scholarly journals Prevention of HLA immunization with leukocyte-poor packed red cells and platelet concentrates obtained by filtration

Blood ◽  
1988 ◽  
Vol 72 (3) ◽  
pp. 964-969 ◽  
Author(s):  
G Andreu ◽  
J Dewailly ◽  
C Leberre ◽  
MC Quarre ◽  
ML Bidet ◽  
...  
Keyword(s):  
Control Group ◽  
Blood Products ◽  
Platelet Concentrates ◽  
Transfusion Therapy ◽  
Immunization Rate ◽  
Significant Difference ◽  
Poor Group ◽  
Main Component ◽  
High Level ◽  
Packed Rbcs

Abstract HLA immunization is a common complication of transfusion therapy in 30% to 60% of oncohematologic patients. Evidence shows that leukocytes present in cellular blood products are the main component involved in the occurrence of HLA immunization, and several studies showed that leukocyte-poor blood products are less able to induce it. However, leukocyte-poor platelet concentrates obtained by conventional techniques, ie, centrifugation, frequently have a high level of remaining leukocytes. Cotton wool filter Imugard IG 500 can be used to obtain leukocyte-poor cellular blood products. The technique is easy to perform, even in an emergency, and can be used with either packed RBCs or platelet concentrates. Means of 97%, 92%, and 76% elimination of leukocytes are obtained for packed RBCs, pooled standard platelet concentrates, and single-donor platelet concentrates, respectively. Patients were randomized to receive either standard (control group) or filtered (leukocyte-poor group) blood products. Of 112 randomized patients, 69 were evaluable, 35 in the control group and 34 in the leukocyte-poor group. Both groups are comparable according to age, diagnosis, sex ratio, previous transfusions, and pregnancies. There is a significant difference in regard to the HLA immunization rate (31.4% in the control v 11.7% in the leukocyte-poor group, P less than .05) and frequency of refractoriness to platelet transfusions (46.6% v 11.7%, P less than .05). We conclude that this filtration technique can be an efficient means to reduce the HLA immunization rate in polytransfused oncohematologic patients.

scholarly journals Prevention of HLA immunization with leukocyte-poor packed red cells and platelet concentrates obtained by filtration

Blood ◽  
1988 ◽  
Vol 72 (3) ◽  
pp. 964-969 ◽  
Author(s):  
G Andreu ◽  
J Dewailly ◽  
C Leberre ◽  
MC Quarre ◽  
ML Bidet ◽  
...  
Keyword(s):  
Control Group ◽  
Blood Products ◽  
Platelet Concentrates ◽  
Transfusion Therapy ◽  
Immunization Rate ◽  
Significant Difference ◽  
Poor Group ◽  
Main Component ◽  
High Level ◽  
Packed Rbcs

HLA immunization is a common complication of transfusion therapy in 30% to 60% of oncohematologic patients. Evidence shows that leukocytes present in cellular blood products are the main component involved in the occurrence of HLA immunization, and several studies showed that leukocyte-poor blood products are less able to induce it. However, leukocyte-poor platelet concentrates obtained by conventional techniques, ie, centrifugation, frequently have a high level of remaining leukocytes. Cotton wool filter Imugard IG 500 can be used to obtain leukocyte-poor cellular blood products. The technique is easy to perform, even in an emergency, and can be used with either packed RBCs or platelet concentrates. Means of 97%, 92%, and 76% elimination of leukocytes are obtained for packed RBCs, pooled standard platelet concentrates, and single-donor platelet concentrates, respectively. Patients were randomized to receive either standard (control group) or filtered (leukocyte-poor group) blood products. Of 112 randomized patients, 69 were evaluable, 35 in the control group and 34 in the leukocyte-poor group. Both groups are comparable according to age, diagnosis, sex ratio, previous transfusions, and pregnancies. There is a significant difference in regard to the HLA immunization rate (31.4% in the control v 11.7% in the leukocyte-poor group, P less than .05) and frequency of refractoriness to platelet transfusions (46.6% v 11.7%, P less than .05). We conclude that this filtration technique can be an efficient means to reduce the HLA immunization rate in polytransfused oncohematologic patients.

