Fabrication of polyvinyl alcohol based fast dissolving oral strips of sumatriptan succinate and metoclopramide HCL

Migraine is a throbbing condition, usually associated with nausea and vomiting and requires concurrent administration of anti-migraine along with anti-emetic therapy. The current study was undertaken with an aim to fabricate fast dissolving oral strips (FDOSs) containing Sumatriptan succinate (anti-migraine) and Metoclopramide HCl (anti-emetic) in combination without involving any superdisintegrant. Hydrophilic polymer polyvinyl alcohol (PVA) was used alone with three concentrations of 100, 125, and 150 mg using variable concentrations of glycerol. The solvent casting technique was employed to formulate FDOSs and were evaluated for surface morphology, mechanical properties, surface pH, % moisture content, disintegration time (DT), total dissolving time (TDT), drug contents, and dissolution profile. PVA (150 mg) with 5% glycerol concentration gave best formulation results. FDOSs have exhibited good tensile strength with smooth and uniform surface morphology. DT was ranged from 7.7 to 28 s; while TDT was from 26.4 to 77.6 s. Both polymer and plasticizer concentrations were found to be influencing the characteristics of the strips. Dissolution studies were carried out in distilled water for 15 min and all the formulations have shown released more than 50% drug within first 2 min thereby highlighting the usefulness of FDOSs for the delivery of both drugs in combination significantly. Optimized combination of ingredients was found to be suitable for the formulation of FDOSs for simultaneous delivery of Metoclopramide HCl and Sumatriptan succinate.

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The Study of Plasticized Amorphous Biopolymer Blend Electrolytes Based on Polyvinyl Alcohol (PVA): Chitosan with High Ion Conductivity for Energy Storage Electrical Double-Layer Capacitors (EDLC) Device Application

Polymers ◽

10.3390/polym12091938 ◽

2020 ◽

Vol 12 (9) ◽

pp. 1938 ◽

Cited By ~ 3

Author(s):

Shujahadeen B. Aziz ◽

Jihad M. Hadi ◽

Elham M. A. Dannoun ◽

Rebar T. Abdulwahid ◽

Salah R. Saeed ◽

...

Keyword(s):

Energy Storage ◽

Polyvinyl Alcohol ◽

Double Layer ◽

Electrical Double Layer ◽

Ammonium Thiocyanate ◽

Structural Features ◽

Electrical Impedance Spectroscopy ◽

Glycerol Concentration ◽

Equivalent Series Resistance ◽

Casting Technique

In this study, plasticized films of polyvinyl alcohol (PVA): chitosan (CS) based electrolyte impregnated with ammonium thiocyanate (NH4SCN) were successfully prepared using a solution-casting technique. The structural features of the electrolyte films were investigated through the X-ray diffraction (XRD) pattern. The enrichment of the amorphous phase with increasing glycerol concentration was confirmed by observing broad humps. The electrical impedance spectroscopy (EIS) portrays the improvement of ionic conductivity from 10−5 S/cm to 10−3 S/cm upon the addition of plasticizer. The electrolytes incorporated with 28 wt.% and 42 wt.% of glycerol were observed to be mainly ionic conductor as the ionic transference number measurement (TNM) was found to be 0.97 and 0.989, respectively. The linear sweep voltammetry (LSV) investigation indicates that the maximum conducting sample is stable up to 2 V. An electrolyte with the highest conductivity was used to make an energy storage electrical double-layer capacitor (EDLC) device. The cyclic voltammetry (CV) plot depicts no distinguishable peaks in the polarization curve, which means no redox reaction has occurred at the electrode/electrolyte interface. The fabricated EDLC displays the initial specific capacitance, equivalent series resistance, energy density, and power density of 35.5 F/g, 65 Ω, 4.9 Wh/kg, and 399 W/kg, respectively.

