potassium (1510.00 mg/kg). Roots are rich on zinc (13.40 mg/100g). Content of other elements are less than 0.1 mg /100 g.Conclusions. 19 elements were found in the roots and fruits of parsnip. Potassium (2010.00 mg/100g), calcium (435.00 mg/100g), magnesium (300.00 mg/100g) are dominated in the roots of parsnip; potassium is dominated in fruits (1510.00 mg/100 g). The results of the research will be used for further phytochemical studies of parsnip and the development of new drugs on it base. 

scholarly journals Molecular Mechanisms of Zinc as a Pro-Antioxidant Mediator: Clinical Therapeutic Implications

Antioxidants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 164 ◽  
Author(s):  
Ananda S. Prasad ◽  
Bin Bao
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Human Health ◽  
Zinc Deficiency ◽  
Molecular Mechanisms ◽  
Zinc Supplementation ◽  
Experimental Studies ◽  
The Body ◽  
Ros Production ◽  
Stress Agent

The essentiality of zinc as a trace mineral in human health has been recognized for over five decades. Zinc deficiency, caused by diet, genetic defects, or diseases, can cause growth retardation, delayed sexual maturation, depressed immune response, and abnormal cognitive functions in humans. Zinc supplementation in zinc-deficient individuals can overcome or attenuate these abnormalities, suggesting zinc is an essential micro-nutrient in the body. A large number of in vitro and in vivo experimental studies indicate that zinc deficiency also causes apoptosis, cellular dysfunction, deoxyribonucleic acid (DNA) damage, and depressed immune response. Oxidative stress, due to the imbalance of reactive oxygen species (ROS) production and detoxification in the anti-oxidant defense system of the body, along with subsequent chronic inflammation, is believed to be associated with many chronic degenerative diseases such as diabetes, heart diseases, cancers, alcohol-related disease, macular degenerative disease, and neuro-pathogenesis. A large number of experimental studies including cell culture, animal, and human clinical studies have provided supportive evidence showing that zinc acts as an anti-oxidative stress agent by inhibition of oxidation of macro-molecules such as (DNA)/ribonucleic acid (RNA) and proteins as well as inhibition of inflammatory response, eventually resulting in the down-regulation of (ROS) production and the improvement of human health. In this article, we will discuss the molecular mechanisms of zinc as an anti-oxidative stress agent or mediator in the body. We will also discuss the applications of zinc supplementation as an anti-oxidative stress agent or mediator in human health and disease.

scholarly journals Are there any gender differences in pain perception? Clinical and experimental studies in oncology

2021 ◽  
Vol 67 (6) ◽  
pp. 755-760
Author(s):  
Elena Frantsiyants ◽  
Inga Kotieva ◽  
Elena Sheiko ◽  
Iurii Sidorenko
Keyword(s):  
Gender Differences ◽  
Chronic Pain ◽  
Cancer Patients ◽  
Pain Perception ◽  
Experimental Studies ◽  
Pain Syndrome ◽  
Living Organism ◽  
The Body ◽  
Protective Function ◽  
Mechanisms Of Development

The review considers and analyzes scientific literature on gender differences in the incidence of pain syndromes, perception of clinical pain, including that in cancer patients and in experimental oncology. The literature highlights theoretical basis, some biological mechanisms and practical results associated with gender differences. Chronic pain no longer performs a protective function and is not biologically appropriate. The review presents results of experimental studies demonstrating the important role of sex hormones and regulatory systems of a living organism in the mechanisms of development, distribution and perception of pain. Some aspects of sexual dimorphism in the processes of nociception and antinociception are covered. We present the data on the causes of chronic pain syndrome and its perception in cancer patients of both sexes indicating genetically determined sexual reactivity of the body which causes an imbalance in the function of peripheral nervous system and CNS under the influence of prolonged permanent pain in a living organism. Various pain effects have been shown to cause changes in the main types of metabolism, mobilization of adaptive metabolic mechanisms, and tissue damage. Conclusions. The high prevalence of chronic pain in both women and men with cancer, heavy humanitarian and social and economic burden explains a significant increase in fundamental and clinical research in this direction.      

