scholarly journals Rhamnolipid-coated W/O/W double emulsion nanoparticles for efficient delivery of doxorubicin/erlotinib and combination chemotherapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yeeun Lee ◽  
Donghyun Lee ◽  
Eunyoung Park ◽  
Seok-young Jang ◽  
Seo Young Cheon ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Combination Therapy ◽  
Combination Chemotherapy ◽  
Tumor Tissue ◽  
Tumor Therapy ◽  
Synergetic Effect ◽  
Double Emulsion ◽  
High Accumulation ◽  
Efficient Delivery ◽  
Multiple Drugs

Abstract Background Combination therapy using more than one drug can result in a synergetic effect in clinical treatment of cancer. For this, it is important to develop an efficient drug delivery system that can contain multiple drugs and provide high accumulation in tumor tissue. In particular, simultaneous and stable loading of drugs with different chemical properties into a single nanoparticle carrier is a difficult problem. Results We developed rhamnolipid-coated double emulsion nanoparticles containing doxorubicin and erlotinib (RL-NP-DOX-ERL) for efficient drug delivery to tumor tissue and combination chemotherapy. The double emulsion method enabled simultaneous loading of hydrophilic DOX and hydrophobic ERL in the NPs, and biosurfactant RL provided stable surface coating. The resulting NPs showed fast cellular uptake and synergetic tumor cell killing in SCC7 cells. In real-time imaging, they showed high accumulation in SCC7 tumor tissue in mice after intravenous injection. Furthermore, enhanced tumor suppression was observed by RL-NP-DOX-ERL in the same mouse model compared to control groups using free drugs and NPs containing a single drug. Conclusions The developed RL-NP-DOX-ERL provided efficient delivery of DOX and ERL to tumor tissue and successful tumor therapy with a synergetic effect. Importantly, this study demonstrated the promising potential of double-emulsion NPs and RL coating for combination therapy. Graphical Abstract

scholarly journals 19F MRI-guided Flexible Low-intensity Focused Ultrasound for Drug Delivery and Molecular Targeted Therapy

2021 ◽  
Author(s):  
Jie Yang ◽  
Yingbo Li ◽  
Jiemei Sun ◽  
Hongyan Zou ◽  
Qian Xie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Therapy ◽  
Focused Ultrasound ◽  
Tumor Tissue ◽  
Local Drug Delivery ◽  
High Accumulation ◽  
Innovative Strategy ◽  
Low Intensity ◽  
On Demand ◽  
Mri Guided

Abstract Non-site-specific, time-release and inefficient tumor penetration remain the major obstacles to the clinical efficacy of anticancer drugs. Novel strategies are therefore urgently needed for developing stimuli-responsive, local drug delivery systems that can increase drug penetration and accumulation at tumor sites. Here, we firstly describe an on-demand drug delivery system, AZD9291-PFCE nanoparticles (NPs) with 19F magnetic resonance imaging (19F MRI)-guided flexible low-intensity focused ultrasound (LIFU). Optimized AZD9291-PFCE NPs (size 73.9 ± 1.9 nm) reach high accumulation in non–small cell lung cancer (NSCLC) tumor tissue. Further, LIFU triggered drug release from AZD9291-PFCE NPs and specifically increased tumor vascular and tumor tissue permeability. Quantitative 19F MRI was used to measure NPs accumulation in tumors in real-time after LIFU irradiation and to monitor therapeutic efficacy. Thus, we present an innovative strategy to achieve on-demand release of AZD9291 and improve NSCLC EGFR-targeted therapy efficacy by integrating theranostic NPs and 19F MRI-guided LIFU.

scholarly journals ROLE OF MICROSPHERES IN NOVEL DRUG DELIVERY SYSTEMS: PREPARATION METHODS AND APPLICATIONS

2020 ◽  
pp. 10-15
Author(s):  
VASUNDHRA KAKKAR ◽  
SHAHID UD DIN WANI ◽  
SURYA PRAKASH GAUTAM ◽  
ZULFKAR LATIEF QADRIE
Keyword(s):  
Drug Delivery ◽  
Half Life ◽  
Interfacial Polymerization ◽  
Double Emulsion ◽  
Therapeutic Effects ◽  
Preparation Methods ◽  
Biological Half Life ◽  
Efficient Delivery ◽  
Bio Compatibility ◽  
Novel Drug

Microsphere based drug delivery system has gained substantial attention in the modern era. Microspheres are normally free-flowing powders that can be made with both natural and synthetic polymers. The sizes of the microspheres ranges from 1 to 1000 µm. Microspheres are matrix systems in which the drug is uniformly dispersed, dissolved or suspended. Microspheres contain solid or liquid drug dissolved or dispersed in a matrix system. The current review provides an inclusive outline of up to date and novel developments on formations of microspheres which have been reported to increase bioavailability, improves stability, enhances biological half-life and reduces the toxicity of the drug. Microsphere provides efficient delivery of various proteins and peptide molecules. There are different types of microspheres such as bio adhesive microsphere, magnetic microsphere, floating microsphere, and polymeric microspheres. Diverse kinds of methods are used in the formulation of microsphere e. g. Simple emulsion-based method, Double emulsion-based method, Interfacial deposition technique, Interfacial polymerization technique, Phase separation method, and Spray drying. Microspheres deliver the drug in a controlled manner through different routes like oral, topical, naso-pulmonary and gene therapy. The Polymeric based microspheres are model carriers for numerous controlled delivery applications owing to their capacity to encapsulate a diversity of drugs, bio-compatibility, high bio-availability and continuous drug release character. Therefore, by developing newer techniques, it can give more therapeutic effects and improves the safety of drugs. The formation of microspheres has been reported to increase bioavailability, improves stability, enhances biological half-life and reduces the toxicity of the drug.

