The effect of preoperative aminophylline on the recovery profile after major pelvic-abdominal surgeries: a randomized controlled double-blinded study

Abstract Background This study compared the effects of premedication with different doses of aminophylline on the recovery profile after general anaesthesia. Methods Forty-five patients scheduled for pelvic-abdominal surgeries were divided into 3 groups: Group C: the patients received 100 ml of IV normal saline, Group A1: the patients received 2 mg/kg IV aminophylline, and Group A2: the patients received 4 mg/kg IV aminophylline 30 min before induction of general anaesthesia. The following data were recorded: demographic data, ASA physical status, duration of anaesthesia and surgery, heart rate, mean arterial blood pressure, propofol dose, fentanyl dose, times to reach BIS (48 ± 2) after induction of anaesthesia and to reach a value of 80 after discontinuation of sevoflurane anaesthesia, time to recovery of consciousness and to tracheal extubation and to discharge from the post-anaesthesia care unit, and side effects of aminophylline. Results The time to reach a BIS of 48 ± 2 was significantly lower for the control group than group A2 (70.67 ± 22.50 and 106.67 ± 34.77 s for groups C and A2, respectively, p -value =0.01). The time to reach a BIS of 80 was significantly longer for the control group than group A1 andA2 (5.6 ± 1.40,3.5 ± 1.93and 2.53 ± 1.72 min for groups C,A1 and A2, respectively, p -value < 0.01). The time to ROC was significantly longer for the control group than groups A1 and A2 (8.93 ± 0.92, 5.6 ± 2.47 and 4.53 ± 3.33 min for groups C, A1 and A2, respectively; p -value < 0.01). The extubation time was significantly longer for the control group than groups A1 and A2 (12.4 ± 1.08, 7.87 ± 3.27 and 6.6 ± 2.47 min for groups C, A1 and A2, respectively; p -value < 0.01). Conclusion Premedication with aminophylline enhanced the recovery profile after pelvic-abdominal surgeries under general anaesthesia without cardiovascular complications. Clinical trial registration Name of the registry: [email protected] Trial registration number: ClinicalTrials.gov Identifier: NCT04151381. Date of registration, November 5, 2019, ‘Retrospectively registered’.

Download Full-text

The Effect of Preoperative Aminophylline on the Recovery Profile After Major Pelvi-abdominal Surgeries: a Randomized Controlled Double-blinded Study

10.21203/rs.3.rs-152371/v1 ◽

2021 ◽

Author(s):

Samaa A. Kasim ◽

Mahmoud Hussien Bahr ◽

Mohamed Abdelkader ◽

Doaa Abu Elkassim Rashwan

Keyword(s):

General Anesthesia ◽

Tracheal Extubation ◽

Saline Group ◽

Cardiovascular Complications ◽

Control Group ◽

P Value ◽

Arterial Blood ◽

Recovery Profile ◽

Extubation Time ◽

Double Blinded

Abstract Background: This study compared the effects of premedication with different doses of aminophylline on the recovery profile after general anesthesia.Methods: 45 patients scheduled for pelvi-abdominal surgeries were divided into 3 groups; Group(C): the patients received 100 ml of IV normal saline, Group (A1): received 2 mg/kg aminophylline IV)and Group(A2): received 4 mg/kg aminophylline(IV)30minutes before induction of general anesthesia . The following data were recorded:demographic data, ASA physical status, duration of anesthesia and surgery, heart rate, mean arterial blood pressure, propofol dose, fentanyl dose ,times to reach BIS (48±2)after induction of anesthesia and to reach 80 after discontinuation of sevoflurane anesthesia,time till recovery of consciousness and to tracheal extubation and to discharge from the post-anesthesia care unit,side effects of aminophylline were also recorded .Results :The time till BIS reach 48±2 was statistically significantly less for the control group compared to group A2 (70.67±22.50 and 106.67±34.77 minutes) for group C and A2 respectively;(p -value =0.00),the time till BIS reached 80 was statistically significantly longer for the control group compared to group A2 (5.6±1.40 and 2.53±1.72 minutes ) for group C and A2 respectively;(p -value =0.00),time for ROC was statistically significantly longer for the control group than group A1 and A2(8.93±0.92, 5.6±2.47 and 4.53±3.33 minutes) for group C, A1 and A2 respectively ; (p -value =0.00 ), the extubation time was statistically significantly longer for the control group being12.4±1.08,7.87±3.27and 6.6±2.47 minutes) for group C, A1 and A2 respectively; (p -value =0.00.Conclusion: Premedication with aminophylline enhanced the recovery profile after pelvi-abdominal surgeries under general anesthesia without cardiovascular complications.Trial registration: Number: NCT04151381, date November 5, 2019, retrospectively

