The Impact of Childhood Experience on Amygdala Response to Perceptually Familiar Black and White Faces

2014 ◽  
Vol 26 (9) ◽  
pp. 1992-2004 ◽  
Author(s):  
Jasmin Cloutier ◽  
Tianyi Li ◽  
Joshua Correll
Keyword(s):  
Neural Substrates ◽  
Relative Reduction ◽  
Childhood Experience ◽  
Childhood Exposure ◽  
Interracial Contact ◽  
Black And White ◽  
Race Perception ◽  
Amygdala Response ◽  
The Impact ◽  
Black Faces

Given the well-documented involvement of the amygdala in race perception, the current study aimed to investigate how interracial contact during childhood shapes amygdala response to racial outgroup members in adulthood. Of particular interest was the impact of childhood experience on amygdala response to familiar, compared with novel, Black faces. Controlling for a number of well-established individual difference measures related to interracial attitudes, the results reveal that perceivers with greater childhood exposure to racial outgroup members display greater relative reduction in amygdala response to familiar Black faces. The implications of such findings are discussed in the context of previous investigations into the neural substrates of race perception and in consideration of potential mechanisms by which childhood experience may shape race perception.

scholarly journals Reduced beta cell number rather than size is a major contributor to beta cell loss in type 2 diabetes

Diabetologia ◽  
2021 ◽  
Author(s):  
Hironobu Sasaki ◽  
Yoshifumi Saisho ◽  
Jun Inaishi ◽  
Yuusuke Watanabe ◽  
Tami Tsuchiya ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Beta Cell ◽  
Cell Size ◽  
Cell Mass ◽  
Cell Number ◽  
Relative Reduction ◽  
Major Contributor ◽  
Islet Morphology ◽  
The Impact

Abstract Aims/hypothesis Type 2 diabetes is characterised by reduced beta cell mass (BCM). However, it remains uncertain whether the reduction in BCM in type 2 diabetes is due to a decrease in size or number of beta cells. Our aim was to examine the impact of beta cell size and number on islet morphology in humans with and without type 2 diabetes. Methods Pancreas samples were obtained from 64 Japanese adults with (n = 26) and without (n = 38) type 2 diabetes who underwent pancreatectomy. Using pancreatic tissues stained for insulin, we estimated beta cell size based on beta cell diameter. Beta cell number was estimated from the product of fractional beta cell area and pancreas volume divided by beta cell size. The associations of beta cell size and number with islet morphology and metabolic status were examined. Results Both beta cell size (548.7 ± 58.5 vs 606.7 ± 65.0 μm3, p < 0.01) and number (5.10 × 108 ± 2.35 × 108 vs 8.16 × 108 ± 4.27 × 108, p < 0.01) were decreased in participants with type 2 diabetes compared with those without diabetes, with the relative reduction in beta cell number (37%) being greater than for beta cell size (10%). Beta cell number but not size was positively correlated with BCM in participants with and without type 2 diabetes (r = 0.97 and r = 0.98, both p < 0.01) and negatively correlated with HbA1c (r = −0.45, p < 0.01). Conclusions/interpretation Both beta cell size and number were reduced in participants with type 2 diabetes, with the relative reduction in beta cell number being greater. Decrease in beta cell number appears to be a major contributor to reduced BCM in type 2 diabetes. Graphical abstract

scholarly journals Potential impact of a modest reduction in salt intake on blood pressure, cardiovascular disease burden and premature mortality: a modelling study

Open Heart ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. e000943 ◽  
Author(s):  
Leopold Ndemnge Aminde ◽  
Linda J Cobiac ◽  
J Lennert Veerman
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Heart Disease ◽  
Salt Intake ◽  
Sodium Intake ◽  
Premature Mortality ◽  
Relative Reduction ◽  
Life Years ◽  
Potential Impact ◽  
The Impact

