Baseline VWF:Ag Level and Body Mass Index Are Inverse Influencing Factors of Annualized Total Bleeding Rate and Annualized Joint Bleeding Rate Respectively in Severe-Type Adult Patients with Hemophilia a (PwHA) with Episodic Treatment with rFVIII

Abstract Introduction: Bleeding phenotypes of severe-type patients with hemophilia A (PwHA) vary greatly, which influence factor consumption and medical cost. Factors affecting bleeding patterns of PwHA include various procoagulant and anticoagulant factors, joint condition and physical activity, etc. We aimed to investigate clinical factors influencing by-nature bleeding frequency of severe-type PwHA during episodic treatment. Methods and materials: There were 19 non-inhibitor, severe-type, previously treated PwHA aged >20 years, who had at least one to five major joints arthropathy, retrospectively enrolled from two hemophilia centers for analysis. They had been refusing prophylaxis therapy with FVIII product due to heavy burden of frequent intravenous FVIII injection and had long-term episodic treatment. Clinical informations were collected from November 2017 to November 2018, including age, body mass index (BMI), body weight, ABO blood grouping, HCV and HIV infection status, baseline VWF:Ag and VWF:activity, mutation of F8 gene. Annualized bleeding rate (ABR) and annualized joint bleeding rate (AJBR), weekly doses and annualized factor consumption costs (calculated by new Taiwan dollars, NTD) were obtained from the patients' medical records. Results: The PwHA with ABR <24 had significantly lower proportion of blood-group-O patients, higher baseline VWF:Ag and VWF:activity than those with ABR >24.(P-value <0.05) The PwHA with AJBR <13 had significantly higher BMI than those with AJBR >13.(P-value <0.05) There was no significant difference in ABR, AJBR, weekly dose, and annualized factor cost between PwHA with O blood group and non-O blood group. Compared with PwHA with baseline VWF:Ag or VWF:activity <145%, those with baseline VWF:Ag or VWF:activity >145% had significantly older age (34.9 vs 53.2 years, P-value <0.05), higher BMI (25.2 vs 29.9, P-value <0.05), lower ABR (58.2 vs 12.2 per year, P-value<0.01), lower AJBR (46.8 vs 10.8 per year, P-value<0.01), lower weekly dose (42.4 vs 10.6 IU/kg/wk, P-value<0.01), and lower annualized factor consumption costs (4,177,732 vs 1,120,704 NTD, P-value<0.01). Compared with PwHA with BMI <28, those with BMI >28 had significantly lower ABR (58.2 vs 12.2 per year, P-value<0.05), lower AJBR (46.8 vs 10.8 per year, P-value<0.05), higher baseline VWF:activity (94.6% vs 190.2%, P-value <0.05), and lower weekly dose (38.5 vs 17.1 IU/kg/wk, P-value <0.05). By backward-stepwise multivariate linear regression, baseline VWF:Ag and BMI were identified as independent and significant inverse influencing factors for ABR and AJBR, respectively.(P-value <0.05) Conclusion: For severe-type adult PwHA with episodic treatment, baseline VWF:Ag or VWF:activity >145% was associated with lower ABR, AJBR, weekly dose, and annualized factor cost. BMI >28 was associated with lower ABR, AJBR, and weekly dose consumption. Baseline VWF:Ag and BMI were revealed as inverse influencing factors for ABR and AJBR, respectively. The results of our study could be useful for clinicians to have an insight into diversity of bleeding phenotypes of by-nature severe-type PwHA. For developing countries where factor concentrate resources are not enough, these clinical influencing factors might be helpful for the management of therapeutic strategies and resource allocation for severe PwHA. Disclosures No relevant conflicts of interest to declare.

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DIFFERENT BLOOD GROUPS

The Professional Medical Journal ◽

10.29309/tpmj/2016.23.08.1677 ◽

2016 ◽

Vol 23 (08) ◽

pp. 1001-1004

Author(s):

Naila Parveen ◽

Javeria Rehman ◽

Syed Hafeezul Hassan ◽

Zoya Hassan ◽

Madiha Rehman

Keyword(s):