Download Full-text

RANDOMISED CONTROLLED STUDY TO EVALUATE THE EFFECTS OF NITROGLYCERINE SUBLINGUAL SPRAY ON TRACHEAL EXTUBATION RESPONSE IN NORMOTENSIVE PATIENTS UNDERGOING SURGERIES UNDER GENERAL ANAESTHESIA

10.36106/ijsr/1600746 ◽

2020 ◽

pp. 1-6

Author(s):

Surendra Kumar Raikwar ◽

Anil Kori* ◽

Aditya Agarwal

Keyword(s):

Stress Response ◽

General Anaesthesia ◽

Tracheal Extubation ◽

Controlled Study ◽

Control Group ◽

Pain Anxiety ◽

Arterial Blood ◽

Variable Success ◽

Related Stress ◽

Randomised Controlled

Tracheal extubation is the translaryngeal removal of a tube from the trachea via the nose or mouth and associated with awakening, pain, anxiety, airway irritation which may cause a cough or difculties in breathing and may contribute to an increase in haemodynamic response (1) .Several modalities, both pharmacological and nonpharmacological have been tried to decrease this stress response with variable success. We undertook this study to assess the efcacy of NTG spray in decreasing extubation related stress response in normotensive patients undergoing elective surgeries under general anaesthesia. Material and methods : Sixty normotensive patients were included in study and randomly subdivided into two groups of 30 patients each – group N receiving NTG spray and Group C not receiving NTG spray prior to extubation. Hemodynamic stress response during extubation was noted in both the groups and compared. Result and conclusion : Extubation was associated with signicant rise in systolic, diastolic and mean arterial blood pressure and heart rate in both the groups, but this stress response was signicantly less in NTG Group as compared to control group.

Download Full-text

Association of interleukin-17A rs2275913 polymorphism with rheumatoid arthritis susceptibility in Sudanese population

SAGE Open Medicine ◽

10.1177/20503121211020207 ◽

2021 ◽

Vol 9 ◽

pp. 205031212110202

Author(s):

Rgda Mohamed Osman ◽

Mounkaila Noma ◽

Abdallah Elssir Ahmed ◽

Hanadi Abdelbagi ◽

Rihab Ali Omer ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Confidence Interval ◽

