scholarly journals Engineering of bioactive metal sulfide nanomaterials for cancer therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Weidong Fei ◽  
Meng Zhang ◽  
Xiaoyu Fan ◽  
Yiqing Ye ◽  
Mengdan Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Degradation Products ◽  
Medical Science ◽  
Metal Sulfide ◽  
Future Expectations ◽  
The Past ◽  
Radiation Enhancement ◽  
Different Types ◽  
Antitumor Properties ◽  
Clinical Transformation

AbstractMetal sulfide nanomaterials (MeSNs) are a novel class of metal-containing nanomaterials composed of metal ions and sulfur compounds. During the past decade, scientists found that the MeSNs engineered by specific approaches not only had high biocompatibility but also exhibited unique physicochemical properties for cancer therapy, such as Fenton catalysis, light conversion, radiation enhancement, and immune activation. To clarify the development and promote the clinical transformation of MeSNs, the first section of this paper describes the appropriate fabrication approaches of MeSNs for medical science and analyzes the features and limitations of each approach. Secondly, we sort out the mechanisms of functional MeSNs in cancer therapy, including drug delivery, phototherapy, radiotherapy, chemodynamic therapy, gas therapy, and immunotherapy. It is worth noting that the intact MeSNs and the degradation products of MeSNs can exert different types of anti-tumor activities. Thus, MeSNs usually exhibit synergistic antitumor properties. Finally, future expectations and challenges of MeSNs in the research of translational medicine are spotlighted.

Anticancer Properties of Essential Oils: An Overview

2018 ◽  
Vol 18 (10) ◽  
pp. 957-966 ◽  
Author(s):  
Milene Aparecida Andrade ◽  
Mariana Aparecida Braga ◽  
Pedro Henrique Souza Cesar ◽  
Marcus Vinicius Cardoso Trento ◽  
Mariana Araújo Espósito ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Essential Oils ◽  
Public Health Problem ◽  
Mechanisms Of Action ◽  
Low Molecular Weight ◽  
Anticancer Properties ◽  
Anti Cancer ◽  
Different Types ◽  
Antitumor Properties ◽  
Pharmaceutical Properties

Background: Essential oils are complex mixtures of low molecular weight compounds extracted from plants. Their main constituents are terpenes and phenylpropanoids, which are responsible for their biological and pharmaceutical properties, such as insecticidal, parasiticidal, antimicrobial, antioxidant, anti-inflammatory, analgesic, antinociceptive, anticarcinogenic, and antitumor properties. Cancer is a complex genetic disease considered as a serious public health problem worldwide, accounting for more than 8 million deaths annually. Objective: The activities of prevention and treatment of different types of cancer and the medicinal potential of essential oils are addressed in this review. Conclusion: Several studies have demonstrated anti-carcinogenic and antitumor activity for many essential oils obtained from various plant species. They may be used as a substitution to or in addition to conventional anti-cancer therapy. Although many studies report possible mechanisms of action for essential oils compounds, more studies are necessary in order to apply them safely and appropriately in cancer therapy.

scholarly journals THE IMPACT OF NEW TARGETING METHODS IN THE CANCER THERAPY

2019 ◽  
pp. 1-6
Author(s):  
ZAKARIYA AL-MASHHADANI ◽  
RUA A. NASER ◽  
MUNAF H. ZALZALA
Keyword(s):  
Cancer Therapy ◽  
Literature Review ◽  
Information Sources ◽  
Rapid Development ◽  
Malignant Cell ◽  
Cancer Targeting ◽  
The Past ◽  
Toxic Drug ◽  
Different Types ◽  
The Impact

Rapid development has achieved in treating tumor to stop malignant cell growth and metastasis in the past decade. Numerous researches have emerged to increase potency and efficacy with novel methods for drug delivery. The main objective of this literature review was to illustrate the impact of current new targeting methods to other previous delivering systems to select the most appropriate method in cancer therapy. This review first gave a brief summary of cancer structure and highlighted the main roles of targeting systems. Different types of delivering systems have been addressed in this literature review with focusing on the latest carrier derived from malarial protein. The remarkable advantages and main limitations of the later have been also discussed. PubMed and Science Direct were the main search engines that have been used as information sources to prepare this review. Articles related to cancer targeting system, active and passive processes, current nanoparticles, antibody carriers, and current novel cancer carriers were used as sources in this review. Important points from many references published in the last decade (2008-2018) were selected and included. Several targeting methods were introduced to enhance the efficacy and tolerability of the toxic drug by active and passive processes, but there is still no conclusive carrier without certain drawbacks. A combination of targeting methods probably shows the most appropriate choice for increasing selectivity and safety of anticancer drugs via reducing the concentration of carriers used.

scholarly journals A Clinical study of Ayurvedic regime (Yogbasti,Yonidhavan, Peechu, and abhyantarchikitsa) in the patient of infertility due to unovulatary cycles – A pilot study.