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Formulation, Optimization and In-vitro Evaluation of Fast Dissolving Oral films of Metoclopramide Hydrochloride by Solvent Casting method

International Journal of PharmTech Research ◽

10.20902/ijptr.2019.130314 ◽

2020 ◽

Vol 13 (3) ◽

pp. 229-241

Author(s):

Chandrajeet Kumar Yadav ◽

Manish Karn ◽

Pinki Yadav ◽

Roshan Mehta

Keyword(s):

Sodium Alginate ◽

Dosage Form ◽

Content Uniformity ◽

Dissolution Profile ◽

Solvent Casting ◽

Disintegration Time ◽

In Vitro Evaluation ◽

Metoclopramide Hydrochloride ◽

Oral Films

The Present study aimed to prepare fast dissolving oral films (FDFs) of metoclopramide hydrochloride, because of its application in emesis condition where fast onset of action and avoidance of water is highly desirable. Moreover, this dosage form is highly useful in pediatrics, geriatrics and unconscious patients. FDFs were prepared by solvent casting technique with film forming polymers HPMC, PVA & Sodium alginate in varying concentrations with excipients like SLS as surfactant, Glycerol as plasticizer, citric acid as saliva stimulating agent, Sodium Saccharin as sweetening agent. The film of 2×3 cm was prepared by casting into a petridish of calculated size and dried in dryer at temperature 40˚c. The In-Vitro evaluation of characteristics like Film Thickness, Weight Variation, disintegration time, dissolution study, surface pH, content uniformity was studied. The best formulation was found to be F5 containing polymer PVA and Sodium alginate in the ratio 2:1, with disintegration time 24 seconds, and dissolution profile of 75% in 60 seconds and 90% in 90 seconds. The content uniformity of all the formulations was found to be within the limit (98-101%). The disintegration time of all the formulations was found to be below 30 seconds except F4 (26 sec.). Thus, fast dissolving Films of Metoclopramide hydrochloride can be successfully formulated and will be used as a novel drug dosage form for paediatric and geriatric with improved patient compliance and enhanced bioavailability.

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FORMULATION, CHARACTERIZATION AND IN-VITRO EVALUATION OF FAST DISSOLVING ORAL FILMS OF CETIRIZINE HCL

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v9i4-a.3392 ◽

2019 ◽

Vol 9 (4-A) ◽

pp. 122-125

Author(s):

Yadagiri Phalguna ◽

Haritha Pasupulati ◽

Sandhya Rudra

Keyword(s):

Sodium Alginate ◽

Solvent Casting ◽

Casting Method ◽

Percentage Elongation ◽

Disintegration Time ◽

Casting Technique ◽

Sodium Starch Glycolate ◽

Folding Endurance ◽

Oral Films

The predominant goal of this work is to formulate and evaluate Cetirizine HCl ODF’s the usage of Sodium starch glycolate (SSG) as superdisintegrant, Sodium alginate as polymer and Glycerol as plasticizer. Films were prepared by way of Solvent casting method and evaluated for thickness, folding endurance, percentage elongation, floor pH and disintegration time. The consequences indicate that method prepared with 17.5% combo of polymer and plasticizer was determined to be optimized. The three special formulations F1, F2 and F3 of CTZ motion pictures were organized via solvent casting technique the usage of sodium alginate as polymer, SSG as disintegrant and glycerol as plasticizer. Menthol was once used as cooling agent along with aspartame as sweetener and citric acid as a style overlaying agent. The formulation (F3) with presence of superdisintegrant and combo of polymer, plasticizer confirmed first-rate results. Keywords: Cetirizine HCl, Oral thin film, superdisintegrant, polymer, plasticizer

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Formulation and Evaluation of Sumatriptan Succinate Fast Disintegrating Films and Tablets

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2013.6.2.11 ◽

2013 ◽

Vol 6 (2) ◽

pp. 2087-2096

Author(s):

Y. Shravan Kumar ◽

R Gowthami ◽

Sujitha H ◽

Nagaraju T ◽

Rajashekar M ◽

...

Keyword(s):

In Vitro Dissolution ◽

Direct Compression ◽

Solvent Casting ◽

Compression Method ◽

Casting Method ◽

Disintegration Time ◽

Sumatriptan Succinate ◽

Film Forming ◽

Fast Disintegrating Tablets

Sumatriptan succinate is a 5-HT1B/1D receptor agonist which has well established efficacy in treating migraine. The main objective of the study was to formulate Oral Fast Disintegrating Films (ODF) and Oral Fast Disintegrating Tablets (ODT) to achieve a better dissolution rate and further improving the bioavailability of the drug. ODFs were prepared by solvent casting method using film forming polymers like HPMC – E15,5cps,50cps in different ratios & prepared batches of films were evaluated for the drug content, film thickness, disintegration time and in vitro dissolution studies. Among the prepared formulation F7 containing HPMC – 50cps (drug: polymer ratios = 1:1) was found to be best formulations which releases 98.2±1.1of the drug within 17±0.02 sec. ODTs prepared by direct compression method using in different concentrations of super-disintegrants. The prepared formulation T12 (combination of disintegrants) containing CP + CCS (6%) was considered to be the best formulation, which releases up to 100±0.38% of the drug in 23±0.75 sec, respectively. Based on these results, it is suggested that ODFs have faster disintegration time and drug release than ODTs.

