Asthma in reproductive-aged women with polycystic ovary syndrome and association with obesity

Recent research suggests that women with polycystic ovary syndrome (PCOS) may have a higher prevalence of asthma. However, there are no epidemiological studies aimed primarily at exploring the relationship between PCOS and asthma, and the effect of body mass index (BMI) on this association.This study is a cross-sectional analyses of data from the Australian Longitudinal Study on Women's Health, a large, community-based, prospective study to examine the association between PCOS and asthma in women aged 28–33 years (n=478 PCOS and n=8134 controls).The prevalence of asthma was 15.2% in women with PCOS and 10.6% in women without PCOS (p=0.004). Women with PCOS who had asthma had a trend for a higher BMI compared with women without asthma (29.9±0.9 versus 27.7±0.4 kg·m−2; p=0.054). Women without PCOS who had asthma had a higher BMI compared with women without asthma (26.4±0.2 versus 24.9±0.1 kg·m−2; p<0.001). After adjusting for age, BMI and smoking status, PCOS was associated with increased odds of asthma (odds ratio 1.34, 95% CI 1.004–1.79; p=0.047).This study showed both PCOS status and overweight/obese status were independently associated with asthma. Further prospective studies are required to explore the possible mechanisms underpinning the association between asthma and PCOS.

Download Full-text

Gestational Diabetes and Type 2 Diabetes in Reproductive-Aged Women With Polycystic Ovary Syndrome

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2013-2007 ◽

2014 ◽

Vol 99 (3) ◽

pp. E447-E452 ◽

Cited By ~ 71

Author(s):

A. E. Joham ◽

S. Ranasinha ◽

S. Zoungas ◽

L. Moran ◽

H. J. Teede

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Body Mass Index ◽

Longitudinal Study ◽

Odds Ratio ◽

Polycystic Ovary ◽

Community Based ◽

Ovary Syndrome ◽

Reproductive Aged Women

Context: Polycystic ovary syndrome (PCOS) affects 6%–21% of women. PCOS has been associated with an increased risk of dysglycemia including gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM). Objective: The objective of the study was to assess the prevalence of dysglycemia and the impact of obesity in young reproductive-aged women with and without PCOS in a community-based cohort. Design: This was a cross-sectional analysis of data from a large longitudinal study (the Australian Longitudinal Study on Women's Health). Setting: The setting for the study was the general community. Participants: Women were randomly selected from the national health insurance database. Standardized data collection occurred at five survey time points (years 1996, 2000, 2003, 2006, and 2009). Data from survey 4 (2006, n = 9145, 62% of original cohort aged 18–23 y) were examined for this study. Main Outcome Measures: Self-reported PCOS, GDM, and T2DM were measured. Results: In women aged 28–33 years, PCOS prevalence was 5.8% [95% confidence interval (CI) 5.3%–6.4%]. The prevalence of GDM (in women reporting prior pregnancy) and T2DM was 11.2% and 5.1% in women with PCOS and 3.8% and 0.3% in women without PCOS, respectively (P for both < .001). PCOS was associated with an increased odds of GDM and T2DM. After adjusting for age, body mass index, hypertension, smoking, and demographic factors, the odds of GDM (odds ratio 2.1, 95% CI 1.1–3.9, P = .02) and T2DM (odds ratio 8.8, 95% CI 3.9–20.1, P < .001) remained increased in women reporting PCOS. Conclusions: In a large community-based cohort of reproductive-aged women, PCOS was independently associated with a higher risk of GDM and T2DM, independent of body mass index. Aggressive screening, prevention, and management of dysglycemia is clearly warranted in women with PCOS.

Download Full-text

Borderline personality disorder and polycystic ovary syndrome: A review of the literature

Australian & New Zealand Journal of Psychiatry ◽

10.1177/0004867417730650 ◽

2017 ◽

Vol 52 (2) ◽

pp. 117-128 ◽

Cited By ~ 3

Author(s):

Raelene YM Tan ◽

Jasmin Grigg ◽

Jayashri Kulkarni

Keyword(s):

Borderline Personality Disorder ◽

Personality Disorder ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Case Reports ◽