scholarly journals Norm and human health

2021 ◽  
Vol 23 (2) ◽  
pp. 229-236
Author(s):  
Yuri S. Malov ◽  
Igor M. Borisov
Keyword(s):  
Human Health ◽  
Golden Ratio ◽  
Mathematical Expression ◽  
Living Organism ◽  
The Body ◽  
Equilibrium System ◽  
Normal Human ◽  
The Stability ◽  
Relationship Of ◽  
The Relationship

The concept of norms is common to biology and medicine. It represents the essence of any phenomenon. In medicine, human health is expressed through the category of norm. The basis of the construction of the norm (normology) should be based on the principle of correspondence of morphofunctional properties of the organism to the environment, and not their nature. And then indicators that reflect the stability of a living non-equilibrium system or the state of an adapted organism will characterize (normal) human health. The norm is always stable, otherwise it will not be the norm. The science of human health developed through analysis the decomposition of a complex whole into simple parts. In this case, the object disappeared as a whole, as a system with all its inherent features. The norm was derived from the fitness, balance of the body with the environment. Recently, it has become possible to consider a person as a system that is determined by the relationship of the whole and its parts (the golden ratio). In biology, the golden ratio manifests itself in many ways, from the structure of polypeptides to the human body. The study of a living organism as a system allowed us to establish the harmonic essence of its structure. The idea of the harmony of the world of systems is connected with the relations of "opposites" within the object. The "golden opposites" of healthy people are a kind of norm reference. What brings "opposites" to unity is harmony. Harmony is closely related to the golden ratio. Golden harmony is the basis of human health. Mathematical expression of harmony, symmetry a method of assessing (norm) human health. Deviations from the "golden" relations can be used in medicine as indicators (criteria) for the diagnosis of pathological disorders.

Preterm Birth, Inflammation and Infection: New Alternative Strategies for their Prevention

2019 ◽  
Vol 20 (5) ◽  
pp. 354-365 ◽  
Author(s):  
Víctor M. Muñoz-Pérez ◽  
Mario I. Ortiz ◽  
Raquel Cariño-Cortés ◽  
Eduardo Fernández-Martínez ◽  
Leticia Rocha-Zavaleta ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Medicinal Plants ◽  
Low Income ◽  
Experimental Studies ◽  
Neonatal Outcomes ◽  
New Drugs ◽  
Alternative Strategies ◽  
Mortality And Morbidity ◽  
Therapeutic Benefits ◽  
Gynecology And Obstetrics

Background:Worldwide, the progress in reducing neonatal mortality has been very slow. The rate of preterm birth has increased over the last 20 years in low-income and middle-income countries. Its association with increased mortality and morbidity is based on experimental studies and neonatal outcomes from countries with socioeconomic differences, which have considered implementing alternative healthcare strategies to prevent and reduce preterm births.Methods:Currently, there is no widely effective strategy to prevent preterm birth. Pharmacological therapies are directed at inhibiting myometrial contractions to prolong parturition. Some drugs, medicinal plants and microorganisms possess myorelaxant, anti-inflammatory and immunomodulatory properties that have proved useful in preventing preterm birth associated with inflammation and infection.Results:This review focuses on the existing literature regarding the use of different drugs, medicinal plants, and microorganisms that show promising benefits for the prevention of preterm birth associated with inflammation and infection. New alternative strategies involving the use of PDE-4 inhibitors, medicinal plants and probiotics could have a great impact on improving prenatal and neonatal outcomes and give babies the best start in life, ensuring lifelong health benefits.Conclusion:Despite promising results from well-documented cases, only a small number of these alternative strategies have been studied in clinical trials. The development of new drugs and the use of medicinal plants and probiotics for the treatment and/or prevention of preterm birth is an area of growing interest due to their potential therapeutic benefits in the field of gynecology and obstetrics.

