scholarly journals Maternal nutrition and the developmental origins of osteoporosis in offspring: Potential mechanisms and clinical implications

2018 ◽  
Vol 243 (10) ◽  
pp. 836-842 ◽  
Author(s):  
Jia Zheng ◽  
Qianyun Feng ◽  
Sheng Zheng ◽  
Xinhua Xiao
Keyword(s):  
Early Life ◽  
Theoretical Basis ◽  
Complex Disease ◽  
Maternal Nutrition ◽  
Developmental Origins ◽  
Early Prevention ◽  
Environment Exposure ◽  
Prevention Of Osteoporosis ◽  
Health And Disease ◽  
Underlying Mechanisms

Osteoporosis, the most frequent metabolic disorder of bone, is a complex disease with a multifactorial origin that is influenced by genes and environments. However, the pathogenesis of osteoporosis has not been fully elucidated. The theory of “Developmental Origins of Health and Disease” indicates that early life environment exposure determines the risks of cardiometabolic diseases in adulthood. However, investigations into the effects of maternal nutrition and nutrition exposure during early life on the development of osteoporosis are limited. Recently, emerging evidence has strongly suggested that maternal nutrition has long-term influences on bone metabolism in offspring, and epigenetic modifications maybe the underlying mechanisms of this process. This review aimed to address maternal nutrition and its implications for the developmental origins of osteoporosis in offspring. It is novel in providing a theoretical basis for the early prevention of osteoporosis. Impact statement Our review aimed to address maternal nutrition and its implications for the developmental origins of osteoporosis in offspring, that can novelly provide a theoretical basis for the early prevention of osteoporosis.

scholarly journals Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects

2021 ◽  
Vol 22 (21) ◽  
pp. 11872
Author(s):  
Chien-Ning Hsu ◽  
Chih-Yao Hou ◽  
Wei-Hsuan Hsu ◽  
You-Lin Tain
Keyword(s):  
Metabolic Syndrome ◽  
Early Life ◽  
Chemical Exposure ◽  
Developmental Origins ◽  
Global Public Health ◽  
Early Life Conditions ◽  
Health And Disease ◽  
Underlying Mechanisms ◽  
The Many ◽  
Health Burdens

One of the leading global public-health burdens is metabolic syndrome (MetS), despite the many advances in pharmacotherapies. MetS, now known as “developmental origins of health and disease” (DOHaD), can have its origins in early life. Offspring MetS can be programmed by various adverse early-life conditions, such as nutrition imbalance, maternal conditions or diseases, maternal chemical exposure, and medication use. Conversely, early interventions have shown potential to revoke programming processes to prevent MetS of developmental origins, namely reprogramming. In this review, we summarize what is currently known about adverse environmental insults implicated in MetS of developmental origins, including the fundamental underlying mechanisms. We also describe animal models that have been developed to study the developmental programming of MetS. This review extends previous research reviews by addressing implementation of reprogramming strategies to prevent the programming of MetS. These mechanism-targeted strategies include antioxidants, melatonin, resveratrol, probiotics/prebiotics, and amino acids. Much work remains to be accomplished to determine the insults that could induce MetS, to identify the mechanisms behind MetS programming, and to develop potential reprogramming strategies for clinical translation.

scholarly journals Animal Models for DOHaD Research: Focus on Hypertension of Developmental Origins

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 623
Author(s):  
Chien-Ning Hsu ◽  
You-Lin Tain
Keyword(s):  
Animal Models ◽  
Early Life ◽  
Later Life ◽  
Convincing Evidence ◽  
Environmental Chemicals ◽  
Developmental Origins ◽  
Critical Window ◽  
Health And Disease ◽  
Underlying Mechanisms

Increasing evidence suggests that fetal programming through environmental exposure during a critical window of early life leads to long-term detrimental outcomes, by so-called developmental origins of health and disease (DOHaD). Hypertension can originate in early life. Animal models are essential for providing convincing evidence of a causal relationship between diverse early-life insults and the developmental programming of hypertension in later life. These insults include nutritional imbalances, maternal illnesses, exposure to environmental chemicals, and medication use. In addition to reviewing the various insults that contribute to hypertension of developmental origins, this review focuses on the benefits of animal models in addressing the underlying mechanisms by which early-life interventions can reprogram disease processes and prevent the development of hypertension. Our understanding of hypertension of developmental origins has been enhanced by each of these animal models, narrowing the knowledge gap between animal models and future clinical translation.

