Pattern of chemotherapy dosing in obese patients in a community hospital.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e13099-e13099
Author(s):  
Malar Thwin ◽  
Aye Min Soe ◽  
Nay Min Tun ◽  
Gina M. Villani
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Dose Adjustment ◽  
Drug Exposure ◽  
Obese Patients ◽  
Chi Square ◽  
Full Dose ◽  
Reduced Dose ◽  
Significant Difference ◽  
Chemotherapy Dose

e13099 Background: Obesity has increased to epidemic proportions, with 32.2% of US adults aged 20 years or older classified as obese (body mass index ≥ 30 mg/m2). In view of altered pharmacokinetics and possible excessive toxicity in obese patients, chemotherapy dose reductions are often employed in treating obese cancer patients. To our knowledge, there are no reports in the literature identifying patients who should have empiric dose adjustment because of obesity or the best method of dosing chemotherapy to standardize drug exposure in patients with varying degrees of obesity. As practice varies among institutions, we carried out a retrospective study to evaluate the chemotherapy dosing pattern in our obese patient population. Methods: Charts of patients who received chemotherapy at our institution during the year 2010 were reviewed. Data on age, height, weight, type and stage of cancer, date of chemotherapy, and type and dose of chemotherapy were retrieved from chart review. Only details of the first chemotherapy cycle at our institution were collected. Body surface area (BSA) was calculated by using the Mosteller formula. Independent samples t-test and Pearson chi-square statistics were used to investigate the difference between the means and proportions respectively. Results: Data from 191 patients were analyzed. Distributions (mean and range) of age, height, weight, body mass index (BMI) and BSA were 60 years (26 - 88), 65 inches (53 - 79), 166 pounds (90 - 340), 27.44 kg/m2 (14.52 - 56.57) and 1.85 m2 (1.36 - 2.66), respectively. Patients who had a full dose (n = 164) had a mean BMI of 27 kg/m2 (standard deviation (SD) 6.5) and a mean BSA of 1.82 m2 (SD 0.24) whereas those with a reduced dose had BMI (n = 27, mean 30.2, SD 7.1) and BSA (mean 1.97, SD 0.25). There is a significant difference between the means of the two groups (full dose and reduced dose) in terms of both BSA and BMI (p = 0.033 and p = 0.01, respectively). Significantly higher proportion of patients with BSA ≥ 2 received reduced dose compared to those with BSA < 2 (14 out of 48 (20.3%) versus 13 out of 143 (9%), p = 0.001). Conclusions: Patients with BSA ≥ 2 were more likely to get empiric chemotherapy dose adjustment at our institution. Further studies on chemotherapy dosing in obese patients are warranted.

scholarly journals TRAUMATIC DISEASE PECULIARITIES COURSE, ITS DIAGNOSTICS AND TREATMENT AT POLYTRAUMA IN SUFFER OBESE PATIENTS

2019 ◽  
Vol 43 (4) ◽  
pp. 47-53
Author(s):  
S.D. Khimich ◽  
O. M. Chemerys
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Overweight And Obesity ◽  
The Body ◽  
Obese Patients ◽  
Prognostic Features ◽  
Normal Body ◽  
Significant Difference ◽  
Normal Body Weight

Abstract Introduction. It’s known that the issue of polytrauma is one of the most urgent problems of surgery, and among injured patients a special approach is required for patients with overweight and obesity of varying degrees. Purpose of the study. To study prognostic features of traumatic disease course and to improve the results of diagnostics and surgical treatment of patients with polytrauma suffer obesity. Materials and methods. Clinical material was made up of 106 patients with combined body trauma, which were divided into three groups according to body mass index. Results. The results of the research showed a significant difference in the course of traumatic disease in patients with normal body weight and obesity. In particular, in the process of diagnostics of blunt chest and abdominal trauma the frequency of application of interventional methods of diagnostics was directly proportional to the increase of body mass index. The course of traumatic disease in the obese patients had a number of characteristic features that formed the basis for the development of diagnostics and differential program of treatment. Conclusions. The results of the research showed that the course of traumatic disease in combined injury obese patients is directly proportional to the body mass index and has certain features that differentiate them from patients with normal body weight. Keywords: polytrauma, obesity, traumatic disease, diagnostics, treatment.

scholarly journals Body mass index in relation to dental maturation of 10 to 14 years old school children in Erbil city. A cross-sectional prospective study.