A multi-method and structure-based in silico vaccine designing against Helicobacter pylori employing immuno-informatics approach

2020 ◽  
Vol 17 ◽  
Author(s):  
Anam Naz ◽  
Tahreem Zaheer ◽  
Hamza Arshad Dar ◽  
Faryal Mehwish Awan ◽  
Ayesha Obaid ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Vaccine Development ◽  
Amino Acid Sequences ◽  
The Body ◽  
New Drugs ◽  
Toll Like Receptor ◽  
Peptide Vaccines ◽  
Hla Alleles ◽  
Vaccine Candidates ◽  
H Pylori

Background: Helicobacter pylori infection and its treatment still remains a challenge to human health worldwide. A variety of antibiotics and combination therapies are currently used to treat H. pylori induced ulcers and carcinoma; however, no effective treatment is available to eliminate the pathogen from the body. Additionally, antibiotic resistance is also one of the main reasons for prolonged and persistent infection. Aim of the study: Until new drugs are available for this infection, vaccinology seems the only alternative opportunity to exploit against H. pylori induced diseases. Methods: Multiple epitopes prioritized in our previous study have been tested for their possible antigenic combinations, and results in 169-mer and 183-mer peptide vaccines containing the amino acid sequences of 3 and 4 epitopes respectively, along with adjuvant (Cholera Toxin Subunit B adjuvant at 5’ end) and linkers (GPGPG and EAAAK). Results: Poly-epitope proteins proposed as potential vaccine candidates against H. pylori include SabAHP0289-Omp16-VacA (SHOV), VacA-Omp16-HP0289-FecA (VOHF), VacA-Omp16-HP0289-SabA (VOHS), VacA-Omp16-HP0289-BabA (VOHB), VacA-Omp16-HP0289-SabA-FecA (VOHSF), VacAOmp16-HP0289-SabA-BabA (VOHSB) and VacA-Omp16-HP0289-BabA-SabA (VOHBS). Structures of these poly-epitope peptide vaccines have been modelled and checked for their affinity with HLA alleles and receptors. These proposed poly-epitope vaccine candidates bind efficiently with A2, A3, B7 and DR1 superfamilies of HLA alleles. They can also form stable and significant interactions with Toll-like receptor 2 and Toll-like receptor 4. Conclusion: Results suggest that these multi-epitopic vaccines can elicit a significant immune response against H. pylori and can be tested further for efficient vaccine development.

scholarly journals Trapping liquid drugs inside crystals

2014 ◽  
Vol 70 (a1) ◽  
pp. C984-C984
Author(s):  
Alessia Bacchi ◽  
Davide Capucci ◽  
Paolo Pelagatti
Keyword(s):  
Human Health ◽  
Crystal Engineering ◽  
Room Temperature ◽  
The Body ◽  
New Materials ◽  
Active Molecule ◽  
Crystalline Materials ◽  
Pharmaceutical Ingredients ◽  
Solid Dosage ◽  
Intellectual Properties

The objective of this work is to embed liquid or volatile pharmaceuticals inside crystalline materials, in order to tune their delivery properties in medicine or agrochemistry, and to explore new regulatory and intellectual properties issues. Liquid or volatile formulations of active pharmaceutical ingredients (APIs) are intrinsically less stable and durable than solid forms; in fact most drugs are formulated as solid dosage because they tend to be stable, reproducible, and amenable to purification. Most drugs and agrochemicals are manufactured and distributed as crystalline materials, and their action involves the delivery of the active molecule by a solubilization process either in the body or on the environment. However some important compounds for the human health or for the environment occur as liquids at room temperature. The formation of co-crystals has been demonstrated as a means of tuning solubility properties of solid phases, and therefore it is widely investigated by companies and by solid state scientists especially in the fields of pharmaceuticals, agrochemicals, pigments, dyestuffs, foods, and explosives. In spite of this extremely high interest towards co-crystallization as a tool to alter solubility, practically no emphasis has been paid to using it as a means to stabilize volatile or labile or low-melting products. In this work we trap and stabilize volatile and liquid APIs and agrochemicals in crystalline matrices by engineering suitable co-crystals. These new materials alter the physic state of the active ingredients allowing to expand the phase space accessible to manufacturing and delivery. We have defined a benchmark of molecules relevant to human health and environment that have been combined with suitable partners according to the well known methods of crystal engineering in order to obtain cocrystals. The first successful results will be discussed; the Figure shows a cocrystal of propofol, a worldwide use anesthetic.