Body Mass Index ◽

Medical Students ◽

Blood Group ◽

Body Mass ◽

Blood Groups ◽

Blood Type ◽

P Value ◽

Cross Sectional ◽

Blood Group A ◽

Group A

Objectives: To find out the association of body mass index with different bloodgroups in medical students. Background: Increased body mass index leads to obesity and is aprominent risk factor for hypertension and diabetes. Blood groups are known to be associatedwith various diseases and recent studies have shown that a particular blood group with thehighest body mass index appeared to be more susceptible to predisposition to hypertension.Study Design: Cross-sectional study. Setting: Liaquat National Medical College, Karachi.Period: June 2015 to September 2015. Methodology: 181 medical students with 85 malesand 96 females and age ranging from 18-22 years. Weight and height of each student wasmeasured using the standard stadiometer and blood groups were determined using the antisera.Results: Mean age of the participants was 19.92 ± 1.10 years. Blood group “O” wasfound to be most prevalent (39.2%) while blood group “AB” was found to be the least (8.3%).Mean BMI of subjects with blood group A, B, AB and O were found to be 24.3 ± 5.04, 22.6 ±3.59, 23.0 ± 2.91 and 23.7 ± 4.20 kg/m2 respectively. The highest BMI was found in subjectswith blood group “A” 24.3 ± 5.04 kg/m2 and lowest in blood group “AB” 23.0 ± 2.91kg/m2. TheRhesus-D positive and male students had greater body mass index 23.6 ± 3.56 than females23.2 ± 3.44. Comparison of overall mean BMI values among different blood groups showedsignificant difference with p-value < 0.001. Conclusion: Blood group “A” and Rhesus-D positivesubjects especially males were found to be the high risk blood type with predisposition tomorbidity associated with increased body mass index.

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Real-World Bleeding Outcomes, Weekly Factor Consumption Doses, Annualized Factor Costs in Severe-Type Patients with Hemophilia a (PwHA) before and after Switching to Extended Half-Life rFVIII-Fc Prophylaxis

Blood ◽

10.1182/blood-2021-152066 ◽

2021 ◽

Vol 138 (Supplement 1) ◽

pp. 3198-3198

Author(s):

Chia-Yau Chang ◽

Shiue-Wei Lai ◽

Mei-Mei Cheng ◽

Pei-Yi Lai ◽

Jung-Tzu Ku ◽

...

Keyword(s):