Statistical Tests ◽

Demographic Data ◽

Control Group ◽

P Value ◽

Case Group ◽

Molecular Technique ◽

Interleukin 17A ◽

Significant Difference

Objectives: Rheumatoid arthritis is a chronic inflammatory autoimmune disease. This study aimed to determine the association of interleukin-17A-197G/A polymorphism with rheumatoid arthritis in Sudanese patients. Methods: A case–control study was conducted between March and December 2018. Clinical and demographic data of the study participants were collected and analyzed. Polymerase chain reaction restriction fragment length polymorphism molecular technique was done to investigate interleukin-17A-197G/A polymorphisms. All statistical tests were considered statistically significant when p < 0.05. Results: The study population included 266 participants aged between 1 and 85 years, with an average of 40 years, classified into 85 (31.2%) cases (mean age 48.5 ± 11.3 years), and 181 (68.8%) controls (mean age 35.3 ± 15.9 years). The interleukin-17A homozygote AA genotype was more frequent among the control group compared to the case group; 95 (52.5%) and 7 (8.2%), respectively. The homozygote GG and the heterozygote AG genotypes were proportionally not different among the cases and control groups; 13 (54.2%) and 11 (45.8%), and 65 (46.4%) and 75 (53.6%), respectively. According to the distribution of interleukin-17A genotypes, a statistically significant difference was observed among cases with the interleukin-17A AA and AG genotypes, p values 0.001 and 0.004, respectively. For the association interleukin-17A genotypes and family history a negatively significant association was reported (95% confidence interval, –0.219, p value = 0.001). There was also a negatively significant association of interleukin-17A genotypes and anti-cyclic citrullinated peptide (95% confidence interval, −0.141, p value = 0.002). Conclusion: This study is the first study in Sudan established the association between interleukin-17A-197G/A (rs2275913) polymorphisms and susceptibly to rheumatoid arthritis. These findings appeal for further research in Sudan to investigate the exact role of IL-17A in immunopathology and disease severity among Sudanese rheumatoid arthritis

Download Full-text

Abstract P790: Landiolol Attenuates Global Cerebral Edema Following Experimental Cardiac Arrest in Mice

Stroke ◽

10.1161/str.52.suppl_1.p790 ◽

2021 ◽

Vol 52 (Suppl_1) ◽

Author(s):

Tomoyuki Iwai ◽

Shin Nakayama

Keyword(s):

Cardiac Arrest ◽

Water Content ◽

Cerebral Edema ◽

Ischemia Reperfusion ◽

Control Group ◽

P Value ◽

Brain Water Content ◽

Arterial Blood ◽

The Brain ◽

Brain Water

Introduction: Cerebral edema following cardiac arrest and cardiopulmonary resuscitation (CA/CPR) is associated with unfavorable neurologic outcome. The Na + -K + -2Cl - water cotransporter NKCC1 is suspected to be a critical mediator of edema formation after ischemia. It is reported that β1 adrenoreceptor antagonists protect neurons following brain ischemia in rodents. β1 adrenoreceptor antagonists inhibit the Na + -K + -ATPase, which can inhibit driving force of NKCC1 that theoretically reduces cerebral edema following ischemia-reperfusion injury. In this study, we examined whether landiolol, a selective β1 adrenoreceptor antagonist, attenuates cerebral edema following CA/CPR. Methods: Isoflurane-anesthetized adult male mice (C57BL/6J, 25-30g) were randomized into landiolol group or control group. After 7-min CA followed by CPR, landiolol (0.5ml, 830μg/ml) was administered by continuous infusion intravenously for 4 hours. Animals in control group were given normal saline (0.5ml) in the same manner. Twenty-four hours after CA/CPR, the brain was removed to assess brain water content using wet-to-dry method. The primary outcome was measurement of the brain water content. Heart rate and arterial blood pressure were recorded. Measured parameters were analyzed by one-way ANOVA with post hoc Tukey-Kramer test using SPSS® statistics 25. Differences were considered statistically significant at a P value < 0.05. Results: Brain water contents was increased in control group mice after CA/CPR (n=10) compared with those in sham operated mice (n=5) (79.5±0.85% vs 78.3±0.14%, P=0.003). Compared with control group, landiolol treatment significantly reduced brain water content in mice subjected to CA/CPR (n=12) (78.9±0.51% vs 79.5±0.85%, P=0.04). Conclusion: Landiolol attenuated brain edema following CA/CPR. These results may suggest selective β1-blocker could be alternative treatment for neuroprotection in patients who suffered CA/CPR.