scholarly journals Migration of Silver and Copper Nanoparticles from Food Coating

Coatings ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 380
Author(s):  
Hamed Ahari ◽  
Leila Khoshboui Lahijani
Keyword(s):  
Copper Nanoparticles ◽  
Inductively Coupled Plasma ◽  
Food Packaging ◽  
Human Life ◽  
Analytical Techniques ◽  
Optical Emission ◽  
Atomic Emission ◽  
The Body ◽  
Toxic Effects ◽  
Inductively Coupled

Packaging containing nanoparticles (NPs) can increase the shelf life of products, but the presence of NPs may hazards human life. In this regard, there are reports regarding the side effect and cytotoxicity of nanoparticles. The main aim of this research was to study the migration of silver and copper nanoparticles from the packaging to the food matrix as well as the assessment techniques. The diffusion and migration of nanoparticles can be analyzed by analytical techniques including atomic absorption, inductively coupled plasma mass spectrometry, inductively coupled plasma atomic emission, and inductively coupled plasma optical emission spectroscopy, as well as X-ray diffraction, spectroscopy, migration, and titration. Inductively coupled plasma-based techniques demonstrated the best results. Reports indicated that studies on the migration of Ag/Cu nanoparticles do not agree with each other, but almost all studies agree that the migration of these nanoparticles is higher in acidic environments. There are widespread ambiguities about the mechanism of nanoparticle toxicity, so understanding these nanoparticles and their toxic effects are essential. Nanomaterials that enter the body in a variety of ways can be distributed throughout the body and damage human cells by altering mitochondrial function, producing reactive oxygen, and increasing membrane permeability, leading to toxic effects and chronic disease. Therefore, more research needs to be done on the development of food packaging coatings with consideration given to the main parameters affecting nanoparticles migration.

scholarly journals What Did We Accomplish in Fighting Radical Species in Human Health?

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 466
Author(s):  
Rachid Skouta
Keyword(s):  
Reactive Oxygen Species ◽  
Human Health ◽  
Reactive Nitrogen Species ◽  
Reactive Oxygen ◽  
The Body ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Radical Species ◽  
Physiological Level

Maintaining the physiological level of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the body is highly important in the fight against radical species in the context of human health [...]

scholarly journals Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 229
Author(s):  
JunHyuk Woo ◽  
Hyesun Cho ◽  
YunHee Seol ◽  
Soon Ho Kim ◽  
Chanhyeok Park ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
Computational Models ◽  
Neuronal Damage ◽  
Living Organism ◽  
The Body ◽  
Mitochondrial Functions ◽  
A Cell ◽  
The Brain ◽  
And Oxidative Stress

The brain needs more energy than other organs in the body. Mitochondria are the generator of vital power in the living organism. Not only do mitochondria sense signals from the outside of a cell, but they also orchestrate the cascade of subcellular events by supplying adenosine-5′-triphosphate (ATP), the biochemical energy. It is known that impaired mitochondrial function and oxidative stress contribute or lead to neuronal damage and degeneration of the brain. This mini-review focuses on addressing how mitochondrial dysfunction and oxidative stress are associated with the pathogenesis of neurodegenerative disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and Parkinson’s disease. In addition, we discuss state-of-the-art computational models of mitochondrial functions in relation to oxidative stress and neurodegeneration. Together, a better understanding of brain disease-specific mitochondrial dysfunction and oxidative stress can pave the way to developing antioxidant therapeutic strategies to ameliorate neuronal activity and prevent neurodegeneration.

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