Abstract P203: Dietary Magnesium, C-reactive Protein and Interleukin-6: The Strong Heart Family Study

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Nandana Rao ◽  
Rozenn Lemaitre ◽  
Colleen Sitlani ◽  
Jason G Umans ◽  
Lyle G BEST ◽  
...  
Keyword(s):  
American Indians ◽  
Interleukin 6 ◽  
Family Study ◽  
The United States ◽  
Future Research ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Strong Heart Family Study

Background: Both experimental animal and human observational studies have suggested that magnesium (Mg) deficiency influences systemic inflammation. Whether this association is modified by genes associated with Mg metabolism and transport is unknown. Objective: To examine associations of reported Mg intake, and the interaction of reported Mg intake with a single nucleotide polymorphisms (SNP) related to Mg metabolism and transport, on serum markers of inflammation (i.e., C-reactive protein (CRP) and interleukin 6 (IL-6)). Methods: This cross-sectional study included 1,924 participants from the Strong Heart Family Study—a study of risk factors for cardiovascular diseases among American Indians (AIs) from 12 communities in the United States. Intake of Mg from foods and dietary supplements was ascertained using a 119-item Block food frequency questionnaire. Serum hsCRP and IL-6 were measured from blood collected after a 12-hour fast, and candidate SNP (rs3740393) was genotyped using MetaboChip. Generalized estimating equations, with clusters defined by family membership, were used to examine associations of Mg intake, and the interaction of rs3740393 with estimated dietary Mg, on CRP and IL-6. Results: FFQ-estimated Mg intake was not associated with CRP or IL-6. We observed no interaction of reported Mg intake with rs3740393 on CRP (p-interaction=0.70). However, we observed an interaction (p-interaction=0.018) of reported Mg intake with rs3740393 on IL-6. (Table). Conclusion: Reported Mg intake is inversely associated with serum IL-6 among carriers of the C allele at rs3740393. Future research is necessary to replicate this finding, and to examine other Mg-related genes that may influence associations of Mg intake or sufficiency with inflammation.

scholarly journals Social Integration, Daily Discrimination, and Biological Markers of Health in Mid- and Later Life: Does Self-Esteem Play an Intermediary Role?

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Jeffrey E Stokes
Keyword(s):  
Social Integration ◽  
Biological Markers ◽  
Interleukin 6 ◽  
Later Life ◽  
The United States ◽  
Self Esteem ◽  
Equation Modeling ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Markers Of Inflammation

Abstract Background and Objectives This cross-sectional study examines associations of social integration and daily discrimination with 4 biological markers of inflammation and cardiovascular health and tests whether self-esteem may mediate any of these effects. Research Design and Methods Data came from 746 participants of the National Survey of Midlife Development in the United States (MIDUS) Refresher (2011–2014) and MIDUS Refresher Biomarker Project (2012–2016). Structural equation modeling estimated direct and indirect associations of social integration and daily discrimination with glycosylated hemoglobin (HbA1c), high-density lipoprotein (HDL), C-reactive protein, and interleukin-6. Results Social integration and daily discrimination were both significantly associated with self-esteem, which was in turn associated with HbA1c, HDL, and interleukin-6 levels. Social integration was indirectly associated with HbA1c, HDL, and interleukin-6 via self-esteem. Daily discrimination was directly associated with HbA1c, C-reactive protein, and interleukin-6 and was indirectly associated with HDL and interleukin-6 via self-esteem. Discussion and Implications Findings identify social correlates of inflammation and cardiovascular risk and suggest that self-esteem may serve as a pathway for effects. Overall, results were somewhat mixed: Daily discrimination was directly associated with both self-esteem and 3 of the 4 biological markers of health; however, although social integration was strongly associated with self-esteem, it was only weakly and indirectly associated with biological health markers. Moreover, the indirect effects of daily discrimination on the biomarker outcomes—while significant—were notably smaller than its direct effects. Implications for theory, practice, and future research are discussed, including the need for further study of self-esteem and physical health across mid- and later life.

scholarly journals Physical activity mediates the association between personality and biomarkers of inflammation

2018 ◽  
Vol 6 ◽  
pp. 205031211877499 ◽  
Author(s):  
Eileen K Graham ◽  
Emily D Bastarache ◽  
Elizabeth Milad ◽  
Nicholas A Turiano ◽  
Kelly A Cotter ◽  
...  
Keyword(s):  
Physical Activity ◽  
United States ◽  
Interleukin 6 ◽  
Serum Levels ◽  
The United States ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Midlife Development ◽  
Health Behavior Model