scholarly journals Association analysis between the polymorphisms of HSD17B5 and HSD17B6 and risk of polycystic ovary syndrome in Chinese population

2015 ◽  
Vol 172 (3) ◽  
pp. 227-233 ◽  
Author(s):  
Rong Ju ◽  
Wei Wu ◽  
Juan Fei ◽  
Yufeng Qin ◽  
Qiuqin Tang ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Chinese Population ◽  
Chinese Women ◽  
Polycystic Ovary ◽  
Control Group ◽  
Model Assessment ◽  
Nucleotide Polymorphisms ◽  
Ovary Syndrome ◽  
Significant Difference ◽  
High Level

ObjectiveTo assess whether single nucleotide polymorphisms of HSD17B5 (AKR1C3) (rs1937845 and rs12529) and HSD17B6 (rs898611) are associated with polycystic ovary syndrome (PCOS) in a Chinese population.DesignA case–control study was conducted to investigate the relation between HSD17B5 and HSD17B6 polymorphisms and PCOS.MethodsIn this study, 335 patients with PCOS and 354 controls were recruited. The genotypes of HSD17B5 (rs1937845 and rs12529) and HSD17B6 (rs898611) were detected by the TaqMan method.Results and conclusionsWe found that the genotypic frequencies of the rs1937845 polymorphism were different in subjects with PCOS compared with control, with the CT genotype being more commonly found in patients with PCOS than in controls (P=0.005). We observed a significantly 1.74-fold higher risk of CT genotype in the polymorphism rs1937845 in women with PCOS vs the control group (adjusted odds ratio (OR), 1.74; 95% CI=1.19–2.54; P=0.005). A similar, significant 1.47-fold higher risk (adjusted OR, 1.47; 95% CI=1.07–2.03; P=0.018) was demonstrated for T allele of polymorphism rs1937845 associated with PCOS. In patients with PCOS, the rs12529 (G>C) and rs1937845 (C>T) polymorphisms were strongly associated with the high level of testosterone. The TT carriers of polymorphism rs1937845 had a significantly increased homeostatic model assessment-B% (HOMA-B%) (P=0.045) and that might be associated with the high risk of insulin resistance. However, no significant difference was found in genotype or allele distributions of the polymorphisms rs12529 of HSD17B5 and rs898611 of HSD17B6 between patients with PCOS and controls. Additionally, the two polymorphisms of HSD17B5 are associated with hyperandrogenemia in patients with PCOS. In conclusion, our findings showed a significant statistical association between HSD17B5 rs1937845 and PCOS risk in Chinese women. The CT genotype and T allele frequency are influenced significantly to a higher extent in patients with PCOS than controls. Further studies are needed to confirm the results and find out the exact molecular mechanism of the polymorphism on the risk of hyperandrogenemia and PCOS.

scholarly journals Wired to Exit: Exploring the Effects of Wayfinding Affordances in Underground Facilities Using Virtual Reality

2020 ◽  
pp. 104687812094456
Author(s):  
Panos Kostakos ◽  
Paula Alavesa ◽  
Mikko Korkiakoski ◽  
Mario Monteiro Marques ◽  
Victor Lobo ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Control Group ◽  
Head Mounted Display ◽  
Significant Difference ◽  
Parking Lot ◽  
Biometric Measurements ◽  
Physiological Outcomes ◽  
High Level ◽  
Experimental Group ◽  
Level Effect

Background Wayfinding has been adopted in several intense evacuation and navigation simulations; however, the use of biometric measurements for characterizing physiological outcomes has been somewhat overlooked and applied only under limited laboratory conditions. Methods Twenty-four participants took part in a virtual reality (VR) experiment using a wayfinding installation with the Oculus Rift S head-mounted display (HMD). They were immersed in a simulation of a burning underground parking lot and tasked to navigate to the exit. The purpose of this research was to investigate the high-level effect of wayfinding assistive lights on behavioral, physiological, and psychological outcomes. Participants were split into two groups: the control group was exposed to a scene without assistive lights, and the experimental group was exposed to the same scene with assistive lights. Results Results indicate there was no statistically significant difference between the groups in traveled distance, pauses, turns, or game completion time. Curiously, differences between the two groups in heart rate (HR) outcomes were found to be statistically significant, with subjects in the control group displaying an increasing HR trend during simulation. Conclusions This finding, in accordance with previous studies that have shown the efficacy of landmarks and wayfinding affordances in reducing cognitive demands, suggests that assistive lights might contribute to improved brain wiring connectivity during the game. We discuss these findings in the context of a rich wayfinding affordances literature.

