A retrospective observational study of vitamin D levels in patients within the Tameside and Glossop early intervention in psychosis team

AimsGrowing evidence indicates that Vitamin D deficiency is associated with psychotic symptoms. Although evidence suggesting a causal relationship is limited, theories regarding neuro-inflammatory modulation are promising. Alternatively, deficiency may signify chronic illness or poor functioning. Nevertheless, Vitamin D levels below 50nmol/L increase the risk of osteoporosis, muscle weakness, falls and fractures, thus identification and treatment are important.The association between Vitamin D levels in patients within the Tameside Early Intervention in Psychosis Team (EIT) was studied, hypothesising a strong correlation.MethodThe records of all patients in the EIT as of 01/07/2020, over the age of 16 years old (n = 183), were studied. The first Vitamin D level taken while under the EIT and the CGI scores closest to the date of this level were recorded. Vitamin D levels of 25nmol/L and under were classified as deficient, levels of 25.1 - 50nmol/L were insufficient.Result45.90% (n = 84) of patients did not have their levels recorded. Of the 55% (n = 99) patients who had Vitamin D levels recorded, 49.50% (n = 49) were insufficient and 22.22% (n = 22) were deficient. Therefore, only 28.28% (n = 28) had either optimal or sufficient Vitamin D levels. The majority of Vitamin D levels were taken in Autumn (36.46% n = 36).75.76% (n = 75) of patients had both vitamin D levels and CGI scores recorded, with an average of 35.65 days between date level and score recorded. A weak negative correlation between overall CGI scores and vitamin D level was calculated, producing Spearman R Correlation Coefficient of -0.15.ConclusionAlmost 3/4 of the studied patients being assessed for psychotic symptoms had either insufficient or deficient levels of Vitamin D. The correlation between symptom severity and Vitamin D level was weak however. While we cannot comment on the causality of the relationship, it appears that there is an association between our studied patient group and Vitamin D insufficiency.The evidence to suggest that supplementation can reduce psychotic symptoms is limited however, supplementation can reduce the risk of osteoporosis and falls, therefore would improve patient care. Only 55% of the patients within the EIT had their Vitamin D levels tested. As a result of this study, the authors recommend that all patients in the EIT have their Vitamin D levels tested as part of their psychosis assessment.The study is limited due to low numbers of patients studied and the fact that recorded CGI scores were often recorded at a later date to Vitamin D levels.

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Suppression of Parathyroid Hormone as a Proxy for Optimal Vitamin D Status: Further Analysis of Two Parallel Studies in Opposite Latitudes

Nutrients ◽

10.3390/nu12040942 ◽

2020 ◽

Vol 12 (4) ◽

pp. 942 ◽

Cited By ~ 1

Author(s):

Marcela M. Mendes ◽

Kathryn H. Hart ◽

Susan A. Lanham-New ◽

Patrícia B. Botelho

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Total Sample ◽

Vitamin D Insufficiency ◽

Vitamin D Supplementation ◽

Vitamin D Status ◽

Low Latitude ◽

Vitamin D Levels ◽

Cubic Model ◽

The Relationship

Optimal vitamin D status has commonly been defined as the level of 25-hydroxyvitamin D (25(OH)D) at which parathyroid hormone (PTH) concentrations would be maximally suppressed, represented by an observed minimum plateau. Previous findings indicate a large variation in this plateau, with values ranging from <30 nmol/L up to 100 nmol/L. This disparity in values might be explained by differences in study design and methodology, ethnicity, age, gender and latitude. This study aimed to investigate the concentration of 25(OH)D at which PTH concentrations were suppressed in Brazilian women living in opposite latitudes (high vs. low: i.e., UK and Brazil), during wintertime. Using data from the D-SOL study (Interaction between Vitamin D Supplementation and Sunlight Exposure in Women Living in Opposite Latitudes), the association between 25(OH)D status and PTH levels were examined in 135 Brazilian women (56 living in England and 79 living in Brazil, aged 20–59 years old). Mean PTH concentrations for Brazilian women with vitamin D deficiency (<25 nmol/L) were significantly higher compared to those with vitamin D insufficiency (25–49.9 nmol/L) (p < 0.01), vitamin D adequacy (50–74.9 nmol/L) (p < 0.01) and those with optimal vitamin D status (>75 nmol/L) (p < 0.001). Regression modelling was used to investigate the relationship between serum 25(OH)D and PTH for the sample as a whole and for each group separately. A cubic model was statistically significant for the total sample (p < 0.001), whereas a linear model presented the best fit for Brazilian women living in England (p = 0.04) and there were no statistically significant models fitted for Brazilian women living in Brazil. The cubic model suggests that 25(OH)D concentrations above 70–80 nmol/L are optimal to suppress the parathyroid gland in Brazilian women. These findings contribute to a better understanding of the relationship between 25(OH)D and PTH in populations living in a low latitude location and are of great relevance for discussions regarding the estimation of optimal cut-offs for vitamin D levels in the Brazilian population as well as for other low latitude locations.