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Orodispersible Films of an Antipsychotic Drug: Development and Physicochemical Characterization

Journal of the chemical society of pakistan ◽

10.52568/000750/jcsp/41.03.2019 ◽

2019 ◽

Vol 41 (3) ◽

pp. 469-469

Author(s):

Muhammad Naeem Aamir Muhammad Naeem Aamir ◽

Aneela Manzoor Aneela Manzoor ◽

Hina Hussain Hina Hussain ◽

Zeeshan Javaid Zeeshan Javaid ◽

Tariq Mahmood Tariq Mahmood ◽

...

Keyword(s):

Hydroxypropyl Methylcellulose ◽

Physicochemical Characterization ◽

Maximum Amount ◽

Solvent Casting ◽

Carrier System ◽

Disintegration Time ◽

Casting Technique ◽

Orodispersible Films ◽

Drug Content ◽

Folding Endurance

To deliver maximum amount of paroxetine in shortest duration of time, the orodispersible films (ODF) were formulated and tested for their suitability as a carrier system. ODF were prepared by using hydroxypropyl methylcellulose and polyvinyl alcohol and different superdisintegrants at a specific proportion. The newly developed ODF were subjected to characterization for folding endurance, weight variations, thickness, disintegration time, drug release pattern and drug content. The surface morphology of orodispersible film was examined by means of scanning electron microscope. Moreover physical compatibility between the drug and excipients was guaranteed in the orodispersible film by Fourier transform infrared spectroscopy. It was found that all films prepared were transparent, smooth and elegant in appearance. ODF showed good folding endurance, uniform thickness, weight and drug content. The surface pH of all orodispersible film was found to be neutral and they disintegrate within few seconds. FTIR spectroscopy supported compatible among all excipients and they can be used together in formulation. It was concluded that stable paroxetine orodispersible films can be made by solvent casting technique with ultrafast dissolution rate.

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Development and Evaluation of Fluoxetine Fast Dissolving Films: An Alternative for Noncompliance in Pediatric Patients

Processes ◽

10.3390/pr9050778 ◽

2021 ◽

Vol 9 (5) ◽

pp. 778

Author(s):

Emőke-Margit Rédai ◽

Paula Antonoaea ◽

Nicoleta Todoran ◽

Robert Alexandru Vlad ◽

Magdalena Bîrsan ◽

...

Keyword(s):

Pediatric Patients ◽

Hydroxypropyl Methylcellulose ◽

Pharmaceutical Formulations ◽

Release Kinetic ◽

Disintegration Time ◽

Casting Technique ◽

First Order ◽

Orodispersible Films ◽

Folding Endurance

The most used pharmaceutical formulations for children are syrups, suppositories, soft chewable capsules, and mini-tablets. Administrating them might create an administration discomfort. This study aimed to develop and evaluate orodispersible films (ODFs) for pediatric patients in which the fluoxetine (FX) is formulated in the polymeric matrix. Six FX fast dissolving films (10 mg FX/ODF), FX1, FX2, FX3, FX4, FX5, and FX6, were prepared by solvent casting technique. In the composition of the ODFs, the concentration of the hydroxypropyl methylcellulose and the concentration of the propylene glycol were varied. Each formulation of fluoxetine ODF was evaluated by determining the tensile strength, folding endurance, disintegration, behavior in the controlled humidity and temperature conditions, and adhesiveness. All the obtained results were compared with the results obtained for six ODFs prepared without FX. The disintegration time of the FX ODFs was of maximum 88 s for FX2. Via the in vitro releasing study of the FX from the ODFs it was noticed that FX1 and FX2 allow a better release of the drug 99.98 ± 3.81% and 97.67 ± 3.85% being released within 15 min. From the obtained results it was also confirmed that FX ODFs were found to follow first-order release kinetic.

