scholarly journals Changing trends in seroprevalence rates of transfusion-transmitted diseases among blood donors in Jordan

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lina Souan ◽  
Mahmoud Siag ◽  
Hala Al-Salahat ◽  
Tareq Al-Atrash ◽  
Maher A. Sughayer
Keyword(s):  
Hepatitis B ◽  
Blood Donors ◽  
Score Test ◽  
Blood Bank ◽  
Cancer Center ◽  
Enzyme Linked Immunosorbent Assay ◽  
Published Data ◽  
Prevalence Rates ◽  
Vaccination Programs ◽  
Blood Banks

Abstract Background Hepatitis B and C infections and transmission are a serious challenge to all healthcare systems. We studied seroprevalence rates of Transfusion Transmitted Diseases (TTD) among blood bank donors in Jordan from 2014 to 2019 as a follow-up study of our previously published work. In addition, we wanted to explore the efficacy of the mandatory vaccination of infants against hepatitis B virus (HBV) which was implemented by the Ministry of Health since 1995 for the eradication of HBV infection in Jordan. Methods We reviewed blood bank donors’ records at King Hussein Cancer Center (KHCC) from January 1st, 2014, until December 31st, 2019. Results of seropositivity prevalence rates for HBsAg, anti-HBcore, and anti-HCV, using Enzyme-Linked ImmunoSorbent Assay (ELISA) were compared to seropositivity rates from our previously published data. In addition, our results were compared to data obtained from other blood banks in Jordan, as well as compared to published information from blood banks in neighboring countries. Results The prevalence rates (%) of seropositive blood donors for viral hepatitis for the years 2014, 2015, 2016, 2017, 2018, and 2019, were as follows: HBsAg rates were 0.3386, 0.2108, 0.1801, 0.1898, 0.2068, and 0.2741; anti-HBcore rates were 4.1112, 3.2271, 2.9748, 2.8405, 2.6879 and 3.0986; and anti-HCV rates were 0.1129, 0.0486, 0.0548, 0.0654, 0.0782, and 0.0839, respectively. There was a significant increase in the prevalence of HBsAg, Anti-HBcore and Anti-HCV antibodies in 2019 (one sample z-score test, p < 0.00001). Conclusions Prevalence rates of hepatitis B and C infections among Jordanian blood bank donors showed a steady decline between 2009 and 2017, and these rates were much lower in Jordan than in neighboring countries. However, an increase in the prevalence rates of hepatitis B and C infections among blood bank donors was documented in 2019. While the reasons for this increase are not clear yet, these findings highlight the importance of renewed efforts to increase public health awareness of HBV and implement effective measures to prevent the transmission and infection with HBV, including national vaccination programs.

SEROPREVALENCE OF HIV AND HBsAg AMONGST BLOOD DONORS IN A TERTIARY CARE HOSPITAL, CHHATTISGARH.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Anusha P ◽  
Bankar Nandkishor J ◽  
Karan Jain ◽  
Ramdas Brahmane ◽  
Dhrubha Hari Chandi
Keyword(s):  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Tertiary Care ◽  
Laboratory Diagnosis ◽  
Blood Bank ◽  
Care Hospital ◽  
Medical College ◽  
The World ◽  
First Time

INTRODUCTION: India being the second highly populated nation in the world. HIV/AIDS has acquired pandemic proportion in the world. Estimate by WHO for current infection rate in Asia. India has the third largest HIV epidemic in the world. HIV prevalence in the age group 15-49 yrs was an estimate of 0.2%. India has been classified as an intermediate in the Hepatitis B Virus (HBV) endemic (HBsAg carriage 2-7%) zone with the second largest global pool of chronic HBV infections. Safety assessment of the blood supply, the quality of screening measures and the risk of transfusion transmitted infectious diseases (TTIs) in any country can be estimated by scrutinizing the files of blood donors. After the introduction of the blood banks and improved storage facilities, it became more extensively used. Blood is one of the major sources of TTIs like hepatitis B, hepatitis C, HIV, syphilis, and many other blood borne diseases. Disclosure of these threats brought a dramatic change in attitude of physicians and patients about blood transfusion. The objective of this study is to determine the seroprevalence of transfusion transmitted infections amidst voluntary blood donors at a rural tertiary healthcare teaching hospital in Chhattisgarh. MATERIAL AND METHODS: This retrospective study was carried out in Chandulal Chandrakar Memorial Medical College, Kachandur, Durg. Blood donors were volunteers, or and commercial donors who donated the blood and paid by patients, their families, or friends to replace blood used or expected to be used for patients from the blood bank of the hospital. After proper donation of blood routine screening of blood was carried out according to standard protocol. Laboratory diagnosis of HIV 1 and HIV 2 was carried out by ELISA test. Hepatitis B surface antigen was screened by using ELISA. RESULTS: A total of 1915 consecutive blood donors’ sera were screened at Chandulal Chandrakar Memorial Medical College, blood bank during study period. Of these 1914 were male and 1 female. The mean age of patients was found to be 29.34 years with standard deviation (SD) of 11.65 Years. Among all blood donors in present study, 759(39.63%) were first time donors and 1156(60.37%) were repeated donors. 1 patient was HIV positive in first donation group while 3 (75%) were positive in repeat donation group. 7 (38.9%) were HBsAg positive in in first donation group while 11(61.1%) were positive in repeat donation group. Two patients in first donation group had dual infection of HIV and HBsAg. CONCLUSION: Seropositivity was high in repeated donors as compared to first time donors. The incidence of HIV is observed to be 0.2% and that of HBsAg is 0.94%. Strict selection of blood donors should be done to avoid transfusion-transmissible infections during the window period.

