scholarly journals Patient values and preferences regarding VTE disease: a systematic review to inform American Society of Hematology guidelines

2020 ◽  
Vol 4 (5) ◽  
pp. 953-968 ◽  
Author(s):  
Itziar Etxeandia-Ikobaltzeta ◽  
Yuan Zhang ◽  
Francesca Brundisini ◽  
Ivan D. Florez ◽  
Wojtek Wiercioch ◽  
...  
Keyword(s):  
Systematic Review ◽  
Health Outcomes ◽  
Qualitative Studies ◽  
Health State ◽  
Cochrane Central Register ◽  
Theory Approach ◽  
Relative Importance ◽  
Health States ◽  
Quantitative Studies ◽  
American Society

Abstract Values and preferences relate to the importance that patients place on health outcomes (eg, bleeding, having a deep venous thrombosis) and are essential when weighing benefits and harms in guideline recommendations. To inform the American Society of Hematology guidelines for management of venous thromboembolism (VTE) disease, we conducted a systematic review of patients’ values and preferences related to VTE. We searched Medline, Embase, Cochrane Central Register of Controlled Trials, PsycINFO, and the Cumulative Index to Nursing and Allied Health Literature from inception to April of 2018 (PROSPERO-CRD42018094003). We included quantitative and qualitative studies. We followed Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidance for rating the certainty and presenting findings for quantitative research about the relative importance of health outcomes and a grounded theory approach for qualitative thematic synthesis. We identified 14 quantitative studies (2465 participants) describing the relative importance of VTE-related health states in a widely diverse population of patients, showing overall small to important impact on patients’ lives (certainty of the evidence from low to moderate). Additionally, evidence from 34 quantitative studies (6424 participants) and 15 qualitative studies (570 participants) revealed that patients put higher value on VTE risk reduction than on the potential harms of the treatment (certainty of evidence from low to moderate). Studies also suggested a clear preference for oral medication over subcutaneous medication (moderate certainty). The observed variability in health state values may be a result of differences in the approaches used to elicit them and the diversity of included populations rather than true variability in values. This finding highlights the necessity to explore the variability induced by different approaches to ascertain values.

scholarly journals Interventions directed at men for preventing intimate partner violence: a systematic review protocol

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Dina Idriss-Wheeler ◽  
Julia Hajjar ◽  
Sanni Yaya
Keyword(s):  
Systematic Review ◽  
Intimate Partner Violence ◽  
Health Outcomes ◽  
Partner Violence ◽  
Intimate Partner ◽  
Cochrane Central Register ◽  
Female Partners ◽  
Key Characteristics ◽  
Unpublished Manuscripts ◽  
The Impact

Abstract Background Intimate partner violence (IPV) is a population health problem linked to a myriad of negative psychological, physical, emotional, sexual and reproductive health outcomes for women. The movement towards working with boys and men over the past couple of decades has increased the number of interventions specifically directed at men who perpetrate violence against a female partner. There is little evidence-based research on key characteristics of effective interventions directed at men to reduce or prevent IPV against female partners. The objective of this systematic review is to identify interventions specifically directed at males , as the perpetrators of violence against women, that have proven to be effective in preventing or reducing intimate partner violence. Methods The following electronic databases will be used to search for peer-reviewed studies: MEDLINE (OVID), Embase (OVID), PsycInfo (OVID), CINAHL (EBSCO), Global Health (EBSCO), Gender Watch (ProQuest), Web of Science (Web of Knowledge), PROSPERO, Cochrane Central Register of Controlled Trials Database (Ovid) and SCOPUS. We will include randomized control trials, non-randomized studies of interventions published in peer-reviewed journals and relevant unpublished manuscripts, books/chapters and clinical or programme study reports. Studies have to demonstrate direction of effect (i.e. pre-post intervention/difference between groups) in terms of prevention or reduction in the outlined outcomes. Primary outcomes include change in behaviour and knowledge of male perpetrator regarding the impact of IPV on women as well as women’s experience of IPV. Secondary outcomes include change in behaviours around substance use and social activities, decrease in negative mental health outcomes and interactions with law enforcement. Studies will be screened, appraised and extracted by two reviewers; any conflicts will be resolved through discussion. Narrative synthesis will be used to analyse and present findings. If sufficient and comparable data is available, a meta-analysis will be conducted. Discussion This review will provide synthesized evidence on interventions directed at males to reduce or prevent their perpetration of intimate partner violence against female partners. Implications for practice will include key characteristics of interventions proven to be effective based on evidence synthesis and certainty of findings. Recommendations for further research will also be considered. Systematic review registration This protocol was submitted for registration in the International Prospective Register of Systematic Reviews (PROSPERO) on September 4, 2020.