Real World ◽

Half Life ◽

Hemophilia A ◽

Conflicts Of Interest ◽

Bleeding Rate ◽

Episodic Treatment ◽

Real World Setting ◽

Before And After ◽

Prophylaxis Therapy ◽

Severe Type

Abstract Introduction: Stand half-life (SHL) rFVIII had been used in patients with hemophilia A (PwHA) for episodic treatment (ET) and prophylaxis therapy (PT) for years. Extended half-life (EHL) rFVIII had been available since 2014, also available in Taiwan since 2018, and resulted in markedly increased willingness for PT because it reduced injection burden. We aimed to investigate the real-world bleeding outcomes, weekly factor doses, and factor costs of severe-type PwHA with pre-switch SHL rFVIII and post-switch EHL rFVIIIFc prophylaxis in Taiwan, and made a pre-switch and post-switch comparison. Methods and Materials: There were totally 51 non-inhibitor, severe-type PwHA, with complete bleeding records before and after switching from SHL rFVIII to EHL rFVIII-Fc, enrolled from two hemophilia centers during Nov, 2018－July, 2019. Most of them had various degree of one to more major joints arthropathy, except children. The medical charts were retrospective reviewed and data were collected, including body features and factor regimen, etc. Patients' annualized bleeding/joint-bleeding rate (ABR/AJBR), weekly doses (WD), annualized factor costs (AFC) were obtained from the chart records of pre-switch 12 months and post-switch at least more-than 6-month until July, 2019. Data from scheduled operation or hospitalization due to trauma or accidence were excluded. Results: There were 8 boys and 43 adults, the median age of all PwHA when switching was 35.6 years (10.5-62). Before switching, these 51 PTP treated with SHL rFVIII who received ET (ET group), irregular prophylaxis (IP group), and regular prophylaxis (RP group) were 19 (37.3%), 7 (13.7%), and 25 (49%), respectively. Bleeding records of 51 PTP treated with SHL rFVIII were traced back with 11.8±0.9 months. After switching to rFVIII-Fc, 3 PwHA receiving ET were excluded, and bleeding records of 48 received RP were obtained with 14.7±4.6 months. Pre-switch and post-switch prophylaxis rate were 62.7% (32/51) and 94.1% (48/51), respectively. For comparison of pre-switch and post-switch outcomes: Median ABR was reduced from 48, 12, and 4 to 1.15, 1.9, and 1.5 for ET, IP, and RP group, respectively. Median AJBR was reduced from 32, 11, and 4 to 0.95, 0.7, and 1.2 for ET, IP, and RP group, respectively. Median WD was increased from 38.4, 52.9, and 63.6 IU/kg/wk to 84.6, 84.5, and 84.9 IU/kg/wk for ET, IP, and RP group, respectively. Median AFC was increased from 4,141,800, 4,064,000 and 5,129,700 NTD to 7,042,325, 5,835,450, and 5,762,810 NTD for ET, IP, and RP group, respectively. Comparing pre-switch and post-switch outcomes of children and adults who received pre-switch and post-switch prophylaxis, median ABR was reduced from 3 and 5 to 1.35 and 1.85 for children and adults, respectively. Median AJBR was reduced from 3 and 4 to 1.35 and 1.15 for children and adults, respectively. Median WD was increased from 58.8 and 58.3 IU/kg/wk to 87.85 and 83.85 IU/kg/wk for children and adults, respectively. Median AFC was increased from 4,104,225 and 5,879,025 NTD to 4,419,800 and 6,024,916 NTD for children and adults, respectively. For all PwHA, zero ABR accounted for 5.9% (3/51) with pre-switch SHL rFVIII treatment and for 20.8% (10/48) with post-switch rFVIII-Fc prophylaxis. Zero AJBR accounted for 9.8% (5/51) with SHL rFVIII treatment and for 33.3% (16/48) with rFVIII-Fc prophylaxis. For PwHA with pre- and post-switch prophylaxis, zero ABR accounted for 12.5% (1/8) and 8.3% (2/24), respectively, for children and adults on SHL rFVIII prophylaxis and 25% (2/8) and 25% (6/24) respectively, for children and adults on rFVIII-Fc prophylaxis. Zero AJBR accounted for 12.5% (1/8) and 16.7% (4/24), respectively, for children and adults on SHL rFVIII prophylaxis and 25% (2/8) and 37.5% (9/24) respectively, for children and adults on rFVIII-Fc prophylaxis. Conclusion: In real-world setting, for pre-switch ET group, switch to rFVIII-Fc prophylaxis made both mean ABR and AJBR reduced >95%, and mean WD increased >50%. For pre-switch IP group, switch to rFVIII-Fc prophylaxis made both mean ABR and AJBR reduced >80%, and mean WD increased >35%. For pre-switch RP group, switch to rFVIII-Fc prophylaxis made both mean ABR and AJBR also reduced >45%, and mean WD increased >20%. The proportions in zero ABR and zero AJBR as post-switch rFVIII-Fc prophylaxis were increased. No matter in ET, IP, or RP group, after switching to RP with rFVIII-Fc, improvement for bleeding outcomes was quite evident. Disclosures No relevant conflicts of interest to declare.

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Correlation of Body Mass Index with Oncologic Outcomes in Colorectal Cancer Patients: A Large Population-Based Study

Cancers ◽

10.3390/cancers13143592 ◽

2021 ◽

Vol 13 (14) ◽

pp. 3592

Author(s):

Chong-Chi Chiu ◽

Chung-Han Ho ◽

Chao-Ming Hung ◽

Chien-Ming Chao ◽

Chih-Cheng Lai ◽

...

Keyword(s):

Colorectal Cancer ◽

Body Mass Index ◽

Body Weight ◽

Body Mass ◽

Survival Rates ◽

Normal Weight ◽

P Value ◽

Administrative Claims ◽

The Impact

It has been acknowledged that excess body weight increases the risk of colorectal cancer (CRC); however, there is little evidence on the impact of body mass index (BMI) on CRC patients’ long-term oncologic results in Asian populations. We studied the influence of BMI on overall survival (OS), disease-free survival (DFS), and CRC-specific survival rates in CRC patients from the administrative claims datasets of Taiwan using the Kaplan–Meier survival curves and the log-rank test to estimate the statistical differences among BMI groups. Underweight patients (<18.50 kg/m2) presented higher mortality (56.40%) and recurrence (5.34%) rates. Besides this, they had worse OS (aHR:1.61; 95% CI: 1.53–1.70; p-value: < 0.0001) and CRC-specific survival (aHR:1.52; 95% CI: 1.43–1.62; p-value: < 0.0001) rates compared with those of normal weight patients (18.50–24.99 kg/m2). On the contrary, CRC patients belonging to the overweight (25.00–29.99 kg/m2), class I obesity (30.00–34.99 kg/m2), and class II obesity (≥35.00 kg/m2) categories had better OS, DFS, and CRC-specific survival rates in the analysis than the patients in the normal weight category. Overweight patients consistently had the lowest mortality rate after a CRC diagnosis. The associations with being underweight may reflect a reverse causation. CRC patients should maintain a long-term healthy body weight.