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Antimicrobial Active Bioplastics Using Triangular Silver Nanoplate Integrated Polycaprolactone and Polylactic Acid Films

Materials ◽

10.3390/ma14051132 ◽

2021 ◽

Vol 14 (5) ◽

pp. 1132

Author(s):

Eduardo Lanzagorta Garcia ◽

Olivia A. Attallah ◽

Marija Mojicevic ◽

Declan M Devine ◽

Margaret Brennan Fournet

Keyword(s):

Polylactic Acid ◽

Scale Up ◽

Composite Films ◽

Antimicrobial Properties ◽

Morphological Structure ◽

Antimicrobial Effect ◽

Solvent Casting ◽

Local Surface Plasmon Resonance ◽

Casting Technique ◽

Triangular Silver Nanoplates

An innovative antimicrobial technology for plastic surfaces is presented. We report the synthesis and scale-up of triangular silver nanoplates (TSNPs) and their integration into polycaprolactone (PCL) and polylactic acid (PLA) polymers through a solvent-casting technique. The TSNPs have a high geometric aspect ratio and strong local surface plasmon resonance (LSPR) response, which provides an effective tool for monitoring their integrity during processing and integration with the biodegradable plastics. An aqueous-based seed-mediated chemical method was used to synthesize the TSNPs, and characterisation was carried out using TEM and UV (Ultraviolet)-VIS (Visible) spectroscopy to measure LSPR profiles. The UV-VIS spectra of silver seeds and TSNPs exhibited characteristic peaks at 395 and 600 nm respectively. Synthesized TSNPs were coated with thiol-terminated polyethylene glycol (SH-PEG) and transferred into chloroform in order to effect compatibility with PCL and PLA. TSNP/PCL and TSNP/PLA composite films were prepared by solvent casting. The morphological structure, thermal, mechanical, and antimicrobial properties of the TSNP-incorporated composite films were evaluated. Results showed the TSNP-treated films had a rougher surface than the bare films. Insignificant changes in the thermal properties of TSNP-treated films compared to bare ones were also observed, which indicated the thermal stability of the composite films. The tensile strength and antimicrobial properties of the composite films were increased after TSNP incorporation. TSNP/PCL and TSNP/PLA films exhibited improved antimicrobial activity against Escherichia coli and Staphylococcus aureus with antimicrobial effect (AE) values ranging between 0.10 and 0.35. The obtained results and demonstrated TSNP production scalability validate the TSNP treated PCL and PLA films as a composite material with desirable antimicrobial effect for wide-ranging surface applications.

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3DP Printing of Oral Solid Formulations: A Systematic Review

Pharmaceutics ◽

10.3390/pharmaceutics13030358 ◽

2021 ◽

Vol 13 (3) ◽

pp. 358 ◽

Cited By ~ 1

Author(s):

Chiara R. M. Brambilla ◽

Ogochukwu Lilian Okafor-Muo ◽

Hany Hassanin ◽

Amr ElShaer

Keyword(s):

Systematic Review ◽

Data Extraction ◽

New Technology ◽

Three Dimensional ◽

Extraction Process ◽

Carcinogenic Risk ◽

Drug Dissolution ◽

Dissolution Profile ◽

Disintegration Time ◽

Advantages And Disadvantages

Three-dimensional (3D) printing is a recent technology, which gives the possibility to manufacture personalised dosage forms and it has a broad range of applications. One of the most developed, it is the manufacture of oral solid dosage and the four 3DP techniques which have been more used for their manufacture are FDM, inkjet 3DP, SLA and SLS. This systematic review is carried out to statistically analyze the current 3DP techniques employed in manufacturing oral solid formulations and assess the recent trends of this new technology. The work has been organised into four steps, (1) screening of the articles, definition of the inclusion and exclusion criteria and classification of the articles in the two main groups (included/excluded); (2) quantification and characterisation of the included articles; (3) evaluation of the validity of data and data extraction process; (4) data analysis, discussion, and conclusion to define which technique offers the best properties to be applied in the manufacture of oral solid formulations. It has been observed that with SLS 3DP technique, all the characterisation tests required by the BP (drug content, drug dissolution profile, hardness, friability, disintegration time and uniformity of weight) have been performed in the majority of articles, except for the friability test. However, it is not possible to define which of the four 3DP techniques is the most suitable for the manufacture of oral solid formulations, because the selection is affected by different parameters, such as the type of formulation, the physical-mechanical properties to achieve. Moreover, each technique has its specific advantages and disadvantages, such as for FDM the biggest challenge is the degradation of the drug, due to high printing temperature process or for SLA is the toxicity of the carcinogenic risk of the photopolymerising material.