2020 ◽  
Vol 3 (2) ◽  
pp. 145-150
Author(s):  
Omar Chawshli ◽  
Yara Ameen
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
School Children ◽  
P Value ◽  
Dental Age ◽  
Chi Square ◽  
Cross Sectional ◽  
Dental Maturation ◽  
Significant Difference ◽  
Chi Square Test

Background and Objectives: Estimation of dental age is based upon the rate of development and calcification of tooth buds and their progressive sequence of eruption in the oral cavity. The tooth calcification provides a valuable indicator of dental age and serves as an index of the maturation of the child. The aim of this study is to determine whether Body Mass Index (BMI) has association with dental maturation. Materials and Methods: A cross sectional study design was applied for the present study, 383 school children were participated in this study which nominated from Erbil city. For the sample to be representative the city was divided in to six geographic areas according to the municipalities, the samples randomly selected school children of 10 to 14 years old from both genders. The height and the weight of each participant had been recorded in the college of dentistry / Hawler Medical University in order to calculate the body mass index of the following the guidelines of centers of disease control (CDC) , at the same time an orthopantomography radiograph had been used to investigate the stage of the dental maturation using the Demirjian method, finally, the relationship between BMI and dental maturation were investigated using chi square test with P value of ≤ 0.05 was considered significant difference. Result: there was a statistically significant relationship between dental maturation and BMI. The majority (93.6%) of samples with under-mature dentition were under-weight at the same time. The vast majority (96%) of samples with mature dentition had normal BMI. In the same manner, majority (91.7%) of samples with over mature dentition were over-weight too. Chi square test was used to find out the association and P-value was 0.001 Conclusion: In conclusion, normal weight students have normal dental maturation, underweight students have under dental maturation and overweight or obese students have over dental maturation. Keywords: body mass index, Demirjian, Orthopantomography.

scholarly journals ACCURACY AND PREDICTIVE CAPABILITY OF BODY MASS INDEX IN EVALUATION OF OBESITY AND BODY FATNESS LEVEL IN POLICE OFFICERS

2020 ◽  
Vol 25 (3) ◽  
Author(s):  
Filip Kukic ◽  
Jay Dawes ◽  
Jillian Joyce ◽  
Aleksandar Čvorović ◽  
Milivoj Dopsaj
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Police Officers ◽  
Age Groups ◽  
Obesity Prevalence ◽  
Regression Analyses ◽  
Predictive Capability ◽  
Chi Square ◽  
Body Fatness ◽  
Significant Difference

This study evaluated the accuracy and predictive value of body mass index (BMI) in evaluation of obesity and body fatness. Data on BMI and percent body fat (PBF) were collected on 953 male police officers who were allocated into age groups: 20-29 years, 30-39 years, and 40-49 years. BMI > 30.0 kg/m2 and PBF > 25% were classified as obese, and those with lower values were classified as non-obese. Chi-square was used to evaluate the accuracy in classification in obese and non-obese when officers’ BMI was matched to PBF. Pearson’s correlation and linear regression analyses determined the prediction value of BMI. Chi-square revealed significant difference in obesity prevalence when evaluated by BMI and PBF, with classification accuracy of 44.5%-71.8%, depending on age. BMI had moderate prediction value of body fatness. If the assessment of PBF is not attainable, BMI needs to be used carefully as it is likely to underestimate obesity among police officers.

scholarly journals Evaluation of the impact of body mass index on warfarin requirements in hospitalized patients

2018 ◽  
Vol 12 (8) ◽  
pp. 207-216 ◽  
Author(s):  
Katie B. Tellor ◽  
Steffany N. Nguyen ◽  
Amanda C. Bultas ◽  
Anastasia L. Armbruster ◽  
Nicholas A. Greenwald ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
International Normalized Ratio ◽  
Hospitalized Patients ◽  
Morbidly Obese ◽  
Weekly Dose ◽  
Obese Patients ◽  
Significant Difference ◽  
Underweight Patients ◽  
The Impact