Download Full-text

Research protocol local ingredients-based supplementary food as an alternative to corn-soya blends plus for treating moderate acute malnutrition among children aged 6 to 59 months: a randomized controlled non-inferiority trial in Wolaita

BMC Public Health ◽

10.1186/s12889-019-8031-3 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Debritu Nane ◽

Anne Hatløy ◽

Elazar Tadesse ◽

Bernt Lindtjørn

Keyword(s):

Intervention Group ◽

Trial Registration ◽

Acute Malnutrition ◽

Control Group ◽

Chi Square ◽

Clinical Trial Registration ◽

Exact Test ◽

Supplementary Food ◽

Randomized Controlled ◽

Moderate Acute Malnutrition

Abstract Background In Ethiopia, 12.5% of children below 5 years are wasted, and 9.7% are moderately wasted. The present strategy for the management of moderate acute malnutrition (MAM) is a supplementary feeding program; however, this is only provided to chronically food-insecure areas. This randomized controlled non-inferiority trial examines if Local ingredients-based supplement (LIBS) is as effective as corn-soya blends plus (CSB+) in treating moderate acute malnutrition among children aged 6–59 months. Methods A randomized controlled non-inferiority trial will be conducted with moderately wasted children aged 6 to 59 months in Wolaita, Ethiopia. The calculated sample size is 324 (i.e. with 162 children in each of two arms, to be assigned by randomization). The daily ration will be: 100 g of LIBS plus 25.2 g of sugar with 8 ml oil in the intervention group, and 150 g of CSB+ with 16 ml of oil in the control group. These interventions will be provided for a maximum period of 12 weeks, with follow-up performed on a weekly basis. Data analysis will be done using SPSS and STATA software. Both intention-to-treat and per protocol analyses will be done. Hazard ratio and Kaplan-Meier (log rank) curves of survival analysis will be done to predict the probability of recovery rate. Logistic regression will be used to test for interactions between independent and dependent variables. Analysis of variances, t-tests, fisher’s exact test and chi-square tests will be used to assess baseline characteristics. Conclusions This paper will introduce to the existing research locally available nutritious foods which have the potential to enhance recovery from moderate acute malnutrition and to reduce the burden of malnutrition. The perceptions of mothers on feeding children with local ingredient-based supplementary food to assist recovery from moderate acute malnutrition will be the focus of in a qualitative study to follow; this will provide a further contribution in an evolving area of research. Trial registration Pan-African Clinical Trial Registration number: PACTR201809662822990, retrospectively registered on 11/09/2018.

Download Full-text

DISTRACTION TECHNIQUES: TELLING STORIES TO DECREASE PAIN FOR PRESCHOOL CHILDREN DURING INFUSION

Jurnal Keperawatan Indonesia ◽

10.7454/jki.v22i1.887 ◽

2019 ◽

Vol 22 (1) ◽

pp. 23-30

Author(s):

Lina Dewi Anggraeni ◽

Widiyanti Widiyanti

Keyword(s):