Borderline Personality ◽

Polycystic Ovaries ◽

Ovary Syndrome ◽

Cross Sectional ◽

The Relationship

Objective: This review examines the existing evidence for the relationship between borderline personality disorder and polycystic ovary syndrome, and to identify commonalities in etiological mechanisms of borderline personality disorder and polycystic ovary syndrome that might explain the relationship between these seemingly disparate disorders. Methods: A search of Medline, EMBASE and Cochrane Central was undertaken on 5 December 2016 to identify studies investigating women with borderline personality disorder and polycystic ovary syndrome (or symptoms and markers specific to polycystic ovary syndrome). Results: Nine studies were identified, including three cross-sectional studies investigating symptoms of polycystic ovary syndrome in women with borderline personality disorder, two cross-sectional and one cohort study examining the prevalence of psychiatric diagnoses in women with polycystic ovary syndrome and three case reports of comorbid borderline personality disorder and polycystic ovary syndrome. Conclusion: Overall, the literature shows women with borderline personality disorder to have higher than expected serum androgen levels and incidence of polycystic ovaries, which can be key features of polycystic ovary syndrome. However, this research is still in its infancy, which limits our understanding of this potential comorbid phenomenon. Given the emerging anecdotal and empirical evidence to date, a theoretical discussion of the potential psychoneuroendocrinological mechanism underlying the borderline personality disorder and polycystic ovary syndrome comorbidity is provided. Further rigorous studies using standardized diagnostic criteria for polycystic ovary syndrome are warranted. Specifically, the use of prospective controlled cohort studies may be able to determine the causality and temporality of observed comorbid borderline personality disorder and polycystic ovary syndrome.

Download Full-text

Circulating leptin concentrations and ovarian function in polycystic ovary syndrome

Acta Endocrinologica ◽

10.1530/eje.0.1450289 ◽

2001 ◽

pp. 289-294 ◽

Cited By ~ 20

Author(s):

IR Pirwany ◽

R Fleming ◽

N Sattar ◽

IA Greer ◽

AM Wallace

Keyword(s):

Polycystic Ovary Syndrome ◽

Ovarian Function ◽

Polycystic Ovary ◽

Ovarian Dysfunction ◽

Ovary Syndrome ◽

Cross Sectional ◽

Serum Leptin ◽

Significant Difference ◽

The Relationship

OBJECTIVE: Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction. Although the role of leptin in the control of reproduction is unclear, it may be involved in the control of ovulation. The aim of this cross-sectional study was to determine the relationship between circulating leptin concentrations, and anthropometric, metabolic and endocrine variables as well as to examine a possible role of leptin in ovarian dysfunction associated with PCOS. DESIGN: Prospective observational study. METHODS: Seventy-one subjects with PCOS and 23 body mass index (BMI)-matched control subjects were recruited from infertility clinics. The association between serum leptin concentrations and the above variables was measured outwith the luteal phase. A subgroup of 24 PCOS subjects underwent more frequent blood sampling to monitor follicular growth and ovulation. The association between variables was measured by univariate, multivariate and partial correlation analyses. RESULTS: Serum leptin concentrations were not different in subjects with PCOS and controls, and were strongly associated with BMI in both groups. Twelve patients ovulated during the study period. There was no significant difference in serum leptin concentrations between ovulatory and anovulatory subjects. The relationship between BMI and leptin was similar in both groups. CONCLUSION: The results indicated that circulating leptin concentrations relate principally to total body fat in subjects with PCOS and controls, and that this is not associated with the facility for follicular development and ovulation in these patients.

Download Full-text

Anti-mullerian hormone is associated with advanced glycosylated end products in lean women with polycystic ovary syndrome

Acta Endocrinologica ◽

10.1530/eje-08-0510 ◽

2009 ◽

Vol 160 (5) ◽

pp. 847-853 ◽

Cited By ~ 36

Author(s):

Evanthia Diamanti-Kandarakis ◽

Athanasia Piouka ◽

Sarantis Livadas ◽

Christine Piperi ◽

Ilias Katsikis ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Oocyte Maturation ◽

