Estimation of the performance stability of the newly developed topical haemostatic agents based on the chitosan/alginate fibrids

Designing medical devices requires a wide range of verification steps for estimation of the performance and safety. Designing the research program needs a rational selection of appropriate testing methods (in preclinical and clinical studies) for determination of the risk of potential incompatibilities resulting in adverse events. The significance of the appropriate selection of the testing method is increased in advanced medical devices. The presented research considers the verification of the functional properties of recently developed topical haemostatic agents with the use of the chitosan/alginate fibrids, based on the previously elaborated risk analysis made according to the guidelines of the PN-EN-ISO 14971:2012 and PN-EN ISO 22442-1:2008 standards. The aim of this research was to verify the stability of the performance of the newly developed haemostatic agents during storage. The defined aim of the study arose from the thesis that the appropriate selection of raw materials and a new manner of reprocessing them enabled keeping the usability of the final product for at least two years.

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Spectrophotometric indicators of the stability of anthocyanin-containing extracts depending on the color of plant materials

Ovidius University Annals of Chemistry ◽

10.2478/auoc-2020-0016 ◽

2020 ◽

Vol 31 (2) ◽

pp. 88-92

Author(s):

Vladimir Mikhailovich Koldaev ◽

Artem Yurevich Manyakhin ◽

Petr Semenovich Zorikov

Keyword(s):

Hydrochloric Acid ◽

Stability Factor ◽

Plant Materials ◽

Herbal Preparations ◽

Violet Color ◽

The Stability ◽

Selection Of ◽

Factor Coefficient ◽

Anthocyanin Degradation

AbstractThis paper aims at spectrophotometric determination of changes in stability of extractable anthocyanins during drying of plant materials depending on their color. Raw and dried colored parts of 50 plant species from 25 families were used for the study. The extracts were prepared over 95% ethanol acidified with hydrochloric acid (pH ~ 1). The absorption spectra were registered within the range of 210 to 680 nm. The extinction variability factor, coefficient of intensity absorption relative and generalized stability factor were used to determine the anthocyanin degradation. The highest values of the stability factor were obtained for the extracts from fruit shells of burgundy or violet color within the range of 0.934±0.024 to 0.973±0.024, while the extracts from flower petals of the same care featured the stability factor that was 1.19 to 1.44 times less. The values of the stability factor of the extracts from black, red and blue materials are 1.15 to 1.19 times, 1.74 to 2.48 times and 4.65 to 4.84 times less respectively than those of the extracts from violet-burgundy materials. It is appropriate to apply the spectrophotometric factors of anthocyanins stability used in this study to selection of promising plants for industrial cultivation as material of anthocyanin-containing herbal preparations. The most stable anthocyanins are those of burgundy-purple and black fruits.

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The issue of "oil shrinkage" during the compounding of oils in the processes of production, collection, preparation and transportation of hydrocarbon raw materials

Oil and Gas Studies ◽

10.31660/0445-0108-2021-2-104-113 ◽

2021 ◽

pp. 104-113

Author(s):

O. P. Deryugina ◽

E. A. Trapeznikov

Keyword(s):

Raw Materials ◽

Raw Material ◽

Colloidal System ◽

Main Pipelines ◽

Different Types ◽

Preliminary Study ◽

The Stability ◽

Mixed Oil

The article discusses the issue of industrial compounding, which improves the quality of the raw materials supplied to the main pipelines. Compounding from "to compound" (English) - to mix. When mixing different types of oil obtained, "incompatibility" is possible, which is expressed in the precipitation of a solid sediment and violation of the stability of the colloidal system and due to the differing properties of oils. Attention to this problem is due to the tightening of requirements for the quality of raw materials that must comply with modern standards. The article discusses the causes of the problem of "incompatibility" of oil during compounding and effective ways of solving it, substantiates the need for a preliminary study of the properties of mixed oil in order to identify possible incompatibility of various types of oil. The standard tests for determination of incompatibility indices characterizing the ability of raw materials to mix are considered. The article substantiates the need to develop methods for diagnosing the incompatibility of oils as the most important task of modern chemical science, the solution of which will improve the quality of the raw material obtained and solve many technological problems in the compounding process.

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DETERMINATION OF THE SENSITIVITY OF THE MICROBIOLOGICAL EXPRESS METHOD FOR DETECTING FLUOROQUINOLONE ANTIBIOTICS IN RAW MATERIALS OF MEAT USING THE TEST CULTURE BACILLUS STEAROTHERMOPHILUS

Problems of Veterinary Sanitation, Hygiene and Ecology ◽

10.36871/vet.san.hyg.ecol.202103002 ◽

2021 ◽

Vol 1 (3) ◽

pp. 249-254

Author(s):

G.M. Goryainova ◽

◽

L.V. Arsenyeva ◽

E.A. Denisova ◽

◽

...

