The Therapeutic Potential of Berberis darwinii Stem-Bark: Quantification of Berberine and In Vitro Evidence for Alzheimer's Disease Therapy
2011 ◽
Vol 6
(8)
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pp. 1934578X1100600
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Keyword(s):
Berberis darwinii is native to South America but has been widely distributed in Europe and other continents following its discovery by Charles Darwin. Herewith, the therapeutic potential of stem-bark of the plant for treating Alzheimer's disease was studied using an in vitro acetylcholinesterase inhibition assay. It was found that the methanolic extract of the stem-bark was a potent inhibitor of the enzyme with an IC50 value of 1.23 ± 0.05 μg/mL. An HPLC-based berberine quantification study revealed an astonishing 38% yield of the dried methanolic extract.
2020 ◽
Vol 17
(2)
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pp. 141-157
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2021 ◽
2016 ◽
Vol 2016
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pp. 1-14
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2019 ◽
Vol 18
(5)
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pp. 352-365
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Keyword(s):
2018 ◽
Vol 17
(1)
◽
pp. 43-53
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