Comparison of Spoilage Rates in Ground Turkey and Ground Beef

1992 ◽  
Vol 55 (7) ◽  
pp. 518-521 ◽  
Author(s):  
N. J. STERN ◽  
C. E. LYON ◽  
M. T. MUSGROVE ◽  
J. A. DICKENS ◽  
R. L. WILSON
Keyword(s):  
Muscle Tissue ◽  
Ground Beef ◽  
Control Group ◽  
Origin Of Species ◽  
Low Level ◽  
Livestock Species ◽  
Plastic Bags ◽  
Significant Difference ◽  
Uninoculated Control ◽  
High Level

Spoilage rates of ground turkey and ground beef were compared. Clean muscle tissue of the two livestock species were ground in a hygienic manner, providing initial mesotrophic counts (72 h at 25°C) in the range of ca. 102–3 CFU/g. Moisture, fat, and protein contents for the ground products were similar. Each ground product was subjected to the following treatments: a) uninoculated control, b) inoculated with a low level of turkey flora, c) inoculated with a high level of turkey flora, d) inoculated with a low level of beef flora, and e) inoculated with a high level of beef flora. Three replicate analyses were performed on the products which were held at 5°C in air-permeable plastic bags. Five subsamples (20–25 g) were taken for each of the five analysis times over 10 d of storage. At completion of storage, bacterial counts varied from 103.5 to 109.2 CFU/g, with the turkey control group at the lower end of the range. Our findings indicate no significant difference between the spoilage rates of the two ground products, regardless of treatment or origin of species.

Intensified Conditioning for Children Undergoing BMT for First Bone Marrow Relapse of Acute Lymphoblastic Leukaemia.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 5169-5169
Author(s):  
John Moppett ◽  
Jerry Hancock ◽  
Christopher J.C. Knechtli ◽  
Anthony Oakhill ◽  
Nicholas J. Goulden
Keyword(s):  
High Risk ◽  
Treatment Failure ◽  
Risk Group ◽  
Control Group ◽  
Childhood All ◽  
High Risk Patients ◽  
Significant Difference ◽  
Risk Patients ◽  
High Level ◽  
Risk Of Treatment

