Association of TyG index and TG/HDL-C ratio with arterial stiffness progression in a non-normotensive population

Abstract Background Cross-sectional studies have reported that insulin resistance (IR) is associated with arterial stiffness. However, the relationship between IR and arterial stiffness progression remains unclear. This study aims to evaluate the association of triglyceride glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio with arterial stiffness progression in a non-normotensive population. Methods A total of 1895 prehypertensive (systolic pressure 120–139 mmHg or diastolic pressure 80–90 mmHg) or hypertensive (systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg or using antihypertensive medication) participants were enrolled in 2013 and 2014, and followed until December 31, 2019. Arterial stiffness progression was measured by brachial-ankle pulse wave velocity (baPWV) change (absolute difference between baseline and last follow-up), baPWV change rate (change divided by following years), and baPWV slope (regression slope between examination year and baPWV). Results During a median follow-up of 4.71 years, we observed an increasing trend of baPWV in the population. There were linear and positive associations of the TyG index and TG/HDL-C ratio with the three baPWV parameters. The difference (95% CI) in baPWV change (cm/s) comparing participants in the highest quartile versus the lowest of TyG index and TG/HDL-C ratio were 129.5 (58.7–200.0) and 133.4 (52.0–214.9), respectively. Similarly, the evaluated baPWV change rates (cm/s/year) were 37.6 (15.3–60.0) and 43.5 (17.8–69.2), while the slopes of baPWV were 30.6 (9.3–51.8) and 33.5 (9.0–58.0). The observed association was stronger in the hypertensive population. Conclusion Our study indicates that the TyG index and TG/HDL-C ratio are significantly associated with arterial stiffness progression in hypertensive population, not in prehypertensive population.

Download Full-text

PERBANDINGAN TEKANAN DARAH ANTARA ANAK YANG TINGGAL DI PEGUNUNGAN DAN PESISIR PANTAI

e-CliniC ◽

10.35790/ecl.3.1.2015.6425 ◽

2015 ◽

Vol 3 (1) ◽

Author(s):

Queen Mandang ◽

Adrian Umboh ◽

Stefanus Gunawan

Keyword(s):

Blood Pressure ◽

Diastolic Pressure ◽

Sodium Intake ◽

Blood Pressure Measurement ◽

Systolic Pressure ◽

Coastal Areas ◽

Cross Sectional ◽

The Difference ◽

Cross Sectional Design ◽

History Of Obesity

Abstract: Blood pressure in children varies because there are many factors that influence. One is geographic factors. Based on data from the Health Research in 2007 found that the prevalence of hypertension is highest in coastal areas while the lowest prevalence of hypertension in the coastal area. Altitude and different sodium intake on mountain and coastal areas are assumed to affect the blood pressure. This study aimed to determine the difference in blood pressure between children who live in the mountains and in the coast. We used descriptive analytic method with cross sectional design, with 107 samples according to criteria of children aged 6-12 years with no family history of obesity and hypertension. Data were obtained by using questionnaire, measurement of weight and height (BMI) and blood pressure measurement using a sphygmomanometer and cuff child. The results showed 15.5% of children with high-normal systolic pressure and 17.4% of children with high diastolic pressure in the mountains. In coastal areas, found 28% of children with normal systolic pressure-high, 13% of children of normal-high diastolic pressure, and 5% of children of high diastolic pressure. These data were analyzed using Mann Whitney test, showing the results were not statistically significantly systolic (p = 0.815) diastolic (p = 0.221) so that H0 and H1 is rejected. Conclusion: There was no difference in blood pressure among children aged 6-12 years who live in the mountains and the coast.Keywords: child's blood pressure, mountains, coastal.Abstrak: Tekanan darah pada anak bervariasi karena ada banyak faktor yang memengaruhi. Salah satunya adalah faktor geografis. Berdasarkan data Riset Kesehatan Dasar tahun 2007 didapatkan prevalensi hipertensi tertinggi di wilayah pantai sedangkan prevalensi hipertensi terendah di wilayah pantai. Ketinggian lokasi dan asupan natrium yang berbeda pada daerah pegunungan dan pesisir pantai diasumsikan berpengaruh terhadap tekanan darah. Penelitian ini bertujuan untuk mengetahui perbedaan tekanan darah antara anak yang tinggal di pegunungan dan pesisir pantai. Metode penelitian deskriptif analitik dengan rancangan potong lintang, dengan 107 sampel sesuai kriteria anak umur 6-12 tahun tanpa obesitas dan riwayat keluarga hipertensi. Data diperoleh melalui kuesioner, pengukuran berat badan dan tinggi badan (IMT) dan pengukuran tekanan darah menggunakan sphygmomanometer dan manset anak. Hasil penelitian menunjukkan 15,5% anak dengan tekanan sistolik normal-tinggi dan 17,4% anak dengan tekanan diastolik tinggi pada daerah pegunungan. Pada daerah pesisir pantai ditemukan 28% anak dengan tekanan sistolik normal-tinggi, 13% anak tekanan diastolik normal-tinggi, dan 5% anak tekanan diastolik tinggi. Data ini dianalisis menggunakan uji mann whitney, menunjukkan hasil secara statistik tidak bermakna sistolik (p=0,815) diastolik (p=0,221) sehingga H0 diterima dan H1 ditolak. Simpulan: Tidak ada perbedaan tekanan darah antara anak berumur 6-12 tahun yang tinggal di pegunungan dan pesisir pantai.Kata kunci: tekanan darah anak, pegunungan, pantai.