scholarly journals Human T-Cell Lymphotropic Virus Types 1 and 2 Seropositivity among Blood Donors at Mbarara Regional Blood Bank, South Western Uganda

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Patience Uchenna Tweteise ◽  
Bernard Natukunda ◽  
Joel Bazira
Keyword(s):  
T Cell ◽  
Blood Donors ◽  
Spastic Paraparesis ◽  
Cross Sectional Study ◽  
Blood Bank ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Adult T Cell Leukemia ◽  
Human T Cell ◽  
Western Uganda

Background. The human T-cell lymphotropic virus types 1 and 2 (HTLV 1/2) are retroviruses associated with different pathologies. HTLV-1 causes adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP); HTLV-2 is not clearly associated with a known clinical disease. Both viruses may be transmitted by whole blood transfusion, from mother to child predominantly through breastfeeding, and by sexual contact. Presently, none of the regional blood banks in Uganda perform routine pretransfusion screening for HTLV. The aim of this study was to determine the prevalence of anti-human T-cell lymphotropic virus types 1/2 (HTLV-1/2) antibodies among blood donors at Mbarara Regional Blood Bank in South Western Uganda. A cross-sectional study was conducted between June 2014 and September 2014. Methodology. Consecutive blood samples of 368 blood donors were screened for anti-HTLV-1/2 antibodies using an enzyme linked immunosorbent assay (ELISA). Samples reactive on a first HTLV-1/2 ELISA were further retested in duplicate using the same ELISA. Of the three hundred and sixty-eight blood donors (229 (62.2%) males and 139 (37.8%) females), only two male donors aged 20 and 21 years were HTLV-1/2 seropositive, representing a prevalence of 0.54%. Conclusion. HTLV-1/2 prevalence is low among blood donors at Mbarara Regional Blood Bank. Studies among other categories of people at risk for HTLV 1/2 infection should be carried out.

scholarly journals VECTOR-BORNE PATHOGENS-TESTING IN A ROMANIAN CANINE BLOOD BANK

2018 ◽  
Vol 6 ◽  
pp. 904-911
Author(s):  
Teodor-Stefan Ionescu ◽  
Sinziana Radulescu ◽  
Ruxandra Florea ◽  
Stelian Baraitareanu ◽  
Doina Danes
Keyword(s):  
Blood Donors ◽  
Holistic Approach ◽  
Blood Bank ◽  
Focused Attention ◽  
Donor Pool ◽  
Blood Samples ◽  
Negative Results ◽  
Blood Banks ◽  
Vector Borne ◽  
Positive Results

INTRODUCTION: Canine blood banking in veterinary medicine is an expanding market. Once the demand for blood products increased all over the world, canine blood banks have focused attention on the risk of spreading diseases through blood transfused products. The need to preserve a healthy donor-pool, free of blood-borne infectious diseases, mainly in endemic areas, led to the implementation of appropriate protocols for screening canine blood donors using specific tests.OBJECTIVES: The aim of this study was to evaluate the presence of Anaplasma phagocytophilum/Anaplasmaplatys, Echrlichiacanis/Echrlichiaewingii, Dirofilariaimmitis and Borrelia burgdorferi using the enzyme immunoassay technology (EIA) among the donors of a Romanian canine blood bank, from January 2015 to December 2016.METHODS: Blood samples from 575 donors were collected and 1253 tests were performed with SNAP 4DX Plus® (IDEXX Laboratories, Fremont, CA) to reveal the presence of D. immitis antigens and the antibodies toward A. phagocytophilum and/or A. platys, E. canis and/or E. ewingii and B. burgdorferi.RESULTS: The results of this holistic approach show that all blood samples provided negative results for B. burgdorferi and E.canis/E. ewingii (0/1253), while 0.87% (11/1253) samples provided positive results for A. phagocytophilum/A. platys and 6.94% (87/1253) for D. immitis.CONCLUSION: The next studied topic would be to compare the results provided by the EIA technology with results of real time PCR and qPCR regarding these vector-borne pathogens.

