Triazolam and Nitrazepam Use in Elderly Outpatients

1993 ◽  
Vol 27 (4) ◽  
pp. 506-509 ◽  
Author(s):  
Naoko Takami ◽  
Akira Okada
Keyword(s):  
Elderly Patients ◽  
Adverse Reactions ◽  
Control Group ◽  
Primary Reason ◽  
Control Groups ◽  
Telephone Interviews ◽  
Elderly Outpatients ◽  
Appropriate Therapy ◽  
Study Participants ◽  
And Control

OBJECTIVE: To determine adverse reactions and effects on sleep among three groups of patients: those taking triazolam, those taking nitrazepam, and a control group. DESIGN: Telephone interviews. PATIENTS: Forty-seven patients taking triazolam, 36 taking nitrazepam, and 40 control patients. All study participants were outpatients over 60 years of age. RESULTS: The rate of awakening in the middle of sleep was not significantly different among patients taking triazolam (61.7 percent) and those taking nitrazepam (69.4 percent). Incidence of nocturia, the primary reason for awakening, was not significantly different between triazolam- (36.2 percent) and nitrazepam-taking patients (41.7 percent). The rate of having difficulty falling back to sleep was significantly different among triazolam (62.1 percent) and nitrazepam (8 percent), and triazolam and control (11.1 percent) groups (p<0.01). No difference was evident, however, between nitrazepam and control groups. CONCLUSIONS: Patients taking nitrazepam have less difficulty returning to sleep compared with those who take triazolam. Thus, for elderly patients who awaken because of nocturia, nitrazepam may be more appropriate therapy.

scholarly journals Efficacy of a herbal toothpaste on patients with established gingivitis: a randomized controlled trial

2006 ◽  
Vol 20 (2) ◽  
pp. 172-177 ◽  
Author(s):  
Fabiana Ozaki ◽  
Claudio Mendes Pannuti ◽  
Ana Vitória Imbronito ◽  
Wellington Pessotti ◽  
Luciana Saraiva ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Controlled Trial ◽  
Test Group ◽  
Experimental Period ◽  
Positive Control ◽  
Control Group ◽  
Control Groups ◽  
Double Blind ◽  
Significant Difference ◽  
And Control

The aim of this randomised, double blind controlled trial was to verify the efficacy of a herbal dentifrice on the reduction of plaque and gingivitis. Forty eight volunteers with established gingivitis were randomly assigned to either a test group (herbal dentifrice) or positive control group (dentifrice with triclosan and fluoride). The dentifrices were distributed in plain white tubes by an independent pharmacy, which revealed the contents of each tube only after the experimental period. Plaque and gingivitis assessments were carried out on baseline and after 28 days of product use. All examinations were conducted by the same calibrated investigator. Subjects were instructed to brush their teeth three times daily using their assigned dentifrice for 28 days. There was a significant reduction in plaque levels in both the test and control groups. However, there was no significant difference between the groups. A significant reduction in gingivitis was observed in both groups, although there was no significant difference between them. No adverse reactions were reported. The authors concluded that both dentifrices were effective in reducing plaque and gingivitis in subjects with established gingivitis.

scholarly journals Staphylococcus aureus Nasal Colonization among Children with Sickle Cell Disease at the Children’s Hospital, Accra: Prevalence, Risk Factors, and Antibiotic Resistance

Pathogens ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 329
Author(s):  
Vera A. Appiah ◽  
George A. Pesewu ◽  
Fleischer C. N. Kotey ◽  
Alahaman Nana Boakye ◽  
Samuel Duodu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Nasal Carriage ◽  
Control Group ◽  
Cell Disease ◽  
Control Groups ◽  
Study Participants ◽  
And Control ◽  
Carriage Prevalence