ObjectiveTo assess the potential impact of reduction in salt intake on the burden of cardiovascular disease (CVD) and premature mortality in Cameroon.MethodsUsing a multicohort proportional multistate life table model with Markov process, we modelled the impact of WHO’s recommended 30% relative reduction in population-wide sodium intake on the CVD burden for Cameroonian adults alive in 2016. Deterministic and probabilistic sensitivity analyses were conducted and used to quantify uncertainty.ResultsOver the lifetime, incidence is predicted to decrease by 5.2% (95% uncertainty interval (UI) 4.6 to 5.7) for ischaemic heart disease (IHD), 6.6% (95% UI 5.9 to 7.4) for haemorrhagic strokes, 4.8% (95% UI 4.2 to 5.4) for ischaemic strokes and 12.9% (95% UI 12.4 to 13.5) for hypertensive heart disease (HHD). Mortality over the lifetime is projected to reduce by 5.1% (95% UI 4.5 to 5.6) for IHD, by 6.9% (95% UI 6.1 to 7.7) for haemorrhagic stroke, by 4.5% (95% UI 4.0 to 5.1) for ischaemic stroke and by 13.3% (95% UI 12.9 to 13.7) for HHD. About 776 400 (95% UI 712 600 to 841 200) health-adjusted life years could be gained, and life expectancy might increase by 0.23 years and 0.20 years for men and women, respectively. A projected 16.8% change (reduction) between 2016 and 2030 in probability of premature mortality due to CVD would occur if population salt reduction recommended by WHO is attained.ConclusionAchieving the 30% reduction in sodium intake recommended by WHO could considerably decrease the burden of CVD. Targeting blood pressure via decreasing population salt intake could translate in significant reductions in premature CVD mortality in Cameroon by 2030.

Race and Cultural Flexibility among Students in Different Multiracial Schools

2010 ◽  
Vol 112 (6) ◽  
pp. 1529-1574 ◽  
Author(s):  
Prudence L. Carter
Keyword(s):  
Black Students ◽  
White Students ◽  
Research Question ◽  
Mixed Race ◽  
Interview Data ◽  
Black And White ◽  
Cultural Flexibility ◽  
White School ◽  
Southern City ◽  
The Impact

Background/Context One of the most critical functions of a well-integrated school is the development of “culturally flexible” students who, over the course of their social development, effectively navigate diverse social environs such as the workplace, communities, and neighborhoods. Most studies, albeit with some exceptions, have investigated the impact of desegregation on short- and long-term gains in achievement and attainment, as opposed to its impact on intergroup relations. Mixed-race schools are vital not only for bolstering achievement outcomes of previously disadvantaged students but also for promoting social cohesion in a diverse society. Purpose/Objective/Research Question/Focus of Study Specifically, this article examines the difference in cultural flexibility between black and white students enrolled in schools with different racial and ethnic compositions. Cultural flexibility is defined as the propensity to value and move across different cultural and social peer groups and environments. Furthermore, this article provides some insight into how students in different mixed-race and desegregated educational contexts experience their school's social organization and cultural environments, which influence their interactions and academic behaviors. Setting The study was conducted over a 6-month period in four high schools: a majority-minority school and a majority-white school located in a northeastern city, and a majority-minority school and a majority-white school located in a southern city. Research Design Survey data were gathered from a randomly stratified sample of 471 Black and White students attending. In addition, ethnographic notes from weeks of school observations and transcribed interview data from 57 group interviews conducted in the four schools with students in Grades 9–12 complemented the survey research. Data Collection and Analysis Findings reveal significant associations among self-esteem, academic and extracurricular placement, and cultural flexibility for black students. Also, black students in majority-minority schools scored significantly higher on the cultural flexibility scale than those in majority-white schools. Among white students, regional location and academic placement showed statistically significant associations with cultural flexibility. The ethnographic and interview data further explicate why these patterns occurred and illuminate how certain school contextual factors are likely linked to students’ cultural flexibility. Overall, this study's findings highlight some connections between student and school behaviors as they pertain to both students’ and educators’ willingness and ability to realize the visions of racial and ethnic integration wholly.

Abstract P181: Contribution of C-Reactive Protein to Racial Disparities in Incident Hypertension: The REasons for Geographic And Racial Differences in Stroke Study (REGARDS)

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Timothy B Plante ◽  
D L Long ◽  
George Howard ◽  
April P Carson ◽  
Virginia J Howard ◽  
...  
Keyword(s):  
Racial Differences ◽  
Medication Use ◽  
Dietary Factors ◽  
C Reactive Protein ◽  
Incident Hypertension ◽  
Black And White ◽  
Reactive Protein ◽  
Stroke Study ◽  
Diet Pattern ◽  
The Impact