2017 ◽  
Vol 5 (5) ◽  
Author(s):  
Gitanjali S. Vaidya ◽  
Abhay Kulkarni ◽  
Archana Jadhav
Keyword(s):  
Medical Science ◽  
Physical And Mental Health ◽  
Successful Pregnancy ◽  
Common Cause ◽  
Vitro Fertilization ◽  
The Past ◽  
Limited Success ◽  
Different Types ◽  
Traditional Mode

Infertility is very common problem arising now a days due to changing lifestyle .according to Ayurveda , Rutu, Kshetra, Ambu, and Beeja are basic important things for garbhadharna and successful pregnancy. Amongst there beeja factor in femalesi.e ovulation contributes 15 to 25% and is the second common cause of infertility.                ovulatory factor is an important subject in infertility among  women,according about 40% cases over the past few decades modern medical science develop different types of modalities for infertility like Hormonal therapy, in- vitro fertilization embryo transfer, gammet intra fallopian transfer etc. but having limited success rate. Additionally their procedures have adverse effect on physical and mental health of couple plus they are costly. To overcome this inconvenience population is turning towards traditional mode of treatment i.e. Ayurveda.

scholarly journals Photosensitivity Reactions Induced by Photochemical Degradation of Drugs

2021 ◽  
Author(s):  
Hajnal Klelemen ◽  
Gabriel Hancu ◽  
Edina Kacsó ◽  
Lajos-Attila Papp
Keyword(s):  
Chemical Structure ◽  
Degradation Products ◽  
Close Relation ◽  
Short Review ◽  
Photochemical Degradation ◽  
Clinical Tests ◽  
The Past ◽  
Different Types ◽  
Photochemical Decomposition

Photochemical degradation of drugs can lead to degradation products with potential toxic or allergizing effects for the human body. A significant amount of work has been carried out over the past few decades to clarify the molecular mechanism of photosensitizing processes observed after the administration of certain drugs and exposure to light. There is a close relation between the photosensitizer effect of a drug and its chemical structure. Compounds possessing certain moieties and functional groups in their molecular structure, like aromatic chromophore systems or photo-dissociable bonds that can form free radicals, and consequently are susceptible to have light-induced adverse effects. Photoionization, photodissociation, photoaddition and photoisomerization are the main chemical processes, which can occur during the photochemical decomposition of a pharmaceutical compound. The current study is a short review describing photochemical degradation of certain pharmaceuticals, presenting specific examples from various pharmaceutical classes for the different types of decomposition mechanisms. In vivo methods and clinical tests available for the investigation of photosensitizing reactions are also discussed.

Study of the Molecular Architecture of Keratin Filaments by Electron Microscopy

1982 ◽  
Vol 40 ◽  
pp. 118-119
Author(s):  
U. Aebi ◽  
P. Rew ◽  
T.-T. Sun
Keyword(s):  
Electron Microscopy ◽  
Structural Organization ◽  
Cell Types ◽  
Structural Features ◽  
Molecular Architecture ◽  
The Past ◽  
Keratin Filaments ◽  
Different Types ◽  
10 Nm Filaments ◽  
Different Cell Types

Various types of intermediate-sized (10-nm) filaments have been found and described in many different cell types during the past few years. Despite the differences in the chemical composition among the different types of filaments, they all yield common structural features: they are usually up to several microns long and have a diameter of 7 to 10 nm; there is evidence that they are made of several 2 to 3.5 nm wide protofilaments which are helically wound around each other; the secondary structure of the polypeptides constituting the filaments is rich in ∞-helix. However a detailed description of their structural organization is lacking to date.

Classic and Novel Signaling Pathways Involved in Cancer: Targeting the NF-κB and Syk Signaling Pathways

2019 ◽  
Vol 14 (3) ◽  
pp. 219-225 ◽  
Author(s):  
Cong Tang ◽  
Guodong Zhu
Keyword(s):  
Cancer Therapy ◽  
Tyrosine Kinase ◽  
Signaling Pathways ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Cell Receptor ◽  
Transmembrane Receptors ◽  
Biological Responses ◽  
Different Types

The nuclear factor kappa B (NF-κB) consists of a family of transcription factors involved in the regulation of a wide variety of biological responses. Growing evidence support that NF-κB plays a major role in oncogenesis as well as its well-known function in the regulation of immune responses and inflammation. Therefore, we made a review of the diverse molecular mechanisms by which the NF-κB pathway is constitutively activated in different types of human cancers and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. We also discussed various pharmacological approaches employed to target the deregulated NF-κB signaling pathway and their possible therapeutic potential in cancer therapy. Moreover, Syk (Spleen tyrosine kinase), non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immune-receptors like the B-cell receptor (BCR), which can also activate the inflammasome and NF-κB-mediated transcription of chemokines and cytokines in the presence of pathogens would be discussed as well. The highlight of this review article is to summarize the classic and novel signaling pathways involved in NF-κB and Syk signaling and then raise some possibilities for cancer therapy.