Objectives: The current study investigated whether personality traits and facets were associated with interleukin-6, C-reactive protein, and fibrinogen, and whether physical activity mediated the relationship between personality and biomarkers of inflammation. Methods: Personality was assessed in the Midlife Development in the United States study using the Multi-Dimensional Personality Questionnaire and Midlife Development Inventory personality scale. Data were included from 960 participants (mean age = 57.86 years, standard deviation = 11.46). Personality was assessed from 2004 to 2009. Serum levels of interleukin-6, fibrinogen, and C-reactive protein were assessed in 2005–2009 as part of the Midlife Development in the United States biomarkers subproject. Results: Lower neuroticism was associated with elevated interleukin-6, and achievement was associated with lower fibrinogen. Higher physical activity was associated with lower interleukin-6 and C-reactive protein. Mediation models suggested that physical activity mediated the associations between achievement and both interleukin-6 and C-reactive protein. Discussion: Physical activity is an important factor in the Health Behavior Model of personality and explains some of the associations between personality and inflammation. These findings contribute to the fields of aging and health by linking individual difference factors to markers of inflammation, and showing that these processes may function partially through specific behaviors, in this case physical activity.

scholarly journals MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN: DIAGNOSTIC MARKERS AND FEATURES OF PHARMACOTHERAPY

2021 ◽  
Vol 17 (1) ◽  
pp. 24-28
Author(s):  
M.V. Кhaitovych ◽  
L.M. Voroniuk ◽  
G.Yu. Borisova ◽  
N.V. Diudenko ◽  
N.M. Miagka
Keyword(s):  
Distress Syndrome ◽  
The United States ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Laboratory Markers ◽  
Mucous Membranes ◽  
Coronavirus Infection ◽  
Polymerase Chain ◽  
Inflammatory Syndrome

Relevance. In 2020, children were hospitalized with fever and multisystem inflammation throughout the world during the COVID-19 pandemic. In the United States, this condition is called MIS-C (Multisystem Inflammatory Syndrome in Children). This syndrome is thought to be similar to the severe course of COVID-19 in adults (cytokine storm). The objective of the work is to evaluate the features of the course and pharmacotherapy of multisystem inflammatory syndrome in children. Materials and methods. The study included 17 children (10 boys and 7 girls) aged 3-16 years (on average – 9.5±3.4 years). Diagnosis of coronavirus infection was performed by polymerase chain reaction with real-time detection, determined the level of immunoglobulins M and G before coronavirus infection. Results. The duration of fever in patients was 5-21 days (average 8.1±4.0 days), the duration of inpatient treatment – 7-35 days (average 15.7±7.0 days). Blood albumin levels were reduced in 53.8% of children; the level of fibrinogen was increased in 88.2% of children, the level of C-reactive protein, ferritin, and D-dimer – in all patients. 15 (88.2%) children had pathology of the digestive system, 13 (76.5%) – cardiovascular system (7 children were diagnosed with carditis, 2 – dilation of coronary arteries, 7 – cardiac arrhythmia). Acute respiratory distress -syndrome was found in a 13-year-old girl, shock - in an 11-year-old boy, 11 children (64.7%) were diagnosed with the pathology of the respiratory system (pleurisy, pneumonia), skin and mucous membranes, and 4 children (23.5%) there were manifestations of central nervous system disorders (meningism, decreased reflexes, ataxia), in 2 (11.8%) – renal failure. On average, each patient had lesions of 3.9 ±1.2 systems. Conclusions. MIS-C was manifested by prolonged fever, high levels of laboratory markers of inflammation, hypoalbuminemia, hypercoagulation, often – pathological manifestations of the cardiovascular, digestive, respiratory systems, skin, and mucous membranes. The treatment included intravenous immunoglobulin, steroids, anticoagulant, and antibacterial therapy and was effective.

Systemic inflammatory response syndrome without systemic inflammation in acutely ill patients admitted to hospital in a medical emergency

1999 ◽  
Vol 96 (3) ◽  
pp. 287-295 ◽  
Author(s):  
Annika TAKALA ◽  
Irma JOUSELA ◽  
Klaus T. OLKKOLA ◽  
Sten-Erik JANSSON ◽  
Marjatta LEIRISALO-REPO ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Systemic Inflammation ◽  
Interleukin 6 ◽  
Systemic Inflammatory Response ◽  
Composite Score ◽  
C Reactive Protein ◽  
Cd11b Expression ◽  
Reactive Protein ◽  
Markers Of Inflammation

