scholarly journals Contagious Bovine Pleuropneumonia: A Comprehensive Overview

2020 ◽  
Vol 57 (4) ◽  
pp. 476-489 ◽  
Author(s):  
Giovanni Di Teodoro ◽  
Giuseppe Marruchella ◽  
Andrea Di Provvido ◽  
Anna Rita D’Angelo ◽  
Gianluca Orsini ◽  
...  
Keyword(s):  
Animal Health ◽  
Lymphatic Vessels ◽  
Alveolar Epithelial Cells ◽  
Sub Saharan Africa ◽  
Pathological Examination ◽  
Special Focus ◽  
Renal Tubules ◽  
Contagious Bovine Pleuropneumonia ◽  
Presumptive Diagnosis ◽  
Lymphoid Follicles

Contagious bovine pleuropneumonia (CBPP) is a respiratory disease of cattle that is listed as notifiable by the World Organization for Animal Health. It is endemic in sub-Saharan Africa and causes important productivity losses due to the high mortality and morbidity rates. CBPP is caused by Mycoplasma mycoides subsp. mycoides ( Mmm) and is characterized by severe fibrinous bronchopneumonia and pleural effusion during the acute to subacute stages and by pulmonary sequestra in chronic cases. Additional lesions can be detected in the kidneys and in the carpal and tarsal joints of calves. Mmm infection occurs through the inhalation of infected aerosol droplets. After the colonization of bronchioles and alveoli, Mmm invades blood and lymphatic vessels and causes vasculitis. Moreover, Mmm can be occasionally demonstrated in blood and in a variety of other tissues. In the lung, Mmm antigen is commonly detected on bronchiolar and alveolar epithelial cells, in lung phagocytic cells, within the wall of blood and lymphatic vessels, inside necrotic areas, and within tertiary lymphoid follicles. Mmm antigen can also be present in the cytoplasm of macrophages within lymph node sinuses, in the germinal center of lymphoid follicles, in glomerular endothelial cells, and in renal tubules. A complete pathological examination is of great value for a rapid presumptive diagnosis, but laboratory investigations are mandatory for definitive diagnosis. The purpose of this review is to describe the main features of CBPP including the causative agent, history, geographic distribution, epidemiology, clinical course, diagnosis, and control. A special focus is placed on gross and microscopic lesions in order to familiarize veterinarians with the pathology and pathogenesis of CBPP.

scholarly journals An Update on African Swine Fever Virology

Viruses ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 864 ◽  
Author(s):  
Axel Karger ◽  
Daniel Pérez-Núñez ◽  
Jesús Urquiza ◽  
Patricia Hinojar ◽  
Covadonga Alonso ◽  
...  
Keyword(s):  
Western Europe ◽  
Topoisomerase Ii ◽  
Virulent Strain ◽  
Animal Health ◽  
African Swine Fever ◽  
Sub Saharan Africa ◽  
Future Research ◽  
Special Focus ◽  
Health Food ◽  
Rna Helicases

Animal diseases constitute a continuing threat to animal health, food safety, national economy, and the environment. Among those, African swine fever (ASF) is one of the most devastating viruses affecting pigs and wild suids due to the lack of vaccine or effective treatment. ASF is endemic in countries in sub-Saharan Africa, but since its introduction to the Caucasus region in 2007, a highly virulent strain of ASF virus (ASFV) has continued to circulate and spread into Eastern Europe and Russia, and most recently into Western Europe, China, and various countries of Southeast Asia. Given the importance of this disease, this review will highlight recent discoveries in basic virology with special focus on proteomic analysis, replication cycle, and some recent data on genes involved in cycle progression and viral–host interactions, such as I215L (E2 ubiquitin-conjugating enzyme), EP402R (CD2v), A104R (histone-like protein), QP509L, and Q706L (RNA helicases) or P1192R (Topoisomerase II). Taking into consideration the large DNA genome of ASFV and its complex interactions with the host, more studies and new approaches are to be taken to understand the basic virus–host interaction for ASFV. Proteomic studies are just paving the way for future research.

scholarly journals Mesenteric Cysts: A Retrospective Review. Its Not All That Simple

