scholarly journals Pre-cancer and cancer-associated depression and anxiety among older adults with blood cancers in the United States

Author(s):  
Thomas Michael Kuczmarski ◽  
Tim Jaung ◽  
Claire E. Mancuso ◽  
Lee Mozessohn ◽  
Lizabeth Roemer ◽  
...  

For patients with blood cancers, comorbid mental health disorders at diagnosis likely affect the entire disease trajectory, as they can interfere with disease information processing, lead to poor coping, and even cause delays in care. We aimed to characterize the prevalence of depression and anxiety in patients with blood cancers. Using the Surveillance, Epidemiology, and End Results-Medicare database, we identified patients 67 years and older diagnosed with lymphoma, myeloma, leukemia, or myelodysplastic syndromes between 2000 and 2015. We determined the prevalence of pre-cancer and cancer-associated (CA) depression and anxiety using claims data. We identified factors associated with CA-depression and CA-anxiety in multivariate analyses. Among 75,691 patients, 18.6% had at least one diagnosis of depression or anxiety. Of the total cohort, 13.7% had pre-cancer depression and/or pre-cancer anxiety, while 4.9% had CA-depression or CA-anxiety. Compared to patients without pre-cancer anxiety, those with pre-cancer anxiety were more likely to have subsequent claims for CA-depression (OR 2.98; 95% CI 2.61-3.41). Other factors associated with higher risk of CA-depression included female sex, non-married status, higher comorbidity, and myeloma diagnosis. Patients with pre-cancer depression were significantly more likely to have subsequent claims for CA-anxiety compared to patients without pre-cancer depression (OR 3.01; 95% CI 2.63-3.44). Female sex and myeloma diagnosis were also associated with CA-anxiety. In this large cohort of older patients with newly diagnosed blood cancers, almost one in five suffered from depression or anxiety, highlighting a critical need for systematic mental health screening and management for this population.

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tian Qi ◽  
Ting Hu ◽  
Qi-Qi Ge ◽  
Xiao-Na Zhou ◽  
Jia-Mei Li ◽  
...  

Abstract Background The COVID-19 pandemic has lasted for more than 1 year, causing far-reaching and unprecedented changes in almost all aspects of society. This study aimed to evaluate the long-term consequences of the COVID-19 pandemic on depression and anxiety, and explore the factors associated with it. Methods A cross-sectional study using an online survey was conducted to assess mental health problems from February 2 to February 9, 2021 by using patient health questionnaire-9 (PHQ-9) and generalized anxiety disorder-7 (GAD-7). The insomnia severity index (ISI), demographic data and COVID-19 related variables were measured by a self-designed questionnaire. The factors associated with depressive and anxiety symptoms were identified by Pearson chi-square test and binary logistic regression analysis. Results In the study that 1171 participants enrolled, the overall prevalence of depressive and anxiety symptoms among general people was 22.6 and 21.4% respectively in the present study. Living alone was a potential risk factor for depressive symptoms, while regular exercises was a potential protective factor. The prevalence of depressive and anxiety symptoms was significantly associated with the severity of insomnia symptoms and the negative feelings about pandemic. Conclusion COVID-19 pandemic- related chronic stress has brought about profound impacts on long-term mental health in the general population. The level of insomnia and a negative attitude towards the pandemic are significantly correlated with unfavorable mental health. However, we failed to found a significant association of age and gender with the mental health symptoms, although they were recognized as well-established risk factors during the outbreak by some other studies. This discrepancy may be because the acute and chronic effects of the pandemic are influenced by different factors, which reminds that more attention should be paid to the intrinsic psychological factors and physical reactions towards COVID-19.


2021 ◽  
Vol 7 ◽  
pp. 237802312199812
Author(s):  
Sirry Alang ◽  
Donna McAlpine ◽  
Malcolm McClain

Stress researchers have emphasized the relationship between social stress and mental health. However, research investigating police brutality as a stressor is scarce. The authors conceptualize police brutality as a stressor, examining racial variation in its effects on mental health. Data came from the Survey of the Health of Urban Residents in the United States ( n = 4,389). Negative encounters with the police were found to be associated with depressed mood and anxiety. The relationship between encounters with the police and depressed mood was stronger among Black respondents and Latinxs compared with Whites. Regardless of personal encounters with the police, the anticipatory stress of police brutality—concern that one might become a victim of police brutality—was associated with depression and anxiety. These findings highlight police brutality as an anticipatory stressor and have implications for whiteness as a resource that protects from the stress of negative police encounters.