Demographic Data ◽

Intervention Group ◽

Pain Scale ◽

Control Group ◽

P Value ◽

Pediatric Nurses ◽

Control Groups ◽

Analysis Technique ◽

Quasi Experimental ◽

And Control

Hospital procedures, such as infusions, are often associated with pain. Preschool-aged children who are hospitalized for infusions will often exhibit a strong fearful response because their concept of body integrity has not fully developed. One way to reduce the fear of infusion pain is by using stories as a distraction technique. The purpose of this study was to identify differences in the scale of pain between members of an intervention group, to which the distraction technique was applied, and a control group, to which it was not applied. The study used quasi-experimental methods, with intervention and control groups. The study was conducted on 46 preschool aged respondents (3-6 years old), divided into a 34 member intervention group and a 12 member control group and ran from September to December 2017 in one of the private hospitals in the East Bekasi. The research employed a questionnaire to collect demographic data and used the Wong-Baker Faces Pain Scale to assess pain levels. The data analysis technique used was the independent t-test. The results showed there was a difference of pain response between the intervention and control groups with P value < 0.05. Pediatric nurses are advised to use storytelling therapy as an option for providing atraumatic care intervention. Keywords: Distraction Technique, Infusion installation, Pain, Stories, Preschool Abstrak Teknik Distraksi: Bercerita Menurunkan Nyeri Pada Anak Usia Pra Sekolah Selama Penggunaan Infus. Rasa sakit seringkali dikaitkan dengan salah satu prosedur rumah sakit yakni pemasangan infus. Reaksi anak prasekolah yang dipasang infus menunjukkan ketakutan yang luar biasa, hal itu disebabkan karena konsep integritas tubuhnya belum berkembang dengan baik. Salah satu cara untuk mengurangi ketakutan akibat nyeri pemasangan infus pada prasekolah adalah teknik distraksi bercerita. Tujuan penelitian ini untuk mengidentifikasi perbedaan skala nyeri antara kelompok intervensi dan kelompok kontrol. Penelitian ini merupakan penelitian kuantitatif dengan metode quasy eksperimen, yang menggunakan kelompok intervensi dan kelompok kontrol. Penelitian dilakukan terhadap 46 responden usia prasekolah (3-6 tahun) yang terdiri dari 34 kelompok intervensi dan 12 kelompok kontrol dari bulan September-Desember 2017 di salah satu Rumah Sakit Swasta di wilayah Bekasi Timur. Instrumen penelitian menggunakan kuisioner data demografi dan lembar observasi skala nyeri Wong Baker Faces Pain. Teknik analisis data menggunakan Uji Independent T test.Hasil penelitian menunjukkan terdapat perbedaan respon nyeri antara kelompok intervensi dan kelompok kontrol dengan nilai p= 0,012 (< 0.05). Perawat anak sebaiknya menggunakan metode bercerita sebagai sarana asuhan keperawatan atraumatik. Kata kunci: Cerita, Nyeri, Pemasangan infus, Prasekolah, Teknik distraksi

Download Full-text

Atorvastatin in Helicobacter Pylori Treatment: A Randomized Controlled Trial and Review

10.21203/rs.3.rs-575317/v1 ◽

2021 ◽

Author(s):

Mohammad Reza Mohammad Hoseini Azar ◽

Parham Porteghali ◽

Amin Sedokani

Keyword(s):

Helicobacter Pylori ◽

Standard Treatment ◽

Controlled Trial ◽

Intervention Group ◽

Trial Registration ◽

Control Group ◽

P Value ◽

Bismuth Subcitrate ◽

Significant Difference ◽

H Pylori

Abstract Background: Considering the increase in drug resistance over time to Helicobacter pylori treatment relying on the anti-inflammatory and antibacterial effects of atorvastatin to increase the success rate of H. pylori eradication, we examined the effect of adding atorvastatin to standard treatment of H. pylori eradication.Results: A total of 186 symptomatic patients who had been diagnosed with Helicobacter pylori infection and tested for H. pylori eradication were examined by a pathological response or positive urea breath test. Patients who received atorvastatin in addition to standard treatment were also identified based on a table of random numbers. Standard treatment included a 240mg bismuth subcitrate tablet, a 40mg pantoprazole tablet, a 500mg metronidazole tablet, and 2 capsules of 500mg amoxicillin, all taken BID for 14 days. After 4 weeks of treatment, all patients underwent stool testing for H. pylori fecal antigen. If the test was positive, the request was considered a failure of treatment, and if the test was negative, it was considered a successful eradication of H. pylori. The clinical trial registration code for this study is IRCT20190823044589N1. The eradication rate of H. pylori was 80% in the control group and 80.9% in the intervention group, which did not show a statistically significant difference between the two groups (P-value=0.971).Conclusion: Adding atorvastatin to 4-drug regimen of PPI, bismuth subcitrate, amoxicillin, and metronidazole as the first line of treatment for H. pylori eradication is ineffective.Trial registration: IRCT, IRCT20190823044589N1. Registered 28 December 2019 - Retrospectively registered, https://en.irct.ir/trial/41734

Download Full-text

Schizophrenia patients with a metabolically abnormal obese phenotype have milder negative symptoms

10.21203/rs.3.rs-15825/v2 ◽

2020 ◽

Author(s):

Juan Wang ◽

Yulong Zhang ◽

Zhiwei Liu ◽

Yating Yang ◽

Yi Zhong ◽

...