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S117-S118
Author(s):  
M Bourgeau ◽  
V Avadhani
Keyword(s):  
Cyst Wall ◽  
Imaging Techniques ◽  
Case Reports ◽  
Lymphatic Vessels ◽  
Mucinous Cystadenoma ◽  
Final Diagnosis ◽  
Cystic Mass ◽  
Pathological Examination ◽  
Urachal Cyst ◽  
Mesenteric Cysts

Abstract Introduction/Objective Mesenteric cysts are rare intra-abdominal lesions in adults. However, with the advanced imaging techniques and laparoscopic techniques, they are more often being identified and resected when clinically significant. There is a lack of detailed information in histopathology (except as case reports) since mesentery is generally neglected in our organ-based textbooks. The aim of our study is to highlight the importance of identifying and classifying mesenteric cystic lesions; they are not all that simple. Methods We performed a retrospective search on all mesenteric cysts submitted as excisions in our electronic database from 2013-2019. We classified them as per the de Perrot (PMID: 11053936) classification with modification. Results Our search showed: A. Lymphatic origin-11 (lymphangioma-10, Lymphangioma hamartomatous-1, associated with LAM-0), B. Mesothelial origin-68 (Benign mesothelial cysts-57, multilocular mesothelial cyst-11), C. Enteric origin- 3, D. Urogenital origin (Urachal cyst, mullerian inclusion cyst)-9, E. Mature cystic teratom-2, F. Pseudocyst-12, G. Epithelial cyst (not urogenital)- 11 (a/w LAMN-3, MCN-4, Mucinous cystadenoma-4), H. Associated with carcinoma-2. Case illustration: A 61-year-old male presented with worsening dysphagia, emesis and hiccups. A CT scan showed a 21.2 cm cystic mass with at least one septation (Fig 1). The cyst was resected. On gross pathological examination, the cyst measured 18 cm in greatest dimension with a thick, rough, tan-brown capsule. Microscopic examination showed a fibrous capsule, and cyst wall composed of numerous lymphatic vessels (CD31 positive) and prominent smooth muscle proliferation (Desmin positive). Scattered lymphoid aggregates were also present throughout the cyst wall. No definite epithelial lining was identified and was suspected to have been denuded. HMB-45 immunostain was negative, ruling out association with LAM. The final diagnosis of a Lymphangiomyoma, hamartomatous was rendered. Conclusion Though most of the mesenteric cysts are benign, some of them are significantly important such as Lymphangiomyoma (esp secondary to LAM), MCN, those associated with LAMN etc. and identifying and differentiating from their mimics has distinct clinical implications.

scholarly journals An afebrile heartwater-like syndrome in goats

2013 ◽  
Vol 84 (1) ◽  
Author(s):  
Rhoda Leask ◽  
Kenneth P. Pettey ◽  
Gareth F. Bath
Keyword(s):  
Clinical Signs ◽  
Control Measures ◽  
Sub Saharan Africa ◽  
Limiting Factor ◽  
Febrile Reaction ◽  
Presumptive Diagnosis ◽  
Appropriate Treatment ◽  
Sub Saharan ◽  
Characteristic Features ◽  
And Control

Heartwater is a serious limiting factor for sheep and goat production in the major endemic area of sub-Saharan Africa and therefore most knowledge, research and control methods originate from this region. Whilst the usual or common clinical presentations can be used to make a presumptive diagnosis of heartwater with a good measure of confidence, this is not always the case, and animals suffering from heartwater may be misdiagnosed because their cases do not conform to the expected syndrome, signs and lesions. One aberrant form found occasionally in the Channel Island breeds of cattle and some goats is an afebrile heartwaterlike syndrome. The most constant and characteristic features of this heartwater-like syndrome comprise normal temperature, clinical signs associated with generalised oedema, and nervous signs, especially hypersensitivity. The presumption that the disease under investigation is the afebrile heartwater-like syndrome entails a tentative diagnosis based on history and clinical signs and the response to presumed appropriate treatment (metadiagnosis). The afebrile heartwater-like syndrome presents similarly to peracute heartwater but without the febrile reaction. Peracute cases of heartwater have a high mortality rate, enabling confirmation of the disease on post-mortem examination. Recognition of the afebrile heartwater-like syndrome is important to prevent deaths and identify the need for appropriate control measures.