Criteria of the systemic inflammatory response syndrome (SIRS) are known to include patients without systemic inflammation. Our aim was to explore additional markers of inflammation that would distinguish SIRS patients with systemic inflammation from patients without inflammation. The study included 100 acutely ill patients with SIRS. Peripheral blood neutrophil and monocyte CD11b expression, serum interleukin-6, interleukin-1β, tumour necrosis factor-α and C-reactive protein were determined, and severity of inflammation was evaluated by systemic inflammation composite score based on CD11b expression, C-reactive protein and cytokine levels. Levels of CD11b expression, C-reactive protein and interleukin-6 were higher in sepsis patients than in SIRS patients who met two criteria (SIRS2 group) or three criteria of SIRS (SIRS3 group). The systemic inflammation composite score of SIRS2 patients (median 1.5; range 0–8, n = 56) was lower than that of SIRS3 patients (3.5; range 0–9, n = 14, P = 0.013) and that of sepsis patients (5.0; range 3–10, n = 19, P< 0.001). The systemic inflammation composite score was 0 in 13/94 patients. In 81 patients in whom systemic inflammation composite scores exceeded 1, interleukin-6 was increased in 64 (79.0%), C-reactive protein in 59 (72.8%) and CD11b in 50 (61.7%). None of these markers, when used alone, identified all patients but at least one marker was positive in each patient. Quantifying phagocyte CD11b expression and serum interleukin-6 and C-reactive protein concurrently provides a means to discriminate SIRS patients with systemic inflammation from patients without systemic inflammation.

T- wave axis deviation is associated with biomarkers of low-grade inflammation

2015 ◽  
Vol 114 (12) ◽  
pp. 1199-1206 ◽  
Author(s):  
Marialaura Bonaccio ◽  
Augusto Di Castelnuovo ◽  
Livia Rago ◽  
Amalia De Curtis ◽  
Deodato Assanelli ◽  
...  
Keyword(s):  
Low Grade ◽  
Axis Deviation ◽  
C Reactive Protein ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Reactive Protein ◽  
T Wave ◽  
Markers Of Inflammation ◽  
T Wave Axis ◽  
Low Grade Inflammation

SummaryT-wave axis deviation (TDev) may help identifying subjects at risk for major cardiac events and mortality, but the pathogenesis of TDev is not well established; in particular, the possible association between TDev and inflammation is unexplored and unknown. We aimed at investigating the association between low-grade inflammation and TDev abnormalities by conducting a cross-sectional analysis on 17,507 subjects apparently free from coronary heart and haematological diseases enrolled in the MOLI-SANI study. TDev was measured from a standard 12-lead resting electrocardiogram. High sensitivity (Hs) C-reactive protein (CRP), leukocyte (WBC) and platelet counts, neutrophil or granulocyte to lymphocyte ratios were used as markers of inflammation. In multivariable model subjects reporting high CRP levels had higher odds of having borderline and abnormal TDev (OR=1.70; 95 %CI: 1.53–1.90 and OR=1.72; 95 %CI: 1.23–2.41, respectively); the association was still significant, although reduced, after controlling for body mass index (OR=1.17; 95 %CI: 1.05–1.32, for borderline and OR=1.46; 95 %CI: 1.03–2.08, for abnormal). Similarly, higher neutrophil or granulocyte to lymphocyte ratios were associated with increased odds of having abnormal TDev. Neither platelet nor leukocyte counts were associated with abnormal TDev. The relationship between CRP with TDev abnormalities was significantly stronger in men, in non- obese or normotensive individuals, and in those without metabolic syndrome. In conclusion, C-reactive protein and some cellular biomarkers of inflammation such as granulocyte or neutrophil to lymphocyte ratios were independently associated with abnormal TDev, especially in subjects at low CVD risk. These results suggest that a low-grade inflammation likely contributes to the pathogenesis of T- wave axis deviation.

Maternal and umbilical cord procalcitonin, high-sensitivity C-reactive protein, and interleukin-6 levels in preeclamptic and normotensive patients: A cross-sectional study

2020 ◽  
Vol 21 ◽  
pp. 218-223
Author(s):  
Mario I. Lumbreras-Marquez ◽  
Jesus Lumbreras-Marquez ◽  
Marcelo Barraza-Salas ◽  
Roberto A. Castillo-Reyther ◽  
Salvador De la Maza-Labastida ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Interleukin 6 ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein

scholarly journals The Impact of Educational Attainment on Black Women’s Obesity Rate in the United States

2019 ◽  
Vol 7 (2) ◽  
pp. 345-354 ◽  
Author(s):  
Gwenetta Denise Curry
Keyword(s):  
Black Women ◽  
Educational Attainment ◽  
White Women ◽  
The United States ◽  
C Reactive Protein ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Protein Levels ◽  
Reactive Protein ◽  
The Impact

AbstractOver the last two decades, Black women have been disproportionately impacted by the obesity epidemic in the USA. According to the Centers for Disease Control and Prevention (CDC), 56.6% of Black women are overweight or obese compared with 44.4% Hispanic and 32.8% of white women. Social scientists and public health researchers have argued that increasing educational attainment would lead to overall improvements in health outcomes. Using the National Health and Nutrition Examination Survey (NHANES), a nationally representative cross-sectional survey, Cycles 1999–2010, I examined how educational attainment impacts Black women’s rate of obesity and C-reactive protein levels (N = 2685). Multiple linear regression was used to analyze the association between body mass index (BMI) and educational attainment. C-reactive protein, inflammation response, was used to measure the body’s reaction to being exposed to stress. The results demonstrated that educational attainment among Black women does not decrease their risk of being obese or levels of C-reactive protein. This article provides evidence to support a need to increase awareness of health disparities that disproportionately impact Black women.