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Cardioautonomic responses to acute ingestion of ice water and its correlation to body mass index

Journal of Basic and Clinical Physiology and Pharmacology ◽

10.1515/jbcpp-2018-0057 ◽

2018 ◽

Vol 30 (2) ◽

pp. 259-264

Author(s):

Priya Arjunwadekar ◽

Savitri Parvatgouda Siddanagoudra

Keyword(s):

Body Mass Index ◽

Standard Deviation ◽

Body Mass ◽

Water Intake ◽

Healthy Subjects ◽

P Value ◽

Cross Sectional ◽

Water Ingestion ◽

Obese Subjects ◽

Ice Water

Abstract Background A significant relationship has been documented in the literature between the autonomic nervous system imbalance and cardiovascular mortality. In patients with autonomic failure, water ingestion has been shown to increase blood pressure (BP), induce bradycardia, and cause low heart rate variability (HRV). A few studies showed the altered HRV as an acute effect of ice water intake in healthy subjects. None of the studies have shown light on the relationship of BP and HRV to ice water intake in obese and overweight subjects. The present study is aimed to correlate BP and HRV with body mass index (BMI) after ice water ingestion. Methods This cross-sectional study included a total of 60 subjects of both sexes aged between 18 and 24 years old. Subjects were assigned into three groups based on their BMI: normal, overweight, and obese. Before and after ice water ingestion, BP and HRV parameters were recorded and compared between the groups. Statistically data were analyzed by Student’s paired t-test and one-way analysis of variance. Results Basal HF was significant (p<0.05) in all three groups after ice water ingestion [F(2, 27), 44.1; p-value, 0.02]. After ice water ingestion, all HRV values were significant (p<0.001) in the three groups. The post-hoc Tukey HSD test demonstrated the less mean score for mean RR interval, standard deviation of all NN interval, standard deviation of differences between adjacent, HF and high for HR, LF, and LHR in overweight and obese subjects. Conclusions Because of the effective buffering system, healthy subjects showed increased HR and unchanged BP. Overweight and obese subjects showed decreased HR and increased BP.

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Effects of replacement therapies with clotting factors in patients with hemophilia: A systematic review and meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0262273 ◽

2022 ◽

Vol 17 (1) ◽

pp. e0262273

Author(s):

Carolina J. Delgado-Flores ◽

David García-Gomero ◽

Stefany Salvador-Salvador ◽

José Montes-Alvis ◽

Celina Herrera-Cunti ◽

...

Keyword(s):

Low Dose ◽

Prophylactic Treatment ◽

Hemophilia A ◽

Clotting Factor ◽

High Dose ◽

Bleeding Rate ◽

Episodic Treatment ◽

Grade Methodology ◽

Inform Decision Making ◽

Intermediate Dose

Background Different prophylactic and episodic clotting factor treatments are used in the management of hemophilia. A summarize of the evidence is needed inform decision-making. Objective To compare the effects of factor replacement therapies in patients with hemophilia. Methods We performed a systematic search in PubMed, Central Cochrane Library, and Scopus. We included randomized controlled trials (RCTs) published up to December 2020, which compared different factor replacement therapies in patients with hemophilia. Random-effects meta-analyses were performed whenever possible. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. The study protocol was registered in PROSPERO (CRD42021225857). Results Nine RCTs were included in this review, of which six compared episodic with prophylactic treatment, all of them performed in patients with hemophilia A. Pooled results showed that, compared to the episodic treatment group, the annualized bleeding rate was lower in the low-dose prophylactic group (ratio of means [RM]: 0.27, 95% CI: 0.17 to 0.43), intermediate-dose prophylactic group (RM: 0.15, 95% CI: 0.07 to 0.36), and high-dose prophylactic group (RM: 0.07, 95% CI: 0.04 to 0.13). With significant difference between these subgroups (p = 0.003, I2 = 82.9%). In addition, compared to the episodic treatment group, the annualized joint bleeding rate was lower in the low-dose prophylactic group (RM: 0.17, 95% CI: 0.06 to 0.43), intermediate-dose prophylactic group (RM of 0.14, 95% CI: 0.07 to 0.27), and high-dose prophylactic group (RM of 0.08, 95% CI: 0.04 to 0.16). Without significant subgroup differences. The certainty of the evidence was very low for all outcomes according to GRADE methodology. The other studies compared different types of clotting factor concentrates (CFCs), assessed pharmacokinetic prophylaxis, or compared different frequencies of medication administration. Conclusions Our results suggest that prophylactic treatment (at either low, intermediate, or high doses) is superior to episodic treatment for bleeding prevention. In patients with hemophilia A, the bleeding rate seems to have a dose-response effect. However, no study compared different doses of prophylactic treatment, and all results had a very low certainty of the evidence. Thus, future studies are needed to confirm these results and inform decision making.