The aim of this study was to investigate S. aureus carriage among children with sickle cell disease (SCD), including the prevalence, risk factors, and antibiotic resistance. The study was cross-sectional, and involved 120 children with SCD recruited at the Princess Marie Louise Children’s Hospital (PML) in Accra and 100 apparently healthy children from environs of the hospital. Nasal swab samples were collected from the study participants and cultured for bacteria. Confirmation of S. aureus and methicillin-resistant Staphylococcus aureus (MRSA) isolates were done using the tube coagulase test and mecA polymerase chain reaction, respectively. All the S. aureus isolates were tested against standard antimicrobial agents using the Kirby-Bauer method. A structured questionnaire was used to obtain the socio-demographic and clinical data of the study participants. Binary logistic regression was used to identify determinants of S. aureus and MRSA carriage among the study participants. The nasal carriage prevalence of S. aureus was 33.3% (n = 40) and 10% (n = 10) among the participants of the SCD and control groups, respectively. As regards MRSA nasal carriage prevalence, the respective values were 3.33% (n = 4) and 0.00% (n = 0). SCD was significantly associated with S. aureus colonization (p < 0.0001, OR = 4.045), but not MRSA colonization (p = 0.128). In the SCD group, the significant predictors of S. aureus carriage were increasing age (p = 0.003; OR = 1.275) and living in self-contained apartments (p = 0.033; OR = 3.632), whereas male gender (p = 0.018; OR = 0.344) and the practice of self-medication (p = 0.039; OR = 0.233) were protective of S. aureus carriage. In the control group, a history of hospitalization in the past year was a risk factor for the carriage of S. aureus (p = 0.048; OR = 14.333). Among the participants of the SCD and control groups, respectively, the resistance prevalence recorded by S. aureus against the various antibiotics investigated were penicillin (100% each), cotrimoxazole (27.5% vs. 20%), tetracycline (25% vs. 50%), rifampicin (82.5% vs. 50%), erythromycin (30% vs. 20%), clindamycin (32.5% vs. 50%), gentamicin (7.5% vs. 20%), cefoxitin (27.5% vs. 20%), linezolid (30% vs. 40%), and fusidic acid (95% vs. 80%). The proportion of S. aureus isolates that were multidrug resistant (MDR) was 92.5% (37/40) in the SCD group and 100% (10/10) in the control group.

scholarly journals Effects of Zoledronate on Mortality and Morbidity after Surgical Treatment of Hip Fractures

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Ömer Cengiz ◽  
Gökhan Polat ◽  
Gökhan Karademir ◽  
Oytun Derya Tunç ◽  
Mehmet Erdil ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Elderly Patients ◽  
Femoral Fractures ◽  
Harris Hip Score ◽  
Control Group ◽  
Control Groups ◽  
Mortality And Morbidity ◽  
Postoperative Control ◽  
Modified Harris Hip Score ◽  
And Control

We aimed to evaluate the effects of intertrochanteric femoral fractures on mortality, morbidity, and cost of zoledronate treatment in elderly patients treated by osteosynthesis. Based on Evans classification, 114 patients with unstable intertrochanteric femoral fractures were treated with osteosynthesis. After the surgical treatment of intertrochanteric fractures, the treatment group (M/F, 24/32; mean age, 76.7 ± SD years) received zoledronate infusion, and the control group (M/F, 20/38; mean age, 80.2 ± SD years) received placebo. Postoperative control visits were performed at 6-week, 3-month, 6-month, and 12-month time points. Functional level of patients was evaluated by the modified Harris hip score and Merle d’Aubigné hip score. By 12 months, the mean HHS in treatment and control groups was 81.93 and 72.9, respectively. For time of death of the patients, mortality was found to be 57.1% (16/28) on the first 3 months and 92.9% (26/28) on the first six months. The mortality rate in the treatment and control groups was 14.3% (8/56) and 34.5% (20/58), respectively. The use of zoledronic acid after surgical treatment of intertrochanteric femoral fractures in osteoporotic elderly patients is a safe treatment modality which helps to reduce mortality, improves functional outcomes, and has less side effects with single dose use per year.

scholarly journals The Effect of Self-Management Educational Program on Pain Intensity in Elderly Patients with Knee Osteoarthritis: A Randomized Clinical Trial

2018 ◽  
Vol 6 (6) ◽  
pp. 1062-1066 ◽  
Author(s):  
Reza Ganji ◽  
Azadeh Pakniat ◽  
Mohammad Reza Armat ◽  
Mahbubeh Tabatabaeichehr ◽  
Hamed Mortazavi
Keyword(s):  
Elderly Patients ◽  
Knee Osteoarthritis ◽  
Pain Intensity ◽  
Educational Program ◽  
Intervention Group ◽  
Self Management ◽  
Control Group ◽  
Control Groups ◽  
The Mean ◽  
And Control