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Is Vitamin D Insufficiency Associated with Mortality of Critically Ill Patients?

Critical Care Research and Practice ◽

10.1155/2013/856747 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 3

Author(s):

Gulbin Aygencel ◽

Melda Turkoglu ◽

Ayse Fitnat Tuncel ◽

Burcu Arslan Candır ◽

Yelda Deligoz Bildacı ◽

...

Keyword(s):

Vitamin D ◽

Risk Factor ◽

Critically Ill ◽

Critically Ill Patients ◽

Independent Risk Factor ◽

Vitamin D Insufficiency ◽

University Hospital ◽

Median Serum ◽

Vitamin D Levels ◽

Sufficient Vitamin

Objective. To evaluate the vitamin D status of our critically ill patients and its relevance to mortality.Patients and Methods. We performed a prospective observational study in the medical intensive care unit of a university hospital between October 2009 and March 2011. Vitamin D levels were measured and insufficiency was defined as <20 ng/mL.Results. Two hundred and one patients were included in the study. The median age was 66 (56–77) and the majority of patients were male (56%). The median serum level of vitamin D was 14,9 ng/mL and 139 (69%) patients were vitamin D insufficient on admission. While we grouped the ICU patients as vitamin D insufficient and sufficient, vitamin D insufficient patients had more severe acute diseases and worse laboratory values on admission. These patients had more morbidities and were exposed to more invasive therapies during stay. The mortality rate was significantly higher in the vitamin D insufficient group compared to the vitamin D sufficient group (43% versus 26%,P=0,027). However, logistic regression analysis demonstrated that vitamin D insufficiency was not an independent risk factor for mortality.Conclusion. Vitamin D insufficiency is common in our critically ill patients (69%), but it is not an independent risk factor for mortality.

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Prevalence of vitamin D deficiency in antenatal women

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20192421 ◽

2019 ◽

Vol 8 (6) ◽

pp. 2302

Author(s):

Anu Bala Chandel ◽

Rita Mittal ◽

Anoop Sharma ◽

Shivika Mittal ◽

Poonam Samyal

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Lung Development ◽

Immune Modulation ◽

Preterm Labour ◽

Obstetrics And Gynaecology ◽

Vitamin D Levels ◽

High Prevalence ◽

Sufficient Vitamin ◽

The Relationship

Background: Vitamin D has an increasingly recognised repertoire of non-classical actions, such as promoting insulin action and secretion, immune modulation and lung development. It therefore has the potential to influence many factors in the developing fetus. Several studies reported the relationship between maternal vitamin D deficiency and adverse maternal and fetal outcomes including gestational diabetes, preeclampsia, preterm labour, low birth weight and increased rate of caesarean section. The present study was undertaken to study the prevalence of vitamin D deficiency in antenatal women of Shimla, India.Methods: The study was conducted in the department of Obstetrics and Gynaecology, Kamla Nehru Hospital, Shimla, India over a period of 12 months. Six hundred women were included in the study.Results: Out of 600 subjects, 568 (94.67%) subjects had vitamin D deficiency and only 32 (5.33%) subjects had sufficient vitamin D levels. Vitamin D deficiency was more common in the vegetarians, dark skinned subjects and in those who were taking vitamin D supplements.Conclusions: It is concluded from this study that there is high prevalence of vitamin D deficiency in antenatal women of Shimla, India.