A Critical Examination of the State versus Non-Governmental Organizations (NGOs) in the Policy Sphere in the Global South: Will the State Die as the NGOs Thrive in Sub-Saharan Africa and Asia?

2005 ◽  
Vol 4 (3) ◽  
pp. 301-326 ◽  
Author(s):  
A. Sat Obiyan
Keyword(s):  
Service Provision ◽  
Market Failure ◽  
Third Sector ◽  
The State ◽  
Sub Saharan Africa ◽  
Critical Examination ◽  
Special Focus ◽  
Governmental Organizations ◽  
Non Governmental Organizations ◽  
Sub Saharan

Abstract This paper examines the role of non-governmental organizations (NGOs) in service provision with a special focus on Sub-Saharan Africa and Asia. First, it reviews the conceptual and taxonomic issues in NGOs. It then proceeds to examine the performance of NGOs in some countries. The paper notes the increased relevance of NGOs in many countries. It, however, argues that any expectation that the NGOs will supplant the state in service provision is likely to be utopian. It contends that just as we have government failure and market failure, we can also have third sector failure. The paper argues for an appropriate balance between the state and NGOs in meeting the needs of the poor. It concludes that while it may be necessary to continue to strengthen the private sector and the third sector, it would be useful to continue to inquire into how the state can be effective.

scholarly journals Multi-Mycotoxin Occurrence in Dairy Cattle and Poultry Feeds and Feed Ingredients from Machakos Town, Kenya

Toxins ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 762
Author(s):  
David Chebutia Kemboi ◽  
Phillis E. Ochieng ◽  
Gunther Antonissen ◽  
Siska Croubels ◽  
Marie-Louise Scippo ◽  
...  
Keyword(s):  
Animal Health ◽  
Ergot Alkaloids ◽  
Sub Saharan Africa ◽  
Contamination Level ◽  
Plant Metabolites ◽  
Feed Ingredients ◽  
Bacterial Metabolites ◽  
Poultry Feeds ◽  
Sub Saharan ◽  
The Eu

Mycotoxins are common in grains in sub-Saharan Africa and negatively impact human and animal health and production. This study assessed occurrences of mycotoxins, some plant, and bacterial metabolites in 16 dairy and 27 poultry feeds, and 24 feed ingredients from Machakos town, Kenya, in February and August 2019. We analyzed the samples using a validated multi-toxin liquid chromatography-tandem mass spectrometry method. A total of 153 mycotoxins, plant, and bacterial toxins, were detected in the samples. All the samples were co-contaminated with 21 to 116 different mycotoxins and/or metabolites. The commonly occurring and EU regulated mycotoxins reported were; aflatoxins (AFs) (70%; range 0.2–318.5 μg/kg), deoxynivalenol (82%; range 22.2–1037 μg/kg), ergot alkaloids (70%; range 0.4–285.7 μg/kg), fumonisins (90%; range 32.4–14,346 μg/kg), HT-2 toxin (3%; range 11.9–13.8 μg/kg), ochratoxin A (24%; range 1.1–24.3 μg/kg), T-2 toxin (4%; range 2.7–5.2 μg/kg) and zearalenone (94%; range 0.3–910.4 μg/kg). Other unregulated emerging mycotoxins and metabolites including Alternaria toxins, Aspergillus toxins, bacterial metabolites, cytochalasins, depsipeptides, Fusarium metabolites, metabolites from other fungi, Penicillium toxins, phytoestrogens, plant metabolites, and unspecific metabolites were also detected at varying levels. Except for total AFs, where the average contamination level was above the EU regulatory limit, all the other mycotoxins detected had average contamination levels below the limits. Ninety-six percent of all the samples were contaminated with more than one of the EU regulated mycotoxins. These co-occurrences may cause synergistic and additive health effects thereby hindering the growth of the Kenyan livestock sector.

scholarly journals Development of a Novel Cocktail Enzyme-Linked Immunosorbent Assay and a Field-Applicable Lateral-Flow Rapid Test for Diagnosis of Contagious Bovine Pleuropneumonia