scholarly journals Health outcomes of sexual and gender minorities after cancer: a systematic review

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Mandi L. Pratt-Chapman ◽  
Ash B. Alpert ◽  
Daniel A. Castillo
Keyword(s):  
Systematic Review ◽  
Health Outcomes ◽  
Cancer Survivors ◽  
Cochrane Central Register ◽  
Transgender Persons ◽  
Patient Reported ◽  
History Of ◽  
Reported Health ◽  
And Gender ◽  
After Cancer

Abstract Purpose Cancer research on sexual and gender minority (SGM) populations is gaining momentum. The purpose of this systematic review was to examine what is currently known in the research literature regarding patient-reported health outcomes after cancer treatment among SGM populations. Methods In March 2021, a medical librarian conducted a systematic keyword search on PubMed, Embase, Scopus, Web of Science, PsycINFO, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials. The primary inclusion criterion was assessment of at least one physical, psychosocial, emotional, or functional patient-reported health outcome related to the impacts of cancer diagnosis and/or treatment. Articles that met inclusion criteria were reviewed in their entirety, charted in a Word Table, and assessed for quality. Quality considerations included study design, sampling approach, diversity of sample, measures used, and analytic procedures. Studies were synthesized based on type of cancer study participants experienced. Results Sixty-four studies were included in the final analysis: most were quantitative, secondary analyses or cross-sectional studies with convenience samples, and focused on people with a history of breast or prostate cancer. Differences between sexual minority men and women in terms of coping and resilience were noted. Few studies reported on experiences of transgender persons and none reported on experiences of intersex persons. Conclusions A growing literature describes the patient-reported health outcomes of SGM people with a history of cancer. This study summarizes important between-group differences among SGM and heterosexual, cisgender counterparts that are critical for clinicians to consider when providing care. Implications for cancer survivors Sexual orientation and gender identity are relevant to cancer survivors’ health outcomes. Subgroups of SGM people have differential experiences and outcomes related to cancer and its impacts.

scholarly journals Loneliness, social isolation, cardiovascular disease and mortality: a synthesis of the literature and conceptual framework

2020 ◽  
Vol 113 (5) ◽  
pp. 185-192 ◽  
Author(s):  
Sam Hodgson ◽  
Isabella Watts ◽  
Simon Fraser ◽  
Paul Roderick ◽  
Hajira Dambha-Miller
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Health Outcomes ◽  
Conceptual Framework ◽  
Social Isolation ◽  
English Language ◽  
Qualitative Studies ◽  
Socially Isolated ◽  
Poor Outcomes

To conduct a systematic review and develop a conceptual framework on the mechanisms linking loneliness, social isolation, health outcomes and mortality. Electronic databases were systematically searched (PubMed, MEDLINE, Scopus and EMBASE) from inception to October 2018 followed by manual searching to identify research on loneliness, social isolation and mortality in adults published in the English language. Articles were assessed for quality and synthesised into a conceptual framework using meta-ethnographical approaches. A total of 122 articles were included. These collated observational designs examining mediators and moderations of the association in addition to qualitative studies exploring potential mechanisms were included. A framework incorporating 18 discrete factors implicated in the association between loneliness, social isolation and mortality was developed. Factors were categorised into societal or individual, and sub-categorised into biological, behavioural and psychological. These findings emphasise the complex multidirectional relationship between loneliness, social isolation and mortality. Our conceptual framework may allow development of more holistic interventions, targeting many of the interdependent factors that contribute to poor outcomes for lonely and socially isolated people.