BACKGROUND: Osteoarthritis is one of the chronic diseases that greatly affect the health and life quality of individuals.AIM: This study aimed to determine the effect of self-management educational program on the pain intensity of the elderly patients with knee osteoarthritis.METHODS: In a randomised clinical trial, a total of 82 elderly patients with knee osteoarthritis were randomly divided into intervention and control groups. The intervention group received six sessions of self-management group education, while the control group received only the routine care during this period. In both groups, patients’ pain intensity, with a visual analogue scale (VAS), were assessed before, immediately after and eight weeks after the start of the study.RESULTS: The mean pain intensity scores of the intervention and control groups were not significantly different before the intervention (P = 0.9), but after the intervention, the mean pain intensity score in the intervention group (3.61 ± 2.36) was significantly lower than that of the control group (4.93 ± 2.00), (P < 0.0001).CONCLUSION: Implementation of a self-management program for the patients with knee osteoarthritis is useful in reducing their pain intensity and can be used as one of the effective methods for their empowerment.

scholarly journals Curative efficacy and safety of peramivir in the treatment of children suspected with influenza

2020 ◽  
Vol 18 ◽  
pp. 205873922094613
Author(s):  
Xuyun Peng ◽  
Yichun Xiao ◽  
Li Li ◽  
Dongxiang Wen ◽  
Xiaoyan Gong ◽  
...  
Keyword(s):  
Treatment Group ◽  
Adverse Reactions ◽  
Influenza Virus Infection ◽  
Medication Cost ◽  
Special Treatment ◽  
Control Group ◽  
Control Groups ◽  
Hospitalization Period ◽  
The Mean ◽  
And Control

The data from a total of 200 children with suspected influenza virus infection were assessed at the febrile clinic of Women and Children’s hospital in Ganzhou of Jiangxi province from January 2018 to March 2019, and the patients were belonged to two groups (peramivir treatment group and oseltamivir treatment group). At the same time, 100 patients without special treatment were evaluated as the control group. We observed the patients’ fever relief time, pharyngeal pain relief time, nasal congestion relief time, runny nose symptoms relief time, days of hospitalization, days of medication, cost of medication, and adverse reactions in the three groups. We analyzed and compared the efficacy and adverse reactions of peramivir and oseltamivir in the treatment of children suspected with influenza. The recovery of body temperature, relief of cough, days of medication, and hospitalization period in the peramivir group were significantly shorter compared to the oseltamivir and control groups. The mean times to alleviation of fever in the three groups were 18.28 ± 17.74 h (peramivir group), 48.20 ± 34.28 h (oseltamivir group), and 72.56 ± 25.78 h (control group). The mean times to alleviation of cough in the three groups were 49.77 ± 27.58 h (peramivir group), 68.53 ± 32.54 h (oseltamivir group), and 59.38 ± 31.26 (control group). The cost of the peramivir group was significantly higher than that of the oseltamivir and control groups. The incidence of drug reactions in the peramivir group was significantly lower than that in the oseltamivir group. The rate of antibiotic usage in the peramivir group was significantly lower than that in the oseltamivir and control groups. Peramivir can significantly alleviate symptoms and reduce the use of antibiotics in children with suspected influenza. Peramivir has demonstrated good efficacy, high safety, and good compliance in treating children with suspected influenza infection.

Effect of yoga practices on general mental ability in urban residential school children

2020 ◽  
Vol 17 (4) ◽  
Author(s):  
A. Verma ◽  
S.U. Shete
Keyword(s):  
School Children ◽  
Control Group ◽  
Mental Ability ◽  
Residential School ◽  
Control Groups ◽  
General Mental Ability ◽  
Time Period ◽  
Study Participants ◽  
And Control ◽  
Experimental Group

AbstractIntroductionMental ability of children represents functioning of brain in different aspects of competency including verbal, mathematical, logical reasoning and spatial, which is of prime importance for academic performance.ObjectiveThe objective of this study was to assess the effect of yoga on general mental ability of urban residential school children.MethodsSixty-six urban school children aged 11–15 years were selected as participants. All the selected participants were staying in a residential school in Pune District. A stratified random sampling method was used to divide the students into experimental and control groups. There were 32 students in experimental group and 29 students in control group. Both experimental and control groups were assessed for general mental ability by using standard questionnaire at the baseline and at the end of 12 weeks of yoga training. The study participants of experimental group underwent yoga training for 12 weeks, for 1 h in the morning for a period of 12 weeks. The control group did not undergo any yoga training during this time period.ResultsThe experimental group participants showed significant improvement in general mental ability as compared to control group.ConclusionThe findings of this study indicate that yoga practices could improve general mental ability of urban residential school children.