Introduction: In the US, blacks are at higher risk of hypertension than whites. The single largest contributor to this disparity is the Southern Diet pattern. Inflammation biomarkers are associated with risk of hypertension, and C-reactive protein (CRP) is higher in blacks than whites. We studied whether elevated CRP in blacks relative to whites contributes to the racial disparity in hypertension in blacks. Methods: We included 6,548 black and white men and women age ≥45 years from the REGARDS cohort without hypertension at baseline ('03-'07) and who completed visit 2 in '13-'16. Incident hypertension was defined as BP ≥140/90 mm Hg or hypertension medication use at visit 2. Using logistic regression, the black:white odds ratio (OR) for incident hypertension was calculated adjusting for age, sex, race, and baseline SBP. We assessed the percent change in the black:white OR for incident hypertension after adding CRP. The 95% CI was calculated using 1,000 bootstrapped samples. We determined the impact of known hypertension risk factors and anti-inflammatory medications on the percent mediation by CRP. Results: Hypertension developed in 46% of blacks and 33% of whites. Adjusting for demographics, the black:white OR (95% CI) was 1.51, which was reduced to 1.46, a 9.3% reduction (95% CI 5.4%, 13.2%) by CRP (Table). In models including exercise, waist circumference, BMI, and depressive symptoms, the percent mediation by CRP was 3.7% (1.0%, 6.4%). Similar patterns were seen for models incorporating socioeconomic factors and medication use. After adding Southern diet pattern and dietary Na/K ratio, CRP no longer attenuated the association (1.3% mediation; -1.5, 4.1). Conclusions: CRP significantly attenuated the black-white difference in incident hypertension; however, once dietary factors were accounted for, CRP had no impact on the black:white difference in incident hypertension. Thus, inflammation as measured by CRP, may be part of the reason that dietary factors influence the black:white disparity in incident hypertension.

Male Youth Activities and Metropolitan Context

1998 ◽  
Vol 30 (3) ◽  
pp. 385-399 ◽  
Author(s):  
S R Holloway
Keyword(s):  
Black Male ◽  
Metropolitan Areas ◽  
White Male ◽  
The United States ◽  
Theoretical Understanding ◽  
Trade Off ◽  
Black And White ◽  
Trade Offs ◽  
Activity Choices ◽  
The Impact

The research reported here examines the impact of metropolitan location on the activity choices of a sample of black and white male youths living in large metropolitan areas in the United States in 1980. The results of the analysis confirm that similar youths living in different metropolitan areas will make different activity choices. Furthermore, black male youths are found to be substantially more sensitive to metropolitan context than white male youths. The analysis also suggests that black and white disadvantaged youths respond differently to metropolitan context in terms of the trade-offs between activities. Disadvantaged black male youths are highly unlikely to be employed in all metropolitan areas and tend to trade-off staying in school with idleness, whereas disadvantaged white male youths tend to trade-off employment with idleness, depending on the metropolitan area they live in. This research confirms the importance of incorporating geographic context into our theoretical understanding of male youths' behavior. We must also, however, continue to address the implications of race as it shapes the context-dependent labor-market experiences of male youths.

scholarly journals The development of the cortisol response to dyadic stressors in Black and White infants

2018 ◽  
Vol 30 (5) ◽  
pp. 1995-2008 ◽  
Author(s):  
Andrew Dismukes ◽  
Elizabeth Shirtcliff ◽  
Christopher W. Jones ◽  
Charles Zeanah ◽  
Katherine Theall ◽  
...  
Keyword(s):  
Urban Life ◽  
First Year ◽  
Strange Situation ◽  
Cortisol Reactivity ◽  
Hypothalamic Pituitary Adrenal ◽  
Black And White ◽  
First Year Of Life ◽  
The Impact ◽  
Still Face Paradigm ◽  
Strange Situation Procedure

AbstractAcute reactivity of the stress hormone cortisol is reflective of early adversity and stress exposure, with some studies finding that the impact of adversity on the stress response differs by race. The objectives of the current study were to characterize cortisol reactivity to two dyadically based stress paradigms across the first year of life, to examine cortisol reactivity within Black and White infants, and to assess the impact of correlates of racial inequity including socioeconomic status, experiences of discrimination, and urban life stressors, as well as the buffering by racial socialization on cortisol patterns. Salivary cortisol reactivity was assessed at 4 months of age during the Still Face paradigm (N = 207) and at 12 months of age across the Strange Situation procedure (N = 129). Infants demonstrated the steepest recovery after the Still Face paradigm and steepest reactivity to the Strange Situation procedure. Race differences in cortisol were not present at 4 months but emerged at 12 months of age, with Black infants having higher cortisol. Experiences of discrimination contributed to cortisol differences within Black infants, suggesting that racial discrimination is already “under the skin” by 1 year of age. These findings suggest that race-related differences in hypothalamic–pituitary–adrenal reactivity are present in infancy, and that the first year of life is a crucial time period during which interventions and prevention efforts for maternal–infant dyads are most likely able to shape hypothalamic–pituitary–adrenal reactivity thereby mitigating health disparities early across the life course.