Keyword(s):

Bacillus Stearothermophilus ◽

Raw Materials ◽

Detection Limits ◽

Animal Husbandry ◽

Express Method ◽

Antimicrobial Drugs ◽

Test Culture ◽

Fluoroquinolone Antibiotics ◽

Wide Range

The article presents the results obtained during experiments to determine the sensitivity of the method according to GOST R 55481-2013 to antibiotics from the group of fluoroquinolones. GOST provides detection limits for such antibiotics as augmentin – 25.0 mcg/kg, benzylpenicillin – 4.0 mcg/kg, doxycycline – 10.0 mcg/ kg, cefazolin – 25.0 mcg/kg. Today, we are familiar with a wide range of different antimicrobial drugs used in animal husbandry, including an extensive group of drugs such as levofloxacin, norfloxacin, ofloxacin, marbocin, marfloxin, pefloxacin, ciprofloxacin, and others related to fluoroquinolones. We experimentally determined the sensitivity parameters for enrofloxacin – 24 mcg/l, levofloxacin – 26 mcg/l, ciprofloxacin – 24 mcg/l, marbofloxacin – 25 mcg/l.

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Numerical Determination of the Response of a Linear Vibration System With a Singular Mass Matrix

Journal of Engineering for Industry ◽

10.1115/1.3428156 ◽

1972 ◽

Vol 94 (1) ◽

pp. 64-69

Author(s):

K. D. Willmert

Keyword(s):

Multistep Methods ◽

Mass Matrix ◽

Linear Equations ◽

Coefficient Matrix ◽

Vibrational System ◽

Wide Range ◽

Mass Matrices ◽

The Stability ◽

The Many

In numerically determining the response of a linear second-order multidegree-of-freedom vibrational system subjected to a general excitation, the common approach of applying one of the many multistep methods of numerical analysis (e.g., Milne-Simpson, Adams-Bashforth, etc.) leads ultimately to the solution of a system of linear equations. However, when the mass matrix of the original vibrational system is singular, the coefficient matrix of the system of equations also becomes singular and thus the response cannot be determined. Presented is a means of applying these multistep methods to vibrational systems which results in a method that is capable of obtaining the response independent of the singularity of the mass matrix. This technique is particularly useful in optimization where the values of the parameters of the system are unknown in advance, and thus the method of determining the response must be applicable for a wide range of values of the parameters. In the development and investigation of this technique, the causes of the stability problems which develop from the application of multistep methods to systems with nearly singular mass matrices become apparent.

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Pendampingan Usaha Mikro dan Masyarakat Desa Balunijuk dalam Mewujudkan Kampung HalalL

Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat ◽

10.29244/agrokreatif.6.2.173-180 ◽

2020 ◽

Vol 6 (2) ◽

pp. 173-180

Author(s):

Occa Roanisca ◽

Maya Yusnita ◽

Robby Gus Mahardika

Keyword(s):

Central Government ◽

Raw Materials ◽

Food And Beverage ◽

Halal Food ◽

Global Concern ◽

The Government ◽

Direct Guidance ◽

The Village ◽

Selection Of

Halal product assurance is a global concern, especially in some Southeast Asian countries. The Government of Indonesia through law No. 33 of 2014 requires food and beverage products circulating in Indonesia to have halal certificates. Responding to the central government program, the Government of Bangka Belitung has issued a Regional Regulation on the Implementation of Safe and Halal Food Guarantees. The purpose of the Community Partnership Program (CPP) is to realize Balunijuk Village as Halal Village. The determination of these objectives is the result of an agreement between the village officials and food and beverage business people in Balunijuk Village. The method of implementation in this activity is in the form of direct guidance to six fostered partners to obtain a Sanitation Hygiene (HS) certificate, and socialization on halal lifestyle targeting the community, village officials and six fostered businesses. Six fostered businesses in the village of Balunijuk have received Sanitation Hygiene (HS) Eligible Certificates. The issuance of HS certificates in the foster stalls shows the seriousness of partners in maintaining the cleanliness of the production process, raw materials and sanitation of production sites. HS Certificate as a requirement for business actors to apply for a Halal Certificate LPPOM MUI in Bangka Belitung. As many as 90% of participants understood about halal lifestyle material, besides that participants felt the need to apply halal lifestyle, especially in the selection of food and drinks to be consumed because it had an impact on physical and spiritual health. The results of this activity are the initiators to realize Balunijuk Village as Halal Village.