scholarly journals Design of Data Mining Techniques for Online Blood Bank Management by CNN Model

2021 ◽  
Vol 3 (3) ◽  
pp. 213-228
Author(s):  
I. Jeena Jacob ◽  
P. Ebby Darney
Keyword(s):  
Machine Learning ◽  
Blood Donors ◽  
Blood Pressure Level ◽  
Blood Bank ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Model Classification ◽  
Bank Management ◽  
Learning Techniques ◽  
Blood Banks

A blood bank is the organisation responsible for storing blood to transfuse it to the patients in need. The primary goal of a blood bank is to be reliable and ensure that patients get the relevant non-toxic blood to avoid transfusion-related complications since blood is a critical medicinal resource. It is difficult for the blood banks to offer high levels of precision, dependability, and automation in the blood storage and transfusion process if blood bank administration includes many human processes. This research framework is proposing to maintain blood bank records using CNN model classification method. In the pre-processing of CNN method, the datasets are tokenized and set the donor’s eligibility. It will make it easier for regular blood donors to donate regularly to charitable people and organizations. A few machine learning techniques offer the automated website updation. Jupyter note book has been used to analyze the dataset of blood donors using decision trees, neural networks, and von Bays techniques. The proposed method operates online through a website. Moreover, the donor's eligibility status with gender, body mass index, blood pressure level, and frequency of blood donations is also maintained. Finally, the comparison of different machine learning algorithms with the suggested framework is tabulated.

scholarly journals HIV, HBsAg and HCV prevalences among voluntary blood donors in Mumbai: trends over a decade

2019 ◽  
Vol 7 (6) ◽  
pp. 2009
Author(s):  
Shilpa Laxmikant Narayankar ◽  
Vikas Chandrahas Maindad
Keyword(s):  
Blood Transfusion ◽  
Blood Donors ◽  
Tertiary Care ◽  
Blood Bank ◽  
Enzyme Linked Immunosorbent Assay ◽  
Medical Reports ◽  
Life Threatening ◽  
Mode Of Transmission ◽  
Low Prevalence

Background: With over 93 million donations made every year worldwide, blood transfusion continues to save millions of lives each year and improve the life expectancy and quality of life of patients suffering from life threatening conditions. At the same time, blood transfusion is an important mode of transmission of infection to the recipient. The present study was conducted to estimate the prevalence of HIV, HBV and HCV infections in voluntary blood donors at a tertiary care teaching hospital in Mumbai over a decade.Methods: All voluntary donors reporting to the blood bank were screened for HIV, HBsAg and HCV by using the appropriate enzyme linked immunosorbent assay. The study was designed for duration of ten years between January 2008 to December 2017. Medical reports of the donors were accessed from the blood bank records and analyzed.Results: A total of 8928 voluntary blood donors were screened. Amongst the blood donors, seropositivity of HBV (6% to 1.52 %) was highest followed by HIV (2.5% to 0.15%) then HCV (1.85% to 0.37%).Conclusions: Decreasing trends with low prevalence observed in the study is an encouraging sign supporting the growing awareness of these life-threatening diseases.

scholarly journals HEPATITIS B AND HEPATITIS C;

2018 ◽  
Vol 25 (08) ◽  
pp. 1245-1251
Author(s):  
Mustansar Billah ◽  
Syed Muhammad Raza Shah ◽  
Muhammad Mujtaba Hashir
Keyword(s):  
Hepatitis B ◽  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Blood Bank ◽  
Research Centre ◽  
Cross Sectional ◽  
Medicine Department ◽  
And Gender

Objectives: To determine the frequency of HBV and HCV among blood donorscoming voluntarily at the blood bank of Ibne- Siena hospital and research centre, Multan,Pakistan, to ascertain the disease burden in the community for their future prevention andcontrol. Study Design: It was a descriptive, cross- sectional study on blood units donated byhealthy individuals coming voluntarily for blood donation, and willing to get their blood testedfor HBV, HCV. Setting: Community medicine department of Multan medical and dental collegeMultan, and blood bank of affiliated tertiary hospital, Ibn-e- Siena hospital Multan. Period: Sixmonths period from Jan 2016 to June 2016. Materials and Methods: Data of the blood donorswas collected. Present study was based on previous well maintained records of hospital bloodbank. During the reported period, a total of 1195 blood donors attended the blood bank, andthey all were screened for HBsAg and anti-HCV. SPSS- 16 was used to analyze the data, fordetermination of frequencies of Hepatitis- B, and C according to the age and gender. Results:Total numbers of blood donors were 1195. 1191 were males, and 4 were females. All thefemales were negative for both HBV, and HCV. Males positive for HBV were 18 (1.5 %), andthose Positive for HCV were 27 (3.2%).