Adverse events when treating XDR tuberculosis

MedAlliance ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 16-24
Keyword(s):  
Clinical Study ◽  
Adverse Events ◽  
Adverse Reactions ◽  
Main Group ◽  
The Other ◽  
Control Group ◽  
Aminosalicylic Acid ◽  
Control Groups ◽  
Drug Induced ◽  
And Control

The article presents the results of a clinical study on the frequency and spectrum of adverse events (AEs) that occur during treatment with an anti-tuberculosis drug (thioureidoiminomethylpyridinium perchlorate, Tpp). The purpose of the study was to determine the frequen-cy and nature of adverse events when TPP is included in the treatment regimen and to develop an algorithm for the prevention of adverse reactions. Materials and methods: 125 (N=125) patients with MDR and XDR tu-berculosis were examined. 70.4% (88) patients developed adverse events. Results and discussion: At the same time, adverse reactions occurred in 58.3% (35) of the main group, and in 69.2% (45) of the control group. There were no significant differences in the frequency of adverse events between the main and control groups (2=1.608, 95% CI 0.298-1.298, p>0.05). In the control group, diges-tive and hepatobiliary AEs were more frequent (up by 8.6% and 3.5%, respectively). On the other hand, derma-tological reactions prevailed in the main group (up by 3.8%). Tpp was not shown to be the main cause of drug induced hypothyroidism, it can jointly reinforce thyrotox-ic effect when used in combination with protionamide and/or PASA (para-aminosalicylic acid). Statistic analy-sis showed no significant differences in any class of AEs between the groups (p>0.05 for all AE categories). Up to 68% of adverse reactions were mild (1 and 2 grade). Con-clusion. Thioureidoiminomethylpyridinium perchlorate is not the main cause of drug induced hypothyroidism, it can jointly reinforce thyrotoxic effect when used in combina-tion with protionamide and/or PASA.

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

Sri Lankan Cleft Lip and Palate Study Model Analysis: Clefts of the Secondary Palate

1993 ◽  
Vol 30 (2) ◽  
pp. 227-230 ◽  
Author(s):  
Andrew Mccance ◽  
David Roberts-Harry ◽  
Martyn Sherriff ◽  
Michael Mars ◽  
William J.B. Houston
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Model Analysis ◽  
Control Group ◽  
Tooth Size ◽  
Sri Lankan ◽  
Control Groups ◽  
Secondary Palate ◽  
Comparable Control ◽  
And Control

The study models of a group of adult Sri Lankan patients with clefts of the secondary palate were investigated. Tooth-size and arch-dimension comparisons were made with a comparable control group. Significant differences were found between the cleft and control groups in tooth sizes, chord lengths, and arch widths. The cleft group dimensions were generally smaller than those of the control group. Overjets were larger in the cleft group.

THE EFFECT OF APPLYING ANIMAL CARTOON PICTURES ON STUDENTS’ ACHIEVEMENT IN WRITING NARRATIVE TEXT

2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Hasanul Arifin Zul And Masitowarni Siregar
Keyword(s):  
T Test ◽  
Narrative Text ◽  
Control Group ◽  
First Year ◽  
Writing Achievement ◽  
Control Groups ◽  
Post Test ◽  
Written Test ◽  
And Control ◽  
Experimental Group

This thesis is focused on the investigation of the effect of applying animal cartoon pictures on students’ achievement in writing narrative text. This study aims to find whether applying animal cartoon pictures significantly affect the students’ writing achievement or not. The data in this study were obtained by administering a written test. The population was the 2015/2016 first year (grade XI) of SMA Swasta Nusantara Lubuk Pakam and 66 students were taken as the sample by using random sampling. The sample was divided into two groups, experimental and control groups. The experimental group was taught by applying animal cartoon pictures while the control group without animal cartoon pictures (x = lecturing). The data were taken the scores from the pre-test and post-test to both experimental and control groups. These data were analyzed by using t-test. The result of computing the t-test obviously showed that t-observed is higher than t-table (5.21 >1,67) with the degree of freedom 64 (df =N-2) at the level significance 0,05 one tail test. It showed that the application of animal cartoon pictures significantly affected the students of SMA Swasta Nusantara Lubuk Pakam achievement in writing narrative text.

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