Abstract P010: Mid-life Vitamin D Levels and Later Life Performance on Neuropsychological Testing: The Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Oluwaseun E Fashanu ◽  
Di Zhao ◽  
Andrea L Schneider ◽  
Andreea M Rawlings ◽  
Richey A Sharrett ◽  
...  
Keyword(s):  
Vitamin D ◽  
Neuropsychological Testing ◽  
Late Life ◽  
Later Life ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Atherosclerosis Risk In Communities ◽  
Vitamin D Levels ◽  
And Performance ◽  
Age Range

Background: Prior cross-sectional studies among older adults have found associations between low vitamin D (vitD) levels and reduced cognitive performance but were unable to distinguish the temporal order between vitD and the onset of dementia. We examined the association between mid-life vitD levels, assessed by serum 25-hydroxyvitD, with later life performance on neuropsychological testing. Methods: We conducted a non-concurrent cross-sectional analysis of 5,887 white and black participants enrolled in the ARIC Neurocognitive Study. We included participants who had serum vitD concentrations measured at visit 2 (1990-1992; age range 47-69 years) and who had neuropsychological and functional testing at visit 5 (2011-2013; age range 67-91 years). Neuropsychological tests were grouped into memory, language, and executive function domains and were standardized. We categorized vitD using clinical cut points as deficient (<20 ng/mL), intermediate (20-<30 ng/mL), or sufficient (≥ 30 ng/mL). We used Poisson and linear regression models adjusted for demographic and socioeconomic factors to examine the associations between vitD with prevalent dementia and performance on neuropsychological testing. Results: In mid-life, the mean (SD) age of participants was 56 (5) years, 60% were female, and 22% black. Mean (SD) vitD was 24.6 (8.4) ng/mL; 30% had deficient, 46% intermediate, and 24% sufficient vitD levels. Compared to participants with sufficient vitD levels, the prevalence ratios (95% CI) of late-life dementia were 1.35 (0.99, 1.84) and 1.27 (0.90, 1.80) for participants with intermediate and deficient vitD levels, respectively. We found no significant association between mid-life vitD and late-life performance on neuropsychological testing ( Table ). Further adjustments for cardiovascular, genetic, and metabolic factors yielded similar results. Conclusion: In this cohort, mid-life serum vitD levels were not associated with prevalent dementia or with performance on neuropsychological testing 20 years later.

scholarly journals The Association Between Hypovitaminosis D Status with Muscle Strength and Functional Capacity in a Brazilian Community-Dwelling Elderly Population: A Cross- Sectional Study

2021 ◽  
Author(s):  
Aimee de Araujo Cabral Pelizari ◽  
Danielle Aparecida Gomes Pereira ◽  
Daniele Sirineu Pereira ◽  
Adriana Netto Parentoni ◽  
Leani Souza Máximo Pereira
Keyword(s):  
Vitamin D ◽  
Muscle Strength ◽  
Functional Capacity ◽  
Elderly Population ◽  
Hypovitaminosis D ◽  
Community Dwelling ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Vitamin D Levels

Abstract Background: Although there have been studies on the association between hypovitaminosis D status with muscle strength and functional capacity, there were few studies on Brazilian community-dwelling elderly population. Therefore, this study aims to assess the association of hypovitaminosis D with muscle strength and functional capacity in a sample Brazilian community-dwelling elderly population.Methods: An analytical, cross-sectional observational study with a convenience sample was conducted. The 25(OH)D levels were assessed using an enzyme-linked fluorescent assay and classified according to the standardization of the Brazilian Society of Clinical Pathology/Laboratory Medicine. Hand grip strength (HGS) and isometric quadriceps strength (IQS) were measured using manual Jamar® and Lafayette® 01165 dynamometers, respectively. Functional capacity was evaluated using the Short Physical Performance Battery (SPPB). Multiple linear regression models were used to assess the association of hypovitaminosis D with the HGS, IQS, and SPPB score via the Enter method. The models were adjusted for age, sex, presence of pain, level of physical activity, and use of vitamin D supplementation. Results: A total of 150 elderly individuals (age: 67.18±5.33 years) were included. According to the 25(OH)D levels, 60.7% had hypovitaminosis D (insufficient: 48%, deficient: 12.7%), and 39.3% had sufficient levels. No associations were found between hypovitaminosis D and the HGS (p=0.84), LogIQS (p=0.462), and SPPB score (p=0.617). In the regression model, the influence of the vitamin D levels on functional capacity was not significant, demonstrating no association between them.Conclusion: Hypovitaminosis D was not associated with decreased muscle strength and functional capacity in the sample Brazilian community-dwelling elderly population. Longitudinal studies with measurement of the time of use and levels of vitamin D are encouraged.