Download Full-text

Association between insulin resistant surrogate index and arterial stiffness in hypertensive population: a five year follow-up cohort study

10.21203/rs.3.rs-123782/v1 ◽

2020 ◽

Author(s):

Zhiyuan Wu ◽

Di Zhou ◽

Jie Zhang ◽

Zhiwei Li ◽

Jinqi Wang ◽

...

Keyword(s):

Blood Pressure ◽

Arterial Stiffness ◽

Blood Pressure Control ◽

Cox Model ◽

Fasting Blood Glucose ◽

Pressure Control ◽

Tyg Index ◽

Hypertensive Population ◽

Poor Blood Pressure Control

Abstract Background Causal association between triglyceride-glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio with arterial stiffness remains unclear. This study aims to assess the effect of TyG index and TG/HDL-C ratio on the incidence of arterial stiffness in hypertensive population, and identify the susceptible subgroups. Methods This study enrolled 1201 hypertensive participants without arterial stiffness aged 18 or above in 2013 and 2014 as baseline. Physical examination and biochemical test including fasting blood glucose (FBG), TG, HDL-C were measured. The TyG index was denoted as ln[TG*FBG/2]. Incident arterial stiffness cases were confirmed during the following annual examination by brachial-ankle pulse wave velocity (baPWV, > 1800 cm/s), until December 31 of 2019. The Cox model was used to explore the association of TyG index and TG/HDL-C ratio with the arterial stiffness. Results During a mean follow-up of 5.09 years, 430 cases of arterial stiffness were confirmed. In the multivariate Cox model, the higher TyG index and TG/HDL-C ratio were positively associated with a higher risk of arterial stiffness (adjusted HR for per-unit increase: 1.39 and 1.08, P < 0.05). The adjusted HR (95% CI) comparing participants in the highest quartile versus lowest quartile of TyG and TG/HDL-C ratio were 1.51 (1.10–2.07) and 1.08 (1.01–1.15), respectively. This positive linear association of evaluated TyG index and TG/HDL-C ratio with arterial stiffness was confirmed using restricted cubic spline function. The observed association was stronger in subgroups with overweight, co-diabetes and poor blood pressure control (systolic pressure ≥ 140 mmHg or without anti-hypertension medication). Conclusion The elevated TyG index and TG/HDL-C ratio independently increased the future risk of arterial stiffness in hypertensive population. Monitoring TyG index and TG/HDL-C ratio deserves more attention in clinical practice, especially in the population with overweight, co-diabetes and poor blood pressure control.

Download Full-text

Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study

Cardiovascular Diabetology ◽

10.1186/s12933-021-01342-2 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Shouling Wu ◽

Luli Xu ◽

Mingyang Wu ◽

Shuohua Chen ◽

Youjie Wang ◽

...

