scholarly journals The effectiveness of inhaled Cannabis flower for the treatment of agitation/irritability, anxiety, and common stress

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Sarah S. Stith ◽  
Xiaoxue Li ◽  
Jegason P. Diviant ◽  
Franco C. Brockelman ◽  
Keenan S. Keeling ◽  
...  
Keyword(s):  
Side Effects ◽  
Fixed Effects ◽  
Symptom Relief ◽  
Observational Research ◽  
User Characteristics ◽  
Product Characteristics ◽  
Symptom Intensity ◽  
Rapid Pulse ◽  
Negative Side Effects ◽  
Symptom Type

Abstract Background An observational research design was used to evaluate which types of commonly labeled Cannabis flower product characteristics are associated with changes in momentary feelings of distress-related symptoms. Methods We used data from 2306 patient-directed cannabis administration sessions among 670 people who used the real-time Cannabis effects recording software, Releaf App, between June 6, 2016, and February 23, 2019, for tracking the effects of Cannabis flower consumption. Fixed effects multivariable panel regression techniques were used to establish overall relief by symptom type and to determine which labeled product characteristics (e.g., subspecies/subtype, inhalation method, and major cannabinoid contents) showed the strongest correlation with changes in momentary feelings of agitation/irritability, anxiety, and stress, along with experienced side effects. Results In total, a decrease in symptom intensity levels was reported in 95.51% of Cannabis usage sessions, an increase in 2.32% of sessions, and no change in 2.16% of sessions. Fixed effects models showed, on average, respondents recorded a maximum symptom intensity reduction of 4.33 points for agitation/irritability (SE = 0.20, p < 0.01), 3.47 points for anxiety (SE = 0.13, p < 0.01), and 3.98 for stress (SE = 0.12, p < 0.01) on an 11-point visual analog scale. Fixed effects regressions showed that, controlling for time-invariant user characteristics, mid and high tetrahydrocannabinol (THC) levels were the primary independent predictor of increased symptom relief, and that when broken out by symptom type, this effect was only statistically significant for our largest sample of users, those reporting anxiety rather than agitation/irritability or stress. Cannabidiol (CBD) levels were generally not associated with changes in symptom intensity levels. In a minority of cannabis use sessions (< 13%), cannabis users reported anxiogenic-related negative side effects (e.g., feeling anxious, irritable, paranoid, rapid pulse, or restless), whereas in a majority of sessions (about 66%), users reported positive anxiolytic side effects (e.g., feeling chill, comfy, happy, optimistic, peaceful, or relaxed). Conclusions The findings suggest the majority of patients in our sample experienced relief from distress-related symptoms following consumption of Cannabis flower, and that among product characteristics, higher THC levels were the strongest predictors of relief.

scholarly journals Identification of Anticancer Active Compound from GC-MS Test Results of Zodia Leaves (Evodia suaveolens) Ethanol Extract

Jurnal Biota ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. 89-95
Author(s):  
Ghea Dionita Sanora ◽  
Elly Yana Mastura ◽  
Muhammad Ongky Muji Handoyo ◽  
Erlix Rakhmad Purnama
Keyword(s):  
Side Effects ◽  
Scientific Literature ◽  
Ethanol Extract ◽  
Alpha Tocopherol ◽  
Observational Research ◽  
Test Results ◽  
Literature Searching ◽  
Active Compounds ◽  
Negative Side Effects ◽  
Prevalence Of Cancer

Cancer is estimated to be the second leading cause of death globally in 2018. The background of the study was the prevalence of cancer in Indonesia in 2018 reaching 775.120 people. Treatments such as surgery, chemotherapy, radiotherapy, immunotherapy, and hormone therapy have negative side effects. Herbal medicine is an alternative treatment with lower side effects that can reduce the side effects of existing treatments. The aim of this study was to identify the results of GC-MS active compounds from ethanol extract of zodia leaves which have the potential as anticancer. The method of this research was observational research through scientific literature. GC-MS results showed 22 active compounds contained in ethanol extract of zodia leaves. Based on the literature searching, there are 17 active compounds that have potential to be anticancer. Menthofuran; evodone; Bicyclopentene; Delta-Selinene; 3,5,7-Octatrien-2-Ol, 2,6-Dimethyl; Aromadendrene oxide 2; Alpha-bisabolol; 2,4-Dimethyl-2,4-Heptadienal; Phytol; Squalene; Beta-Tocopherol; D-alpha-Tocopherol; Stigmasta-5,23-dien-3.beta.-ol; (23S)-ethylcholest-5-en-3.beta.ol; 24,25-Dihydrolanosterol; Lanosterol; and Obtusifoliol. The compounds are targeted in breast, lung, and ovarian cancer.