2016 ◽  
Vol 54 (6) ◽  
pp. 1557-1565 ◽  
Author(s):  
Martin Heller ◽  
Nimmo Gicheru ◽  
Georgina Tjipura-Zaire ◽  
Cecilia Muriuki ◽  
Mingyan Yu ◽  
...  
Keyword(s):  
Immunosorbent Assay ◽  
Rapid Test ◽  
Lateral Flow ◽  
Sub Saharan Africa ◽  
Enzyme Linked Immunosorbent Assay ◽  
Contagious Bovine Pleuropneumonia ◽  
Serum Samples ◽  
Content Type ◽  
Mycoplasma Mycoides ◽  
Sub Saharan

Contagious bovine pleuropneumonia (CBPP) is a severe respiratory disease that is widespread in sub-Saharan Africa. It is caused byMycoplasma mycoidessubsp.mycoides, a bacterium belonging to theMycoplasma mycoidescluster. In the absence of an efficient CBPP vaccine, improved and easy-to-use diagnostic assays for recurrent testing combined with isolation and treatment of positive animals represent an option for CBPP control in Africa. Here we describe the comprehensive screening of 17 immunogenicMycoplasma mycoidessubsp.mycoidesproteins using well-characterized bovine sera for the development of a novel cocktail enzyme-linked immunosorbent assay (ELISA) for laboratory use. Two recombinantMycoplasmaimmunogens, MSC_0136 and MSC_0636, were used to set up a standardized cocktail ELISA protocol. According to the results from more than 100 serum samples tested, the sensitivity and specificity of the novel cocktail ELISA were 85.6% and 96.4%, respectively, with an overall diagnostic accuracy comparable to that of the Office International des Epizooties (OIE)-prescribed serological assays. In addition, we provide a proof of principle for a field-applicable, easy-to-use commercially produced prototype lateral-flow test for rapid (<30-min) diagnosis of CBPP.

scholarly journals Food system consequences of a fungal disease epidemic in a major crop

2016 ◽  
Vol 371 (1709) ◽  
pp. 20150467 ◽  
Author(s):  
H. Charles J. Godfray ◽  
Daniel Mason-D'Croz ◽  
Sherman Robinson
Keyword(s):  
Food System ◽  
Animal Health ◽  
Sub Saharan Africa ◽  
Health Food ◽  
Global Food System ◽  
Rice Prices ◽  
Sub Saharan ◽  
Equilibrium Economic ◽  
Political Economic ◽  
Global Food

Fungal diseases are major threats to the most important crops upon which humanity depends. Were there to be a major epidemic that severely reduced yields, its effects would spread throughout the globalized food system. To explore these ramifications, we use a partial equilibrium economic model of the global food system (IMPACT) to study a hypothetical severe but short-lived epidemic that reduces rice yields in the countries affected by 80%. We modelled a succession of epidemic scenarios of increasing severity, starting with the disease in a single country in southeast Asia and ending with the pathogen present in most of eastern Asia. The epidemic and subsequent crop losses led to substantially increased global rice prices. However, as long as global commodity trade was unrestricted and able to respond fast enough, the effects on individual calorie consumption were, to a large part, mitigated. Some of the worse effects were projected to be experienced by poor net-rice importing countries in sub-Saharan Africa, which were not affected directly by the disease but suffered because of higher rice prices. We critique the assumptions of our models and explore political economic pressures to restrict trade at times of crisis. We finish by arguing for the importance of ‘stress-testing’ the resilience of the global food system to crop disease and other shocks. This article is part of the themed issue ‘Tackling emerging fungal threats to animal health, food security and ecosystem resilience’.

Niger-congo, with a Special Focus on Benue-congo

2020 ◽  
pp. 137-160
Author(s):  
Jeff Good
Keyword(s):  
Morphological Character ◽  
Sub Saharan Africa ◽  
Special Focus ◽  
Large Core ◽  
Bantu Languages ◽  
Class System ◽  
Core Set ◽  
The Family ◽  
Distinctive Type ◽  
Sub Saharan

Niger-Congo is the largest referential language group in Africa. The extent to which it represents a true genealogical grouping is not established, though there is a large core set of members of the family that all specialists currently accept as related. These languages spread across sub-Saharan Africa, and their most significant common feature from a comparative perspective is a distinctive type of noun class system. The largest subgroup of Niger-Congo is Benue-Congo, which includes the Bantu languages that dominate the southern part of the continent. From a typological perspective, Niger-Congo languages are quite varied, especially with respect to their degree of morphological elaboration. This is also true of Benue-Congo, with some of its languages having an isolating morphological character and others showing extensive agglutinating morphology. Future comparative work on the family would likely benefit from greater integration of the results of sociolinguistic investigations into models of its historical development.