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Development and Evaluation of Trans Buccal Patches based on Natural and Synthetic Polymers Loaded with Rivastigmine using Solvent Casting Technique

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00894 ◽

2021 ◽

pp. 5133-5140

Author(s):

Prasanta Kumar Mohapatra ◽

Boddu Pavan Kumar ◽

Pankaj Singh Patel ◽

Harish Chandra Verma ◽

Satyajit Sahoo

Keyword(s):

Drug Release ◽

Kinetic Equations ◽

Moisture Loss ◽

Release Mechanism ◽

Solvent Casting ◽

Casting Technique ◽

Weight Variation ◽

Zero Order Release ◽

Buccal Films

Mucoadhesive buccal films of rivastigmine were prepared by the solvent casting technique using HPMC K15M, sodium alginate, glycerine, and Eudragit RL100. Arranged films assessed for weight variation, thickness, % drug substance, % moisture loss, % moisture take-up, folding endurance, in-vitro medicament release, and Fourier transform Infrared spectroscopy (FTIR). The films showed a controlled release (CR) over 8 h. The preparation observed to be a worthy candidate for the development of buccal patches for therapeutic purposes. Drug-polymer compatibility considers FTIR demonstrated no contradiction between the medicament and the polymers. The optimized formulation found F7 indicated drug release 85% at the end of 8 h. Thinking about the correlation coefficient (R2) values got from the kinetic equations, the drug release from the formulations F1-F8 has discovered zero-order release mechanism. It can be concluded that oral buccal patches of rivastigmine, for treatment of Alzheimer’s and Parkinson’s disease, can be formulated. The study suggests that rivastigmine can be conveniently administered orally in the form of buccal patches, with the lesser occurrence of its side effects and improved bioavailability.

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Physicochemical Evaluation of Brands of Amlodipine Besylate Tablets.

Journal of Basic and Social Pharmacy Research ◽

10.52968/27459534 ◽

2020 ◽

Vol 1 (5) ◽

pp. 24-33

Author(s):

C.A. Anyanwu-Ndulewe ◽

◽

L.E. Mogbolu ◽

M.A. Oladunni ◽

A.A. Adepoju-Bello

Keyword(s):

Hardness Test ◽

Drug Market ◽

The United States ◽

Financial Strain ◽

Average Weight ◽

Dissolution Profile ◽

Amlodipine Besylate ◽

Disintegration Time ◽

Physicochemical Evaluation ◽

Dissolution Efficiency

Background: Hypertension is a chronic condition, and the cost of filling prescriptions has a potential of putting a financial strain on patients, hence the need for lower priced but bioequivalent generics. The Nigerian drug market is awash with generics of Amlodipine besylate, a first line drug in the treatment of hypertension, therefore, any prescribed alternative must be bioequivalent to the originator. Objectives: This study assessed the physicochemical properties of some brands in order to predict pharmaceutical and bioequivalence and invariably, the interchangeability with the innovator brand. Methods: Compendial parameters of average weight, friability, disintegration, drug content and dissolution profile of ten generic brands were evaluated using the United States Pharmacopeia (USP) as well as the non-official hardness test. Results: Two brands failed the test for hardness, while still keeping to the stipulated friability limit. All the brands met the required disintegration time, irrespective of the discordance of some brands in the breaking force and friability values. All brands were found to contain between 92.00 and 103.57% (w/w) of Amlodipine besylate. Two brands failed to achieve ≥75% dissolution expected at 30 minutes and this was reflected in the low f2 values of 35.06% and 28.73%. The dissolution curves displayed a similarity for two brands, which was also corroborated by the high percentage dissolution efficiency (DE) of 92.00%, as well as the f1 and f2 values, compared to the innovator brand. Conclusion: Although the parameters used may predict therapeutic equivalence, interchangeability with the comparator brand is subject to relevant bioequivalence studies.

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