scholarly journals Impact of Liposomal Drug Formulations on the RBCs Shape, Transmembrane Potential, and Mechanical Properties

2021 ◽  
Vol 22 (4) ◽  
pp. 1710
Author(s):  
Sylwia Cyboran-Mikołajczyk ◽  
Przemysław Sareło ◽  
Robert Pasławski ◽  
Urszula Pasławska ◽  
Magdalena Przybyło ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Side Effects ◽  
Blood Cells ◽  
Transmembrane Potential ◽  
Drug Formulations ◽  
Liposomal Drug ◽  
Irregular Shapes ◽  
Liposomal Formulations ◽  
Current Therapies ◽  
Negative Side Effects

Liposomal technologies are used in order to improve the effectiveness of current therapies or to reduce their negative side effects. However, the liposome–erythrocyte interaction during the intravenous administration of liposomal drug formulations may result in changes within the red blood cells (RBCs). In this study, it was shown that phosphatidylcholine-composed liposomal formulations of Photolon, used as a drug model, significantly influences the transmembrane potential, stiffness, as well as the shape of RBCs. These changes caused decreasing the number of stomatocytes and irregular shapes proportion within the cells exposed to liposomes. Thus, the reduction of anisocytosis was observed. Therefore, some nanodrugs in phosphatidylcholine liposomal formulation may have a beneficial effect on the survival time of erythrocytes.

scholarly journals Acceptance and Intake of COVID-19 Vaccines among Older Germans

2021 ◽  
Vol 10 (7) ◽  
pp. 1388
Author(s):  
Marta Malesza ◽  
Erich Wittmann
Keyword(s):  
Side Effects ◽  
Long Term Effects ◽  
Negative Side ◽  
Factors Influencing ◽  
Vaccination Acceptance ◽  
Negative Side Effects

The main aim of this study was to investigate the various factors influencing COVID-19 vaccination acceptance and actual intake among older Germans aged over 75 years old (n = 1037). We found that the intention to get vaccinated or intake of the COVID-19 vaccine were positively related to the perceptions of becoming infected, perceptions of the severity of the potential long-term effects, the vaccine’s efficacy, and the benefits of vaccination. Meanwhile, the intention to get the vaccine or vaccine intake were decreased by perceptions of the negative side-effects and the general impediments to vaccination.

Silencing the virus? Government communication and MMR vaccination campaigns – the Australian case

2021 ◽  
pp. 2046147X2110140
Author(s):  
Roumen Dimitrov
Keyword(s):  
Side Effects ◽  
Health Workers ◽  
Winning Strategy ◽  
Herd Immunity ◽  
Actor Network Theory ◽  
Strategic Communication ◽  
Long Run ◽  
Australian Case ◽  
Negative Side Effects ◽  
Vaccination Campaigns

In this paper I analyse a series of Australian MMR (measles-mumpsrubella) vaccination campaigns and policies from the last decade. Using the Bruno Latour’s Actor Network Theory (ATN), I locate human and non-human mediators – including the virus and vaccine – in the complex pro-vaccination alliance led by government campaigners. I identify the vaccine hesitant parents – a large group that ‘sits on the fence’ between the ‘vaccine confident’ and ‘vaccine refusing’ parents – as the main target of pro-vaccination campaigns. PR literature on pro-vaccination campaigns has applied ATN to the independence of the media as network agents. This paper contributes with the problematisation of several more actors such as the health workers, medical experts and the vaccine hesitant parents themselves. Even when they are keen members of a pro-vaccination network, they cannot be taken for granted. This is where understanding of stigma, silence and voice helps. To align their group interests and discourses, government should know how to communicate strategically – including how to communicate indirectly, avoiding stigma and keeping certain internal affinities and communicative distances intact. In conclusion, I make suggestions about strategic communication in pro-vaccination campaigns. Communication of statistical risks and side effects should be central. It is a winning strategy because it establishes a more credible balance between individual rights and collective obligations in achieving herd immunity. And mandating vaccination cannot replace communication. Research shows that legislating compulsory vaccination may have short-term and relatively small effects. They are almost negligible in the long run. Mandate may trigger compliance, but it also causes anger and mistrust. Mandating vaccine has negative side effects. It punishes with economic and cultural sanctions the socially disadvantaged, who are not active refusers. It also has the opposite effect on vaccine hesitant parents. It does not weaken but rather strengthens their resistance to the vaccine and pushes them to the lager of antivaxxers.