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Relationships between Vitamin D and Selected Cytokines and Hemogram Parameters in Professional Football Players—Pilot Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18137124 ◽

2021 ◽

Vol 18 (13) ◽

pp. 7124

Author(s):

Anna Książek ◽

Aleksandra Zagrodna ◽

Anna Bohdanowicz-Pawlak ◽

Felicja Lwow ◽

Małgorzata Słowińska-Lisowska

Keyword(s):

Vitamin D ◽

Serum Levels ◽

Significant Negative Correlation ◽

Vitamin D Insufficiency ◽

Football Players ◽

Professional Football ◽

Innate And Adaptive Immunity ◽

Vitamin D Levels ◽

Tnf Α ◽

The Relationship

Vitamin D affects both innate and adaptive immunity. Most of the effects of vitamin D on innate immunity are anti-inflammatory. In monocytes/macrophages, vitamin D suppresses the production of the inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8. Therefore, the aim of our study was to investigate the relationship between 25(OH)D concentration and selected cytokines—IL-6, TNF-α, and IL-1β, which are hemogram parameters for professional football players. We enrolled 41 Polish premier league soccer players. The mean age, career duration, and VO2max were, respectively: 22.7 ± 5.3 years, 14.7 ± 4.5 years, and 55.8 ± 4.0 mL/kg/min. Serum levels of 25(OH)D were measured by electrochemiluminescence (ECLIA) using the Elecsys system (Roche, Switzerland). Serum levels of IL-6, IL-1β, and TNF-α were measured by ELISA (R&D Systems, Minneapolis). Blood count with smear was measured on a Sysmex XT-4000i analyzer (Sysmex Corporation, Japan). Our study showed decreased serum 25(OH)D levels in 78% of the professional players. We found a significant negative correlation between 25(OH)D levels and TNF-α and LYMPH (%). The results also demonstrated a statistically significant positive correlation between vitamin D levels and NEUTH (%), NEUTH (tys/µL), and EOS (tys/µL). Based on the results of our study, we concluded that football players from Poland are not protected against vitamin D insufficiency in winter months. Moreover, vitamin D deficiency may be associated with an increased pro-inflammatory risk in well-trained athletes.

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Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection

10.21203/rs.3.rs-121748/v1 ◽

2020 ◽

Author(s):

Alireza Davoudi ◽

Narges Najafi ◽

Mohsen arabi ◽

Atefe Tayebi ◽

Roja Nikaeen ◽

...

Keyword(s):

Vitamin D ◽

Clinical Outcomes ◽

Underlying Disease ◽

Vitamin D Insufficiency ◽

Mazandaran Province ◽

Vitamin D Levels ◽

Duration Of Hospitalization ◽

North Of Iran ◽

Definition Of ◽

Sufficient Vitamin

Abstract Background A protective effect of vitamin D against COVID-19 is under investigation. We aimed to analyze the effect of vitamin D sufficiency on clinical outcomes of patients with COVID-19 infection. Methods In this retrospective study we analyzed the vitamin D levels of COVID-19 patients who were admitted to Razi Hospital (an infectious disease referral center in Mazandaran province in north of Iran) from February to March 2020. Overall, a cutoff point of 30 ng/mL was used for the definition of vitamin D sufficiency. Results 153 patients were analyzed in this study who had laboratory documentation of a 25(OH) D level at the time of hospitalization. In total, 62.7% (n-=96) of the patients had a 25(OH) D level of less than 30 ng/mL and 37.25% (n = 57) had a 25(OH) D level of more than 30 ng/mL. In total, 49% (n = 75) of the patients suffered from at least one underlying disease. Vitamin D sufficiency was not associated with a statistically significant lower risk of adverse clinical outcomes of COVID-19 such as duration of hospitalization, lung involvement, intensive care unit (ICU) admission, invasive and non-invasive ventilation, the severity of disease or death. Conclusions Sufficient vitamin D levels were not found to be protective against adverse clinical outcomes in patients infected with COVID-19.

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The Relationship between Vitamin D Status and Rotator Cuff Muscle Strength in Professional Volleyball Athletes

Nutrients ◽

10.3390/nu11112768 ◽

2019 ◽

Vol 11 (11) ◽

pp. 2768 ◽

Cited By ~ 2

Author(s):

Do Kyung Kim ◽

Geon Park ◽

Liang-Tseng Kuo ◽

Won Hah Park

Keyword(s):

