Prognostic value of age in nasopharyngeal carcinoma patients: A single institution analysis

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 6080-6080
Author(s):  
N. L. Downing ◽  
P. Wong ◽  
D. Petrik ◽  
W. Hara ◽  
Q. Le
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Treatment Outcomes ◽  
Induction Chemotherapy ◽  
Age Groups ◽  
External Beam Radiation ◽  
Definitive Treatment ◽  
Single Institution ◽  
Treatment Characteristics ◽  
Significant Difference ◽  
Two Age Groups

6080 Background: Nasopharyngeal carcinoma (NPC) has a bimodal age distribution with peaks at 15–25 and 40–50 years of age, though it is unclear if the prognosis differs significantly between the two age groups. Here, we compare treatment outcomes between two age groups of patients treated at a single institution. Methods: We retrospectively analyzed the data of 99 NPC patients who received definitive treatment at our institution between March 1985 and June 2004. All patients received a median dose of 66 Gy of external beam radiation therapy and 70% received either concurrent or induction chemotherapy. We compared patient, tumor, and treatment characteristics as well as treatment outcomes in juvenile patients (age = 25 years at diagnosis), versus adult patients (age > 25 years at diagnosis). Survival curves were estimated by the Kaplan-Meier method. Results: There was a significant difference in the ethnic composition between the age groups, with more Asians and fewer Whites and Hispanics in the adult group (see table ). Also, there was a significant difference between the groups in the proportion of patients receiving chemotherapy, especially induction chemotherapy (see table ). There was no difference in the distribution of tumor stage and WHO histology between the two age groups. At a median follow-up for all patients of 42 months (range 4 to 234), there were no statistically significant differences in treatment outcomes between the two age groups although the survival data numerically favored the juvenile patients (see table ). Conclusions: Although there were significant differences in racial distributions and treatment characteristics between the two age groups, treatment outcomes were similar. Aggressive treatment with radiotherapy and chemotherapy resulted in excellent outcomes for both patient populations. No significant financial relationships to disclose. [Table: see text]

scholarly journals Differences in Treatment Outcomes and Prognosis between Elderly and Younger Patients Receiving Definitive Radiotherapy for Cervical Cancer

2020 ◽  
Vol 17 (12) ◽  
pp. 4510
Author(s):  
PeiYu Hou ◽  
ChenHsi Hsieh ◽  
MingChow Wei ◽  
ShengMou Hsiao ◽  
PeiWei Shueng
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factors ◽  
Elderly Patients ◽  
Treatment Outcomes ◽  
Clinical Outcomes ◽  
Age Groups ◽  
Definitive Radiotherapy ◽  
Regional Control ◽  
Group 2 ◽  
Two Age Groups

The aim was to compare the clinical outcomes and prognostic factors of cervical cancer between elderly and younger women, and to explore which treatment strategy is more appropriate for elderly patients. We retrospectively reviewed patients with cervical cancer receiving definitive radiotherapy (RT) between 2007 and 2016, and divided them into two age groups: age < 70 vs. age ≥ 70. The clinical outcomes were compared between the two age groups. The median follow-up was 32.2 months. A total of 123 patients were eligible, 83 patients in group 1 (age < 70), and 40 patients in group 2 (age ≥ 70). Patients in group 2 received less intracavitary brachytherapy (ICRT) application, less total RT dose, and less concurrent chemoradiotherapy (CCRT), and tended to have more limited external beam radiotherapy (EBRT) volume. The treatment outcomes between the age groups revealed significant differences in 5-year overall survival (OS), but no differences in 5-year cancer-specific survival (CSS), 66.2% vs. 64.5%, and other loco-regional control. In multivariate analyses for all patients, the performance status, pathology with squamous cell carcinoma (SCC), International Federation of Gynecology and Obstetrics (FIGO) stage, and ICRT application were prognostic factors of CSS. The elderly patients with cervical cancer had comparable CSS and loco-regional control rates, despite receiving less comprehensive treatment. Conservative treatment strategies with RT alone could be appropriate for patients aged ≥ 70 y/o, especially for those with favorable stages or histopathology.