Granulosa Cells ◽

Polycystic Ovary ◽

Cross Sectional Study ◽

Ovary Syndrome ◽

Cross Sectional ◽

End Products ◽

Normal Women ◽

The Relationship

ObjectiveOocyte maturation process characterizes polycystic ovary syndrome (PCOS). The mechanisms of this abnormality leading to chronic anovulation are under investigation. Advanced glycosylated end products (AGEs), a marker of oxidative stress linked with oocyte maturation are localized in granulosa cells and are increased in sera, in women with PCOS. The aim of this study was to investigate the relationship, whether there is an association between the anti-mullerian hormone (AMH), a hormone produced by granulosa cells and AGEs in ovulatory and anovulatory PCOS (PCOS-Anov), as well as in non-PCOS anovulatory (Non-PCOS Anov) women.DesignCross-sectional study.MethodsData from sixty women with PCOS (37 anovulatory and 23 regularly ovulating) were compared with eleven Non-PCOS Anov women and 25 normal women. In each subject biochemical, hormonal, and ultrasonographic parameters were studied.ResultsAMH values were statistically significantly higher in PCOS-Anov (7.63±3.12) in comparison with ovulatory PCOS (PCOS-Ov; 4.92±2.50), Non-PCOS Anov (3.66±1.4), and controls (4.02±1.27 ng/ml). AGEs demonstrated a similar pattern: 8.70±1.65 in PCOS-Anov, 7.43±1.79, PCOS-Ov, 5.21±0.09, Non-PCOS Anov, and 5.85±0.89 U/ml in controls (P<0.005 for all comparison respectively). Follicle number was significantly higher in PCOS-Anov in comparison with other groups. A significant positive correlation between AMH and AGEs was observed (r: 0.326,P<0.01), and with the estimated AMH/AGEs ratio to follicle number (r: 0.42,P: 0.0001) and the presence of anovulation.ConclusionsThese data suggest that an oxidative marker, AGEs, and AMH, may interact in the anovulatory mechanisms in women with PCOS.

Download Full-text

Predictors of Scalp Hair Thinning in Women with Polycystic Ovary Syndrome

US Endocrinology ◽

10.17925/use.2016.12.01.26 ◽

2016 ◽

Vol 12 (01) ◽

pp. 26

Author(s):

Deborah E Ikhena ◽

Joanne Williams ◽

Nighat Naqvi ◽

Lubna Pal ◽

◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Scalp Hair ◽

Polycystic Ovary ◽

Smoking Status ◽

Tertiary Care ◽

Density Lipoprotein ◽

Tolerance Test ◽

Oral Glucose ◽

Ovary Syndrome ◽

Cross Sectional

Objective: To determine the prevalence and predictors of perceived scalp hair thinning (SHT) among women with polycystic ovary syndrome (PCOS). Materials and Methods: A cross-sectional study of women with PCOS to determine the prevalence and predictors of SHT in this population. The sample included 263 women presenting to a reproductive endocrinologist at a tertiary care teaching institution for symptoms relating to PCOS. The main outcome measures were symptoms of PCOS including SHT, quality of life, hormonal and metabolic parameters. Clinical, hormonal and metabolic predictors of SHT were determined utilizing multivariable logistic regression analyses. Results: SHT was acknowledged by 27% of subjects. Advancing age (p=0.024), subjective hirsutism (odds ratio [OR] 2.0, 95% CI 1.1–3.91), disturbed sleep (OR 1.91, 95% CI 1.1–3.4) and smoking (OR 1.90, 95% CI 1.0–3.9) were associated with significantly increased likelihood of SHT (p<0.05). Serum androgen levels did not relate to SHT. On analyses adjusting for age, body mass index, race, and smoking status, abnormal two-hour oral glucose tolerance test (OR 9.9, 95% CI 3.1–30.2), serum low-density lipoprotein (LDL) (OR 0.96, 95% CI 0.97–0.99), and skipped meals (OR 3.1, 95% CI 1.3–7.3) were independent predictors of SHT in women with PCOS. Conclusions: Similar to acanthosis nigricans, our data identify SHT as a phenotypic reflection of concomitant metabolic burden in women with PCOS.

