Efficacy of Injury Prevention Training Is Greater for High-Risk vs Low-Risk Elite Female Youth Soccer Players

Background: The efficacy of robustness training for high- versus low-risk individuals within high-risk groups is currently unknown. Purpose: To explore the efficacy of robustness training on injury risk factors among female youth soccer players and to examine if high-risk athletes are greater responders to such training. Study Design: Controlled laboratory study. Methods: A total of 125 elite youth female soccer players on the English FA talent pathway were randomly selected into a training group (n = 71) or a control group (n = 54). Relative leg stiffness, 2-dimensional knee valgus and knee flexion range of motion from a single-legged countermovement jump, and probability of high knee abduction moment (pKAM) risk were all determined before and after a 16-week robustness training program. For further analysis, participants in the training group were split into groups based on risk: high risk (pKAM >0.80, n = 33) and low risk (pKAM <0.55, n = 33). Magnitude-based inferences were used to explore differences between the control and intervention groups and the high- and low-risk groups. Results: Magnitude-based inferences demonstrated significant beneficial effects in the training group for knee valgus, pKAM, and leg stiffness as compared with the control group. The control group demonstrated possible worthwhile differences in knee flexion range of motion as compared with the intervention group. The high-risk group demonstrated likely/very likely worthwhile differences versus the low-risk group for all parameters. Conclusion/Clinical Relevance: Robustness training induces significant beneficial improvements in injury risk factors among female youth soccer players. The beneficial effects of this multidimensional program are greater for those classified as high risk.

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Rituximab Maintenance Benefits Less for Follicular Lymphoma Patients with Low Risk of the Follicular Lymphoma International Index

Blood ◽

10.1182/blood-2021-147114 ◽

2021 ◽

Vol 138 (Supplement 1) ◽

pp. 3544-3544

Author(s):

Tingyu Wang ◽

Ru Li ◽

Rui Lv ◽

Ying Yu ◽

Jiawen Chen ◽

...

Keyword(s):

High Risk ◽

Follicular Lymphoma ◽

Progression Free Survival ◽

Risk Groups ◽

Low Risk ◽

Control Group ◽

Intermediate Risk ◽

Free Survival ◽

Rituximab Maintenance ◽

Risk Patients

Abstract Background Follicular lymphoma (FL) is an incurable indolent disease with a heterogeneous course. The Follicular Lymphoma International Prognostic Index (FLIPI) is the most commonly used prognostic system to predict survival. Rituximab-based immunochemotherapy is now the standard choice for the first-line therapy of FL, followed by rituximab maintenance (RM) in patients with response, which prolongs the progression-free survival (PFS). However, the role of RM in different FLIPI risk groups has never been studied as we know. In this study, we aimed to illustrate the effect of RM in FLIPI risk groups. Methods Newly diagnosed FL patients at our center were enrolled in this analysis. All the patients received the rituximab-based chemoimmunotherapy induction regimens. Response assessments were determined according to Lugano's 2014 criteria. Patients who didn't respond to induction were excluded. Categorical variables were compared using Fisher's exact test. Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method and compared with the log-rank test. Results From May 2003 to September 2020, 203 newly diagnosed FL were included. 192 patients (95.0%) achieved remission (complete response, CR/partial response, PR) after immunochemotherapy induction, of whom 96 patients continued rituximab maintenance therapies every 3 months for 1-2 years (RM group) (median 7 times，range 4 to 12). 96 patients received no maintenance or fewer than 4 times (control group) (median 0 times, range 0-3). There were no significant differences in baseline characteristics other than the Ann Arbor stage and pathological grade. The RM group patients were more likely to be at low grade (71.8% vs 54.9%, P = 0.042) and advanced stage (90.6% vs 78.7% , P = 0.027) (Table 1). After a median follow-up of 36.4 months (95% confidence interval [CI], 32.2 to 40.6), median OS and PFS were not reached. The 5-year OS rates and PFS rates were 95.1% (95%CI, 90.2%-100%) and 83.0% (95%CI, 75%-91%)(Fig 1). And RM significantly prolonged the PFS, with 5-year PFS rates 92.2% (95%CI, 85.1%-99.3%) and 70.3%(95%CI, 55%-85.6%) (P = 0.0003) (Fig 2). According to FLIPI risk stratification, patients were classified into low-risk, intermediate-risk, and high-risk groups. The 5-year PFS rates were 97.7% (95%CI, 93.2%-100%), 84.7% (95%CI, 70.4%-99%), and 67.8% (95%CI, 49%-86.6%), respectively (Fig 3). For low-risk patients, there was no significant difference in PFS for the RM group vs the control group. However, for both intermediate risk and high-risk patients, PFS was significantly longer in the RM group compared to the control group (P < 0.0001). The PFS rates at 5 years in intermediate-risk patients were 100% and 77.8% (95%CI, 40.8%-92.6%), for the RM group vs control group, high risk 76.4% (95%CI, 54.3%-98.5%), and 54.9% (95%CI, 21.6%-88.2%), respectively (Fig 4). Conclusion Standard rituximab maintenance significantly prolongs progression-free survival in FLIPI intermediate risk and high-risk patients with FL, but not in the FLIPI low risk group. Figure 1 Figure 1. Disclosures Wang: AbbVie: Consultancy; Astellas Pharma, Inc.: Research Funding.