A Systematic Review and Meta-Analysis of Radioimmunotherapy Consolidation for Untreated Patients with Follicular Lymphoma (FL)

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 101-101
Author(s):  
Adam C. Rose ◽  
Gia Garrett ◽  
Miray Seward ◽  
Pareen J Shenoy ◽  
Roy A Kucuk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Maintenance Therapy ◽  
Follicular Lymphoma ◽  
Annual Meeting ◽  
Research Funding ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Cochrane Central Register ◽  
Inclusion Criteria ◽  
American Society

Abstract Abstract 101 Background: The disease course of FL is characterized by multiple relapses and progressively shorter response durations with subsequent therapies. As a result, numerous treatment strategies have been developed to reduce the risk of progression including consolidation with transplantation, radio-immunotherapy (RIT), or maintenance therapy with rituximab (R). At present, the optimal therapeutic strategy for FL patients (pts) remains undefined. R maintenance and RIT with an anti-CD20 antibody linked to iodine-131 (I131 Tositumomab) or to yttrium-90 (Y90-ibritumomab tiuxetan) have emerged as well tolerated treatments following induction. To quantify the benefits of consolidative RIT, we conducted a systematic review of the literature and a meta-analysis of selected studies. Methods: As part of a broader review, we searched the Cochrane Central Register of Controlled Trials (Cochrane Library Issue, 2011), MEDLINE (1/1966-6/2011), American Society of Hematology Annual Meeting abstracts (2004–2010), and American Society of Clinical Oncology Annual Meeting abstracts (2007–2010). Each database was searched using combinations of the term ‘follicular lymphoma' and the terms for treatment regimens. Inclusion criteria for studies were as follows: 1) reports on phase 2/3 studies; 2) n≥30; 3) previously untreated patients 4) treatment with RIT targeted at the CD20 antigen following an induction regimen; 5) original reporting in English of the following treatment outcome measures for pts with FL: CR/CR-unconfirmed, OR, and at least one form of survival data. Extracted data included pre-treatment disease status, pt characteristics, treatment regimen, progression free survival (PFS), overall survival (OS), complete response (CR) and overall response (OR). Pooled estimates of the CR rate, OR rate, 2-year PFS and 5-year PFS for pts treated with consolidative RIT were computed using DerSimonian and Laird random effects models. Results: Over 1136 records were reviewed with 8 studies meeting inclusion criteria with 556 patients. Between 1998 and 2007, pts were accrued at multiple sites in all but one study. Median ages ranged from 49–57 years with 41–61% male subjects, among the studies reporting gender. A weighted average of 97.2% of patients had stage III/IV disease with 73–98% pts having grade 1/2 disease, among those studies reporting histology. Among studies reporting this information, 19–44% of patients had abnormal LDH values, and 25–100% had bulky lymph nodes. CR rates ranged from 51% to 97%, 2-year PFS ranged from 65% to 86%, and 5-year PFS ranged from 38% to 67%. The pooled estimates of the CR rate and OR rate following consolidative RIT were 78% (95% CI 66%–87%) and 98% (95% CI 92.9%–99.5%), respectively (Figure A). The pooled estimates for the 2-year and 5-year PFS were 77.0% (95% CI 70.5–82.4%) and 56.0% (95% CI 41.9–69.2%), respectively (Figure B). Conclusions: This analysis suggests that consolidative RIT is beneficial to patients with previously untreated FL with meaningful CR rates and 5-year PFS. In addition, consolidative RIT compares favorably to maintenance therapy with R given after chemotherapy (ECOG 1496) in both 2-year PFS (77.0% vs. 73.5%) and 5-year PFS (56.0% vs. 46.4%), and needs to be compared to maintenance R following R-chemotherapy induction. Disclosures: Flowers: Genentech/Roche (unpaid): Consultancy; Celgene: Consultancy, Research Funding; Millennium/Takeda: Consultancy, Research Funding; Seattle Genetics: Consultancy; Novartis: Research Funding; Spectrum: Consultancy, Research Funding.