Abstract BMT remains the treatment of choice for early BM relapse of childhood ALL. We reasoned that further intensification of cytoreductive therapy pre-BMT may further improve survival amongst those with the highest risk of treatment failure, early BM relapse (BFM groups S3/4) and high level MRD pre-BMT. A cohort of 32 patients transplanted at a single institution (1996–1999) provided an historical control. 8 high risk patients transplanted 1999–2000 received additional fludarabine cytoreduction therapy at the time of transplant (FLA group). MRD analysis and time to relapse were used in a subsequent cohort of 22 patients (BMT 2000–2002) to allocate those at highest risk of treatment failure to receive a further cytoreductive block, FLX, pre-BMT. Method. All patients were conditioned with cyclophosphamide (60mg/m2 x2) and TBI (14.4 Gy). UD and haplo-BMT were T-cell depleted with Campth-1M in vitro and Campath-1G day -9 to -5 (Control and FLA group), and by Miltenyi CD34+ cell depletion (FLX group). GvHD prophylaxis - CSA + MTX for matched related, CSA for Campath treated grafts and none for Miltenyi grafts. The FLA group received fludarabine 25mg/m2 from d −12 to d −10. Patients with on treatment relapse (S4) or high level MRD pre-BMT (MRD++) in the FLX group received DaunoXome 100mg/m2, fludarabine 30mg/m2 x 5d and cytosine 2g/m2 x 5d 3 weeks prior to BMT. Patients and donors. Control group: 28 precursor-B ALL 4 T-ALL; donors - 7 matched related, 13 matched unrelated (MUD) and 12 mismatched unrelated (MMUD); 14 S2, 18 S3/4. FLA group: 5 presursor-B ALL and 3 T-ALL; donors - 2 SIB, 4 MUD, 1 MMUD and 2 haplo; all S4. FLX group: 21 precursor-B and 1 T-ALL; donors - 6 SIB, 7 MUD, 5 MMUD and 4 haplo;13 S2, 9 S4. 7 patients received FLX intensified conditioning (6 S4, 5 high level MRD ++). 3 high risk patients violated protocol and did not receive FLX (1 age <1yr on treatment relapse, 2 S2 MRD ++). Results. Considering those in the high-risk S3/4 group, there was no significant difference in OS between the 3 groups. Survival by study and risk group Study S2 S3/4 Overall Control 10/14 (71%) 3/18 (17%) 13/32 (41%) FLA 2/8 (25%) 2/8 (25%) FLX 11/13 (85%) 3/9 (33%) 14/22 (64%) No excess cardiac events were seen. The TRM is higher in the FLX group than in the control. Outcome data Study TRM Relapse Alive Total Control 3 16 13 32 S2 2 2 10 14 S3/4 1 14 3 18 FLA 3 3 6 12 S2 - - - - S3/4 3 3 3 9 FLX 6 2 14 22 S2 2 0 11 13 S3/4 4 2 3 9 Total 12 21 33 66 2 of 7 patients treated with FLX are in CCR, 2 relapsed and 3 died of TRM. The 3 high risk patients in the FLX study, but who did not receive FLX, are also in CCR. Survival in those in the S2 group (late BM relapse) has been good throughout the study period. Conclusion. In this study the addition of intensive pre-BMT conditioning has not improved survival amongst high risk (S3/4 or MRD ++ pre-BMT) relapses. The number of post-BMT relapses has fallen but this is not clearly related to the use of FLX. The use of more haploidentical donors, more immunosupressive BMT regimes and additional cytoreductive chemotherapy may have contributed to the increased TRM seen. Time and site of relapse remain the clearest predictor of outcome. Further novel strategies are required to improve survival for the S4 risk group. The good OS for children receiving BMT in the S2 group should be noted.

scholarly journals DIAGNOSIS OF HEALTHCARE COMPETENCE OF THE FUTURE TEACHER OF BIOLOGY

2020 ◽  
pp. 42-51
Author(s):  
Світлана Совгіра ◽  
Тамара Миронюк
Keyword(s):  
Value Orientations ◽  
Educational Process ◽  
Control Group ◽  
Biology Teachers ◽  
Practical Activity ◽  
Health Competence ◽  
Formative Experiment ◽  
Significant Difference ◽  
High Level ◽  
Experimental Group

The article reveals the course of diagnosis of health competence of a future biology teacher. The complexity and structure of the studied phenomenon were revealed under such criterions: motivational-value (motives, needs, value orientations), cognitive-informational (mastery of health-preserving knowledge and skills), practical-activity (health-preserving skills) criteria. Experimental work was carried out in two stages: ascertaining and forming. At the ascertaining stage the organization of  educational process of future biology teachers was comprehensively investigated. The initial low level of health competence of future biology teachers was determined, which showed no significant difference between the levels of health competence of future biology teachers according to motivational-value, cognitive-informational, practical-activity criteria. According to the results of the ascertaining stage of the research, a formative experiment was carried out, which proved the existence of a high level of health competence of future biology teachers on motivational-value, cognitive-informational, practical-activity criteria in experimental and average in control groups. It was found that the students of the experimental group showed higher levels of health competence. It is proved that in the experimental group of students there have been significant changes in the direction of increasing the level of health competence. The obtained data from the experimental group in comparison with the indicators from the control group indicate that the efficiency of using the whole set of proposed innovations is higher than using them separately, without further updating.

scholarly journals Peculiarities of the chest’s size in female volleyball players of different constitutional types