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Effects of Plyometric Training with Agility Ladder on Physical Fitness in Youth Soccer Players

International Journal of Sports Medicine ◽

10.1055/a-1308-3316 ◽

2021 ◽

Author(s):

Alexis Padrón-Cabo ◽

Miguel Lorenzo-Martínez ◽

Alexandra Pérez-Ferreirós ◽

Pablo B. Costa ◽

Ezequiel Rey

Keyword(s):

Physical Fitness ◽

Linear Mixed Model ◽

Group Analysis ◽

Training Group ◽

Soccer Players ◽

Control Group ◽

Plyometric Training ◽

Countermovement Jump ◽

Squat Jump ◽

Youth Soccer

AbstractThe aim of this study was to assess the effects of plyometric training with an agility ladder on components of physical fitness in youth soccer players. A total of twenty male under-13 soccer players were randomly assigned to a plyometric training group with an agility ladder (n=10) or a control group (n=10). Before and after training intervention linear sprint test (5 m, 10 m, 20 m), vertical jump ability (squat jump, countermovement jump and countermovement jump with arms), agility test, and slalom dribble test were assessed. The plyometric training with agility ladder was applied two times per week over six weeks. Data were analyzed using linear mixed model. The plyometric training group showed significant improvements (p<0.001) from pre-test to post-test in countermovement jump, countermovement jump with arms, and slalom dribble test. In the control group, no significant enhancements were obtained in all performance tests (p>0.05). The between-group analysis showed significant differences in countermovement jump with arms (p=0.03), but no significant differences (p>0.05) were found in squat jump, countermovement jump, sprint, agility test, and slalom dribble test. In conclusion, the short-term plyometric training with agility ladder seems to be ineffective and not time-efficient to improve physical fitness in youth soccer players. However, the interpretation of these results must be understood within the sample size limitations.

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Effects of different sprint training programs with ball on explosive, high-intensity and endurance-intensive performances in male young soccer players

International Journal of Sports Science & Coaching ◽

10.1177/17479541211072225 ◽

2022 ◽

pp. 174795412110722

Author(s):

Hamza Marzouki ◽

Ibrahim Ouergui ◽

Bilel Cherni ◽

Karim Ben Ayed ◽

Ezdine Bouhlel

Keyword(s):