scholarly journals Reppoductive ability of ukrainian black and white dairy cows

2016 ◽  
Vol 18 (2) ◽  
Author(s):  
M. I. Kuziv ◽  
E. I. Fedorovych
Keyword(s):  
Milk Yield ◽  
Milk Fat ◽  
Reproductive Capacity ◽  
Dry Period ◽  
Black And White ◽  
Reproductive Ability ◽  
Service Period ◽  
Lactation Duration ◽  
The Impact ◽  
Period Duration

The major components of economically useful traits in cattle dairy productivity, which conducted the selection is milk productivity and reproductive ability of cows. Studies conducted on animals Ukrainian black and white dairy cattle in the «Milk River» farm in the Sokal and Brody offices breeding reproducers «Breeder» Lviv region and plant breeding «Yamnytsya» Ivano–Frankivsk region. Ukrainian black and white dairy breed in the western region of Ukraine is characterized by good reproductive ability. Depending on the husbandry and lactation duration, service period lasted within 87.4 – 121.5 day, intercalving period – within 364 – 402.6 day, dry period within – 47.3 – 72.9 day, the fertility index was 46.3 – 48.0, coefficient of reproductive ability – within 0.92–0.99,  output of calves per 100 cows – within 91.8 – 98.8. The duration of pregnancy in cows of different  farms and lactations were in range 277 – 283.5 day and meet the requirements of the physiological norm. It has been shown that the milk yield of cows depends on the parameters of reproductive capacity. The correlation between duration of service–period and intercalving period, and milk yield, milk fat in most cases was positive. Correlation dry period duration and parameters of milk yield changed from negative to positive. Depending on the husbandry, lactation and index the impact share of service–period duration on milk yield was 7.0 – 29.7, for intercalving period – 8.8 – 31.8, for dry period – 9.2 – 23.8% respectively.

scholarly journals Policy Evaluation Network (PEN): Protocol for systematic literature review examining the evidence for impact of school policies on physical activity

2020 ◽  
Vol 3 ◽  
pp. 62
Author(s):  
Kevin Volf ◽  
Liam Kelly ◽  
Enrique García Bengoechea ◽  
Blathin Casey ◽  
Anna Gobis ◽  
...  
Keyword(s):  
Physical Activity ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Policy Evaluation ◽  
Physical Inactivity ◽  
Action Plan ◽  
Relative Reduction ◽  
Global Action ◽  
The Impact ◽  
Global Action Plan

Introduction: Over 40 million deaths annually are due to noncommunicable diseases, 15 million of these are premature deaths and physical inactivity attributes an estimated 9% to this figure. Global responses have included the sustainable development goals and the global action plan on physical activity. Both point to policy action in physical activity (PA) to address change, yet the impact of policy is unknown.  The protocol described outlines a systematic literature review that will be undertaken by the Policy Evaluation Network to address this knowledge gap. Protocol: This review of school PA policies is the first of seven planned reviews. The seven best investments for promotion of population PA identified in the Toronto Charter (whole-of-school programmes, transport policy, urban design policy, primary health care policy, public education policy, community programmes and sport programmes) will form the basis of these reviews. Seven individual scientific literature searches across six electronic databases, using key concepts of policy, PA, evaluation and a distinct concept for each area will be conducted. This will be supplemented with a search of the reference list of included articles. Methodological quality will be assessed and overall effectiveness for each included study will be described according to pre-determined categories. Conclusions: The review will provide policy makers with a list of policy statements and corresponding actions which the evidence has determined impact on PA directly or indirectly. By collating the evidence, and demonstrating the depth of the science base which informs these policy recommendations, this review will provide guidance to policymakers to use evidence-based or evidence-informed policies to achieve the 15% relative reduction in physical inactivity as defined by the ‘Global Action Plan on Physical Activity’. Registration:  PROSPERO CRD42020156630 (10/07/2020).

scholarly journals Influence of seasonal changes on the karyotype stability of Ukrainian Black and White dairy cows

2020 ◽  
Vol 22 (93) ◽  
pp. 29-34
Author(s):  
N. Y. Temekh ◽  
L. F. Starodub
Keyword(s):  
Seasonal Changes ◽  
Age Groups ◽  
Summer Season ◽  
Black And White ◽  
Structural Disorders ◽  
Different Seasons ◽  
The Stability ◽  
The Impact ◽  
Dairy Breed ◽  
Karyotype Stability