Epigenetics and DOHaD: how translation to predictive testing will require a better public understanding

2021 ◽  
pp. 1-7
Author(s):  
Fiona Lynch ◽  
Sharon Lewis ◽  
Ivan Macciocca ◽  
Jeffrey M. Craig
Keyword(s):  
Health Professionals ◽  
Early Life ◽  
Predictive Testing ◽  
Public Understanding ◽  
Future Research ◽  
Developmental Origins ◽  
Needed Information ◽  
Genes And Environment ◽  
Increased Risk ◽  
Health And Disease

Abstract Epigenetics is likely to play a role in the mediation of the effects of genes and environment in risk for many non-communicable diseases (NCDs). The Developmental Origins of Health and Disease (DOHaD) theory presents unique opportunities regarding the possibility of early life interventions to alter the epigenetic makeup of an individual, thereby modifying their risk for a variety of NCDs. While it is important to determine how we can lower the risk of these NCDs, it is equally important to understand how the public’s knowledge and opinion of DOHaD and epigenetic concepts may influence their willingness to undertake such interventions for themselves and their children. In this review, we provide an overview of epigenetics, DOHaD, NCDs, and the links between them. We explore the issues surrounding using epigenetics to identify those at increased risk of NCDs, including the concept of predictive testing of children. We also outline what is currently understood about the public’s understanding and opinion of epigenetics, DOHaD, and their relation to NCDs. In doing so, we demonstrate that it is essential that future research explores the public’s awareness and understanding of epigenetics and epigenetic concepts. This will provide much-needed information which will prepare health professionals for the introduction of epigenetic testing into future healthcare.

The developing world of DOHaD

2017 ◽  
Vol 9 (3) ◽  
pp. 266-269 ◽  
Author(s):  
K. Suzuki
Keyword(s):  
Life Events ◽  
Early Life ◽  
Developing World ◽  
Biomedical Science ◽  
Developmental Origins ◽  
Health And Disease ◽  
Early Life Events

Since its debut in a ground-breaking report by Barker and Osmond in 1986, the concept of the Developmental Origins of Health and Disease (DOHaD) has been further developed in several aspects. Its methodology and conclusions relating to proposed origins and outcomes of early life events have been developing and spreading internationally. Indeed, the DOHaD concept now seems to have influenced many fields of research. This article aims to briefly review why the DOHaD concept is important in biomedical science, how it has developed, is currently developing, and how it should develop in future.

The establishment of DOHaD working groups in Australia and New Zealand

2016 ◽  
Vol 7 (5) ◽  
pp. 433-439 ◽  
Author(s):  
S. L. Prescott ◽  
K. Allen ◽  
K. Armstrong ◽  
C. Collins ◽  
H. Dickinson ◽  
...  
Keyword(s):  
New Zealand ◽  
Early Life ◽  
Developmental Origins ◽  
Effect Change ◽  
Cohort Group ◽  
Disease Outcomes ◽  
Working Groups ◽  
Health And Disease ◽  
Translational Strategies ◽  
The Impact

The evidence underpinning the developmental origins of health and disease (DOHaD) is overwhelming. As the emphasis shifts more towards interventions and the translational strategies for disease prevention, it is important to capitalize on collaboration and knowledge sharing to maximize opportunities for discovery and replication. DOHaD meetings are facilitating this interaction. However, strategies to perpetuate focussed discussions and collaborations around and between conferences are more likely to facilitate the development of DOHaD research. For this reason, the DOHaD Society of Australia and New Zealand (DOHaD ANZ) has initiated themed Working Groups, which convened at the 2014–2015 conferences. This report introduces the DOHaD ANZ Working Groups and summarizes their plans and activities. One of the first Working Groups to form was the ActEarly birth cohort group, which is moving towards more translational goals. Reflecting growing emphasis on the impact of early life biodiversity – even before birth – we also have a Working Group titled Infection, inflammation and the microbiome. We have several Working Groups exploring other major non-cancerous disease outcomes over the lifespan, including Brain, behaviour and development and Obesity, cardiovascular and metabolic health. The Epigenetics and Animal Models Working Groups cut across all these areas and seeks to ensure interaction between researchers. Finally, we have a group focussed on ‘Translation, policy and communication’ which focusses on how we can best take the evidence we produce into the community to effect change. By coordinating and perpetuating DOHaD discussions in this way we aim to enhance DOHaD research in our region.

scholarly journals Developmental origins of health and disease: a new approach for the identification of adults who suffered undernutrition in early life

2018 ◽  
Vol Volume 11 ◽  
pp. 543-551
Author(s):  
Haroldo da Silva Ferreira ◽  
Antonio Fernando Silva Xavier Junior ◽  
Monica Lopes Assunção ◽  
Tainá Cardoso Caminha Uchôa ◽  
Abel Barbosa Lira-Neto ◽  
...  
Keyword(s):  
Early Life ◽  
Developmental Origins ◽  
New Approach ◽  
Health And Disease

scholarly journals Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Chan Hee Lee ◽  
Do Kyeong Song ◽  
Chae Beom Park ◽  
Jeewon Choi ◽  
Gil Myoung Kang ◽  
...  
Keyword(s):  
Early Life ◽  
Primary Cilia ◽  
Maternal Nutrition ◽  
Hypothalamic Neurons ◽  
Axonal Projections ◽  
Early Life Programming ◽  
Body Weights ◽  
Cilia Formation ◽  
Obesity In Mice ◽  
Underlying Mechanisms