Training Programs ◽

Maximal Oxygen Consumption ◽

Training Group ◽

Soccer Players ◽

Control Group ◽

Sprint Training ◽

Youth Soccer ◽

Change Of Direction ◽

Jump Test ◽

Main Effect

This study compared the effects of different sprint ball-based training programs on fitness-related performances in youth soccer players. Forty male players (age: 15.2 ± 0.6 yrs) participated in a short-term (8 weeks) randomized parallel fully controlled training study, with pre-to-post measurements. Players were randomly assigned to 3 sprint ball-based training groups: training with combined sprint (performing linear and change of direction sprints; CST), or using linear sprint (LST), or performing sprint with change of direction (CODT) and to a control group (CONT). Pre- and post-training players completed a test battery involving linear sprinting (10 and 20 m, and flying 10 m), 505 test (COD), 15 m test with ball (CODB), countermovement jump test (CMJ test) and maximal oxygen consumption (VO2max). All physical performance’ variables improved after the training intervention (all p < 0.05; ES ≥ 0.2). No main effect of groups was observed in linear sprinting, CMJ and VO2max (p > 0.05; ES < 0.2). A training group main effect was found (p < 0.0001; ES = 0.50) for COD with CODT induced better performance than LST and CONT (all p <0.0001; ES > 0.8). Also, a training group main effect (p = 0.009; ES = 0.35) was found for CODB with CODT elicited better performance than LST and CONT (all p = 0.001; ES > 0.80). Our findings suggest that ball-based training programs were more effective to improve fitness levels in youth players during the in-season period and that CODT modality was more effective to improve COD and CODB performances.

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The Effects of Six-Weeks Change of Direction Speed and Technique Modification Training on Cutting Performance and Movement Quality in Male Youth Soccer Players

Sports ◽

10.3390/sports7090205 ◽

2019 ◽

Vol 7 (9) ◽

pp. 205 ◽

Cited By ~ 3

Author(s):

Thomas Dos’Santos ◽

Alistair McBurnie ◽

Paul Comfort ◽

Paul A. Jones

Keyword(s):

Completion Time ◽

Injury Risk ◽

Intervention Group ◽

Cutting Performance ◽

Soccer Players ◽

Ligament Injury ◽

Control Group ◽

Male Youth ◽

Movement Quality ◽

Youth Soccer

Cutting manoeuvres are important actions associated with soccer performance and a key action associated with non-contact anterior cruciate ligament injury; thus, training interventions that can improve cutting performance and movement quality are of great interest. The aim of this study, therefore, was to determine the effects of a six-week change of dire[ction (COD) speed and technique modification training intervention on cutting performance and movement quality in male youth soccer players (U17s, n = 8) in comparison to a control group (CG) (U18s, n = 11) who continued ‘normal’ training. Cutting performance was assessed based on completion time and COD deficit, and the field-based cutting movement assessment score (CMAS) qualitative screening tool was used to assess cutting movement quality. Significant main effects for time (pre-to-post changes) (p ≤ 0.041, η2 = 0.224–0.839) and significant interaction effects of time and group were observed for cutting completion times, COD deficits, and CMASs. Improvements in completion time (p < 0.001, g = 1.63–1.90, −9% to −11% vs. −5% to 6%) and COD deficit (p ≤ 0.012, g = −1.63 to −2.43, −40–52% vs. −22% to −28%) for the COD intervention group (IG) were approximately two-times greater than the CG. Furthermore, lower CMASs (i.e., improved cutting movement quality) were only observed in the IG (p ≤ 0.025, g = −0.85 to −1.46, −23% to −34% vs. 6–19%) compared to the CG. The positive changes in CMASs were attributed to improved cutting technique and reduced incidences of high-risk deficits such as lateral trunk flexion, extended knee postures, knee valgus, hip internal rotation, and improved braking strategies. The results of this study indicate that COD speed and technique modification training, in addition to normal skills and strength training, improves cutting performance and movement quality in male youth soccer players. Practitioners working with male youth soccer players should implement COD speed and technique modification training to improve cutting performance and movement quality, which may decrease potential injury-risk.

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Effects of Plyometric and Short Sprint with Change-of-Direction Training in Male U17 Soccer Players

Applied Sciences ◽

10.3390/app11114767 ◽

2021 ◽

Vol 11 (11) ◽

pp. 4767

Author(s):

Ghaith Aloui ◽

Souhail Hermassi ◽

Lawrence D. Hayes ◽

Nilihan E. M. Sanal Hayes ◽

El Ghali Bouhafs ◽

...