Character introductions in oral narratives of Swedish–German bilingual preschoolers

2020 ◽  
pp. 014272371989744
Author(s):  
Josefin Lindgren ◽  
Valerie Reichardt ◽  
Ute Bohnacker
Keyword(s):  
Language Proficiency ◽  
Language Skills ◽  
Age Groups ◽  
Age Group ◽  
Morphological Form ◽  
Information Status ◽  
Significant Difference ◽  
Old Swedish ◽  
As Effects ◽  
Two Age Groups

Closely related Swedish and German both mark information status of referents morphologically, though little is known about its acquisition. This study investigates character introductions in the narratives of 4- and 6-year-old Swedish–German bilinguals ( N = 40) in both languages, elicited with MAIN Cat/Dog. We analyse effects of age group, language and animacy (human vs nonhuman characters) on the type of referring expression (indefinite NP and pronoun), as well as effects of language proficiency and exposure on the use of indefinite NPs for each language. We also explore which syntactic constructions indefinite NPs occur in. A significant difference was found between the two age groups, but not between languages. No effect was found of language skills or exposure. Four-year-olds used more pronouns and a lower proportion of indefinite NPs than 6-year-olds. Pronouns were more frequent for the human character than for nonhuman animate characters. Whilst animacy (humanness) promoted the use of pronouns, it did not affect the choice of morphological form for lexical NPs (indefinite/definite). The age groups differed in how indefinite NPs were used. Four-year-olds produced fewer narrative presentations (where a character is introduced as part of a typical story opening, e.g. Once upon a time there was a cat) than 6-year-olds, and more labellings (with only an NP, or a clausal predicative, e.g. That’s a cat). Qualitative analyses suggest that the children’s indefinite NPs in labelling constructions can be both referential (when setting the narrative scene), and type-denoting (when naming referents in individual pictures). Whilst the children’s abilities to introduce story characters develop measurably from 4 to 6 years in Swedish and German, appropriateness of character introductions not only depends on whether an indefinite NP is chosen, but also on the syntactic construction this indefinite NP is used in.

Acute Leukemia in Patients Sixty Years of Age and Older: A Retrospective Review.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4605-4605
Author(s):  
Chantal S. Leger ◽  
Ann Lee ◽  
Heather A. Leitch ◽  
Paul F. Galbraith ◽  
Charles H. Li ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Treatment Outcomes ◽  
Induction Chemotherapy ◽  
De Novo ◽  
Disease Free Survival ◽  
Retrospective Chart Review ◽  
Prolonged Survival ◽  
Entire Group ◽  
Secondary Leukemia ◽  
Significant Difference

Abstract Acute leukemia, especially acute myeloid leukemia (AML), occurs more frequently in the elderly population. Treatment outcomes for this condition have traditionally been poor and very few patients survive for prolonged periods following diagnosis. We performed a retrospective chart review of all patients sixty years of age and older diagnosed with acute leukemia at St. Paul’s hospital, Vancouver, Canada, from June 1984 to July 2004. One hundred and three patients were diagnosed with acute leukemia [AML- 81; ALL- 15; ALN (acute leukemia not otherwise specified)- 7]. The median age was 72 (range 60–88) years. Fifty-seven (55%) and 46 (45%) patients had de novo and secondary leukemia, respectively. Sixteen patients (28%) had an unfavourable karyotype. Fifty-three patients (51%) received induction chemotherapy (treated) and 50 (49%) were provided with supportive care only (untreated). Treated patients were younger [67 years (60–79)] than untreated patients [76 years (61–88)], (p<0.0001), and no patients >/= 80 years were treated (n=17). Of the treated patients, 33 (62%) achieved a complete remission (CR), 10 (19%) had resistant disease and 10 (19%) died from complications related to treatment. The median overall survival for the entire group was 103 (1–1229) days, and for treated versus untreated patients was 216 (1–1213) and 38 (2–1229) days, respectively (p=0.0021). The disease free survival in treated patients achieving a CR (n=33) was 262 days (9–722). Less than 5% of patients were alive at 4 years from diagnosis. Univariate variables predictive of prolonged survival included receiving induction chemotherapy (p=0.0027), de novo as opposed to secondary leukemia (p=0.0420), and younger age, with a relative increase in death in older subgroups (60–69, 70–79, 80+), (p=0.0311). Induction chemotherapy was the only independent predictor of prolonged survival in multivariate analysis (p=0.0027). There was no statistically significant difference in the number of treated patients and treatment outcomes between 1984–1993 and 1994–2004. In conclusion, this single-institution series of 103 patients aged sixty years and older with acute leukemia, shows that the prognosis of this disease in older patients is extremely poor. Even though induction chemotherapy seems to prolong survival in patients who are fit to receive treatment, the prognosis remains grim and most patients ultimately die of leukemia, supporting a role for investigational regimens focusing solely on this age group. It is no longer appropriate to follow regimens that have remained largely unsuccessful and unchanged over 20 years.