Keyword(s):

Growth Rate ◽

Linear Regression ◽

Arterial Stiffness ◽

Multivariate Linear Regression ◽

Annual Growth ◽

Annual Growth Rate ◽

Cross Sectional ◽

Tyg Index ◽

Longitudinal Association ◽

The Cross

Abstract Background Triglyceride–glucose (TyG) index, a simple surrogate marker of insulin resistance, has been reported to be associated with arterial stiffness. However, previous studies were limited by the cross-sectional design. The purpose of this study was to explore the longitudinal association between TyG index and progression of arterial stiffness. Methods A total of 6028 participants were derived from the Kailuan study. TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Arterial stiffness progression was assessed by the annual growth rate of repeatedly measured baPWV. Multivariate linear regression models were used to estimate the cross-sectional association of TyG index with baPWV, and Cox proportional hazard models were used to investigate the longitudinal association between TyG index and the risk of arterial stiffness. Results Multivariate linear regression analyses showed that each one unit increase in the TyG index was associated with a 39 cm/s increment (95%CI, 29–48 cm/s, P < 0.001) in baseline baPWV and a 0.29 percent/year increment (95%CI, 0.17–0.42 percent/year, P < 0.001) in the annual growth rate of baPWV. During 26,839 person-years of follow-up, there were 883 incident cases with arterial stiffness. Participants in the highest quartile of TyG index had a 58% higher risk of arterial stiffness (HR, 1.58; 95%CI, 1.25–2.01, P < 0.001), as compared with those in the lowest quartile of TyG index. Additionally, restricted cubic spline analysis showed a significant dose–response relationship between TyG index and the risk of arterial stiffness (P non-linearity = 0.005). Conclusion Participants with a higher TyG index were more likely to have a higher risk of arterial stiffness. Subjects with a higher TyG index should be aware of the following risk of arterial stiffness progression, so as to establish lifestyle changes at an early stage.

Download Full-text

Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Patients With Abdominal Aortic Aneurysm and Its Alterations After Treatment

Vascular and Endovascular Surgery ◽

10.1177/15385744211023281 ◽

2021 ◽

pp. 153857442110232

Author(s):

Spyridon N. Mylonas ◽

Konstantinos G. Moulakakis ◽

Nikolaos Kadoglou ◽

Constantinos Antonopoulos ◽

Thomas E. Kotsis ◽

...

Keyword(s):

Arterial Stiffness ◽

Surgical Repair ◽

Open Repair ◽

Abdominal Aortic ◽

Gender And Age ◽

Baseline Values ◽

The Difference ◽

The Impact ◽

Repair Group

Purpose: The aim of the present study was to investigate a potential difference on the arterial stiffness among aneurysm patients and non-aneurysm controls, as well as to explore potential changes between patients treated either with endovascular or open repair. Materials and Methods: A 110 patients with an infrarenal AAA were prospectively enrolled in this study. Fifty-six patients received an EVAR, whereas 54 patients received an open surgical repair. Moreover, 103 gender and age-matched subjects without AAA served as controls. The cardio-ankle vascular index (CAVI) was applied for measurement of the arterial stiffness. Results: CAVI values were statistically higher in the AAA patients when compared with control subjects. Although at 48 hours postoperatively the CAVI values were increased in both groups when compared to baseline values, the difference in CAVI had a tendency to be higher in the open group compared to the endovascular group. At 6 months of follow up the CAVI values returned to the baseline for the patients of the open repair group. However, in the endovascular group CAVI values remained higher when compared with the baseline values. Conclusion: Patients with AAAs demonstrated a higher value of CAVI compared to healthy controls. A significant increase of arterial stiffness in both groups during the immediate postoperative period was documented. The increase in arterial stiffness remained significant at 6 months in EVAR patients. Further studies are needed to elucidate the impact of a decreased aortic compliance after stentgraft implantation on the cardiac function of patients with AAA.

Download Full-text

Use of Multiple Visits to Increase Blood Pressure Tracking Correlations in Childhood

PEDIATRICS ◽

10.1542/peds.87.5.708 ◽

1991 ◽

Vol 87 (5) ◽

pp. 708-711

Author(s):

Matthew W. Gillman ◽

Bernard Rosner ◽

Denis A. Evans ◽

Laurel A. Smith ◽

James O. Taylor ◽

...