Of the total dairy cattle, 49 % belong to the Ukrainian black-and-white dairy breed. Animals are demanding to the conditions of detention, so the aim of the study was to study the impact of seasonal changes in the environment on the stability of the karyotype of cows of three age groups (first-born, adult and cows 8–10 years). The variability of the karyotype of the studied animals in different seasons of the year was manifested in the form of quantitative and structural disorders of chromosomes. Of the total dairy cattle, 49 % belong to the Ukrainian black-and-white dairy breed. Animals are demanding to the conditions of detention, so the aim of the study was to study the impact of seasonal changes in the environment on the stability of the karyotype of cows of three age groups (first-born, adult and cows 8–10 years). The variability of the karyotype of the studied animals in different seasons of the year was manifested in the form of quantitative and structural disorders of chromosomes. In primiparous women, the most pronounced genomic variability (aneuploidy) was observed in summer and winter and was 16.4 % and 8.8 %. In summer, this variability was more than twice the limit of spontaneous chromosomal variability. The highest percentage of structural chromosome abnormalities (chromosomal breaks) in cows of three age groups was observed in winter and was 2.5 %, 2.8 %, 3.0 %, respectively, and did not exceed the limit of spontaneous mutagenesis characteristic of cattle. An increased proportion of lymphocytes with a micronucleus in first-borns and cows aged 8–10 years (5.6 ‰, 6.4 ‰, respectively) was observed in the summer. The increased proportion of dinuclear lymphocytes appeared in the first-born in the summer season and amounted to 7.6 ‰ (at P > 0.99), and in cows 8–10 years, this variability in the summer season was 6.2 ‰, in winter – 6.7 ‰ with a statistically significant difference (P > 0.95) between the spontaneous level of cytogenetic variability. The association between karyotype stability of the studied animals and seasonal environmental factors was determined using a correlation coefficient (r). A significant positive correlation was found between aneuploidy and air temperature in primiparous and cows aged 8–10 years, relative humidity, precipitation and wind strength and chromosomal gaps in primiparous and adult cows, atmospheric pressure, relative humidity and asynchronous divergence. in adult cows and cows aged 8–10 years. A positive reliable associative dependence of the appearance of micronucleus lymphocytes and dinuclear lymphocytes on the amount of precipitation and wind strength in this area in primiparous and adult cows was established.

scholarly journals Pokoleniowe różnice w artystycznym obrazowaniu doświadczenia totalitarnej przeszłości w czeskim teatrze najnowszym

2016 ◽  
Vol 4 ◽  
pp. 49-58
Author(s):  
Sylwia Czachór
Keyword(s):  
Collective Identity ◽  
Generational Differences ◽  
Growing Up ◽  
History And Memory ◽  
Black And White ◽  
The Past ◽  
Artistic Representations ◽  
The 1960S ◽  
Short Time ◽  
The Impact

Generational differences in artistic representations of the experience of totalitarian past in the new Czech theatre. The article presents an analysis of a number of Czech performances from the years 2007–2013 on the topic of the communist era and reflecting on the changes that have occurred over the past 25 years. Selected directors belong to three generations of artists: the ones already creating in the 1960s, the ones debuting just before or just after the Velvet Revolution and the ones beginning their career in 2000. The comparison of performances produced within a short time clearly shows the differences, both aesthetic and ideological, in the method of recognizing similar issues by the authors growing up in a completely different socio-political conditions. Works of the oldest generation, using conventional theatrical means, reveal the strongest judgmental tendencies, the need to show the ambiguous choices in black and white colors. The average generation contend with the legend of past years, asking difficult questions about the impact of the past on the shape of collective identity. The youngest generation, however, intentionally emphasize that their knowledge about communism is mediated, which encourages them to analyze the history and memory of their families in search of their own roots.Generační rozdíly v uměleckém zobrazování zkušenosti totalitární minulosti v nejnovějším českém divadle. Příspěvek obsahuje analýzu několika českých představení z let 2007–2013, jejichž tématem se stalo období komunismu a reflexe nad proměnami posledních 25 let. Vybraní režiséři patří ke třem generacím umělců:  jedni inscenovali dlouho před rokem 1989, druzí debutovali krátce po sametové revoluci, zatímco třetí zahájili kariéru v roce 2000. Soubor představení vzniklých v malém časovém rozpětí výrazně ukazuje jak estetické, tak světonázorové rozdíly ve způsobu uchopení podobné tematiky autory, kteří vyrůstali ve zcela odlišných společensko-politických podmínkách. Díla nejstarší generace pomocí konvenčních divadelních prostředků projevují nejsilnější tendence posuzovat a odsuzovat, nutnost ukázat nejednoznačné volby v černo-bílých barvách. Střední generace se poměřuje s legendami mi­nulých dob, pokládá obtížné otázky po vlivu minulosti na podobu kolektivní identity. Nejmladší tvůrci pak vědomě zdůrazňují, že jejich znalost komunismu je zprostředkovaná, což je vede k analyzování historie a rodinné paměti při hledání vlastních kořenů.  

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