Download Full-text

Is polycystic ovary syndrome appropriately diagnosed by obstetricians and gynaecologists across China: a nationwide survey

Journal of Ovarian Research ◽

10.1186/s13048-021-00780-6 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Deng Yan ◽

Wang Yan-Fang ◽

Zhu Shi-Yang ◽

Ma Rui-Lin ◽

Ding Xue-Song ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Diagnostic Criteria ◽

Polycystic Ovary ◽

Final Analysis ◽

Nationwide Survey ◽

Care Quality ◽

Cross Sectional Survey ◽

Ovary Syndrome ◽

Cross Sectional ◽

Rotterdam Criteria

Abstract Background To describe the diagnostic criteria used and their application accuracy in the practice of polycystic ovary syndrome (PCOS) caring among obstetricians and gynaecologists across China. Methods This was an Online cross-sectional survey of Obstetricians and gynecologists involved in PCOS caring conducted via the largest continuing education platform of obstetrics and gynecology across China from September 2019 to November 2019. Results A total of 2,328 respondents were eligible for the final analysis. Of these, 94.5 % were general obstetricians and gynaecologists (Ge-ObGyn), and 5.5 % were reproductive endocrinologists (Re-ObGyn). Overall, the most frequently used criteria were the Androgen Excess and Polycystic Ovary Syndrome Society (AE-PCOS) criteria (48.2 %), followed by the Rotterdam criteria (35.7 %) and NIH criteria (12.1 %). Of the respondents, 31.3 % used their diagnostic criteria in their clinical practice. More respondents who chose the Rotterdam criteria could accurately apply the diagnostic criteria than those who chose the AE-PCOS criteria (41.2 % vs. 32.1 %, P < 0.001). Compared with Ge-ObGyn, Re-ObGyn were less likely to use the AE-PCOS criteria (adjusted odds ratio, 0.513; 95 % CI, 0.328–0.802; P < 0.05) and 1.492 times more likely to accurately use their criteria (95 % CI, 1.014–2.196; P < 0.05). Conclusions Less than one-third of obstetricians and gynaecologists across China could accurately use the diagnostic criteria they choose to diagnose PCOS. There is an urgent need to train obstetricians and gynaecologists on PCOS diagnosis in an effort to improve the medical care quality of patients with PCOS.

Download Full-text

Urinary bisphenol A in women with polycystic ovary syndrome – a possible suppressive effect on steroidogenesis?

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2020-0032 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Zora Lazúrová ◽

Jana Figurová ◽

Beáta Hubková ◽

Jana Mašlanková ◽

Ivica Lazúrová

Keyword(s):

Polycystic Ovary Syndrome ◽

Bisphenol A ◽

Steroid Hormones ◽

Polycystic Ovary ◽

Suppressive Effect ◽

Human Reproduction ◽

Control Group ◽

Ovary Syndrome ◽

Ovarian Steroidogenesis ◽

The Relationship

Abstract Objectives There is a growing evidence indicating an impact of endocrine distrupting chemicals such as bisphenol A (BPA) on human reproduction. Its higher levels in serum or urine have been documented in women with polycystic ovary syndrome (PCOS), however the relationship to ovarian steroidogenesis remains unclear. Aim of the study was to compare urinary BPA (U-BPA) concentrations among PCOS women and control group. Second aim was to assess the relationship of U-BPA to ovarian steroidogenesis in the group with PCOS. Methods Eighty six Caucasian women (age 28.5 ± 5.1 years) diagnosed with PCOS and 32 controls of age 24.9 ± 4.4 years were included in the study. Fasting blood samples were analyzed for biochemical parameters and steroid hormones. U-BPA was measured in the morning urine sample using high pressure liquid chromatography. Results PCOS women had significantly higher U-BPA as compared with control group (p=0.0001). Those with high levels of U-BPA (U-BPA ≥2.14 ug/g creatinine) demonstrated higher serum insulin (p=0.029) and HOMA IR (p=0.037), lower serum estrone (p=0.05), estradiol (p=0.0126), FSH (p=0.0056), and FAI (p=0.0088), as compared with low-BPA group (U- BPA <2.14 ug/g creatinine). In PCOS women, U-BPA positively correlated with age (p=0.0026; R2=0.17), negatively with estradiol (p=0.0001, R2=0.5), testosterone (p=0.0078, R2=0.15), free-testosterone (p=0.0094, R2=0.12) and FAI (p=0.0003, R2=0.32), respectively. Conclusions PCOS women have significantly higher U-BPA concentrations than healthy controls. U-BPA positively correlates with age and negatively with ovarian steroid hormones suggesting a possible suppressive effect of bisphenol A on ovarian steroidogenesis.

Download Full-text