Prognostic Significance of NQO1 Polymorphism and GST-M1 Deletion in De Novo Acute Myeloid Leukemia

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 4846-4846
Author(s):  
Yeo-Kyeoung Kim ◽  
Hee-Je Kim ◽  
Woo-Sung Min ◽  
Jong- Ho Won ◽  
Deog-Yeon Jo ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Treatment Outcomes ◽  
Induction Chemotherapy ◽  
Myeloid Leukemia ◽  
De Novo ◽  
Remission Induction ◽  
Repair System ◽  
Significant Difference ◽  
Normal Cytogenetics ◽  
Acute Myeloid

Abstract Background: Although the most powerful prognostic factor of acute myeloid leukemia (AML) patients is the karyotype of the leukemic blast, data have not been obtained almost entirely in patients with heterogeneous cytogenetics. Further, some patients with favorable cytogenetics may show the poor treatment outcomes. Previous reports suggested that the single nucleotide polymorphisms of genes coding drug detoxification enzymes such as cytochrome P450 family or DNA repair system may influence the treatment outcomes in the patients with AML. We evaluated the role of polymorphisms in XRCC1, XRCC4, CYP1A1, GST-T1, GST-M1, NOQ1, and NAT2*6A in predicting therapeutic outcomes of adults with AML. Methods: XRCC1 (rs25487), XRCC4 (rs1056503), NQO1 (rs1800566), CYP-4501A1*2B (rs1048943), NAT2*6A (rs1799930) gene polymorphisms and deletion of GST-M1/GST-T1 were evaluated in 460 bone marrow (BM) samples obtained at initial diagnosis from de novo AML patients. Genotyping method is pyrosequencing using genomic DNA from BM samples. Homozygous deletions of GST-M1 and GST-T1 genes were detected with a multiplex PCR technique. All patients except APL (acute promyelocytic leukemia) received one or two rounds of intensive induction chemotherapy consisting of 3 days of idarubicin and 7 days of cytarabine. APL patients treated with AIDA regimen consisting of 45 days of ATRA (all-trans retinoic acid) and 3 days of idarubicin. Results: Of total 460 patients, ninety-nine patients (21.5%) were APL. Seventy-one (15.4%) were AML with t(8;21), twenty-three (5%) were AML with inv(16), and 179 patients (38.9%) showed normal cytogenetics. The median age of patients was 44 years (range, 14–75 years). In all cytogenetic risk group, the patients carrying homozygous NQO1 gene polymorphism (TT) showed significantly lower rate of complete remission (CR) than in those with negative or heterogyzous polymorphisms (TT: 72.7% vs. CC/CT: 85.9%, p=0.03). There was no significant difference in relapse rate, leukemia-free survival (LFS) and overall survival between homo- and heterozygote groups in these polymorphsims. In subgroup analysis, APL patients carrying TT genotype in NQO1 also showed lower rate of CR (TT: 77.8% vs. CC/CT: 95.4%, p=0.04). In AML patients except APL, NQO1 homozygous polymorphsim (TT) was also associated with lower CR rate (TT: 69.6% vs. CC/CT: 84.2%, p=0.005). In normal cytogenetics, the patients with del GST-M1 showed shorter LFS compared with those carrying GST-M1 (18.0 ± 5.7ms. vs. 34.6 ± NA. p=0.04). Conclusions: This study revealed an association between NQO1 polymorphism and GST-M1 deletion and the treatment outcomes for AML patients. Further study and larger sample size are needed to reach the definite conclusion on these associations. However, a stratified treatment plan in remission induction chemotherapy such as augmentation or addition of other chemotherapeutic agents may be warranted for AML patients harvoring homozygous NQO1 polymorphism (TT) or del GST-M1.