Keyword(s):

Body Mass ◽

Body Fat ◽

Training Group ◽

Soccer Players ◽

Control Group ◽

Static Balance ◽

Post Intervention ◽

Balance Test ◽

Youth Soccer ◽

Change Of Direction

This project investigated the effect of adding 8 weeks of bi-weekly plyometric and short sprint with change-of-direction (PSSCoD) training into standard training for elite youth soccer players from Tunisia. A training group (n = 18; age: 16.6 ± 0.5 years; body mass: 63.2 ± 4.8 kg; stature: 1.73 ± 0.07 m; body fat: 11.2 ± 1.7%), and control group (n = 16; age: 16.6 ± 0.5 years; body mass: 63.6 ± 4.3 kg; height: 1.73 ± 0.06 m; body fat: 11.6 ± 1.5%) participated. The pre- and post-intervention measures were squat-jump (SJ), countermovement jump (CMJ), standing long jump (SLJ), 5 m and 20 m sprint, change-of-direction ability (4 × 5 m sprint test (S 4 × 5 m)), repeated sprint ability (RSA), and static balance (stork balance test). The training group displayed superior jump (all p < 0.05; d > 0.49), sprint (p < 0.05; d > 0.52), change-of-direction ability (p < 0.01; d = 0.78), RSA (p < 0.01; d > 0.70), and static balance (p < 0.05; d > 0.49) improvements. Adding bi-weekly PSSCoD improves the athletic performance of young soccer players.

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PET Parameters are Useful in Predicting Endometrial Cancer Risk Classes and Prognosis

Nuklearmedizin ◽

10.1055/a-1267-8976 ◽

2020 ◽

Author(s):

Adnan Budak ◽

Emrah Beyan ◽

Abdurrahman Hamdi Inan ◽

Ahkam Göksel Kanmaz ◽

Onur Suleyman Aldemir ◽

...

Keyword(s):

Endometrial Cancer ◽

High Risk ◽

Myometrial Invasion ◽

Risk Groups ◽

Total Sample ◽

Tumor Stage ◽

Low Risk ◽

Tumor Diameter ◽

Grade 3 ◽

Fdg Pet Ct

Abstract Aim We investigate the role of preoperative PET parameters to determine risk classes and prognosis of endometrial cancer (EC). Methods We enrolled 81 patients with EC who underwent preoperative F-18 FDG PET/CT. PET parameters (SUVmax, SUVmean, MTV, TLG), grade, histology and size of the primary tumor, stage of the disease, the degree of myometrial invasion (MI), and the presence of lymphovascular invasion (LVI), cervical invasion (CI), distant metastasis (DM) and lymph node metastasis (LNM) were recorded. The relationship between PET parameters, clinicopathological risk factors and overall survival (OS) was evaluated. Results The present study included 81 patients with EC (mean age 60). Of the total sample, 21 patients were considered low risk (endometrioid histology, stage 1A, grade 1 or 2, tumor diameter < 4 cm, and LVI negative) and 60 were deemed high risk. All of the PET parameters were higher in the presence of a high-risk state, greater tumor size, deep MI, LVI and stage 1B-4B. MTV and TLG values were higher in the patients with non-endometrioid histology, CI, grade 3 and LNM. The optimum cut-off levels for differentiating between the high and low risk patients were: 11.1 for SUVmax (AUC = 0.757), 6 for SUVmean (AUC = 0.750), 6.6 for MTV(AUC = 0.838) and 56.2 for TLG(AUC = 0.835). MTV and TLG values were found as independent prognostic factors for OS, whereas SUVmax and SUVmean values were not predictive. Conclusions The PET parameters are useful in noninvasively differentiating between risk groups of EC. Furthermore, volumetric PET parameters can be predictive for OS of EC.

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Short-term risk stratification using CADILLAC risk score in patients with ST elevation myocardial infarction

European Heart Journal ◽

10.1093/ehjci/ehaa946.1352 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

T Satou ◽

H Kitahara ◽

K Ishikawa ◽

T Nakayama ◽

Y Fujimoto ◽

...

Keyword(s):