scholarly journals Changes in vitamin D levels and depressive symptoms in later life in England

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Giorgio Di Gessa ◽  
Jane P. Biddulph ◽  
Paola Zaninotto ◽  
Cesar de Oliveira
Keyword(s):  
Vitamin D ◽  
Depressive Symptoms ◽  
Later Life ◽  
Vitamin D Supplementation ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Representative Study ◽  
Increased Risk ◽  
Vitamin D Levels

AbstractInadequate vitamin D levels have been associated with increased risk of depression. However, most of these studies are cross-sectional and failed to investigate the effect of changes in vitamin D levels. This study aimed to investigate the longitudinal association of changes in serum 25-hydroxyvitamin D levels with depressive symptoms in 3365 participants of the English Longitudinal Study of Ageing, a large nationally-representative study of older adults. Based on their vitamin D levels at baseline and follow-up (sufficient ≥ 50 nmol/L; insufficient < 50 nmol/L), participants were classified as follows: with sufficient levels at both waves; with sufficient levels at baseline but not at follow-up; with insufficient levels at baseline but ≥ 50 nmol/L at follow-up; and with levels < 50 nmol/L at each time point. Depressive symptoms were measured using the 8-point CES-D scale. Data were analysed using logistic regression models. Compared with those with sufficient levels of vitamin D at both waves, only those with insufficient levels throughout were more likely to report elevated depressive symptoms (OR = 1.39, 95% CI = 1.00–1.93). Becoming or no longer being vitamin D deficient was, in the short term, not associated with elevated depressive symptoms. Further evidence is required on whether vitamin D supplementation might contribute to the prevention or treatment of depression as well as on the duration of time for changes in vitamin D levels to lead to detectable changes in depressive symptoms.

Abstract MP22: Vitamin D and Subclinical Cerebrovascular Disease: The Atherosclerosis Risk in Communities (ARIC) Brain MRI Ancillary Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Andrea L Schneider ◽  
Kathryn A Carson ◽  
Pamela L Lutsey ◽  
Li Xing ◽  
Alvaro Alonso ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cerebrovascular Disease ◽  
Repeated Measures ◽  
Brain Mri ◽  
Brain Magnetic Resonance Imaging ◽  
Cross Sectional ◽  
Atherosclerosis Risk In Communities ◽  
Logistic Regression Models ◽  
Ancillary Study ◽  
Vitamin D Levels

Introduction: Vitamin D deficiency has been associated with incident clinical stroke. Less is known about the association of vitamin D levels, measured by 25-hydroxyvitamin D [25(OH)D], with subclinical cerebrovascular disease. Hypothesis: We hypothesized that lower levels of 25(OH)D would be associated both cross-sectionally and longitudinally with subclinical cerebrovascular disease, defined by white matter hyperintensities (WMHs) and infarcts on brain magnetic resonance imaging (MRI). Methods: We conducted cross-sectional (1993-1995) and longitudinal (1993-1995 to 2004-2006) analyses of 1,622 participants in the ARIC Brain Ancillary Study with measured 25(OH)D (1993-1995) and without a history of clinical stroke/TIA. These participants underwent a brain MRI in 1993-1995 and a subset underwent a second brain MRI in 2004-2006 (n=888). 25(OH)D measurement was repeated in a subset of blacks in 2004-2006 (n=404). 25(OH)D was analyzed in race-specific quartiles and continuously. Brain MRIs were scored for WMHs and infarcts. Adjusted race-stratified linear and logistic regression models were used. Results: Mean age of participants was 62 years, 60% were female, and 49% were black. Mean 25(OH)D was higher in whites than blacks (25.6 versus 17.3 ng/ml, p0.05). In prospective analyses, lower 25(OH)D levels were also not significantly associated with change in WMH volume or with incident infarcts (Table). In the subset of blacks with repeated measures of 25(OH)D, there was no association between change in 25(OH)D levels with incident infarcts on brain MRI over 10 years (OR [per 1 SD decrease in 25(OH)D]: 1.30, 95% CI: 0.94, 1.81). Conclusion: 25(OH)D was not significantly associated with WMHs, subclinical infarcts, or their progression on serial brain MRIs obtained approximately 10 years apart, suggesting that 25(OH)D levels are not associated with subclinical cerebrovascular disease.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Association of Vitamin D Status With Liver and Kidney Disease: A Systematic Review of Clinical Trials, and Cross-Sectional and Cohort Studies