Vitamin D ◽

Muscle Strength ◽

Vitamin D Insufficiency ◽

Vitamin D Status ◽

Shoulder Muscle ◽

Vitamin D Levels ◽

Volleyball Players ◽

The Relationship ◽

Shoulder Muscle Strength ◽

External Rotator

This study aimed to examine the vitamin D status of professional volleyball athletes and to determine its correlation with shoulder muscle strength. We included 52 healthy male professional volleyball players (23.2 ± 4.5 years), who were categorized by vitamin D status (<20 ng/mL: deficiency, 20–30 ng/mL: insufficiency, and >30 ng/mL: sufficiency). We examined the strength of the internal rotator (IR) and external rotator (ER) muscles of the shoulder by using an isokinetic dynamometer. Fourteen players (26.9%) had vitamin D deficiency, 24 players (46.2%) were vitamin D-insufficient, and 14 players (26.9%) were vitamin D-sufficient. There was no significant correlation between vitamin D level and shoulder muscle strength at 60°/s (IR, r = 0.159, p = 0.26; ER, r = 0.245, p = 0.08) and at 180°/s (IR, r = −0.093, p = 0.51; ER, r = −0.037, p = 0.79). Moreover, the isokinetic shoulder strengths were not significantly different across the three groups in all settings. In conclusion, vitamin D insufficiency was common in elite volleyball players. Though not being associated with isokinetic muscle weakness, vitamin D levels should be regularly monitored, and vitamin D should be supplied to young elite athletes, considering its importance for musculoskeletal health.

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An audit of vitamin D monitoring and management of deficiency in women's secure services

BJPsych Open ◽

10.1192/bjo.2021.91 ◽

2021 ◽

Vol 7 (S1) ◽

pp. S12-S12

Author(s):

Claire Bustin ◽

Shay-Anne Pantall ◽

Jeremy Rampling

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Maintenance Treatment ◽

Vitamin D Insufficiency ◽

Electronic Patient Records ◽

Number Of Patients ◽

Vitamin D Levels ◽

African Caribbean ◽

One Year ◽

Sufficient Vitamin

AimsTo audit the investigation, identification and treatment of vitamin D deficiency within Women's Secure Services.BackgroundIt has been suggested that vitamin D and vitamin D deficiency may play a role in the pathogenesis of psychiatric illness. There is evidence that vitamin D inadequacy is prevalent among patients in long-term hospital settings. Patients within secure hospitals are considered to be at high risk due to their often lengthy admissions, having been transferred from other hospital or prison settings. Ardenleigh in Birmingham is a blended female secure unit. Here we present the findings of an audit, completed in 2019, of vitamin D monitoring and treatment in this service.MethodA retrospective review of electronic patient records, for all inpatients admitted within women's secure services at Ardenleigh as of 1st September 2019 (n = 27). Standards were based on the Trust accepted guidelines for management of vitamin D deficiency.ResultKey findings included:-The majority of inpatients were Caucasian (44%) and African-Caribbean (41%). Median age was 31 years (range 20–56).Approximately two-thirds (60%) had been in hospital for over a year.89% of patients had their vitamin D level checked at some point during admission.Of those checked, 25% were tested within 1 week of admission. Seven patients were tested after being in hospital for over one year (30%).Only 25% of patients tested were found to have adequate vitamin D levels. Nine patients were found to have insufficient levels of vitamin D (37.5%) or deficiency (37.5%).89% of those identified as requiring treatment were prescribed supplementation, of which the majority was prescribed at the correct dose for the appropriate duration (94%). One patient refused treatment. Of those with sufficient levels, 67% were prescribed ongoing maintenance treatment due to previously detected deficiency.Of those found to have sufficient vitamin D in the last 12 months (n = 14), 71% were continued on maintenance treatment.ConclusionWe identified a high prevalence of vitamin D insufficiency in women admitted to secure services. Testing was delayed for a number of patients from the point of admission. However, once identified, the vast majority of those in need of treatment were managed appropriately by the medical team. We advise that vitamin D be considered an essential routine blood test at the point of admission to minimise delays in identifying those with deficiency and establishing necessary supplementation.