Background: Despite well established empiric dose adjustments for drug and disease-state interactions, the impact of body mass index (BM) on warfarin remains unclear. The objective of this study is to evaluate warfarin requirements in hospitalized patients, stratified by BMI. Methods: This retrospective review included two cohorts of patients: cohort A (patients admitted with a therapeutic international normalized ratio (INR)) and cohort B (newly initiated on warfarin during hospitalization). Exclusion criteria included: age under 18 years, pregnancy, INR (goal 2.5–3.5), and warfarin thromboprophylaxis post orthopedic surgery. The primary outcome was mean total weekly dose (TWD) of warfarin based on weight classification: underweight (BMI <18 kg/m2), normal/overweight (BMI 18–29.9 kg/m2), obese (BMI 30–39.9 kg/m2), and morbidly obese (BMI ⩾ 40 kg/m2). Data were extracted from two community hospitals in reverse chronologic order during July 2015–June 2013 until both study institutions evaluated 100 patients per cohort in each BMI classification or until all patients had been evaluated within the prespecified timeframe. Results: A total of 585 patients were included in cohort A (26 underweight, 200 normal/overweight, 200 obese, 159 morbidly obese). There was a statistically significant difference in TWD as determined by one-way analysis of variance ( p < 0.05). A Tukey post hoc test revealed a statistically significantly higher TWD in morbidly obese (41.5 mg) compared with underweight (25.6 mg, p < 0.05), normal/overweight (28.8 mg, p < 0.05) and obese patients (32.4 mg, p < 0.05). In cohort B, 379 patients were evaluated (9 underweight, 166 normal/overweight, 152 obese, 52 morbidly obese). Overall, 191 patients had a therapeutic INR on discharge (88.9% underweight, 52.4% normal/overweight, 44.1% obese, 55.8% morbidly obese, p = 0.035). Of those, there was a statistically significant difference in TWD ( p = 0.021) with a higher TWD in the morbidly obese (41 mg) compared with underweight patients (24.4 mg, p = 0.017). Conclusions: Based on the results of this study, morbidly obese patients may require higher TWD to obtain and maintain a therapeutic INR.

Correlation of high body mass index and circulating tumor cell positivity in patients with early-stage breast cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1600-1600 ◽  
Author(s):  
Uta Ortmann ◽  
Wolfgang Janni ◽  
Ulrich Andergassen ◽  
Thomas Beck ◽  
Matthias W. Beckmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Body Mass Index ◽  
Body Mass ◽  
Early Breast Cancer ◽  
Early Stage ◽  
High Body Mass Index ◽  
Obese Patients ◽  
Cellsearch System ◽  
Significant Difference

1600^ Background: The prognostic relevance of both body mass index (BMI) and circulating tumor cells (CTC) has been confirmed in different trials for patients with early breast cancer. This analysis evaluates the correlation between high BMI and CTC positivity as risk factors for reduced disease free and overall survival. Methods: Data of 3658 patients of the SUCCESS A trial have been analyzed. CTC count and BMI were documented before (N = 2026) and after (N = 1504) chemotherapy. Within this trial patients with early breast cancer were randomized to two chemotherapy regimens and received either 3 cycles of fluorouracil, epirubicin and cyclophosphamide followed by 3 cycles of docetaxel (FE100C-Doc) or 3 cycles of fluorouracil, epirubicin and cyclophosphamide followed by 3 cycles of docetaxel and gemcitabine(FE100C-DG). In addition, patients were randomized to zoledronic acid either for 2 or 5 years. CTC were analyzed using the CellSearch System (Veridex, USA). Different groups of bodyweight were classified according to the WHO’s international definition: Underweight (BMI < 18,5 kg/m2), normal range (BMI > 18,5- < 25), overweight (BMI >25- < 30), obesity (BMI > 30). Correlation between CTC count and BMI was analyzed using frequency-table methods. Results: At study entry 24 (1.2%) patients were underweight, 952 (47%) patients were normal weight, 658 (32.5%) patients were overweight and 392 (19.4%) patients were obese. Before the start of chemotherapy, CTC were detected in 435 (21.5%) patients. We did not find a correlation between CTC positivity and BMI (p=0.94). After chemotherapy CTC were detected in 330 (16,3%) patients. Again, there was no statistically significant correlation between BMI and CTC positivity (p=0.86). In particular, CTC positivity was not observed more frequently in obese patients neither before (p=0.70) nor after chemotherapy (p=0.95) compared to patients with a BMI < 30 kg/m2. Conclusions: As compared to patients with normal BMI, there was no significant difference in the prevalence of CTC in underweight, overweight and obese patients, respectively, neither before nor after chemotherapy. The risk factors obesity and prevalence of CTC seem to be independent prognostic factors.