2019 ◽  
pp. 1-13 ◽  
Author(s):  
Seyed Mostafa Parizadeh ◽  
Majid Rezayi ◽  
Reza Jafarzadeh-Esfehani ◽  
Amir Avan ◽  
Hamideh Ghazizadeh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Kidney Disease ◽  
Renal Disease ◽  
Cohort Studies ◽  
Cochrane Library ◽  
Major Public Health Problem ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Beneficial Effects ◽  
Vitamin D Levels

Abstract. Background: Vitamin D deficiency (VDD) is a major public health problem. There are few comprehensive systematic reviews about the relationship between Vitamin D status and liver and renal disease in Iran. Methods: We systemically searched the following databases: Web of Science; PubMed; Cochrane Library; Scopus; Science Direct; Google Scholar and two Iranian databases (Scientific Information Database (SID) and IranMedex) up until November 2017 to identify all randomized control trials (RCTs), case control, cross-sectional and cohort studies investigating the association between vitamin D and any form of liver or kidney disease. Results: Vitamin D insufficiency, or deficiency (VDD), is highly prevalent in Iran, reports varying between 44.4% in Isfahan to 98% in Gorgan. There is also a high prevalence of VDD among patients with liver or kidney disease, and the administration of vitamin D supplements may have beneficial effects on lipid profile, blood glucose, liver function and fatty liver disease, and bone health. Low serum vitamin D levels are related with abnormalities in these laboratory and clinical parameters. Conclusion: VDD is prevalent in patients with chronic liver or renal disease in Iran. There appear to be several beneficial effects of vitamin D supplementation in vitamin D deficient patients with liver or kidney disease.

Vitamin D Levels, APOE Allele, and MRI Volumetry Assessed by NeuroQuant in Norwegian Adults with Cognitive Symptoms

2021 ◽  
Vol 79 (1) ◽  
pp. 311-321
Author(s):  
Jelena Zugic Soares ◽  
Renate Pettersen ◽  
Jūratė Šaltytė Benth ◽  
Karin Persson ◽  
Carsten Strobel ◽  
...  
Keyword(s):  
Vitamin D ◽  
Late Onset ◽  
Apoe Genotype ◽  
Serum Levels ◽  
Grey Matter Volume ◽  
Cognitive Symptoms ◽  
Cross Sectional ◽  
Brain Volumes ◽  
Vitamin D Levels ◽  
Mri Volumetry

Background: Allele ɛ4 of the apolipoprotein (APOE ∈4) gene is the strongest known genetic risk factor for late-onset sporadic Alzheimer’s disease. A possible relationship between vitamin D and APOE is not yet clear. Objective: In this exploratory, cross-sectional study, we examined the association between serum levels of 25-hydroxyvitamin D [25(OH)D] and brain volumes and the associations of both serum levels of 25(OH)D and APOE polymorphism to brain volumes in 127 persons (mean age 66 years) with cognitive symptoms. Methods: All subjects were examined with fully automated software for MRI volumetry, NeuroQuant. Results: After adjustment for relevant covariates, higher serum 25(OH)D levels were associated with greater volumes of cortical gray matter on both left (p = 0.02) and right (p = 0.04) sides. When both 25(OH)D levels and APOE genotype were used as the main covariates, no significant associations were found between vitamin D level and brain volume in any of the 11 brain regions. In adjusted models, only homozygous but not heterozygous APOE ∈4 allele carriers had significantly larger inferior lateral ventricles (p = 0.003) and smaller hippocampal volume (p = 0.035) than those without ɛ4. Homozygous APOE ∈4 carriers also had significantly higher vitamin D levels (p = 0.009) compared to persons without the APOE ∈4 allele. Conclusion: Higher vitamin D levels might have a preserving effect on cortical grey matter volume.

scholarly journals High prevalence of peripheral neuropathy in multiple myeloma patients and the impact of vitamin D levels, a cross-sectional study

2021 ◽  
Author(s):  
B. E. Oortgiesen ◽  
J. A. Kroes ◽  
P. Scholtens ◽  
J. Hoogland ◽  
P. Dannenberg - de Keijzer ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Clinical Trial Registration ◽  
Cross Sectional ◽  
Validated Questionnaire ◽  
Vitamin D Levels ◽  
The Impact