2021 ◽  
Vol 12 ◽  
Author(s):  
Christi J. Guerrini ◽  
Sophie C. Schneider ◽  
Andrew G. Guzick ◽  
Gifty N. Amos Nwankwo ◽  
Isabel Canfield ◽  
...  

The COVID-19 pandemic is taking a significant global toll on emotional well-being, but evidence of mental health impacts in the United States remains limited. In April 2020, we conducted an exploratory survey of U.S. residents to understand prevalence of and factors associated with psychological distress during the pandemic. Data collection was conducted using Qualtrics, an online survey platform, and U.S. adult respondents were recruited via Amazon's Mechanical Turk platform. Among 1,366 respondents, 42% (n = 571) reported clinically significant anxiety and 38% (n = 519) reported clinically significant depression. Factors associated with anxiety and depressive symptoms included Hispanic/Latino ethnicity; younger age; lower income; employment as or living with a health care worker-first responder; caregiver status; SARS-CoV-2 infection status; decreased frequency of engagement in healthy behaviors; and changed frequency of engagement in unhealthy behaviors. That some of these factors are associated with elevated distress during the pandemic is not yet widely appreciated and might be useful in informing management of mental health care resources.


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S935-S935
Author(s):  
Patricia M Morton ◽  
Blakelee Kemp ◽  
Frass Ahmed

Abstract Numerous studies have demonstrated that child abuse is associated with poor adult mental health, but few have investigated the extent to which the frequency of different types of abuse increase mental health conditions, especially at the nexus of gender. The present study examines whether parental abuse frequency and abuse perpetrator have distinct effects for men and women on three mental health outcomes—depressive symptoms, generalized anxiety, and global self-reported mental health. Data came from three waves of the National Survey of Midlife Development in the United States (MIDUS), comprising a baseline sample of 3,032 adults aged 25-74. Estimating a series of mixed effects models revealed that maternal abuse and frequent abuse during childhood were associated with poorer adult mental health during our 20-year observation period, net of childhood and adult risk factors. Specifically, maternal emotional abuse raised the risk of depression, anxiety, and lower self-rated mental health, and was more strongly associated with depression and anxiety for women than men. Compared to adults who did not experience parental abuse during childhood, adults who experienced frequent emotional and physical abuse by either parent were more likely to experience depression and anxiety and report lower ratings of mental health in adulthood. Frequent child abuse was more strongly associated with anxiety for women than men. These results demonstrate that gender differences in adult mental health have early-life antecedents. Future research investigating the long-term mental health consequences of child abuse should consider the type and magnitude of abuse as well as the perpetrator.


Author(s):  
Syeda Beenish Bareeqa ◽  
Syed Ijlal Ahmed ◽  
Syeda Sana Samar ◽  
Waqas Yasin ◽  
Sani Zehra ◽  
...  

Background The novel coronavirus disease which is believed to have initially originated in Wuhan city of China at the end of 2019 was declared as pandemic by March 2020 by WHO. This pandemic significantly impacted the mental health of communities around the globe. This project draws data from available research to quantify COVID-19 mental health issues and its prevalence in China during the early period of the COVID-19 crisis. It is believed that this pooling of data will give fair estimate of the effects of the COVID-19 pandemic on mental health. Methods We conducted this study in accordance with PRISMA guidelines 2009. The protocol for this review is registered and published in PROSPERO (CRD42020182893). The databases used were Pubmed, Medline, Google scholar and Scopus. The studies were extracted according to pre-defined eligibility criteria and risk of bias assessment was conducted. The Meta-analysis was done using OpenMeta [analyst]. Results Total of 62382 participants in nineteen studies fulfilled the eligibility criteria. Stress was the most prevalent (48.1%) mental health consequence of Covid-19 pandemic, followed by depression (26.9%) and anxiety (21.8%). After performing subgroup analysis, prevalence of depression and anxiety in both females and frontline health care workers were high as compared to the prevalence in general Chinese population. Conclusion The prevalence of depression and anxiety is moderately high whereas pooled prevalence of stress was found to be very high in Chinese people during this Covid-19 crisis.


2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Tiziana Jäggi ◽  
Lena Jellestad ◽  
Salvatore Corbisiero ◽  
Dirk J. Schaefer ◽  
Josef Jenewein ◽  
...  