Inflammation-Related Factors Identified as Biomarkers of Dehydration and Subsequent Acute Kidney Injury in Agricultural Workers

2021 ◽  
pp. 109980042110160
Author(s):  
Madelyn C. Houser ◽  
Valerie Mac ◽  
Daniel J. Smith ◽  
Roxana C. Chicas ◽  
Nezahualcoyotl Xiuhtecutli ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Muscle Damage ◽  
Interleukin 6 ◽  
Kidney Injury ◽  
Agricultural Workers ◽  
Unknown Etiology ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Markers Of Inflammation ◽  
Work Shifts

Globally, there is increasing recognition that agricultural workers are at risk for chronic kidney disease of unknown etiology (CKD u). Recurrent heat exposure, physical exertion, dehydration, muscle damage, and inflammation are hypothesized to contribute to the development of CKD u, but the relative importance of these processes and the interactions among them remain unclear. Moreover, there is a need to identify biomarkers that could distinguish individuals who are at greatest risk for kidney damage to target preventative interventions for CKD u. In this study, we evaluated dehydration and markers of inflammation, muscle damage, and renal function in agricultural workers at a non-workday baseline assessment. Urine specific gravity and kidney function were measured before and after work shifts on three subsequent days, and heat index, core body temperature, and heart rate were monitored during the work shifts. A combination of direct comparisons and machine learning algorithms revealed that reduced levels of uromodulin and sodium in urine and increased levels of interleukin-6 and C-reactive protein in serum were indicative of dehydration at baseline, and that dehydration, high body mass index, reduced urine uromodulin, and increased serum interleukin-6, C-reactive protein, and lipopolysaccharide-binding protein at baseline were predictive of acute kidney injury on subsequent workdays. Our findings suggest a method for identifying agricultural workers at greatest risk for kidney injury and reveal potential mechanisms responsible for this process, including pathways overlapping in dehydration and kidney injury. These results will guide future studies confirming these mechanisms and introducing interventions to protect kidney health in this vulnerable population.

scholarly journals Evaluation of Serum Interleukin-6 and C-Reactive Protein Levels among Women During Term Labour

2020 ◽  
pp. 69-76
Author(s):  
Ubongabasi A. James ◽  
John O. Imaralu ◽  
Ijeoma Esiaba
Keyword(s):  
Interleukin 6 ◽  
Venous Blood ◽  
University Teaching ◽  
Enzyme Linked Immunosorbent Assay ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Blood Samples ◽  
Reactive Protein ◽  
Significant Difference ◽  
Term Labour

Aims: To determine the serum concentrations of C-reactive protein (CRP) and interleukin 6 (IL-6) as well as level of leukocytosis, as inflammatory contributory factors in women with uncomplicated term pregnancies before, during and after labour. Study Design:  This is a cross-sectional study. Place and Duration of Study: The study was carried out in the Department of Obstetrics and Gynaecology of Babcock University Teaching Hospital (BUTH) and Department of Biochemistry, Babcock University, Ogun State Nigeria between June 2019 and February 2020. Methodology: 45 venous blood samples were obtained from 34 selected women and grouped into three; prenatal (≥ 32 weeks, n = 18), labour (4 to 6 cm dilation, n = 12) and postnatal (≤ 24 hour postpartum, n = 15). Sixteen blood samples were also obtained from the umbilical cord. Levels of CRP and IL-6 were determined by Enzyme Linked Immunosorbent Assay (ELISA) techniques and the leukocyte count, by hematologic method. Differences in statistical mean were evaluated by one way analysis of variance (ANOVA) with Bonferroni post hoc comparison. The level of significance was set at P < 0.05. Results: Concentration of serum IL-6 was significantly high during labour (1354.79 ± 189.16 pg/mL) compared to the prenatal (14.94 ± 4.86 pg/mL, P < .001) and postnatal (13.17 ± 3.06 pg/mL, P < .001) periods. The low level of CRP observed during active labour compared to the prenatal and postnatal periods did not reach significant difference. The levels of these inflammatory markers were low in the cord blood. Leukocyte counts (P = .011) as well as neutrophils (P = .014) and MID cell fractions (P = .004) were significantly higher during the postnatal period. Conclusion: The high levels of serum IL-6 observed in this study supports human term labour as an inflammatory event not associated with increased leukocytosis.

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