scholarly journals Impact of body mass index on perioperative outcomes during the learning curve for robot-assisted radical prostatectomy

2013 ◽  
Vol 4 (4) ◽  
pp. 250 ◽  
Author(s):  
Venu Chalasani ◽  
Carlos H. Martinez ◽  
Darwin Lim ◽  
Reem Al Bareeq ◽  
Geoffrey R. Wignall ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Radical Prostatectomy ◽  
Learning Curve ◽  
Body Mass ◽  
Independent Predictor ◽  
Postoperative Outcomes ◽  
Obese Patients ◽  
Entire Cohort ◽  
Significant Difference

Introduction: Previous studies of robotic-assisted radical prostatectomy(RARP) have suggested that obesity is a risk factor for worseperioperative outcomes. We evaluated whether body mass index(BMI) adversely affected perioperative outcomes.Methods: A prospective database of 153 RARP (single surgeon)was analyzed. Obesity was defined as BMI ≥ 30 kg/m2; normalBMI < 25 kg/m2; and overweight as 25 to 30 kg/m2. Two separateanalyses were performed: the first 50 cases (the initial learningcurve) and the entire cohort of 153 RARP.Results: In the initial cohort of 50 cases (14 obese patients), therewas no statistically significant difference with regards to operativetimes, port-placement times and estimated blood loss (EBL). Lengthof stay (LOS) was longer in the obese group (4.3 vs. 2.9 days); BMIremained an independent predictor of increased LOS on multivariatelinear regression analysis (p = 0.002). There was no statisticallysignificant difference in the postoperative outcomes of leak rates,margin rates and incisional herniae. In the entire cohort, whencomparing obese patients to those with a normal BMI, there wasno statistically significant difference in operative times, EBL, LOS,or immediate postoperative outcomes. However, on multivariatelinear regression analysis, BMI was an independent predictor ofincreased operative time (p = 0.007).Conclusion: Obese patients do not have an increased risk of bloodloss, positive margins or the postoperative complications of incisionalhernia and leak during the learning curve. They do, however,have slightly longer operative times; we also noted an increasedLOS in our first 50 cases.Introduction : Des études antérieures sur la prostatectomie radicaleassistée par robot (PRAR) ont laissé entendre que l’obésité était unfacteur de risque de complications périopératoires. Nous avonsévalué si l’indice de masse corporelle (IMC) affectait de façonnégative les résultats de l’opération.Méthodologie : Une base de données prospective comptant153 PRAR (effectuées par un seul chirurgien) a été analysée. On adéfini l’obésité comme un IMC ≥ 30 kg/m2, un IMC normal étant< 25 kg/m2, et un IMC entre 25 et 30 kg/m2 représentant un surplusde poids. Deux analyses distinctes ont été réalisées : les 50 premierscas (courbe d’apprentissage initiale) et la cohorte entière des153 patients ayant subi une PRAR.Résultats : Dans la cohorte initiale de 50 cas (dont 14 patientsobèses), on n’a noté aucune différence significative sur le planstatistique en ce qui concerne la durée de l’opération, le tempsrequis pour installer l’accès vasculaire et la perte de sang approximative.La durée du séjour était plus longue dans le groupe despatients obèses (4,3 contre 2,9 jours), et l’IMC est demeuré unfacteur indépendant de prédiction d’une durée prolongée du séjourlors de l’analyse de régression linéaire multivariée (p = 0,002).Aucune différence significative sur le plan statistique n’a été notéedans les résultats postopératoires quant aux taux de fuite, aux tauxde marges positives et aux hernies incisionnelles. Dans toute lacohorte, on n’a noté aucune différence significative sur le planstatistique entre les patients obèses et les patients dont l’IMC étaitnormal en ce qui a trait à la durée de l’opération, la perte desang, la durée du séjour et les résultats postopératoires immédiats.Néanmoins, l’IMC s’est révélé un facteur de prédiction indépendantd’une durée prolongée de l’opération lors de l’analyse de régressionlinéaire multivariée (p = 0,007).Conclusion : Les patients obèses ne courent pas un risque plus élevéde perte de sang, de marges positives ou de complications postopératoirescomme une hernie incisionnelle ou une fuite pendantla période de la courbe d’apprentissage du chirurgien. Ils nécessitenttoutefois une opération légèrement plus longue; une duréeplus longue du séjour a aussi été notée chez les 50 premiers cas.