Compared to the general population, transpersons are exposed to higher levels of discrimination and violence. The stigmatization of transpersons can lead to physical and psychological problems. In particular, transindividuals exhibit a higher prevalence of depression compared to the cispopulation. The gender minority stress model (GMSM) provides a comprehensive theoretical basis to interpret these biopsychosocial interactions. Using the GMSM, this study aimed to identify associations between experience of stigmatization and the mental health of transitioned transpersons using correlational analyses and multiple regression models. In total, 143 transpersons were recruited. Multivariate analyses identified three variables (i.e., unemployment, nonaffirmation of gender identity, and internalized transphobia) to explain variance of depressive symptoms. Furthermore, a mediation of the proximal factors between distal factors and depressive symptoms was found. However, the moderating effect of resilience factors was not demonstrated. The results confirmed the importance of distal and proximal minority stressors for the mental health of transpersons. At the same time, the protective influence of resilience factors seemed to be surprisingly minor. In the treatment of transpersons, practitioners should not only focus on somatic aspects, but also consider the person’s previous experiences of stigmatization.


2021 ◽  
Author(s):  
Esther O Okogbenin ◽  
Omonefe J Seb-Akahomen ◽  
Osahogie I. Edeawe ◽  
Mary Ehimigbai ◽  
Helen Eboreime ◽  
...  

Objective The Coronavirus Disease 2019 (COVID-19) has had devastating effects globally. These effects are likely to result in mental health problems at different levels. Although studies have reported the mental health burden of the pandemic on the general population and frontline health workers, the impact of the disease on the mental health of patients in COVID-19 treatment and isolation centres have been understudied in Africa. We estimated the prevalence of depression and anxiety and associated risk factors in hospitalized persons with COVID-19. Methods A cross-sectional survey was conducted among 489 patients with COVID-19 at the three government-designated treatment and isolation centres in Edo State, Nigeria. The 9-item Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder-7 (GAD-7) tool were used to assess depression and anxiety respectively. Binary logistic regression was applied to determine risk factors of depression and anxiety. Results Of the 489 participants, 49.1% and 38.0% had depressive and anxiety symptoms respectively. The prevalence of depression, anxiety, and combination of both were 16.2%, 12.9% and 9.0% respectively. Moderate-severe symptoms of COVID-19, ≥14 days in isolation, worrying about the outcome of infection and stigma increased the risk of having depression and anxiety. Additionally, being separated/divorced increased the risk of having depression and having comorbidity increased the risk of having anxiety. Conclusion A substantial proportion of our participants experienced depression, anxiety and a combination of both especially in those who had the risk factors we identified. The findings underscore the need to address these risk factors early in the course of the disease and integrate mental health interventions into COVID-19 management guidelines.


2021 ◽  
Vol 9 ◽  
Author(s):  
Celia B. Fisher ◽  
Xiangyu Tao ◽  
Tingting Liu ◽  
Salvatore Giorgi ◽  
Brenda Curtis

Background: The mental health of racial/ethnic minorities in the U.S. has been disproportionately impacted by the COVID-19 pandemic. This study examined the extent to which disruptions in employment and housing, coronavirus-specific forms of victimization and racial bias independently and conjointly contributed to mental health risk among Asian, Black, and Latinx adults in the United States during the pandemic.Methods: This study reports on data from 401 Asian, Black, and Latinx adults (age 18–72) who participated in a larger national online survey conducted from October 2020–June 2021, Measures included financial and health information, housing disruptions and distress in response to employment changes, coronavirus related victimization distress and perceived increases in racial bias, depression and anxiety.Results: Asian participants had significantly higher levels of COVID-related victimization distress and perceived increases in racial bias than Black and Latinx. Young adults (<26 years old) were more vulnerable to depression, anxiety, and coronavirus victimization distress than older respondents. Having at least one COVID-related health risk, distress in response to changes in employment and housing disruptions, pandemic related victimization distress and perceived increases in racial bias were positively and significantly related to depression and anxiety. Structural equation modeling indicated COVID-related increases in racial bias mediated the effect of COVID-19 related victimization distress on depression and anxiety.Conclusions: COVID-19 has created new pathways to mental health disparities among racial/ethnic minorities in the U.S. by exacerbating existing structural and societal inequities linked to race. Findings highlight the necessity of mental health services sensitive to specific challenges in employment and housing and social bias experienced by people of color during the current and future health crises.


2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Dereseh BA ◽  
◽  
Abraha M ◽  
Haile K ◽  
Fanta T ◽  
...  