Abstract Purpose Peripheral neuropathy (PN) is common in patients with multiple myeloma (MM). We hypothesized that the relationship between hypovitaminosis D and PN described in diabetes mellitus patients may also be present in MM patients. Methods To study this potential association, we assessed the incidence of hypovitaminosis D (vitamin D < 75 nmol/L [= 30 ng/mL]) in smouldering and active MM patients in two Dutch hospitals. Furthermore, a validated questionnaire was used to distinguish different PN grades. Results Of the 120 patients included between January 2017 and August 2018, 84% had an inadequate vitamin D level (median vitamin D level 49.5 nmol/L [IQR 34–65 nmol/L]; mean age: 68 years [SD ± 7.7]; males: 58%). PN was reported by 69% of patients (n = 83); however, of these 83 patients, PN was not documented in the medical records of 52%. An association was found between lower vitamin D levels and higher incidence of PN in the total population (P = 0.035), and in the active MM patients (P = 0.016). Conclusion This multi-centre cohort study showed that PN and hypovitaminosis D are common in MM patients, and addressing low vitamin D levels in the treatment of MM patients might be beneficial in reducing the risk of PN. More attention for PN is warranted, as PN is underreported by clinicians. Further research is needed to fully understand the implications of vitamin D in the development of PN in patients with MM. Clinical trial registration Netherland Trial Register NL5835, date of registration July 28, 2016

The Biochemical Parameters and Vitamin D Levels in ICU Patients with Covid-19: A Cross-Sectional Study

2021 ◽  
Vol 21 ◽  
Author(s):  
Hamed Abdollahi ◽  
Farahnaz Salehinia ◽  
Mostafa Badeli ◽  
Elmira Karimi ◽  
Hossein Gandomkar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Immune System ◽  
Liver Enzymes ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Elevated Liver Enzymes ◽  
Vitamin D Levels

Background: In Covid-19 infection, leukopenia, inflammation, and elevated liver enzymes are found in most patients. Also, vitamin D deficiency attenuate the immune system and predispose a person more susceptible to infection. In this context, we aimed to evaluate vitamin D, Electrolytes, Complete blood count, Liver enzymes, Urea, Creatinine, Albumin, CRP and ESR levels in patients with Covid-19. Methods: We conducted a cross-sectional study on 118 patients with Covid-19 who were hospitalized from 2020/2/19 to 2020/4/3 in ICU. Serum levels of electrolytes, liver enzymes, blood factors, urea, creatinine, CRP and ESR as well as anthropometric parameters and serum vitamin D concentration were measured. Results: A total of 118 patients (80 male and 38 female) was enrolled in the study (65.05±15.75 years). Only 5.08% of patients had no risk factors and 55.9% had ≥ 2 risk factors. Diabetes (44.1%) and obesity (23.7%) were more common among patients. Laboratory finding showed that 80.50% of patients had hyponatremia, but other electrolytes included K, Mg, Ca and P were normal in majority of participants as well as CBC, Cr, Urea, Alb, ALT and ALKP. The AST concentration increased in most patients (66.94%). All patients had high levels of inflammatory factors such as CRP and ESR. The mean of 25-hydroxy-vitamin D levels in participants (25.95 ± 14.56 ng/mL) was lower than its levels in general papulation. However, it was not statistically significant (P= 0.88). A significant negative correlation found between vitamin D and ALT (P= 0.02, -0.21) as well as vitamin D and CRP (P= 0.05, -0.17). Conclusion: Regarding to the regulatory role of vitamin D in immune system and low levels of vitamin D in Covid-19 infected patients, the evaluation of vitamin D levels and prescribe supplements if necessary is suggested.

A CORRELATIONAL STUDY BETWEEN VITAMIN D LEVELS IN COVID 19 POSITIVE PATIENTS IN GCS HOSPITAL.

2021 ◽  
pp. 53-53
Author(s):  
Shraddha Tewari ◽  
Tushar Patel ◽  
Rushi Patel ◽  
Naresh Patel
Keyword(s):  
Vitamin D ◽  
Clinical Outcome ◽  
Clinical Presentation ◽  
Inclusion Criteria ◽  
Oxygen Requirement ◽  
Presentation Duration ◽  
Cross Sectional ◽  
Prolonged Hospitalisation ◽  
Duration Of Hospital Stay ◽  
Vitamin D Levels

This is a study to correlate vitamin D levels in Covid positive patients admitted in GCS medical hospital, Ahmedabad .Covid 19 can vary in clinical presentation in different patients owing to their age , comorbidities and various other factors. It is now being studied whether Vitamin D levels have any bearing on initial presentation, duration of hospital stay, oxygen requirement and clinical outcome. It is a cross sectional observational study taking into account 100 patients. After applying inclusion criteria, 94 patients were selected ,out of which 37 were vitamin D decient.(39.36%). Mean vitamin D was 17.16 ±10.85 ng/ml. Out of 94 patients 55 were males and 39 were females.34% males(18) were found to be vitamin D decient and in females 51%(19)were vitamin D decient. 38% (14)of vitamin D decient people required oxygen and 48%of vitamin D decient Covid positive patients(17) required prolonged hospitalisation.

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