scholarly journals A systematic review of health state utility values for thyroid cancer

2020 ◽  
Author(s):  
Rachel Houten ◽  
Nigel Fleeman ◽  
Eleanor Kotas ◽  
Angela Boland ◽  
Tosin Lambe ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Cancer ◽  
Cost Effectiveness ◽  
Differentiated Thyroid Cancer ◽  
Health State ◽  
Health States ◽  
Utility Values ◽  
Sf 36 ◽  
Health State Utility Values ◽  
Eortc Qlq

Abstract Purpose Health state utility values are commonly used to inform economic evaluations and determine the cost-effectiveness of an intervention. The aim of this systematic review is to summarise the utility values available to represent the health-related quality of life (HRQoL) of patients with thyroid cancer. Methods Eight electronic databases were searched from January 1999 to April 2019 for studies which included assessment of HRQoL for patients with thyroid cancer. Utility estimates derived from multiple sources (EuroQol questionnaire 5-dimension (EQ-5D), time trade-off [TTO] and standard gamble [SG] methods) were extracted. In addition, utility estimates were generated by mapping from SF-36 and EORTC QLQ-30 to the EQ-5D-3L UK value set using published mapping algorithms. Results Searches identified 33 eligible studies. Twenty-six studies reported HRQoL for patients with differentiated thyroid cancer and seven studies for patients with general thyroid cancer. We identified studies which used different methods and tools to quantify the HRQoL in patients with thyroid cancer, such as the EQ-5D-3L, SF-36, EORTC QLQ-30 and SG and TTO techniques to estimate utility values. Utility estimates range from 0.205 (patients with low-risk differentiated thyroid cancer) to utility values approximate to the average UK population (following successful thyroidectomy surgery and radioiodine treatment). Utility estimates for different health states, across thyroid cancer sub-types and interventions are presented. Conclusion A catalogue of utility values is provided for use when carrying out economic modelling of thyroid cancer; by including mapped values, this approach broadens the scope of health states that can be considered within cost-effectiveness modelling.

scholarly journals Roma populations and health inequalities: a systematic review of multiple intersecting determinants

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
L Orton ◽  
R M Anderson de Cuevas
Keyword(s):  
Systematic Review ◽  
Health Outcomes ◽  
Citation Index ◽  
Economic Status ◽  
Poor Health ◽  
Bibliographic Databases ◽  
Qualitative And Quantitative ◽  
Socio Economic Status ◽  
Quantitative Studies ◽  
The Impact

Abstract Background Roma populations experience significantly poorer health than majority populations. Health outcomes are often worse than for others in similar social positions, suggesting differences are not simply the effect of poverty. Roma women are thought to be worst affected. However, data pertaining to the multiple social inequalities affecting Roma populations, their interaction and cumulative effect on health over time, have yet to be synthesised. Methods We searched four bibliographic databases (MEDLINE, Science Citation Index, Social Sciences Citation Index and Scopus), screened reference lists, consulted key informants and searched organisational websites for studies providing empirical evidence on more than one determinant of health for Roma populations in Europe. Two reviewers carried out screening, data extraction, quality appraisal and performed a narrative synthesis. Results From 2,043 bibliographic records, 37 studies met our inclusion criteria. The median number of influencing factors explored through qualitative and quantitative methodologies was 2 (range 1 - 5) and 3 (range 1 - 11), respectively. Quantitative studies focussed on poverty (10 studies) and other indicators of socio-economic status including education (13 studies), housing (9 studies) and employment (9 studies). Very few studies unpicked interactive effects instead testing each factor’s contribution to poor health independently. Qualitative studies tended to explore “Roma culture” (11 studies) and the impact of discrimination/racism on health behaviour (10 studies). There is a lack of gender-disaggregated data and little analysis of the impact of social policy on the health of Roma populations. Conclusions Evidence for associations between determinants and health outcomes among European Roma populations is patchy. Research needs to pay more attention to the health impact of social policies that have the potential to reinforce (as well as mitigate) the exclusion of Roma populations. Key messages This systematic review critically analyses the state and shape of research evidence on the multiple interacting axes of inequality that contribute to poor health among Europe’s Roma populations. There is a divergence between qualitative and quantitative studies, with the former providing some evidence on socio-economic status and the latter exploring aspects of culture and discrimination.