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Determination of sources of sulfur dioxide in confectionery

Proceedings of the Voronezh State University of Engineering Technologies ◽

10.20914/2310-1202-2018-4-203-208 ◽

2019 ◽

Vol 80 (4) ◽

pp. 203-208

Author(s):

N. B. Kondratyev ◽

E. V. Kazantsev ◽

M. V. Osipov ◽

O. S. Rudenko ◽

E. N. Krylova

Keyword(s):

Sulfur Dioxide ◽

Raw Materials ◽

Customs Union ◽

White Sand ◽

Wide Range ◽

Confectionery Products ◽

Definition Of ◽

The Impact ◽

Technological Methods

Sulfur dioxide is used to ensure the safety of fruit raw materials and semi-finished products used for the production of confectionery. This preservative has allergenic properties. In accordance with the Technical Regulations of the Customs Union TR CU 022/2011 "Food products in terms of their labeling" the content of sulfur dioxide must be specified when labeling confectionery products, if its content exceeds 10 mg per kg. The definition of this preservative in raw materials, semi-finished products and confectionery in accordance with the current GOST 26811 “Confectionery. The iodometric method for determining the mass fraction of total sulfuric acid is often difficult because of the complexity of confectionery products, the formation of intensive staining of the solutions under study and the ability of sulfur dioxide to react with other components of the objects under study. Therefore, the task of developing methods with the optimization of the sample preparation stage of the samples under study, which allow one to fully determine sulfur dioxide in confectionery products, semi-finished products and raw materials, is relevant. The purpose of this work was to develop methods for determining sulfur dioxide in raw materials, semi-finished products and various names of confectionery products, as well as assessing the impact of these types of raw materials and semi-finished products on the content of sulfur dioxide in confectionery products. The results showed that sulfur dioxide is present in many raw materials. In mg per 1 kg of sugar in white sand from 1 to 9, molasses from 25 to 52, wheat flour from 9 to 15, starch from 3 to 17. In fruit raw materials from 5 to 545 mg per kg. In confectionery: marshmallow and marshmallow from 8 to 29, gingerbread from 6 to 25, biscuits from 0 to 16, chocolate from 8 to 13. Based on the data obtained, it can be concluded that the content of sulfur dioxide in raw materials and semi-finished confectionery products is a very wide range, which makes it necessary to control the quality of all raw materials entering the production. Sulfur dioxide, used as a preservative for fruit raw materials, can significantly increase the content of this allergen in confectionery made using such raw materials. Ensuring the level of sulfur dioxide less than 10 mg / kg is achieved using raw materials with low content of sulfur dioxide and technological methods.

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Determination of the chemical and hydrothermal stability of the Claus catalyst

E3S Web of Conferences ◽

10.1051/e3sconf/202126401023 ◽

2021 ◽

Vol 264 ◽

pp. 01023

Author(s):

Farkhod Yusupov ◽

Murodali Mamanazarov ◽

Bobomurod Xursandov ◽

Gulnoza Baimatova

Keyword(s):

Thermal Stability ◽

Water Vapor ◽

Raw Materials ◽

Hydrothermal Stability ◽

Catalyst Activation ◽

Claus Process ◽

Tio2 Catalyst ◽

So2 Adsorption ◽

The Stability

The hydrothermal and thermal stability used in the Claus process are important indicators in their workflow. In this work, the stability of two catalyst samples obtained from local raw materials was studied. The samples were processed with SO2 / O2 oxides and water vapor, and their properties were studied. As a result, SO2 adsorption reduced catalyst activation. The process is reductive; the recovery of catalyst activation by reducing SO2 in the system has been determined. The stability of sulfation of MgO / TiO2 catalyst in comparison with CaO / V2O5 samples was also determined.

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Effect of surfactant - assisted enzymatic treatment on the structure and specific properties of wool fibre

Revista de Chimie ◽

10.37358/rc.17.12.6006 ◽

2018 ◽

Vol 68 (12) ◽

pp. 2918-2921

Author(s):

Irina Chican ◽

Dana Varasteanu ◽

Loti Cornelia Oproiu ◽

Sanda Maria Doncea ◽

Marian Deaconu ◽

...