scholarly journals Analysis of the applied technique of intravenous anesthesia for in vitro fertilization in obese and patients with normal body mass index

2019 ◽  
Vol 147 (9-10) ◽  
pp. 588-594
Author(s):  
Nebojsa Videnovic ◽  
Jovan Mladenovic ◽  
Aleksandar Pavlovic ◽  
Sladjana Trpkovic ◽  
Milan Filipovic ◽  
...  
Keyword(s):  
Body Mass Index ◽  
In Vitro Fertilization ◽  
Body Mass ◽  
Muscle Relaxation ◽  
Normal Body Mass Index ◽  
Obese Patients ◽  
Vitro Fertilization ◽  
Normal Body ◽  
Significant Difference

Introduction/Objective. In this study, the effects of applied anesthetic techniques were investigated in a retrospective analysis of obese patients and those with normal body mass index undergoing in vitro fertilization, using bispectral index as an indicator of anesthetic depth. Methods. In total 116 patients with normal body mass index were allocated to group N. Another 116 patients with body mass index > 30 kg/m2 were allocated to group O. Anesthetic protocol comprised midazolam for premedication, diclofenac for pre-emptive analgesia, propofol for induction and maintenance, alfentanil for analgesia, suxamethonium for muscle relaxation. We recorded and compared the monitored parameters using t-test and ?2 test. Results. Procedure duration and recovery time were significantly longer in O group (p < 0.01). There is a statistically significant difference (p = 0.000181) in the number of patients requiring mechanical ventilation after induction of anesthesia. Propofol consumption was significantly higher (p < 0.0001) in O group (2.7 ? 1.6 mg/kg) as compared to group N (2.1 ? 0.4 mg/kg). The incidence of postoperative nausea and vomiting was observed in six patients in N group (5.17%) and nine patients in O group (7.76%). Pain intensity was found higher in group O compared to group N (p < 0.0001). Assessment of patients? sedation using verbal scale reported no statistically significant difference between N and O groups (p = 0.2548). Conclusion. Induction and maintenance of anesthesia in obese patients results in increased consumption of propofol and the need for muscle relaxation. The statements of the patients who underwent the procedure under intravenous propofol and alfentanil serve as the best recommendation for clinical practice.

scholarly journals Higher Body Mass Index Is Associated with Subjective Olfactory Dysfunction

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Z. M. Patel ◽  
J. M. DelGaudio ◽  
S. K. Wise
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Feeding Habits ◽  
Tertiary Care ◽  
Olfactory Dysfunction ◽  
Control Group ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Olfactory Loss ◽  
Significant Difference