scholarly journals Antimicrobial Resistance in Fecal Escherichia coli Isolates from Healthy Urban Children of Two Age Groups in Relation to Their Antibiotic Therapy

2011 ◽  
Vol 55 (6) ◽  
pp. 3005-3007 ◽  
Author(s):  
Ivan Literak ◽  
Radim Petro ◽  
Monika Dolejska ◽  
Erika Gruberova ◽  
Hana Dobiasova ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Czech Republic ◽  
Antimicrobial Resistance ◽  
Age Groups ◽  
Antibiotic Resistant ◽  
The Czech Republic ◽  
Content Type ◽  
E Coli ◽  
Significant Difference ◽  
Two Age Groups

ABSTRACTThe study was performed in the Czech Republic during 2007 to 2009. OfEscherichia coliisolates from 275 children aged 6 weeks, 36% (n= 177) were resistant to 1 to 7 antibiotics. Of isolates from 253 children aged 6 to 17 years, 24% (n= 205) were resistant to 1 to 5 antibiotics. There was no significant difference in the prevalences of antibiotic-resistantE. coliisolates between these groups of children, even though the consumptions of antibiotics were quite different.

scholarly journals Orbital Apex Lesions: A Diagnostic and Therapeutic Challenge

2017 ◽  
Vol 79 (04) ◽  
pp. 386-393 ◽  
Author(s):  
Sung-Woo Cho ◽  
Won-Wook Lee ◽  
Dae Ma ◽  
Ji-hoon Kim ◽  
Doo Han ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Clinical Characteristics ◽  
Inflammatory Pseudotumor ◽  
Definitive Treatment ◽  
Fungal Sinusitis ◽  
Orbital Apex ◽  
Radiological Findings ◽  
Presenting Symptoms ◽  
Invasive Fungal Sinusitis ◽  
Significant Difference

Objective To analyze the clinical characteristics of and treatment outcomes for orbital apex lesions according to their pathological diagnosis and identify clinical characteristics that could aid in their differential diagnosis. Design Retrospective analysis design was used for this study. Setting The study was conducted in a single tertiary institution. Participants Patients with pathologically confirmed lesions centered in the orbital apex who were admitted between January 2011 and December 2015. Main Outcome Measures Clinical characteristics, including demographics, predisposing factors, presenting symptoms, radiological findings, intraoperative findings, biopsy results, and treatment outcomes. Results Nine patients with invasive fungal sinusitis, six with inflammatory pseudotumor, and six with neoplastic or tumorous lesions were enrolled. The most common presenting symptom was orbital pain or headache, followed by ophthalmoplegia and vision loss, which exhibited overall recovery rates of 62.5% and 33.3%, respectively, after definitive treatment. The prognosis was worse for patients with invasive fungal sinusitis. There was no significant difference in age, underlying medical conditions, absolute neutrophil count, C-reactive protein level, and radiological findings among the three groups. Grossly necrotic tissues around the orbital apex area at biopsy were more frequently found in patients with invasive fungal sinusitis than in the other patients. In most cases, pain ameliorated after surgical intervention. There were no surgery-related morbidities. Conclusions Lesions centered in the orbital apex included invasive fungal sinusitis, inflammatory pseudotumor, and tumorous lesions. However, clinical features that clearly differentiated chronic invasive fungal sinusitis from inflammatory pseudotumor could not be identified. Our findings suggest that prompt biopsy is warranted for timely diagnosis, symptom relief, and early implementation of definitive treatment.