Keyword(s):

Blood Pressure ◽

Diastolic Blood Pressure ◽

Correlation Coefficient ◽

Diastolic Pressure ◽

Pearson Correlation ◽

Systolic Pressure ◽

Pearson Correlation Coefficient ◽

Increase Blood Pressure ◽

Multiple Visit

Previous studies of childhood blood pressure have shown tracking correlations, which estimate the magnitude of association between initial and subsequent measurements, to be lower than corresponding adult values. Inasmuch as this disparity could arise from failing to account for a larger week-to-week variability in children, blood pressure was measured for 4 successive years, on four weekly visits in each year, and with three measurements at each visit, using a random-zero sphygmomanometer, in a cohort of 333 schoolchildren aged 8 through 15 at entry. Ninety percent of subjects had measurements in 1 or more years of follow-up. For all follow-up periods (1, 2, and 3 years from baseline), the Pearson correlation coefficient (r) for both systolic and diastolic blood pressure rose substantially with the number of weekly visits used to calculate each subject's yearly blood pressure (P < .0001). For systolic pressure, the 3-year r values for 1, 2, 3, and 4 visits were .45, .55, .64, and .69, respectively. For diastolic pressure (Korotkoff phase 4), the corresponding values were .28, .41, .47, and .54. These higher multiple-visit estimates of tracking approximate published adult values and raise the possibility that prediction of adult blood pressure from childhood measurements may be improved by averaging readings from multiple weekly visits.

Download Full-text

The Relationship Between the Atherogenic Index of Plasma and Arterial Stiffness in Essential Hypertensive Patients from China: A Cross-Sectional Study

10.21203/rs.3.rs-215251/v1 ◽

2021 ◽

Author(s):

Juan Yin ◽

Minghui Li ◽

Lingling Yu ◽

Feng Hu ◽

Yu Yu ◽

...

Keyword(s):

Essential Hypertension ◽

Arterial Stiffness ◽

Linear Regression Analysis ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Atherogenic Index ◽

Multivariate Linear Regression Analysis ◽

Sectional Study ◽

Cross Sectional ◽

Atherogenic Index Of Plasma

Abstract Background: The atherogenic index of plasma (AIP) always remains in a potential association with the arterial stiffness, however, in large hypertensive patient populations, this relation is not fully discovered and needs to be studied in depth. The present analysis thus sought to further explore the association that exists between AIP and arterial stiffness in patients diagnosed with arterial hypertension in China.Methods: This cross-sectional study analyzed 4744 Chinese individuals with essential hypertension. AIP was defined as the base 10 logarithm of the ratio of plasma of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-c) levels indicates as in molar concentrations. Measurement of arterial stiffness was carried out via brachial-ankle pulse wave velocity (baPWV).Results: Data were adjusted for potential confounding variables, after which a multivariate linear regression analysis revealed AIP to be positively correlated with baPWV (β = 1.34, 95% CI: 0.96 to 1.72, P < 0.001). When AIP was instead treated as a categorical variable divided into quartiles, this same relationship was observed (P for trend < 0.001). We additionally found AIP and baPWV had a stronger positive association in individuals with a body mass index (BMI) < 24 kg/m2 (P for interaction < 0.05).Conclusion: AIP and arterial stiffness were positively correlated in essential hypertension patients in China, especially in those with a BMI < 24 kg/m2.

Download Full-text

Hubungan kadar natrium dengan tekanan darah pada remaja di Kecamatan Bolangitang Barat Kabupaten Bolaang Mongondow Utara

Jurnal e-Biomedik ◽

10.35790/ebm.4.2.2016.14862 ◽

2016 ◽

Vol 4 (2) ◽

Author(s):

Rivanli Polii ◽

Joice N.A. Engka ◽

Ivonny M. Sapulete

Keyword(s):