scholarly journals Identification of Mycoplasma species and related organisms from ruminants in England and Wales during 2005–2019

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Alannah S. Deeney ◽  
Rachael Collins ◽  
Anne M. Ridley
Keyword(s):  
Respiratory Disease ◽  
Denaturing Gradient Gel Electrophoresis ◽  
Animal Health ◽  
Small Ruminants ◽  
Health Agency ◽  
Mycoplasma Species ◽  
Rrna Gene ◽  
Contagious Bovine Pleuropneumonia ◽  
England And Wales ◽  
The Uk

Abstract Background Mycoplasma species have been associated with economically important diseases affecting ruminants worldwide and include contagious bovine pleuropneumonia (CBPP), contagious caprine pleuropneumonia (CCPP) and contagious agalactia, listed by the World Organisation for Animal Health (OIE). The Mycoplasma Team at the Animal and Plant Health Agency provides an identification service for Mycoplasma and Ureaplasma species of veterinary importance to the United Kingdom (UK), supporting the detection of new and emerging pathogens, as well as contributing to the surveillance of endemic, and the OIE listed diseases exotic to the UK. Mycoplasma and other Mollicutes species were identified from diagnostic samples from farmed ruminants in England and Wales using a combination of culture and 16S rRNA gene-based PCR-denaturing gradient gel electrophoresis, submitted between 2005 and 2019. Results A total of 5578 mollicutes identifications, which include mycoplasmas and the related acholeoplasmas and ureaplasmas, were made from farmed ruminant animals during the study period. Throughout the study period, the pathogen Mycoplasma bovis was consistently the most frequently identified species, accounting for 1411 (32%) of 4447 molecular identifications in cattle, primarily detected in the lungs of pneumonic calves, followed by joints and milk of cattle showing signs of arthritis and mastitis, respectively. M. bovirhinis, M. alkalescens, M. dispar, M. arginini and Ureaplasma diversum, were also common. Mixed species, principally M. bovis with M. alkalescens, M. arginini or M. bovirhinis were also prevalent, particularly from respiratory samples. The non-cultivable blood-borne haemoplasmas Candidatus ‘Mycoplasma haemobos’ and Mycoplasma wenyonii were identified from cattle, with the latter species most often associated with milk-drop. M. ovipneumoniae was the predominant species identified from sheep and goats experiencing respiratory disease, while M. conjunctivae preponderated in ocular samples. The UK remains free of the ruminant mycoplasmas listed by OIE. Conclusions The continued high prevalence of M. bovis identifications confirms its ongoing dominance and importance as a significant pathogen of cattle in England and Wales, particularly in association with respiratory disease. M. ovipneumoniae has seen a general increase in prevalence in recent years, notably in coughing lambs and should therefore be considered as a primary differential diagnosis of respiratory disease in small ruminants.

scholarly journals Geography versus institutions and sub-Saharan aid

2017 ◽  
Vol 13 (1) ◽  
Author(s):  
Chris W. Callaghan
Keyword(s):  
Sub Saharan Africa ◽  
Special Focus ◽  
Poor Countries ◽  
Practical Development ◽  
Sub Saharan ◽  
Normative Argument ◽  
Unequal Opportunities ◽  
Big Push

This article sets out to review two opposing viewpoints in the literature, namely long-standing geographic versus institutionalist perspectives and their opposing predictions for development of poor countries, particularly those in sub-Saharan Africa. A special focus is on the differing predictions of the effectiveness of aid of these two perspectives. On the basis of a consideration of different literatures and final Millenium Development Report, it is argued that ‘Big Push’ theory may still offer important theoretical and practical development contributions. Arguably, these contributions echo Keynes’s legacy in their consideration of the most vulnerable and marginalised. It is also argued that a global birth lottery allocates people to countries and regions with unequal opportunities and that a normative argument can be made to justify aid to mitigate birth lottery effects.

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