The Impact of Medications on Esophageal Motility
2021 ◽
Vol 1
(3)
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pp. 277-285
Keyword(s):
The purpose of this review is to highlight the impact of common medications on esophageal motility. Esophageal motility is mediated through a complex network of neural innervation. Opioids lead to excitatory esophageal motor abnormalities termed opioid-induced esophageal dysfunction or OIED. Prokinetics have mixed effects on esophageal motility. Nitrates and calcium channel blockers relax esophageal smooth muscle, but they are limited clinically due to side effects. Sildenafil also relaxes smooth muscle, but it is costly. Peppermint oil may reduce distal esophageal spasm. Anticholinergics, selective serotonin reuptake inhibitors, estrogen, and cannabis need further study to evaluate their effects on esophageal motility.
1995 ◽
Vol 269
(3)
◽
pp. G378-G385
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2009 ◽
Vol 58
(S2)
◽
pp. 193-200
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Keyword(s):
2021 ◽
Vol 1
(3)
◽
pp. 254-262
2010 ◽
Vol 298
(5)
◽
pp. G706-G713
◽
1999 ◽
Vol 277
(6)
◽
pp. C1284-C1290
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