Blood Pressure ◽

Diastolic Pressure ◽

Systolic Pressure ◽

Extracellular Fluid ◽

Sampling Technique ◽

Cross Sectional Study ◽

Coastal Areas ◽

The Body ◽

Cross Sectional ◽

Purposive Sampling

Abstract: Sodium is an extracellular fluid cation which is the highest in amount, 35-40% sodium (Na) is found in the body skeleton. The function of sodium is the regulation of fluid volume, the regulation of fluid balance, the regulation of osmolarity, and the regulation of blood pressure. Blood pressure is the force that is needed to keep the blood flowing inside the blood vessel and circulates to reach all the tissues in human body. Blood pressure consists of two components, the systolic pressure and diastolic pressure. According to the study conducted by Riset Kesehatan Dasar on 2007, it was found that the Natuna Islands (coastal areas) has the highest prevalence of hypertension, which is 53,3%, while the highlands of Jayawijaya has the lowest prevalence of hypertension, which is 6,8%. The North Bolaang Mongondow regency, especially West Bolangitang district is an area which is conditioned around the coastal areas. Adolescents, according to WHO, are those aged 12-24 years old. This was an analytical descriptive research is conducted with a cross sectional study design. Afterward, the collected datas are processed using the help of SPSS software. The population is all of the students in SMAN 1 Bolangitang Barat, North Bolaang Mongondow regency and the samples were collected with purposive sampling technique. The results showed that the number of respondents who follow the research were 60 students, consisting 16 boy and 44 girl by spearman’s correlation statistical test.This study shows no correlation between the levels of sodium and blood pressure on adolescents in West Bolangitang district North Bolaang Mongondow regency. Conclusion: there is no correlation between the levels of sodium and blood pressure on adolescents in West Bolangitang district, North Bolaang Mongondow regency. Keywords: sodium, blood pressure, adolescent Abstrak: Natrium ialah kation terbanyak dalam cairan ekstrasel , 35-40% natrium (Na) ada didalam kerangka tubuh. Fungsi natrium untuk mengatur volume cairan, mengatur keseimbangan cairan, mengatur osmolaritas, dan mengatur tekanan darah. Tekanan darah adalah kekuatan yang diperlukan agar darah dapat mengalir di dalam pembuluh darah dan beredar mencapai semua jaringan tubuh manusia. Tekanan darah terdiri atas 2 bagian tekanan sistolik dan tekanan diastolik. Berdasarkan data yang dilakukan Riset Kesehatan Dasar tahun 2007 didapatakan bahwa prevalensi hipertensi tertinggi di Kepulauan Natuna (wilayah pantai) sebanyak 53,3 % sedangkan prevalensi hipertensi terendah di pegunungan jayawijaya sebanyak 6,8%. Kabupaten Bolaang mongondow utara khususnya Kecamatan Bolangitang Barat merupakan suatu wilayah yang terletak disekitaran pesisir pantai, Remaja menurut WHO adalah mereka yang berumur 12-24 tahun. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang. Data diolah dengan menggunakan program SPSS. Populasi ialah semua siswa/i SMAN 1 Bolangitang Barat Kabupaten Bolaang Mongondow Utara dan sampel diambil dengan cara purposive sampling. Hasil uji korelasi Spearman menunjukkan tidak terdapat hubungan antara kadar natrium dengan tekanan darah pada remaja di Kecamatan Bolangitang Barat Kabupaten Bolaang Mongondow Utara. Simpulan: Tidak terdapat hubungan antara kadar natrium dengan tekanan darah pada remaja di Kecamatan Bolangitang Barat Kabupaten Bolaang Mongondow Utara.Kata kunci: natrium, tekanan darah, remaja

Download Full-text

Evaluation of blood pressure in school children aged 12-16 years

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20172607 ◽

2017 ◽

Vol 4 (4) ◽

pp. 1218

Author(s):

Balakrishnan Nadesan ◽

Mani Madhavan Sachithananthamoorthi ◽

Sivaraman Thirumalaikumarasamy ◽

Ezhilarasu Ramalingam

Keyword(s):

Blood Pressure ◽

Family History ◽

Diastolic Blood Pressure ◽

School Children ◽

Diastolic Pressure ◽

Systolic Pressure ◽

Cross Sectional ◽

Significant Difference ◽

History Of ◽

Family History Of Hypertension

Background: Hypertension is considered as a major health issue in developed as well as developing countries and its possible origin during childhood prompts pediatricians to routinely include measurement of blood pressure (BP) as an integral part of pediatric physical examination. The objectives of the study were to evaluate the normal range of blood pressure in adolescent school going students of 12-16 years, prevalence of hypertension and relationship of BP with variables like age, body mass index (BMI), socioeconomic status and family history of hypertension.Methods: A cross sectional study was undertaken for a period of one year in adolescent school children in age groups between 12-16 years. Detailed clinical examination was done in 1060 adolescent school children and BP was recorded in right upper limb and correlation of BP with BMI, family history of hypertension and diabetes were studied.Results: Mean systolic and diastolic pressure showed linear relationship with age. There was a highly statistically significant difference between mean systolic and diastolic blood pressure between lower and middle socio-economic class. Prevalence of obesity in our study was 1.13%, overweight was 7.83%. Prevalence of hypertension in obese children was 33.33% and in overweight children 18.07%. Family history of hypertension and diabetes carry a significant correlation with elevated systolic and diastolic blood pressure in adolescents.Conclusions: This study revealed that socio economic factors play a significant role in determining the blood pressure of the individual. Children of middle class have significantly elevated mean systolic pressure and mean diastolic pressure than low socio-economic groups.