Keyword(s):

Ftir Spectroscopy ◽

Raw Materials ◽

Enzymatic Treatment ◽

Wool Fibre ◽

Renewable Raw Materials ◽

Wool Fibers ◽

Fiber Process ◽

Surfactant Assisted ◽

Selection Of

The objective of this study is to perform an enzymatic treatment on wool fibers in the presence of a mild detergent containing surfactants obtained from renewable raw materials, in order to obtain a reduction in the felting of wool fibers. This treatment is designed to replace the classic wool fiber process using chlorine compounds, aggressive to people and the environment. FTIR spectroscopy has demonstrated the effect of enzymes by breaking down bonds from the functional groups characteristic of the keratin protein of wool. Determination of relaxation shrinkage and felting shrinkage allowed the selection of the samples that led to a minimal felting phenomenon.

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The Application of Petroleum Geochemical Methods to Production Allocation of Commingled Fluids

10.2118/205130-ms ◽

2021 ◽

Author(s):

Richard Patience ◽

Mark Bastow ◽

Martin Fowler ◽

Julian Moore ◽

Craig Barrie

Keyword(s):

Best Practice ◽

Statistical Treatment ◽

Laboratory Analysis ◽

Chemical Compositions ◽

Production Allocation ◽

Wide Range ◽

Operational Activity ◽

End Members ◽

Selection Of

Abstract Production allocation from petroleum geochemistry is defined here as the quantitative determination of the amount or portion of a commingled fluid to be assigned to two or more individual fluid sources (e.g., a pipeline, field, reservoir, well) at a particular moment in time, based on the fluid chemistry. It requires: i) knowledge of the original chemical compositions of each of the fluids prior to mixing (referred to here as the "end members"), and ii) that statistically valid differences in their chemistries can be identified. Petroleum geochemical-based methods for production monitoring and allocation are much lower cost than using production logging tools, as there is no additional rig time or extra personnel required at the well site. Additionally, no intervention to the production of hydrocarbons from a well is required and, hence, there is none of the risk entailed in additional operational activity. Geochemical methods are applicable to a wide range of fields, irrespective of pressure, temperature, reservoir quality and reservoir fluid type. The method has been in existence for over 30 years, during which time a number of different analytical methods, data pre-processing and treatment approaches have been applied. This paper summarises these approaches, and provides examples, but also describes a "best practice" which is not a "one size fits all" approach, as is sometimes seen in the literature. A successful production allocation study consists of the following steps: i) Selection of end member samples that contribute to the commingled production fluid; ii) Determination of the differences in chemical composition of the end members through laboratory analysis of the end members (e.g. by WO-GC), replicate analyses of samples and statistical treatment of the data (e.g. PCA); iii) If statistically significant differences exist, laboratory analysis of the end members and commingled fluids with appropriate replicate analyses of samples; iv) Data selection, pre-processing (e.g. selection of ratios or concentrations of components); v) Determination of end member contributions by solving equations (e.g. least squares best fit) and uncertainty estimation (e.g. Monte Carlo or Bootstrap methods). The differences in approach for conventional versus unconventional plays are also discussed.

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Limited Influence of Excipients in Extemporaneous Compounded Suspensions

Hospital Pharmacy ◽

10.1177/0018578717717393 ◽

2017 ◽

Vol 52 (6) ◽

pp. 428-432 ◽

Cited By ~ 2

Author(s):

Eli Dijkers ◽

Valerie Nanhekhan ◽

Astrid Thorissen ◽

Diego Marro ◽

Marta Uriel

Keyword(s):

Raw Materials ◽

Active Pharmaceutical Ingredient ◽

Time Frame ◽

Product Characteristics ◽

Suitable Alternative ◽

Summary Of Product Characteristics ◽

Wide Range ◽

Flecainide Acetate ◽

Pharmaceutical Materials ◽

The Stability

Objective: The objective of this study was to identify whether compounding oral suspensions with SyrSpend SF based on tablets or capsules is a suitable alternative for using raw pharmaceutical materials. Methods: Suspensions based on 5 different tablets and capsules were studied in SyrSpend SF. The summary of product characteristics of these different tablets and capsules were obtained from the manufacturer. Our hypothesis was that, if the maximum beyond-use date of the study was reached, the excipient did not seem to have an influence on the stability of the active pharmaceutical ingredient (API) within the studied time frame. Results: All excipients used in flecainide acetate, labetalol HCl, and tiagabine HCl tablets as well as in celecoxib and oseltamivir capsules did not seem to influence the beyond-use date of the overall suspension based on SyrSpend SF. Conclusion: Although using raw materials as API sources is preferred, oral suspensions with SyrSpend SF prepared from crushed tablets or opened capsules could be a possible alternative. Based on this study, a wide range of different excipients does not seem to impact the beyond-use date of different APIs compounded in SyrSpend SF.

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