scholarly journals Characterizing health state utilities associated with Duchenne muscular dystrophy: a systematic review

2019 ◽  
Vol 29 (3) ◽  
pp. 593-605 ◽  
Author(s):  
Shelagh M. Szabo ◽  
Ivana F. Audhya ◽  
Daniel C. Malone ◽  
David Feeny ◽  
Katherine L. Gooch
Keyword(s):  
Systematic Review ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Patient Characteristics ◽  
Included Study ◽  
Health State ◽  
Health States ◽  
Published Evidence ◽  
Health State Utilities ◽  
The Impact

Abstract Background Preferences for health states for Duchenne muscular dystrophy (DMD) are necessary to assess costs and benefits of novel therapies. Because DMD progression begins in childhood, the impact of DMD on health-related quality-of-life (HRQoL) affects preferences of both DMD patients and their families. The objective of this review was to synthesize published evidence for health state utility from the DMD patient and caregiver perspectives. Methods A systematic review was performed using MEDLINE and Embase, according to best practices. Data were extracted from studies reporting DMD patient or caregiver utilities; these included study and patient characteristics, health states considered, and utility estimates. Quality appraisal of studies was performed. Results From 888 abstracts, eight publications describing five studies were identified. DMD utility estimates were from preference-based measures presented stratified by ambulatory status, ventilation, and age. Patient (or patient–proxy) utility estimates ranged from 0.75 (early ambulatory DMD) to 0.05 (day-and-night ventilation). Caregiver utilities ranged from 0.87 (for caregivers of adults with DMD) to 0.71 (for caregivers of predominantly childhood patients). Both patient and caregiver utilities trended lower with higher disease severity. Variability in utilities was observed based on instrument, respondent type, and country. Utility estimates for health states within non-ambulatory DMD are under reported; nor were utilities for DMD-related health states such as scoliosis or preserved upper limb function identified. Conclusion Published health state utilities document the substantial HRQoL impacts of DMD, particularly with disease progression. Additional research in patient utilities for additional health states, particularly in non-ambulatory DMD patients, is warranted.

scholarly journals Evidence on the contribution of community gardens to promote physical and mental health and well-being of non-institutionalized individuals: A systematic review

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255621
Author(s):  
Tarsila Lampert ◽  
Joana Costa ◽  
Osvaldo Santos ◽  
Joana Sousa ◽  
Teresa Ribeiro ◽  
...  
Keyword(s):  
Mental Health ◽  
Systematic Review ◽  
Health Outcomes ◽  
Community Gardens ◽  
Well Being ◽  
Physical And Mental Health ◽  
Community Gardening ◽  
Quantitative Studies ◽  
Health Gains ◽  
Health And Well Being