scholarly journals Seroprevalence of markers of transfusiontransmissible diseases in positive blood donors detected in routine screening in the Blood Bank of Hospital Carlos Luis Valverde Vega, Costa Rica. Period 2015 – 2019

2021 ◽  
Vol 9 (4) ◽  
pp. 70-73
Author(s):  
Jean Pablo Castro-Ruiz
Keyword(s):  
Infectious Diseases ◽  
Blood Donors ◽  
Blood Donation ◽  
Individual Characteristics ◽  
Blood Bank ◽  
Health Centers ◽  
Blood Components ◽  
Blood Banks ◽  
Scientific Ethics ◽  
The Individual

Blood is one of the fundamental tissues of our body. Blood donation allows blood banks to meet hospital needs for blood components. Blood transfusion is an activity that carries a risk, originated by a series of causal actions derived from the individual characteristics of donors and patients. Blood components are biological products and as such, they can never be exempt from the risk of transmitting infectious diseases, such as hepatitis B, HIV, syphilis, among others. Thanks to the investigation of the donor database of the Blood Bank of Hospital Dr. Carlos Luis Valverde Vega and the annual statistics of the blood bank, the statistics referring to donations were obtained, according to the type, grade of acceptance and as well as the prevalence of mandatory screening infectious diseases in the blood bank, between the years 2015 and 2019, with the respective authorization of the corresponding scientific ethics committee. This study reported a prevalence for Anti HB Core of 0.99%, 0.14% for HBsAg, 0.11% for syphilis, 0.05% for hepatitis C, 0.02% for HIV and 0% for the disease de Chagas and HTLV I / II. By using the bases of this work, future analyzes with a similar premise may be developed in different blood banks of the different health centers in our country.

scholarly journals Blood transfusion-transmissible malaria and its cost analysis in Hawassa regional blood bank, Southern Ethiopia

2020 ◽  
Vol 8 ◽  
pp. 205031212093693
Author(s):  
Seblewongel Tsehay ◽  
Fatuma Hassen ◽  
Agete Tadewos Hirigo ◽  
Zinegnaw Abiy ◽  
Kassu Desta
Keyword(s):  
Hepatitis B Virus ◽  
Blood Transfusion ◽  
Hepatitis B ◽  
Diagnostic Test ◽  
Blood Donors ◽  
Total Cost ◽  
Screening Cost ◽  
B Virus ◽  
Blood Banks ◽  
The Cost

Background: Blood transfusion is an intervention used to save life particularly for those patients who survive only with receiving blood. Establishing effective diagnostic test menus concerning the screening of transfusion-transmissible infections in the blood banks play a vital role to safeguard recipients from transfusion-transmissible infections. Objective: The aim of this study was to assess blood transfusion-transmissible malaria and its screening cost analysis in Hawassa regional blood bank, Hawassa, Sothern Ethiopia. Methods: An institutional-based cross-sectional study was conducted from April to May 2018 among 414 voluntary blood donors. Each participant’s blood sample was screened for most transfusion-transmissible infections using antigen/antibody tests, while rapid diagnostic test and microscopy were used for malaria screening and confirmation. In addition, the cost screening of transfusion-transmissible infections was calculated using activity-based costing method. Results: The overall seropositivity of transfusion-transmissible infections was 7.0% and the positivity rate of hepatitis B virus, syphilis, and Plasmodium falciparum was 5.6%, 1.0%, and 0.5%, respectively. The cost per test of each transfusion-transmissible infection was US$5.04 for human immunodeficiency virus, US$4.61 for hepatitis B virus, US$5.11 for hepatitis C virus, and US$4.75 for syphilis, while the cost per test of malaria rapid diagnostic test was US$4.74 and this is comparatively lower than the cost per test of other transfusion-transmissible infections except for hepatitis B virus. In addition, total cost of laboratory incurred for transfusion-transmissible infections screening is estimated to be US$213,634.5 per year, while it becomes US$265,537.5 if the malaria screening cost is added. This means 19.54% of the total cost of laboratory incurred per year or US$51,903. Conclusion: The positivity rate of malaria parasites among voluntary blood donors was 0.5%, and it might be increased if the study was conducted in high transmission seasons. A cost of malaria screening is comparatively lower than costs of other transfusion-transmissible infections except for hepatitis B virus. Therefore, the screening of malaria parasites should be considered as one of the test menus of transfusion-transmissible infections in blood banks, especially in malaria-endemic areas.

Sign in / Sign up

Export Citation Format

Share Document