Download Full-text

Abstract 412: Obesity is an Independent Predictor Of Arterial Stiffness

Hypertension ◽

10.1161/hyp.62.suppl_1.a412 ◽

2013 ◽

Vol 62 (suppl_1) ◽

Author(s):

Mohan Thanikachalam ◽

Shasha Bai ◽

Vijayakumar Harivanzan ◽

Ragavendra R Baliga ◽

William T Abraham ◽

...

Keyword(s):

Blood Pressure ◽

Regression Analysis ◽

Arterial Stiffness ◽

Multivariate Regression ◽

Independent Predictor ◽

Density Lipoprotein ◽

Multivariate Regression Analysis ◽

Population Based ◽

Cross Sectional Survey ◽

Cross Sectional

Background Arterial stiffness assessed by carotid-femoral pulse wave velocity (PWV) is an independent predictor of cardiovascular morbidity and mortality. We aimed to investigate how various measures of obesity affect arterial stiffness. Methods We conducted a population-based cross-sectional survey in 8,042 South Indians above the age of 20 years. Following completion of a detailed medical history questionnaire, all participants underwent haemodynamic screening including brachial and central blood pressure, and PWV measurements using a high-fidelity applanation tonometry. The study included anthropometric measurements and fasting blood for total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and blood glucose (BG) levels. After the exclusion of people with previous history of diabetes, hypertension and dyslipidemia on drug therapy, 5,841 subjects (mean age 41.6 years; 58% women) constituted the study sample Results In an univariate analysis, PWV correlated positively with age, mean blood pressure (MAP), heart rate (HR), body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), body fat percent (BF%), TC, TG, LDL and BG levels (P <0.001) and negatively with HDL levels (P=0.005). In a multivariate regression analysis, majority of the PWV variability in the model was accounted for by MAP and age, (cumulative adjusted R2 change of 32.79% as compared to the total adjusted R2 change of 35.25%). However, BMI (β= 0.042; adjusted R2 change=2.83%; p<0.001) independently correlated with PWV and its contribution to the PWV variability was far more significant compared to LDL, BG and TG (cumulative adjusted R2 change=1.08%). Multivariate regression analysis using the WC, WHR, or BF% instead of the BMI continued to demonstrate a significant independent effect of obesity parameters on PWV. Conclusion: In a large a population-based cross-sectional survey the study demonstrates a positive, independent association between obesity parameters and increased arterial stiffness.

Download Full-text

Factors related to Juvenile Idiopathic Arthritis Complicated with Hyperuricemia

10.21203/rs.3.rs-31609/v1 ◽

2020 ◽

Author(s):

ling wu ◽

Yazhen Di ◽

Yuanling Chen ◽

Yunyan Li ◽

Jiapei Wang

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Diastolic Pressure ◽

Statistical Significance ◽

Low Density Lipoprotein ◽

Laboratory Data ◽

Systolic Pressure ◽

Density Lipoprotein ◽

Clinical Findings ◽

Lipoprotein Cholesterol ◽

Necrosis Factor Alpha

Abstract Background Clinical findings reported that some cases of Juvenile Idiopathic Arthritis(JIA) gradually suffer from hyperuricemia(HUA) during the course of follow-up, followed by the detection of high urate crystal, gout, renal impairment, and other manifestations. And thoes patients would influence the prognosis. Methods This was a retrospective study of 60 patients diagnosed with JIA between October 2016 and March 2019 and followed up for > 1 year. Single-factor analyses of the clinical data, laboratory data, and the special drug used for JIA complicated with hyperuricemia (Group A, n = 18) and JIA without hyperuricemia (Group B, n = 42) were conducted. Results Comparison between Groups A and B revealed differences in sex; disease course; high disease activity; diastolic pressure; the levels of serum albumin (ALB), alanine aminotransferase (ALT), aspartate transaminase (AST), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), glucose (GLU), and urea nitrogen (BUN); NSAIDS application, systemic glucocorticoid application, MTX application, and tumor necrosis factor-alpha (TNF-α) inhibitors application were not statistically significant (P > 0.05). However, the differences in age, active sacroiliitis, body mass index (BMI), systolic pressure, serum creatinine (Scr) level, and salicylazosulfapyridine (SASP) application showed a statistical significance (P < 0.05). Conclusions JIA patients were obese ,with high systolic pressure, and after SASP treatment will be more likely to be complicated with hyperuricemia.

Download Full-text