Keyword(s):

Metabolic Syndrome ◽

Negative Symptoms ◽

Psychiatric Symptoms ◽

Normal Weight ◽

Trial Registration ◽

Control Group ◽

Clinical Trial Registration ◽

Negative Factor ◽

Syndrome Scale ◽

Mental Symptoms

Abstract Background: Schizophrenia patients with a metabolically abnormal obese (MAO) phenotype have been shown poor cardiovascular outcomes, but the characteristics of their current psychiatric symptoms have not been characterized. This study mainly explored the psychiatric symptoms of schizophrenia patients with the MAO phenotype. Methods: A total of 329 patients with schizophrenia and 175 sex- and age-matched people without schizophrenia from Anhui Province in China were enrolled. The Positive and Negative Syndrome Scale (PANSS) was used to evaluate the mental symptoms of the schizophrenia patients. The MAO phenotype was defined as meeting 1-4 metabolic syndrome criteria (excluding waist circumference) and having a body mass index (BMI) ≥ 28 kg/m2. And, metabolically healthy normal-weight (MHNW) phenotype was defined as meeting 0 criteria for metabolic syndrome and 18.5 ≤ BMI < 24 kg/m2. Results: Overall, 15.8% of the schizophrenia patients and 9.1% of the control group were consistent with the MAO phenotype, and the prevalence of MAO in the schizophrenia group was higher than that in the control group. Among the patients with schizophrenia, the MAO group had lower negative factor, cognitive factor and total PANSS scores than the MHNW group. However, when confounding factors were controlled, only the negative factor remained lower. The correlation analysis showed that the MAO phenotype was strongly correlated with C-peptide and insulin levels.Conclusion: we found that schizophrenia patients with the MAO phenotype had reduced negative symptoms, which may indicate an internal mechanism linking metabolic disorders and negative symptoms.Trial registration: This study was registered in the China Clinical Trial Registration Center (No. chiCTR 1800017044)

Download Full-text

PENINGKATAN MOTIVASI KONSUMSI SAYUR DAN BUAH MELALUI COGNITIVE BEHAVIOUR THERAPY (CBT)

Adi Husada Nursing Journal ◽

10.37036/ahnj.v1i1.6 ◽

2015 ◽

Vol 1 (1) ◽

pp. 23

Author(s):

Etika Purnama Sari

Keyword(s):