Myocardial Infarction ◽

High Risk ◽

Adverse Events ◽

Risk Score ◽

Risk Group ◽

Risk Groups ◽

Low Risk ◽

Short Term ◽

Recurrent Myocardial Infarction ◽

St Elevation

Abstract Background The recent reperfusion therapy for ST-elevation myocardial infarction (STEMI) has made the length of hospital stay shorter without adverse events. CADILLAC risk score is reportedly one of the risk scores predicting the long-term prognosis in STEMI patients. Purpose To invenstigate the usefulness of CADILLAC risk score for predicting short-term outcomes in STEMI patients. Methods Consecutive patients admitted to our university hospital and our medical center with STEMI (excluding shock, arrest case) who underwent primary PCI between January 2012 and April 2018 (n=387) were enrolled in this study. The patients were classified into 3 groups according to the CADILLAC risk score: low risk (n=176), intermediate risk (n=87), and high risk (n=124). Data on adverse events within 30 days after hospitalization, including in-hospital death, sustained ventricular arrhythmia, recurrent myocardial infarction, heart failure requiring intravenous treatment, stroke, or clinical hemorrhage, were collected. Results In the low risk group, adverse events within 30 days were significantly less observed, compared to the intermediate and high risk groups (n=13, 7.4% vs. n=13, 14.9% vs. n=58, 46.8%, p<0.001). In particular, all adverse events occurred within 3 days in the low risk group, although adverse events, such as heart failure (n=4), recurrent myocardial infarction (n=1), stroke (n=1), and gastrointestinal bleeding (n=1), were substantially observed after day 4 of hospitalization in the intermediate and high risk groups. Conclusions In STEMI patients with low CADILLAC risk score, better short-term prognosis was observed compared to the intermediate and high risk groups, and all adverse events occurred within 3 days of hospitalization, suggesting that discharge at day 4 might be safe in this study population. CADILLAC risk score may help stratify patient risk for short-term prognosis and adjust management of STEMI patients. Initial event occurrence timing Funding Acknowledgement Type of funding source: None

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A prognostic model based on seven immune-related genes predicts the overall survival of patients with hepatocellular carcinoma

BioData Mining ◽

10.1186/s13040-021-00261-y ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Qian Yan ◽

Wenjiang Zheng ◽

Boqing Wang ◽

Baoqian Ye ◽

Huiyan Luo ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Overall Survival ◽

High Risk ◽

Risk Score ◽

Immune Cells ◽

Prognostic Model ◽

Risk Groups ◽

Low Risk ◽

Prognostic Performance ◽

Immune Related Genes

Abstract Background Hepatocellular carcinoma (HCC) is a disease with a high incidence and a poor prognosis. Growing amounts of evidence have shown that the immune system plays a critical role in the biological processes of HCC such as progression, recurrence, and metastasis, and some have discussed using it as a weapon against a variety of cancers. However, the impact of immune-related genes (IRGs) on the prognosis of HCC remains unclear. Methods Based on The Cancer Gene Atlas (TCGA) and Immunology Database and Analysis Portal (ImmPort) datasets, we integrated the ribonucleic acid (RNA) sequencing profiles of 424 HCC patients with IRGs to calculate immune-related differentially expressed genes (DEGs). Survival analysis was used to establish a prognostic model of survival- and immune-related DEGs. Based on genomic and clinicopathological data, we constructed a nomogram to predict the prognosis of HCC patients. Gene set enrichment analysis further clarified the signalling pathways of the high-risk and low-risk groups constructed based on the IRGs in HCC. Next, we evaluated the correlation between the risk score and the infiltration of immune cells, and finally, we validated the prognostic performance of this model in the GSE14520 dataset. Results A total of 100 immune-related DEGs were significantly associated with the clinical outcomes of patients with HCC. We performed univariate and multivariate least absolute shrinkage and selection operator (Lasso) regression analyses on these genes to construct a prognostic model of seven IRGs (Fatty Acid Binding Protein 6 (FABP6), Microtubule-Associated Protein Tau (MAPT), Baculoviral IAP Repeat Containing 5 (BIRC5), Plexin-A1 (PLXNA1), Secreted Phosphoprotein 1 (SPP1), Stanniocalcin 2 (STC2) and Chondroitin Sulfate Proteoglycan 5 (CSPG5)), which showed better prognostic performance than the tumour/node/metastasis (TNM) staging system. Moreover, we constructed a regulatory network related to transcription factors (TFs) that further unravelled the regulatory mechanisms of these genes. According to the median value of the risk score, the entire TCGA cohort was divided into high-risk and low-risk groups, and the low-risk group had a better overall survival (OS) rate. To predict the OS rate of HCC, we established a gene- and clinical factor-related nomogram. The receiver operating characteristic (ROC) curve, concordance index (C-index) and calibration curve showed that this model had moderate accuracy. The correlation analysis between the risk score and the infiltration of six common types of immune cells showed that the model could reflect the state of the immune microenvironment in HCC tumours. Conclusion Our IRG prognostic model was shown to have value in the monitoring, treatment, and prognostic assessment of HCC patients and could be used as a survival prediction tool in the near future.