2018 ◽  
pp. 47-52
Author(s):  
L. A. Sarafyniuk ◽  
V. I. Pivtorak ◽  
V. O. Khavtur ◽  
L. Ia. Fedoniuk ◽  
O. P. Khapitska
Keyword(s):  
Young Women ◽  
Great Influence ◽  
Control Group ◽  
Constitutional Type ◽  
Significant Difference ◽  
Volleyball Players ◽  
High Level ◽  
Medical University ◽  
Different Levels ◽  
Anterior Posterior

During qualified sport selection special attention should be paid to those features and abilities that have a great influence on the effectiveness, and those, that are mainly under the influence of genetic factor. Such morphogenetic markers of sports selection include, firstly, the constitutional features of athletes, in particular the shape of the chest. The purpose of work is to determine the differences between the anthropometric dimensions of the chest between female volleyball players of high level of athletic skill and non-sportsmen, who belonged to different constitutional types. On the base of the Scientific-Research Center of the Vinnytsya National Pirogov Memorial Medical University an anthropo-somatotypological investigation of 113 female volleyball players of high level athletic skill (from 16 to 20 years old) was done. The control group included 204 practically healthy young women, who were not engaged in sports of the corresponding age. Anthropometric research was performed according to the V. V. Bunak (1941) method, somatotypological study was based on the estimated modification of the Heath-Carter method (1990). In young women, who were not engaged in sports, more than in half of the cases were indicated constitutional types, which were characterized by good development of fatty body composition. Between female volleyball players were dominated individuals with mesomorphic somatotype (26.66%), ectomorphic somatotype (23.01%), ecto-mesomorphic somatotype (23.89%), and representatives of the intermediate somatotype (23.01%) were almost uniformly represented in the sample. The analysis of the results was carried out in the licensing program "Statistica 5.5" using nonparametric methods of estimating the parameters. We have found that the female volleyball players of the ectomorphic somatotype have the smallest anthropometric dimensions of the chest, as compared with athletes of other constitutional groups. In the mesomorphs female volleyball players all transverse and the most of overall sizes of the chest were the largest. Parameters of the athletes with the ecto-mesomorphic somatotype were slightly small to the size of the somatometric parameters of the mesomorphs, but they had the highest values of the anterior-posterior size of the chest. Female volleyball players with intermediate somatotype had larger values of the chest size than volleyball players with ectomorphic somatotype, although no significant difference was found when comparing them. It was found, that the most of the overall, transverse, and anterior-posterior dimensions of the chest in female volleyball players are statistically significantly higher than that of girls, who were not engaged in sports, and belonged to the same constitutional type as athletes. We have made a conclusion that belonging to one of the constitutional type does not provide similarity of morphometric parameters of the chest in persons with different levels of physical activity.

scholarly journals Forensic evaluation of persons with destructive behavior in the postwar Bosnia and Herzegovina

2007 ◽  
Vol 64 (3) ◽  
pp. 183-188 ◽  
Author(s):  
Milan Novakovic ◽  
Milanko Cabarkapa ◽  
Tanja Ille ◽  
Andrej Ilankovic
Keyword(s):  
Bosnia And Herzegovina ◽  
Forensic Evaluation ◽  
Control Group ◽  
Security Measures ◽  
Basic Emotions ◽  
Destructive Behavior ◽  
Significant Difference ◽  
Mental Diseases ◽  
Discriminative Function ◽  
High Level

Background/Aim. Different persons show forensic differences related to aggressive behavior in criminal and violation acts. The aim of this study was to forensically analyze the influence of socio-dynamic conditions and stress in testing the forensic hypothesis of hetero-destruction, and analysis of persons with destructive behavior in Bosnia and Herzegovina (B&H) in the period from 1996?2005. Methods. The experimental group consisted of 125 persons who had committed a crime according to the Criminal Law of B&H and, thus were under security measures or treatment. The control group consisted of 125 persons who had committed a violation. The following psychometric tests/questionnaires were used in the study: Eysenek Personality Questionnaire (EPQ), Beck Anxiety Inventory (BAI) and Profile Index of Emotions (PIE). Results. There were a significant difference between the respondents? groups related to gender (p < 0.01), while broken family, migration, and family comorbidity showed insignificant differences. EPQ test showed statistically significant differences between the groups for all four variables, and Beck test found significant differences only for some ones. PIE test proved the relations of the basic emotions confirmed by discriminative function. Conclusion. High level of hetero-destruction in crime was proven in the study. Criminal acts and violations were committed by the persons without psychopathology, as well as by the persons with mental diseases, which rendered a forensic responsibility and analysis of such an influence on behavior.