Is Healthcare Special?

2018 ◽  
Author(s):  
Gordon Moore ◽  
John A. Quelch ◽  
Emily Boudreau
Keyword(s):  
Consumer Choice ◽  
Special Relationship ◽  
Individual Choice ◽  
Health Consequences ◽  
Critical Question ◽  
The Past ◽  
Different Types ◽  
Collective Benefit ◽  
Patient Ethics

Chapter 2 asks the critical question of whether healthcare is different from other consumer-driven markets. In the past, many pushed back on the notion that healthcare could be a consumer-driven industry, arguing that it is fundamentally different from other markets. This chapter acknowledges and reviews these critiques, highlighting four areas that might present challenges to increasing consumer choice in healthcare: the special relationship between doctor and patient, ethics and morality, individual choice versus collective benefit, and the health consequences of consumer choice. In doing so, this chapter also presents a schematic for thinking about the different types of healthcare choices, arguing that not all choices are equal and consumers may be more prepared to make decisions in some areas as opposed to others. In presenting the counterargument to consumer choice, this chapter asks the reader to consider the drawbacks and potential limitations of consumer choice in healthcare.

Vietnamese Historical Writing

2018 ◽  
Author(s):  
Patricia Pelley
Keyword(s):  
Cold War ◽  
East Asian ◽  
History Writing ◽  
Southern State ◽  
The Past ◽  
South Vietnam ◽  
Political Function ◽  
Different Types ◽  
The Cold War ◽  
North Vietnam

This chapter demonstrates how the process of decolonization and the ensuing separation of Vietnam into a northern and southern state as part of the Cold War in Asia led to different types of history-writing. In both Vietnamese regimes, the writing of history had to serve the state, and in both countries historians emphasized its political function. Whereas North Vietnam located itself in an East Asian and Marxist context, historians of South Vietnam positioned it within a Southeast Asian setting and took a determinedly anti-communist position. After 1986—over a decade after reunification—with past tensions now relaxed, the past could be revaluated more openly under a reformist Vietnamese government that now also permitted much greater interaction with foreign historians.

Bi19S27I3 nanorods: a new candidate for photothermal therapy in the first and second biological near-infrared windows

Nanoscale ◽  
2021 ◽  
Author(s):  
Jinsong Xiong ◽  
Qinghuan Bian ◽  
Shuijin Lei ◽  
Yatian Deng ◽  
Kehan Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Research Interest ◽  
The Past ◽  
Nir Light ◽  
Considerable Research ◽  
Key Factor

Near-infrared (NIR) light induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in the photothermal therapy...

Different Types of Auricular Keloids and Treatment by Intralesional Cryosurgery: Best Practice for Obtaining Long-Lasting Clinical Results

Dermatology ◽  
2021 ◽  
pp. 1-10
Author(s):  
Yaron Har-Shai ◽  
Lior Har-Shai ◽  
Viktor A. Zouboulis ◽  
Christos C. Zouboulis
Keyword(s):  
Quality Of Life ◽  
Body Image ◽  
Recurrence Rate ◽  
Best Practice ◽  
Clinical Results ◽  
Psychosocial Impact ◽  
Aesthetic Outcome ◽  
The Past ◽  
Different Types

<b><i>Background:</i></b> Auricular keloids belong to the most perplexing medical conditions, which have significant psychosocial impact on the patient’s body image and quality of life. <b><i>Summary:</i></b> The article is purposed to provide dermatologists and plastic surgeons with the best proven practice using intralesional cryosurgery for the treatment of the different auricular keloid types in order to obtain superior clinical results by minimizing the probability of recurrence. In the past 20 years, the authors have developed novel procedures in order to increase the effectiveness of intralesional cryosurgery on auricular keloids, including hydrodissection, warm gauze technique, and excision of dangling skin. Long-lasting clinical results with a low recurrence rate and a satisfactory aesthetic outcome are achieved with no deformation of the ear framework.

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