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A Submaximal Exercise Patterns Intervention on the Plasmatic Leptin Level and Insulin Resistance for Overweight / Obesity Boys Adolescences

Iranian journal of diabetes and obesity ◽

10.18502/ijdo.v12i4.5182 ◽

2021 ◽

Author(s):

Farzad Nazem ◽

Salman Lotfi

Keyword(s):

Insulin Resistance ◽

Body Mass Index ◽

Body Mass ◽

Exercise Intervention ◽

Exercise Program ◽

Serum Levels ◽

Medical Problem ◽

Control Group ◽

P Value ◽

Training Interval

Objective: Obesity is a medical problem that increases the risk of health problems like diabetes. Hormones secreting from fat tissue, Leptin, are correlated with body mass index. Leptin reduces the personchr('39')s appetite by acting on specific centers of their brain to reduce their urge to eat. And insulin, a hormone produced by the pancreas, is essential for regulating carbohydrates and the metabolism of fat. A positive relationship between leptin levels and insulin resistance in children showing in this study is to determine the effect of continues-endurance and interval-endurance on leptin serum levels and insulin resistance in over-weighted youths. Materials and Methods: This study is a semi-experimental design. Thirty boys were voluntarily selected as a matched two experimental groups and a control. Physical profiles included aged 16-19, BMI; 37.75 (±4.46) KG/M2, base functional capacity: 32.8 (±3.6) ml/kg/min which dividing by three equal groups: the submaximal training interval, a continuum and interval and control group performed the submaximal running program for six weeks on 3 D/W. The selected parameters were evaluated for an intervention pre and post-conditions. Results: weight and body mass index variables were decreased by about 2.5-3% after exercise intervention. Plasmatic leptin levels were reduced by about 45% in the continuum and interval control groups. HOMA-IR & QUICKI indexes altered in the EG (8.9 %, 7.8%) (P-value < 0.05). Conclusion: Presumably, 2 exercise program patterns lower than lactate threshold could change body composition profile, basal leptin level, and blood glucose /insulin concentrations, which probably induced changes in resistance to insulin.

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Correlation between Core Strength and Stability with Body Mass Index among Postmenopausal Women.

International Journal of Pharma and Bio Sciences ◽

10.22376/ijpbs/lpr.2021.11.4.l23-28 ◽

2021 ◽

Vol 11 (4) ◽

Author(s):

S Bhosale Komal ◽

V Bhosale Siddhi ◽

Anandh Dr. S

Keyword(s):