Introduction There has been growing interest in community gardens as an effective and affordable health promotion strategy. However, most available evidence is derived from qualitative studies, whereas quantitative research on this subject is limited. Objectives To synthetize the literature about physical and mental health outcomes associated with community gardening. Two main questions were addressed: a) is there evidence, from quantitative studies, that community gardening is associated to physical and mental health and well-being of non-institutionalized individuals? b) Does community gardening provokes any discomfort in terms of physical health, i.e., bodily pain, to their beneficiaries? Methods A systematic review of the literature was carried out following PRISMA guidelines by searching relevant electronic databases (PubMed, Scopus, and Web of Science). Empirical, quantitative studies published in English with no restrictions concerning the date of publication were considered eligible. The quality of the evidence was appraised using the tool developed by the National Heart, Lung, and Blood Institute of the National Institutes of Health for Observational Cohort and Cross-Sectional Studies. Results Overall, 8 studies were considered eligible, of which seven studies were rated as having good methodological quality (one scored as fair). Community gardeners had significantly better health outcomes than their neighbours not engaged in gardening activities in terms of life satisfaction, happiness, general health, mental health, and social cohesion. Conclusion Community gardens are associated to health gains for their users, irrespective of age, being an affordable and efficient way of promoting physical and mental health and well-being. To encourage the design, maintenance, and prospective evaluation of supportive urban environments promoting healthy and, at the same time, sustainable lifestyles, is essential to achieve public health gains and environmental sustainability.

scholarly journals Caring Experience of Childbirth Primipara Undergone Emergency Cesarean Section: A Systematic Review

2019 ◽  
Vol 2 (1) ◽  
pp. 25
Author(s):  
Regina Vidya Trias Novita
Keyword(s):  
Systematic Review ◽  
Health Care ◽  
Cesarean Section ◽  
Health Care Professional ◽  
Qualitative Studies ◽  
Fear Of Death ◽  
Maternity Ward ◽  
Negative Experience ◽  
Quantitative Studies ◽  
Emergency Cesarean

Introduction: Childbirth is natural phenomenon. The statement ‘fear of death’ and ‘losing the child’ is manifest childbirth among the primipara (Nakano et al, 2012).  Childbirth among the primipara manifest by ‘fear of death’ and ‘losing the child’. Even the mother was happy met her baby, but negative feelings, such as fear, guilt, or anger could lead their memories of the birth (Ryding, 1998). The problems during childbirth process can be affected  both of the mother’s health and baby in the future. Even birth by EmCS,  women could be helped to have more positive chilbirth experiences (Ayers et al., 2006), by created positive athmosphere in maternity ward. There is need to explore caring experience among of primiparaous undergone EmCS, so health care professional understand how to empowerment mothers in  the emergency situation.Objectives :  To conduct a systemetic review of the literatur to explore caring experience of primipara childbirth with emergency cesarean section, to understand the factors internal contributing of caring and the factors hindering or enhancing by health care professional. Methods: A systematic review was performed to explore experience primipara and identify the strategies which measure health care professional delivered care before, during and after emergency emegergency cesarean section (EmCS). The search strategy included database ProQuest and grey literature using Google scholar. Caring experience of childbirth among the primipara were evaluate with explore their experience, expactation and contributing factors which influence physical and psychological the primiparaous mothers who get EmCS. Results : Seven qualitative and four quantitative studies were found. This systemtic shows same experiences primiparous mother EmCS in qualitative studies, the dominant feeling is ”fear”. The other expereinces are pain in high intensity, have negative expereince, losing the child, lose of control, disappointed, feelings of failure and alienation for their infant, and difficulties to breastfeed esspecialy in holding and childcare the baby when already at home.The results from qualitative studies are supported by quantitative studies showed mothers with EmCS significant fear of delivery and have a more negative experience of childbirth (P< 0.001) and 80% more higher negative experience. Care before, during and after should be guided by foundation that mothers are the central of chilbirth actions, that grant their have autonomy and empowerment in this situation. Conclusion: This systematic review identified the primiparous mothers’ experience EmCS.“Fear” is the dominant felling for mothers’ EmCS, mothers needed social support and caring very approprietly in this situation esspecially in maternity ward. Caring for mothers as nurses being fully present in this moment,  avoid lack of the communication and give a control to get comfortable and feeling treated with respect and as an individual, mothers’ experience more positively.The suggest for this study is to development instrument include before, during and after delivery with caring, control and communication both for mothers and nurses. 

Sign in / Sign up

Export Citation Format

Share Document