Depression Among Tunisian Young Mothers

2017 ◽  
Vol 41 (S1) ◽  
pp. s244-s244
Author(s):  
O. Zerriaa ◽  
O. Moula ◽  
S. Ben Saadi ◽  
S. Chebli ◽  
R. Ghachem
Keyword(s):  
Cultural Context ◽  
Age Groups ◽  
Public Health Problem ◽  
Working Hours ◽  
Well Being ◽  
University Education ◽  
Significant Difference ◽  
Competing Interest ◽  
Transversal Study ◽  
Two Age Groups

IntroductionIn the Tunisian cultural context, the mother is in charge of childcare, housekeeping and the well-being of the whole family, which can lead to exhaustion and depression.ObjectiveTo estimate the frequency of depression among mothers aged between 20 and 40 years, its consequences and the possible solutions.MethodTransversal study using an anonymous questionnaire of 26 questions published through social media sites to mother with young aged children.ResultsThree hundred and twenty-seven mothers participated in the study: 20% of them aged between 20 and 30 years and 80% between 30 and 40. Ninety-seven percent of the participants were married; 96% of them had university education. Seventy-nine percent of them were working mothers and 50% of them did not get any help in childcare. Forty-two percent of the participants had only 1 child, 49% had 2 children, 8% 3 children and only 1 mother had 4 children. Depressive symptoms were present in 73% of the participants and were significantly higher among mothers aged between 30 and 40. However, depression was certain in only 36% of them and there was no significant difference between the two age groups. Eighteen percent of the participants noticed an increase in consummation of cigarettes, 31% resorted to tranquilizers, 25% needed sick leaves, and 2% resorted to alcohol use. Less working hours was suggested as a solution in 36% cases, sharing house chores in 30% cases.ConclusionDepression among young mother is a public health problem in Tunisia. It is underestimated and not always treated, which can have a serious impact on the whole family well-being.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Association between comorbidities and death from COVID-19 in different age groups

2021 ◽  
Author(s):  
Pedro Emanuel Fleitas ◽  
Maria Cristina Almazan ◽  
Sabrina Daniela Cortez ◽  
Jorge Augusto Paz ◽  
Ruben Oscar Cimino ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Decision Trees ◽  
Health Personnel ◽  
Age Groups ◽  
Cardiac Diseases ◽  
Fatality Rate ◽  
Significant Difference ◽  
The World ◽  
Logistic Regressions ◽  
Two Age Groups

Background: This new COVID-19 pandemic challenges health systems around the world; therefore, it is extremely important to determine which patients with COVID-19 can evolve to more severe outcomes. Accordingly, we decided to assess the role that comorbidities play in death from COVID-19. Methods: Two age groups (<60 and ≥ 60 years) were defined for analysis. Decision trees were made to identify which comorbidities had the highest fatality rate (FR). Multiple logistic regressions were performed to measure the association between comorbidities and death. Results: A significant difference was found between the FR of <60 group and ≥ 60 group. The most frequent comorbidity were cardiac diseases and diabetes. The combination of comorbidities with the highest FR was diabetes with kidney disease. Combinations of more than two comorbidities presented higher FR. The comorbidities had higher Odd ratios in the younger group than in the older group. Conclusions: Comorbidities seem to play a greater role in death from COVID-19 in the younger group, while in the ≥ 60 group, age seems to be the most important factor. We assigned a score to the comorbidities and their combinations for both age groups to help the health personnel make decisions.

scholarly journals A Comparative Analysis of Speech Disfluencies in Children Aged 10-12 Years and Adults, Native Russian Speakers

2020 ◽  
pp. 91-101
Author(s):  
Tatiana A. Slabodkina ◽  
Keyword(s):  
Comparative Analysis ◽  
Age Groups ◽  
Russian Speakers ◽  
Two Samples ◽  
Significant Difference ◽  
Quantitative Characteristics ◽  
Oral Speech ◽  
Ongoing Development ◽  
Children Speech ◽  
Two Age Groups

The article presents a psycholinguistic study of the oral speech of pre-adolescent Russian speakers. The current study compared the quantitative characteristics of speech disfluencies (silent and filled hesitation pauses, false starts, and repetitions among them) on the material of two corpora of oral texts: one of which was an annotated transcript of dialogues of children asged 10-12 solving in pairs a certain problem, and the second corpus consisted of dialogues between adults in the identical situation. Through the comparison of the two corpora, the author aimed at determining differences in speech behavior of two age groups put in the same conditions. The analysis of the collected data showed that there is a statistically significant difference between the two samples in the number of silent pauses and their length between the interlocutors’ utterances, as well as by one of the types of repairs, which may indicate the ongoing development of certain speech skills in children of this age. These results support the theory of late discursive development which indicates the need for further comprehensive research of pre-adolescent children speech, even though this period traditionally is neglected by researchers.

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