Body Mass Index ◽

Postmenopausal Women ◽

Body Mass ◽

Pearson Correlation ◽

The Body ◽

P Value ◽

Endurance Test ◽

Core Strength ◽

The Core ◽

Flexion Test

Women in postmenopausal period of their life face various physical and physiological changes causing lack of estrogen and progesterone hormones, changes in the reproductive and genitals organs, vasomotor system in the body along with mood related symptoms such as anxiety, etc. Lifestyle, body fat distribution and anthropometric changes adds on to the bone strength in postmenopausal women. It may be a risk factor for osteoporotic fracture, cardiovascular, metabolic diseases, etc. Core strength and stability is greatly influenced by body composition and adiposity. The aim of the study was to correlate the core strength assessed with the Body Mass Index (BMI) among postmenopausal women. The objective of the study is to find the correlation between the core strength assessed with the Body Mass Index using 60° flexion test, Beiring Sorenson test and Unilateral Hip Bridge Endurance test among postmenopausal women with age ranging from 46-70 years. 96 healthy postmenopausal women in Karad city with a natural history of menopause were selected for the study. Based upon BMI values, the subjects were grouped as Underweight (<18.5 kg/m2), Normal weight (18.5-24.9 kg/m2), Overweight (25-29.9 kg/m2 and more). The outcome values for strength were correlated with the BMI of postmenopausal women. In the study, the Pearson correlation(r) was -0.361 and the P value was 0.0003 showing extremely significant correlation between the BMI and 60° Flexion test. For the Beiring Sorenson Test, the Pearson correlation value was -0.305 and the P value was 0.0025 showing very significant correlation between the BMI and Beiring Sorenson Test. Correlation of BMI and Unilateral Hip Bridge Endurance Test shows a Pearson Correlation value of -0.322 and the P value 0.0013 claiming very significant correlation between the BMI and Unilateral Hip Bridge Endurance Test. The study concludes that there is a significantly negative correlation between the core strength and stability with the Body Mass Index among postmenopausal women.

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HUBUNGAN KECANDUAN GAME ONLINE DENGAN KEGEMUKAN PADA REMAJA DI WILAYAH JEMBER [THE RELATIONSHIPS OF ADDICTION TOONLINE GAMES WITH OVERWEIGHT ON ADOLESCENTS IN JEMBER DISTRICT]

Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) ◽

10.22435/pgm.v43i1.2545 ◽

2020 ◽

Vol 43 (1) ◽

pp. 11-19

Author(s):

Atik Rohmawati Mulyaningsih ◽

Tantut Susanto ◽

Latifa Aini Susumaningrum

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Random Sampling ◽

Sedentary Lifestyle ◽

P Value ◽

Stratified Random Sampling ◽

Online Game ◽

Cross Sectional ◽

Spearman Rank ◽

Game Addiction

Playing online games is a favorite activity for adolescents to fill their free time. This habit affects the occurrence of addiction if done for a long time. In addition, the long duration of play leads to sedentary lifestyle behaviors, which contribute to overweight among adolescents. The purpose of this study was to identify the relationship between online gaming addiction and being overweight among adolescents in Jember district. The cross-sectional study design was conducted among 162 overweight students from 16 senior high schools in Jember with stratified random sampling. The development of the Indonesian online game addiction questionnaire is used to assess online game addiction, weight scales, and stature meters are used to measure body mass index (overweight). The Spearman Rank test was performed to answer the objective of this study. The results of this study indicate that body mass index in 162 adolescents is overweight (Median=1,44; Standard Deviation=0,26) which indicates obesity. Adolescents who were identified as having addiction in the study were (27,2%) and mild addictions were (72,8%). There was a significant relationship between online game addiction and overweight (r=0.212 ; p-value = 0.007). The sedentary lifestyle of online game addiction contributes to the occurrence of overweight among adolescents. Therefore, regular physical activity patterns need to be applied to reduce sedentary lifestyle and overweight problems among adolescents.ABSTRAKBermain game online menjadi kegiatan favorit bagi remaja untuk mengisi waktu luang. Kebiasaan ini berdampak pada terjadinya kecanduan jika dilakukan dalam waktu yang lama. Selain itu, durasi bermain yang cukup lama mengarah pada perilaku gaya hidup yang menetap, yang berkontribusi pada terjadinya kelebihan berat badan di kalangan remaja. Tujuan dari penelitian ini adalah untuk mengidentifikasi hubungan antara kecanduan game online dan kelebihan berat badan di kalangan remaja di Kabupaten Jember. Desain penelitian cross sectional dilakukan di antara 162 siswa yang kelebihan berat badan dari 16 SMA di Jember dengan stratified random sampling. Kuesioner The development of Indonesian online game addiction questionnaire digunakan untuk menilai kecanduan game online, timbangan berat badan dan stature meter digunakan untuk mengukur indeks massa tubuh (kegemukan). Analisis uji menggunakan uji spearman rank untuk menjawab tujuan penelitian ini. Hasil penelitian ini menunjukkan bahwa indeks massa tubuh pada 162 remaja adalah (M = 1,44; SD = 0,26) didapatkan median >1 untuk Z score antropometri yang mengindikasikan kegemukan. Remaja yang diidentifikasi mengalami kecanduan pada penelitian adalah (27,2%) dan kecanduan ringan adalah (72,8%). Terdapat hubungan yang signifikan antara kecanduan game online dan kegemukan (r = 0,212; p value = 0,007). Gaya hidup menetap dari kecanduan game online berkontribusi terhadap terjadinya kegemukan di kalangan remaja. Oleh karena itu, perlu diterapkan pola aktivitas fisik secara teratur untuk mengurangi gaya hidup yang menetap dan masalah kelebihan berat badan di kalangan remaja. [Penel Gizi Makan 2020, 43(1):11-20]