Cognitive Behaviour Therapy ◽

Demographic Data ◽

Intervention Group ◽

Mean Value ◽

Control Group ◽

P Value ◽

Behaviour Therapy ◽

Purposive Sampling ◽

Cognitive Behaviour ◽

Vegetables And Fruits

Many children didn’t like to consume vegetables and fruit, they consumed it in value standard below from WHO. The aim from this study explained the increasing motivation within consume vegetables and fruits through Cognitive Behaviour Therapy (CBT). The study design was quasy experiment with prepost control group design. The variables studied were motivation within consume vegetables and fruits. The samples obtained were 27 respondents for intervention group and 28 respondents for control group using purposive sampling. Collecting data includes demographic data and motivation data with questionnaire. Based on Mann Whitney U Test, p value for pretest between intervention and control group was 0,495 with α=0,05 it means that there wasn’t different in motivation consume vegetables and fruit, but for posttest p value was 0,029 it means that there was different in motivation. Based on mean value, there was increasing value for intervention group from 29,30 to 31,91 it means that CBT could increasing motivation to concume vegetables and fruits in children. The increasing motivation could happen because CBT changes the irrational thinking or negative thinking about vegetables and fruit to rational thinking or positive thinking. CBT could be an alternative method to motivate children to consume vegetables and fruits. Banyak anak-anak tidak suka mengkonsumsi sayur dan buah sehingga menunjukkan angka dibawah standar WHO. Tujuan dari penelitian ini adalah menjelaskan tentang peningkatan motivasi konsumsi sayur dan buah melalui Cognitive Behaviour Therapy (CBT). Desain penelitian yang digunakan adalah quasy experiment dengan kelompok kontrol pre-post. Variabel yang diteliti adalah motivasi dalam mengkonsumsi sayur dan buah. Sampel yang digunakan terdapat 27 responden untuk kelompok perlakuan dan 28 reponden untuk kelompok kontrol dengan menggunakan purposive sampling. Pengambilan data menggunakan kuesioner demografi dan motivasi. Berdasarkan hasil tes Mann Whitney U dengan signifikansi p=0,05 didapatkan nilai p=0,495 pada pretest antara kelompok kontrol dan perlakuan, sehingga tidak terdapat perbedaan motivasi sedangkan pada hasil posttest kelompok kontrol dan perlakuan menunjukkan p= 0,029 sehingga terdapat perbedaan dan dan terdapat peningkatan mean value pada kelompok kontrol dari 29,30 menjadi 31,91. Hal tersebut membuktikan bahwa CBT mempengaruhi motivasi anak-anak dalam mengkonsumsi sayur dan buah. Peningkatan motivasi terjadi karena CBT dapat mengubah pemikiran irasional dan negatif terhadap sayur dan buah menjadi lebih rasional dan positif. CBT dapat digunakan sebagai metode alternatif dalam meningkatkan motivasi anak untuk mengkonsumsi sayur dan buah. DOWNLOAD FULL TEXT PDF >>

Download Full-text

Small dose of ephedrine for prevention of hypotension following propofol and fentanyl administration during induction of general anesthesia

Annals of African Medical Research ◽

10.4081/aamr.2020.126 ◽

2021 ◽

Vol 3 (2) ◽

Author(s):

Gamal Ejaimi ◽

Abla Saab ◽

Sittelnissa Ahmed ◽

Areeg Ahmed ◽

Hussain Abujamilah ◽

...

Keyword(s):

General Anesthesia ◽

Small Dose ◽

Elective Surgery ◽

Statistical Significance ◽

Control Group ◽

P Value ◽

Chi Square ◽

Arterial Blood ◽

Chi Square Test ◽

Study Participants

Induction of general anesthesia with propofol and fentanyl could result in hypotension and bradycardia. Various methods are being used to prevent these adverse effects. The aim of our study was to assess the efficacy and safety of a small dose of ephedrine in prevention of hypotension following administration of propofol and fentanyl. This prospective, randomized, comparative study was conducted among a total of 50 patients, both genders, age 18 years up to 60 years with ASA grade Ι and ΙΙ and some of class ΙΙΙ, presented for elective surgery under general anesthesia. Patients were randomly allocated into one of two groups (25 patients in each): CG (the control group), which received propofol in a dose of 2 mg/kg, intravenously, over 20–30 s mixed with 2 mL normal saline: and EphG (Ephedrine group), while received propofol in a dose of 2 mg/kg, intravenously, over 20–30 s mixed with 2 mL of ephedrine (10 mg). The Mean Arterial Blood Pressure (MAP) and Heart Rate (HR) were recorded before induction and then every 1 min up to 6 min after induction. The categorical data are presented as a number and percentage and were subjected to Fisher’s exact or Chi-square test for analysis. The statistical significance was p≤0.05. The significant differences in HR were observed in the 3rd,4th, and 5th minutes with P-value, 0.018, 0.000, 0.000, respectively. However, no patient in the study participants had bradycardia. The significant differences in MAP were observed in the 2nd, 3rd,4th, and 5th minutes with P-value, 0.035, 0.000, 0.000, and 0.000, respectively. The percentage of patient in CG who developed hypotension in the 3rd and 4th is 44% and 32% compared to 8% and 0% in EphG, with significant differences (P-value 0.004 and 0.002, respectively). Administration of small dose of ephedrine with propofol could attenuate propofol/fentanyl hypotensive and bradycardic effects.

Download Full-text