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Relationship of vitamin D, BMI and BMD in age and gender linked population

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20181439 ◽

2018 ◽

Vol 4 (3) ◽

pp. 406

Author(s):

Ritwik Ganguli ◽

Priyanka Pahari

Keyword(s):

Vitamin D ◽

Vitamin D Insufficiency ◽

Healthy Individuals ◽

Mineral Density ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

And Gender ◽

Relationship Of ◽

The Relationship

Background: Vitamin D insufficiency prevalence has been related to low bone mineral density (BMD). However, controversial results have been reported for the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and BMD. This study was done to investigate whether serum 25(OH)D levels were associated with BMD in different age group and sex link population.Methods: This study involved, aged 40-70 yr, who is consecutively selected from KPCMCH, BMD camp. BMD was measured at the lumbar spine and femoral neck. The correlation between serum 25(OH)D levels and BMD was investigated.Results: Vitamin D levels for healthy and patients individuals at hospital. The age of 40 healthy subjects ranged from 40 to 70 years with the average of 55.30±10.30 years and body mass index (BMI) ranged from 18 to 37 kg/m2, with the of average of 28.90±5.20 kg/m2. Comparison between healthy and patients based on BMI and vitamin D level for the overweight BMI healthy individuals was 29.78±9.40 ng/ml, and that of hyperlipidemic patients was 24.47±8.78 ng/ml.Conclusions: In this study, there is significant different between healthy and patients group in vitamin D3level.BMD significantly decreased in patients group more elderly.

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Vitamin D deficiency and maternal complications

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20202303 ◽

2020 ◽

Vol 9 (6) ◽

pp. 2314

Author(s):

Anu B. Chandel ◽

Rita Mittal ◽

Anoop Sharma ◽

Shivika Mittal

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Preterm Labour ◽

Maternal Complications ◽

Tropical Country ◽

Maternal Vitamin ◽

Vitamin D Levels ◽

The World ◽

Sufficient Vitamin ◽

The Relationship

Background: Vitamin D deficiency is prevalent in India, a finding that is unexpected in a tropical country with abundant sunshine. Vitamin D deficiency is recognized as the most untreated nutritional deficiency currently in the world. Several studies reported the relationship between maternal vitamin D deficiency and adverse maternal and fetal outcomes including gestational diabetes, preeclampsia, preterm labour, low birth weight and increased rate of caesarean section.Methods: The study was conducted in the department of obstetrics and gynecology, Kamla Nehru Hospital, Shimla, Himachal Pradesh, India over a period of 12 months. Six hundred women were included in the study.Results: Forty-eight (8%) subjects developed preeclampsia-eclampsia syndrome, of which none had sufficient vitamin D levels, whereas 48 (100%) subjects had vitamin D deficiency.Conclusions: Maternal antenatal complications are more common in vitamin D deficient group.

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The Relationship between Serum Vitamin D Levels, C-Reactive Protein, and Anxiety Symptoms

Psychiatry Investigation ◽

10.30773/pi.2019.0290 ◽

2020 ◽

Vol 17 (4) ◽

pp. 312-319

Author(s):

Sun-Young Kim ◽

Sang-Won Jeon ◽

Weon-Jeong Lim ◽

Kang-Seob Oh ◽

Dong-Won Shin ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Anxiety Symptoms ◽

C Reactive Protein ◽

Serum Vitamin D ◽

Reactive Protein ◽

Vitamin D Levels ◽

Korean Adult ◽

Sufficient Vitamin ◽

The Relationship

Objective The aim of study is to investigate the relationship between serum vitamin D, c-reactive protein (CRP) levels, and anxiety symptoms.Methods Serum vitamin D and CRP levels of 51,003 Korean adult participants were collected retrospectively. Anxiety symptoms were assessed using the Korean version of Beck Anxiety Inventory. Logistic regression was used to estimate the odds ratio (ORs) of anxiety symptoms by serum vitamin D and CRP levels. The regression was adjusted for covariates, and each model was adjusted mutually for vitamin D and CRP levels.Results Compared with sufficient vitamin D levels (≥20 ng/mL), insufficient (10–19.99 ng/mL) and deficient (<10 ng/mL) vitamin D levels were significantly associated with risk of anxiety symptoms. Also, continuous vitamin D levels were negatively associated with the risk of anxiety symptoms. CRP levels did not affect the relationship between vitamin D levels and risk of anxiety symptoms.Conclusion Insufficient (10–19.99 ng/mL) and deficient (<10 ng/mL) vitamin D levels were significantly associated with risk of anxiety symptoms. After adjusting for CRP levels, the results were not changed, and no evidence of interaction between vitamin D and CRP levels was found. CRP levels did not account for the association between vitamin D levels and risk of anxiety symptoms.

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