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Long-Term Postoperative Total Knee Arthroplasty Flexion Scores in Relation to Body Mass Index

The Journal of Knee Surgery ◽

10.1055/s-0040-1718601 ◽

2020 ◽

Author(s):

Matthew A. Siegel ◽

Michael J. Patetta ◽

Angie M. Fuentes ◽

Armaan S. Haleem ◽

Craig W. Forsthoefel ◽

...

Keyword(s):

Body Mass Index ◽

Total Knee Arthroplasty ◽

Body Mass ◽

Knee Arthroplasty ◽

Statistical Significance ◽

P Value ◽

Preoperative Body Mass Index ◽

Total Knee

AbstractKnee range of motion (ROM) is an important postoperative measure of total knee arthroplasty (TKA). There is conflicting literature whether patients who are obese have worse absolute ROM outcomes than patients who are not obese. This study analyzed whether preoperative body mass index (BMI) influences knee ROM after patients' primary TKA. A retrospective investigation was performed on patients, who underwent primary TKA at an academic institution, by one of three fellowship-trained adult reconstruction surgeons. Patients were stratified according to their preoperative BMI into nonobese (BMI < 30.0 kg/m2) and obese (BMI ≥ 30.0 kg/m2) classifications. Passive ROM was assessed preoperatively as well as postoperatively at patients' most recent follow-up visit that was greater than 2 years. Mann–Whitney U tests were performed to determine statistical significance at p-value <0.05 for ROM outcomes. No statistically significant differences were observed when ROM in the nonobese group was compared with ROM in the obese group both preoperatively (105.73 ± 11.58 vs. 104.14 ± 13.58 degrees, p-value = 0.417) and postoperatively (105.83 ± 14.19 vs. 104.49 ± 13.52 degrees, p-value = 0.777). Mean follow-up time for all patients was 4.49 ± 1.92 years. In conclusion, long-term postoperative ROM outcomes were similar between patients who were nonobese and patients who were obese.

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Association between Acne and Body Mass Index: A Hospital Based Cross Sectional Study

Nepal Journal of Dermatology Venereology & Leprology ◽

10.3126/njdvl.v16i1.19408 ◽

2018 ◽

Vol 16 (1) ◽

pp. 53-56

Author(s):

Saraswoti Neupane ◽

Binamra Basnet ◽

Tara Devi Sharma

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Acne Vulgaris ◽

Cross Sectional Study ◽

Normal Weight ◽

P Value ◽

Cross Sectional ◽

Middle Income ◽

Medical College ◽

Middle Income Countries

Introduction: Acne vulgaris is a common and chronic inflammatory skin disease of pilosebaceous unit. Obesity is one of the biggest problems in western life style but nowadays, the problem is increasing even in low and middle-income countries. Body Mass Index (BMI) is used to accurately measure obesity.Objective: To find out the association between different categories of BMI and severity of acne.Materials and methods: This was a cross sectional prospective study conducted in the outpatient department of Gandaki Medical College from January to July, 2017. All the newly diagnosed patients with acne were included in the study. Height and weight of the patients was recorded and BMI was calculated. BMI was categorized as underweight, normal weight, overweight and obese. Type of lesions were noted and severity of acne was graded from 1 to 4.Statistical analysis was performed using SPSS version 17.0 for windows. One-way Analysis of Variance between groups (ANOVA) test was applied. P value of less than 0.05 was considered significant.Results: There were altogether 249 patients with acne. Age of the patients ranged from 10 to 44 years with mean age of 20.82 ±5.9 years. Most of the patients were in the age group of 11-20 years. Female: male ratio was 1:1.4. Majority of patients (65.5%) had normal BMI. Most of the patients had Grade 2 acne (52.6%). There was no significant association between the BMI and severity of acne (p=0.129).Conclusion: There was no significant association between BMI and severity of acne.

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