Background: Since December 2019, an outbreak of corona virus disease 2019(COVID-19), caused by the Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) has widely and rapidly spread in China and around the world. Since 31 December 2019 and as of 30 April 2020, more than 25,000,000 cases of COVID-19 and 800,000 deaths have been reported. The grim epidemic has caused increasing public panic and mental health stress. Mental health is becoming an issue that cannot be ignored, while trying to control the outbreak. Cross sectional study was conducted to assess magnitude and factors associated depression among patients with COVID-19 in St. Peter Specialized Hospital Treatment Centers Addis Ababa, Ethiopia. Methods: Institutional based cross-sectional study was conducted among 422 Patients with COVID-19 admitted at St. Peter Specialized Hospital COVID-19 treatment center. The Anxiety and Depression was assessed through face to face interviews by trained psychiatry nurses using 14-items Hospital Anxiety and Depression Scale (HADS).Correlates for depression & anxiety were assessed using a structured questionnaire and Oslo social support scale. Result: A total of 373 participants were volunteer to be included in the study which makes the response rate88.4%. The mean age of the respondents was 37.46 (±SD=16.09) years. This study revealed that the Magnitude of Depression 36.5 % (136) and Anxiety 21.2 % (79) among COVID-19 patients. By using Multivariate (Anxiety) Logistic Regression, Patients who were Male (AOR 5.01, 95%CI (2.11, 11.87)), Housewife (AOR 11.43, 95%CI ( 2.67, 48.90)), Selfemployed (AOR 2.45,, 95%CI (1.07, 5.60)), having Diagnosed Chronic illness (AOR 2.56, 95%CI (1.19, 5.53)), having COVID-19 Symptoms for below 7 days and for 8-14 days ((AOR 3.21, 95%CI (1.21, 8.58)) & AOR 3.70, 95%CI (1.55, 8.84)) respectively) and those who had Poor/low Social Support (AOR 3.42, 95%CI (1.21, 9.63)) had Statistically Significant Association with Anxiety. By using Multivariate (Depression) Logistic Regression, Patients who were 41 and above years of old (AOR 3.95, 95% CI (1.80, 8.69)), had Monthly Income of less than 1000 birr (AOR 2.99, 95%CI (1.11, 8.05)), Having COVID-19 Symptoms for 8-14 days (AOR 2.63, 95% CI (1.34, 5.17)) and who had Poor Social Support (AOR 3.13, 95% CI (1.34, 7.30)) were Statistically Significant Associated with Depression. Conclusion: In the current study area the magnitude of depression and anxiety was high. Factors like sex, Job, having Diagnosed Chronic illness, Duration of COVID-19 symptom and social support with anxiety and factors such as age, income, duration of COVID-19 symptom and social support had statistically significant associated with depression.


2021 ◽  
Author(s):  
Adrian Aguilera ◽  
Rosa Hernandez-Ramos ◽  
Alein Yaritza Haro ◽  
Claire Elizabeth Boone ◽  
Tiffany Luo ◽  
...  

BACKGROUND Social distancing and stay-at-home orders are critical interventions to slow down person-to-person transmission of COVID-19. While these societal changes help to contain the pandemic, they also have unintended negative consequences, including anxiety and depression. We developed StayWell, a daily skills-based SMS text messaging program, to mitigate COVID-19 related depression and anxiety symptoms among people who speak English and Spanish in the United States. OBJECTIVE This paper describes the changes in the anxiety and depression levels of participants in the StayWell program after 60 days of exposure to skills-based SMS text messages. METHODS We used self-administered, empirically supported web-based questionnaires to assess the demographic and clinical characteristics of StayWell participants. Anxiety and depression were measured using the 2-item Generalized Anxiety Disorder (GAD-2) scale and the 8-item Patient Health Quesstionanire-8 (PHQ-8) scale at baseline and 60-day timepoints. We used paired t-tests to detect the change in PHQ-8 and GAD-2 scores from baseline to follow-up measured 60 days later. RESULTS The analytic sample includes 193 participants who completed both the baseline and 60-day exit questionnaires. At the 60-day time point, there were statistically significant reductions in both PHQ-8 and GAD-2 scores from baseline. We found an average reduction of -1.72 (95% CI: -2.35, -1.09) in PHQ-8 scores and -0.48 (95% CI: -0.71, -0.25) in GAD-2 scores. This translated to an 18.5% and 17.2% reduction in mean PHQ-8 scores and GAD-2, respectively. CONCLUSIONS StayWell is a low-intensity, cost-effective, and accessible population-level mental health intervention. Participation in StayWell focused on COVID-19 mental health coping skills and was related to improved depression and anxiety symptoms. In addition to improvements in outcomes, we found high levels of engagement during the 60-day intervention period. Text messaging interventions could serve as an important public health tool for disseminating strategies to manage mental health. CLINICALTRIAL ClinicalTrials.gov Identifier: NCT04473599 INTERNATIONAL REGISTERED REPORT RR2-10.2196/23592


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