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CanAssist Breast Impacting Clinical Treatment Decisions in Early-Stage HR+ Breast Cancer Patients: Indian Scenario

Indian Journal of Surgical Oncology ◽

10.1007/s13193-019-01014-4 ◽

2019 ◽

Cited By ~ 2

Author(s):

Satish Sankaran ◽

Jyoti Bajpai Dikshit ◽

Chandra Prakash SV ◽

SE Mallikarjuna ◽

SP Somashekhar ◽

...

Keyword(s):

High Risk ◽

Early Stage ◽

Risk Groups ◽

Treatment Decisions ◽

Low Risk ◽

Not Given ◽

Breast Cancer Patients ◽

Number Of Patients ◽

Risk Of Cancer ◽

The Impact

AbstractCanAssist Breast (CAB) has thus far been validated on a retrospective cohort of 1123 patients who are mostly Indians. Distant metastasis–free survival (DMFS) of more than 95% was observed with significant separation (P < 0.0001) between low-risk and high-risk groups. In this study, we demonstrate the usefulness of CAB in guiding physicians to assess risk of cancer recurrence and to make informed treatment decisions for patients. Of more than 500 patients who have undergone CAB test, detailed analysis of 455 patients who were treated based on CAB-based risk predictions by more than 140 doctors across India is presented here. Majority of patients tested had node negative, T2, and grade 2 disease. Age and luminal subtypes did not affect the performance of CAB. On comparison with Adjuvant! Online (AOL), CAB categorized twice the number of patients into low risk indicating potential of overtreatment by AOL-based risk categorization. We assessed the impact of CAB testing on treatment decisions for 254 patients and observed that 92% low-risk patients were not given chemotherapy. Overall, we observed that 88% patients were either given or not given chemotherapy based on whether they were stratified as high risk or low risk for distant recurrence respectively. Based on these results, we conclude that CAB has been accepted by physicians to make treatment planning and provides a cost-effective alternative to other similar multigene prognostic tests currently available.

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Preventive effect of trimetazidine on contrast-induced nephropathy undergoing percutaneous coronary intervention in elderly moderate and high risk diabetics stratified by mehran score

Perfusion ◽

10.1177/0267659120952057 ◽

2020 ◽

pp. 026765912095205

Author(s):

Xue Zhang ◽

Peng Zhang ◽

Shicheng Yang ◽

Wenyuan Li ◽

Xiuzhen Men ◽

...

Keyword(s):

Percutaneous Coronary Intervention ◽

High Risk ◽

Serum Creatinine ◽

Coronary Intervention ◽

Low Risk ◽

Control Group ◽

Preventive Effect ◽

Contrast Induced Nephropathy ◽

Risk Population ◽

Percutaneous Coronary

Background: The aim of this research was to use the Mehran risk score to classify elderly diabetics with coronary heart disease to assess the preventive effect of trimetazidine on contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in different risk population. Methods: An uncompromised of 760 elderly diabetics that went through PCI were included in this research. The patients were first divided into three groups in the light of MRS: low-risk, moderate-risk, and high-risk group, then randomized into trimetazidine group and the control group respectively. The first endpoint was the amount of CIN, which is described as a rise in serum creatinine levels by ⩾44.2 μmol/L or ⩾25% ratio within 48 or 72 hours after medication. Second endpoint included differences in creatinine clearance rate (CrCl), blood urea nitrogen (BUN), serum creatinine (Scr), cystatin-C (Cys-C), and the incidence of major adverse events after administration. Results: In the three groups, the incidence of CIN in trimetazidine and control group was 5.0% versus 4.9%(χ2 = 0.005, p > 0.05), 8.0% versus 18.0% (χ2 = 7.685, p < 0.05), 10.4% versus 27.1% (χ2 = 4.376, p < 0.05), respectively. The multivariable logistic regression result demonstrated that trimetazidine intervention was a profitable element of CIN in moderate and high-risk groups (OR = 0.294, 95% CI 0.094-0.920, p = 0.035). Conclusion: Our study confirmed that trimetazidine can be considered for preventive treatment of CIN occurrence in elderly diabetics with moderate and high-risk population, while there is no obvious advantage compared with hydration therapy in low-risk patients.

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