AbstractHypothalamic neurons including proopiomelanocortin (POMC)-producing neurons regulate body weights. The non-motile primary cilium is a critical sensory organelle on the cell surface. An association between ciliary defects and obesity has been suggested, but the underlying mechanisms are not fully understood. Here we show that inhibition of ciliogenesis in POMC-expressing developing hypothalamic neurons, by depleting ciliogenic genes IFT88 and KIF3A, leads to adulthood obesity in mice. In contrast, adult-onset ciliary dysgenesis in POMC neurons causes no significant change in adiposity. In developing POMC neurons, abnormal cilia formation disrupts axonal projections through impaired lysosomal protein degradation. Notably, maternal nutrition and postnatal leptin surge have a profound impact on ciliogenesis in the hypothalamus of neonatal mice; through these effects they critically modulate the organization of hypothalamic feeding circuits. Our findings reveal a mechanism of early life programming of adult adiposity, which is mediated by primary cilia in developing hypothalamic neurons.

scholarly journals Early-Life Programming and Reprogramming of Adult Kidney Disease and Hypertension: The Interplay between Maternal Nutrition and Oxidative Stress

2020 ◽  
Vol 21 (10) ◽  
pp. 3572 ◽  
Author(s):  
Chien-Ning Hsu ◽  
You-Lin Tain
Keyword(s):  
Oxidative Stress ◽  
Kidney Disease ◽  
Early Life ◽  
Maternal Nutrition ◽  
Current Knowledge ◽  
Developmental Origins ◽  
Future Health ◽  
Adult Kidney ◽  
Origins Research ◽  
And Oxidative Stress

Kidney disease and hypertension both have attained the status of a global pandemic. Altered renal programming resulting in kidney disease and hypertension can begin in utero. Maternal suboptimal nutrition and oxidative stress have important implications in renal programming, while specific antioxidant nutrient supplementations may serve as reprogramming strategies to prevent kidney disease and hypertension of developmental origins. This review aims to summarize current knowledge on the interplay of maternal nutrition and oxidative stress in response to early-life insults and its impact on developmental programming of kidney disease and hypertension, covering two aspects. Firstly, we present the evidence from animal models supporting the implication of oxidative stress on adult kidney disease and hypertension programmed by suboptimal maternal nutrition. In the second part, we document data on specific antioxidant nutrients as reprogramming strategies to protect adult offspring against kidney disease and hypertension from developmental origins. Research into the prevention of kidney disease and hypertension that begin early in life will have profound implications for future health.

scholarly journals Sex Differences in the Developmental Origins of Cardiovascular Disease

Physiology ◽  
2014 ◽  
Vol 29 (2) ◽  
pp. 122-132 ◽  
Author(s):  
Suttira Intapad ◽  
Norma B. Ojeda ◽  
John Henry Dasinger ◽  
Barbara T. Alexander
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Sex Differences ◽  
Cardiovascular Risk ◽  
Early Life ◽  
Experimental Models ◽  
Developmental Origins ◽  
Proof Of Concept ◽  
Increased Risk ◽  
Health And Disease

The Developmental Origins of Health and Disease (DOHaD) proposes that adverse events during early life program an increased risk for cardiovascular disease. Experimental models provide proof of concept but also indicate that insults during early life program sex differences in adult blood pressure and cardiovascular risk. This review will highlight the potential mechanisms that contribute to the etiology of sex differences in the developmental programming of cardiovascular disease.

scholarly journals Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol?

2018 ◽  
Vol 19 (9) ◽  
pp. 2584 ◽  
Author(s):  
You-Lin Tain ◽  
Chien-Ning Hsu
Keyword(s):  
Metabolic Syndrome ◽  
Early Life ◽  
Wide Spectrum ◽  
Molecular Targets ◽  
Developmental Programming ◽  
Developmental Origins ◽  
Polyphenolic Compound ◽  
Beneficial Effects ◽  
The Metabolic Syndrome ◽  
Health And Disease

Metabolic syndrome (MetS) is a mounting epidemic worldwide. MetS can start in early life, in a microenvironment that is now known as the developmental origins of health and disease (DOHaD). The concept of DOHaD also offers opportunities for reprogramming strategies that aim to reverse programming processes in early life. Resveratrol, a polyphenolic compound has a wide spectrum of beneficial effects on human health. In this review, we first summarize the epidemiological and experimental evidence supporting the developmental programming of MetS. This review also presents an overview of the evidence linking different molecular targets of resveratrol to developmental programming of MetS-related disorders. This will be followed by studies documenting resveratrol as a reprogramming agent to protect against MetS-related disorders. Further clinical studies are required in order to bridge the gap between animal models and clinical trials in order to establish the effective dose and therapeutic duration for resveratrol as a reprogramming therapy on MetS disorders from developmental origins.

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