scholarly journals Protection of Renal Function ByHyperbaric OxygenDuring Plasmodium berghei ANKA Infection

2020 ◽  
Vol 13 (1) ◽  
pp. 69-74
Author(s):  
Prawesty Diah Utami ◽  
Herin Setianingsih
Keyword(s):  
Renal Function ◽  
Control Group ◽  
Group 4 ◽  
Wistar Strain ◽  
Significant Difference ◽  
Post Test ◽  
Group 3 ◽  
Group 5 ◽  
Major Factors ◽  
High Level

Background:Malaria cases have consistently increased and the number of deaths remains largely unchanged.Malaria associated renal injury has a high level of morbidity and mortality. High level of blood urea nitrogen / BUN and plasma creatinine is one of the major factors associated with mortality in humans infected with malaria, indicating that impairment of renal function. HBO is widely used as an adjunctive therapy for many diseases, it is known that HBO hasan action as antiplasmodium, antiinflammation and antioxidant effects. Objective: The aim of this study was to determine the effect of HBO on BUN and creatinine levels in rats infected with P. berghei ANKA. Methods:This research was conducted experimentally post-test only control group on six groups of rats. The samples used were 24 male Rattus norvegicus wistar strain that have been infected by Plasmodium bergheiANKA and divided into 6 groups. Group 1 was given combination artesunate and 1, 5 ATA HBO, grup 2 was given combination artesunate and 3, 0 ATA HBO, group 3 was given 1, 5 ATA HBO, group 4 was given 3, 0 ATA HBO, group 5 was given artesunate and group 6 was given aquadest. HBO therapy is carried out for 10 days and the observation of the levels of BUN and creatinine in mice after treatment on tenth day. Results:Descriptive analysis and statistical analysis (Kruskal wallis snd Mann whitney U posthoc) showed a significant difference (p < α = 0.05) on mean levels of BUN and creatinine group receiving combination of artesunate and HBO 3,0 ATA compared to other groups.Hyperbaric oxygen has the effect of reducing the levels of BUN and creatinine in rats infected by P.berghei ANKA.

scholarly journals Emotion Expression when Teaching with Creative Movement

2020 ◽  
Vol 22 ◽  
Author(s):  
Simona Prosen ◽  
Vesna Geršak ◽  
Helena Smrtnik Vitulić
Keyword(s):  
Teaching Method ◽  
Anger Expression ◽  
Emotion Expression ◽  
Second Grade ◽  
Control Group ◽  
Expression Recognition ◽  
Creative Movement ◽  
Significant Difference ◽  
High Level ◽  
Recognition Software

The study focuses on students emotion expression during geometry teaching including creative movement (experimental group or EG) and without it (control group or CG). The sample (N = 104) was made up of primary school (second-grade) students: 66 were assigned to the EG and 38 to the CG. Of these, 12 students from the EG and 8 from the CG were randomly selected for observation of emotion: type, intensity, triggering situation, and response of others. For the observed students, the intensity of emotion expression was also measured by the facial expression recognition software FaceReader. All of the students self-assessed their contentedness with the teaching. The students in the EG and the CG expressed various emotions, with joy being the most prevalent, followed by anger. The most frequent situations triggering joy were activities in the EG and the CG. The intensity of joy was higher in the EG than in the CG when assessed by observation, but there was no significant difference when assessed by FaceReader. The intensity of anger expression was at a similar level in both groups. Both students and teachers responded to students joy expression, but only the students responded to anger expression in the EG and the CG. The students in both groups expressed a high level of contentedness with the teaching. Key words: creative movement; emotion expression; intensity of emotions; students; teaching method.

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