Co-delivery of doxorubicin and methotrexate by dendritic chitosan-g-mPEG as a magnetic nanocarrier for multi-drug delivery in combination chemotherapy

2017 ◽  
Vol 8 (47) ◽  
pp. 7333-7350 ◽  
Author(s):  
Mahdi Rahimi ◽  
Kazem D. Safa ◽  
Roya Salehi
Keyword(s):  
Drug Delivery ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Combination Chemotherapy ◽  
Anticancer Agents ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Synergistic Effects ◽  
Delivery Systems ◽  
Promising Strategy

Nanoparticulate drug delivery systems have the potential to improve the therapeutic efficacy of anticancer agents, and combination therapy is a promising strategy for clinical cancer treatment with synergistic effects.

Dendrimer–doxorubicin conjugate as enzyme-sensitive and polymeric nanoscale drug delivery vehicle for ovarian cancer therapy

2014 ◽  
Vol 5 (18) ◽  
pp. 5227-5235 ◽  
Author(s):  
Chengyuan Zhang ◽  
Dayi Pan ◽  
Kui Luo ◽  
Ning Li ◽  
Chunhua Guo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Antitumor Activity ◽  
Click Chemistry ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Tissue ◽  
Delivery Vehicle ◽  
High Accumulation

Dendrimer–doxorubicin conjugate prepared via click chemistry was employed as enzyme-sensitive nanoscale drug delivery system for ovarian cancer therapy, showing high accumulation in tumor tissue, significantly increased antitumor activity and good biosafety.

Hypoxia Responsive Drug Delivery Systems in Tumor Therapy

2016 ◽  
Vol 22 (19) ◽  
pp. 2808-2820 ◽  
Author(s):  
Houman Alimoradi ◽  
Siddharth S. Matikonda ◽  
Allan B. Gamble ◽  
Gregory I. Giles ◽  
Khaled Greish
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Delivery Systems

Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications

2020 ◽  
Vol 20 (4) ◽  
pp. 271-287 ◽  
Author(s):  
Kuldeep Rajpoot
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Cancer Therapies ◽  
Medication Delivery ◽  
Lipid Nanocarriers ◽  
Targeted Drug ◽  
Drug Nanocarriers

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

Hyaluronan based Multifunctional Nano-carriers for Combination Cancer Therapy

2020 ◽  
Vol 20 ◽  
Author(s):  
Menghan Gao ◽  
Hong Deng ◽  
Weiqi Zhang
Keyword(s):  
Cancer Therapy ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Drug Carriers ◽  
Functional Sites ◽  
Therapeutic Modalities ◽  
Combination Cancer Therapy ◽  
Targeting Strategy

: Hyaluronan (HA) is a natural linear polysaccharide that has excellent hydrophilicity, biocompatibility, biodegradability, and low immunogenicity, making it one of the most attractive biopolymers used for biomedical researches and applications. Due to the multiple functional sites on HA and its intrinsic affinity for CD44, a receptor highly expressed on various cancer cells, HA has been widely engineered to construct different drug-loading nanoparticles (NPs) for CD44- targeted anti-tumor therapy. When a cocktail of drugs is co-loaded in HA NP, a multifunctional nano-carriers could be obtained, which features as a highly effective and self-targeting strategy to combat the cancers with CD44 overexpression. The HA-based multidrug nano-carriers can be a combination of different drugs, various therapeutic modalities, or the integration of therapy and diagnostics (theranostics). Up to now, there are many types of HA-based multidrug nano-carriers constructed by different formulation strategies including drug co-conjugates, micelles, nano-gels and hybrid NP of HA and so on. This multidrug nano-carrier takes the full advantages of HA as NP matrix, drug carriers and targeting ligand, representing a simplified and biocompatible platform to realize the targeted and synergistic combination therapy against the cancers. In this review, recent progresses about HA-based multidrug nano-carriers for combination cancer therapy are summarized and its potential challenges for translational applications have been discussed.

A Triple-responsive Targeted Hybrid Liposomes with High MRI Performance for Tumor Diagnosis and Therapy

2021 ◽  
Author(s):  
Weihe Yao ◽  
Chenyu Liu ◽  
Ning Wang ◽  
Hengjun Zhou ◽  
Hailiang Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Delivery Systems ◽  
Tumor Diagnosis ◽  
Diagnosis And Therapy ◽  
Promising Strategy ◽  
Therapy And Diagnosis

The targeted multi-responsive drug delivery systems with MRI capacity were anticipated as a promising strategy for tumor therapy and diagnosis. Herein, we successfully synthesized anisamide-modified and non-modified UV/GSH-responsive molecules (10,10-NB-S-S-P-AA...

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