Scam Alert 2022 !! Best Health Keto UK Reviews – Negative Side Effects or Safe Diet Pills? Is £39.76 Worthy for “Best Health Keto United Kingdom” Customers? Read This Before Buy v1

2022 ◽  
Author(s):  
health not provided
Keyword(s):  
Weight Loss ◽  
United Kingdom ◽  
Side Effects ◽  
Fat Cells ◽  
Promote Weight Loss ◽  
Negative Side ◽  
Negative Side Effects ◽  
Official Site ◽  
Diet Pills ◽  
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Essential CBD Extract Gummies [Australia] AU Reviews – Hidden Negative Side Effects Or Real Benefits? v1

2021 ◽  
Author(s):  
hengstla not provided
Keyword(s):  
Side Effects ◽  
Negative Side ◽  
Negative Side Effects ◽  
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scholarly journals Antioxidative and antimicrobial potentials of Parmelia saxatilis and Pseudoevernia furfuracea

2016 ◽  
pp. 9-18
Author(s):  
Jasmina Cilerdzic ◽  
Mirjana Stajic ◽  
Jelena Vukojevic
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Side Effects ◽  
Klebsiella Pneumoniae ◽  
Bacterial Species ◽  
Phenol Content ◽  
Negative Side Effects ◽  
Highly Correlated ◽  
Ethanol Extracts

Even though numerous lichen species possess significant medical potentials they are still unexplored, and particularly species and strains originating from Serbia. Therefore, the aim of this study was to evaluate the antioxidative and antimicrobial potential of ethanol extracts of Parmelia saxatilis and Pseudoevernia furfuracea collected in Serbia. The tested extracts were good scavengers of DPPH radicals, with capacities ranging from 14.76% to 79.76% in P. saxatilis and from 21.39% to 90.04% in P. furfuracea. In P. saxatilis level of DPPH? neutralisation was highly correlated with phenol content (r2 = 0.9981) and in P. furfuracea with amount of total flavonoides (r2 = 0.9641). The extract of P. furfuracea inhibited the growth of all tested microorganisms with exception of Aspergillus flavus, while P. saxatilis extract affected only growth of bacterial species. Among tested microorganisms, Staphylococcus aureus and Klebsiella pneumoniae were the most sensitive, while Enterococcus faecalis, Pseudomonas aeruginosa as well as micromycetes were the least sensitive to tested extracts. Because of these potentials and the fact that their long term usage does not have any negative side effects on organism and development of microbial resistance, the extracts could be included in conventional therapy.

scholarly journals Essential Oil-Based Bioherbicides: Human Health Risks Analysis

2021 ◽  
Vol 22 (17) ◽  
pp. 9396
Author(s):  
Chloë Maes ◽  
Jeroen Meersmans ◽  
Laurence Lins ◽  
Sandrine Bouquillon ◽  
Marie-Laure Fauconnier
Keyword(s):  
Side Effects ◽  
Essential Oil ◽  
Essential Oils ◽  
Health Risks ◽  
Good Alternative ◽  
Aquatic Systems ◽  
Air Transport ◽  
Human Health Risks ◽  
Potential Risks ◽  
Negative Side Effects

In recent years, the development of new bio-based products for biocontrol has been gaining importance as it contributes to reducing the use of synthetic herbicides in agriculture. Conventional herbicides (i.e., the ones with synthetic molecules) can lead to adverse effects such as human diseases (cancers, neurodegenerative diseases, reproductive perturbations, etc.) but also to disturbing the environment because of their drift in the air, transport throughout aquatic systems and persistence across different environments. The use of natural molecules seems to be a very good alternative for maintaining productive agriculture but without the negative side effects of synthetic herbicides. In this context, essential oils and their components are increasingly studied in order to produce several categories of biopesticides thanks to their well-known biocidal activities. However, these molecules can also be potentially hazardous to humans and the environment. This article reviews the state of the literature and regulations with regard to the potential risks related to the use of essential oils as bioherbicides in agricultural and horticultural applications.

scholarly journals A Multi-Objective Approach to Mitigate Negative Side Effects

2020 ◽  
Author(s):  
Sandhya Saisubramanian ◽  
Ece Kamar ◽  
Shlomo Zilberstein
Keyword(s):  
Side Effects ◽  
Empirical Evaluation ◽  
Primary Objective ◽  
Maximum Deviation ◽  
Negative Side ◽  
Multi Objective ◽  
Markov Decision ◽  
Secondary Objective ◽  
Negative Side Effects ◽  
The Impact

Agents operating in unstructured environments often create negative side effects (NSE) that may not be easy to identify at design time. We examine how various forms of human feedback or autonomous exploration can be used to learn a penalty function associated with NSE during system deployment. We formulate the problem of mitigating the impact of NSE as a multi-objective Markov decision process with lexicographic reward preferences and slack. The slack denotes the maximum deviation from an optimal policy with respect to the agent's primary objective allowed in order to mitigate NSE as a secondary objective. Empirical evaluation of our approach shows that the proposed framework can successfully mitigate NSE and that different feedback mechanisms introduce different biases, which influence the identification of NSE.

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