Background. Morbidly obese patients demonstrate altered olfactory acuity. There has been no study directly assessing Body Mass Index (BMI) in patients with olfactory dysfunction. Our purpose was to compare BMI in a group of patients with subjective olfactory dysfunction to those without subjective olfactory complaints.Methods. Retrospective matched case-control study. Sixty patients who presented to a tertiary care otolaryngology center with subjective smell dysfunction over one year were identified. Neoplastic and obstructive etiologies were excluded. Demographics, BMI, and smoking status were reviewed. Sixty age, gender, and race matched control patients were selected for comparison. Chi-square testing was used.Results. 48 out of 60 patients (80%) in the olfactory dysfunction group fell into the overweight or obese categories, compared to 36 out of 60 patients (60%) in the control group. There was a statistically significant difference between the olfactory dysfunction and control groups for this stratified BMI(p= 0.0168).  Conclusion. This study suggests high BMI is associated with olfactory dysfunction. Prospective clinical research should examine this further to determine if increasing BMI may be a risk factor in olfactory loss and to elucidate what role olfactory loss may play in diet and feeding habits of obese patients.

scholarly journals Study on the Effect of Intermittent Fasting on Body Mass Index, Physical Activity and Sleep in Adults

2021 ◽  
Author(s):  
Maha H Alhussain ◽  
Dawa M Almarri ◽  
Shaista Arzoo
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Body Mass ◽  
Sleep Pattern ◽  
Intermittent Fasting ◽  
Chi Square ◽  
Exact Probability ◽  
Beneficial Effects ◽  
Significant Difference ◽  
Time Required

Introduction: Recently, Intermittent Fasting (IF) has gained popularity as an effective approach for obesity management. Many types of IF have been practiced for either religious or health purposes. Muslims, for example, are encouraged by Islam to voluntarily fast two days/week (Monday and Thursday) from sunrise to sunset. Aim: This study investigated the association between Muslims’ voluntary fasting (two days/week) with Body Mass Index (BMI), Physical Activity (PA), and sleep pattern. Materials and Methods: The present survey-based study was conducted for three months on 1242 adults (245 males and 997 females) who completed the completed self-administered study questionnaire. The questionnaire comprised questions on sociodemographic and anthropometric variables, fasting-related questions, PA, and sleep pattern. Participants were classified into fasting and non-fasting groups according to their responses to the question “Do you fast two days (i.e., Monday and Thursday) every week? The differences between the two groups were tested using Chi-square test, an exact probability test and unpaired t-test. Results: A total of 1,242 valid responses (age 18 years and above) were collected. Among those participants, only 18.4% (n=229) reported fasting Monday and Thursday every week. The BMI of those who used to fast two days/week was significantly higher (p < 0.05) than those who did not fast. The desire to lose weight (47.59%), followed by religious views (44.54%) were the main reasons for fasting. A significant difference (p < 0.05) in PA was observed between the two groups, but overall, the participants were involved in low PA only. No significant differences (p ≥ 0.05) in sleep pattern, such as sleepiness during the day, and sleep duration were observed between the two groups. However, significant differences in the time required to sleep and waking up during sleep were found between the two groups. Conclusion: This study indicated that fasting two days/week does not affect BMI when meal timings are restrained to early evening and pre-dawn periods, with adequate night sleep. It may be an appropriate beginning point to further develop strategies to sustain any beneficial effects of the voluntary IF on obesity.

Comparison of the effectiveness of venous thromboembolism prophylaxis with enoxaparin between obese and non-obese patients

2018 ◽  
Vol 25 (4) ◽  
pp. 813-817 ◽  
Author(s):  
Abdelmajid H Alnatsheh ◽  
Robert D Beckett ◽  
Stacy Waterman
Keyword(s):  
Body Mass Index ◽  
Venous Thromboembolism ◽  
Body Mass ◽  
Hospitalized Patients ◽  
Obese Group ◽  
Obese Patients ◽  
Thromboembolism Prophylaxis ◽  
Venous Thromboembolism Prophylaxis ◽  
Significant Difference ◽  
Group 2

Objective The purpose of this study is to compare the incidence of venous thromboembolism between obese and non-obese hospitalized patients who received United States Food and Drug Administration-approved prophylactic enoxaparin doses and to describe enoxaparin dosing strategies used in obese patients. Methods This was a retrospective cohort study including patients who were admitted to Parkview Regional Medical Center, Parkview Hospital, or Parkview Orthopedic Hospital between September 2011 and August 2012 and received at least one dose of enoxaparin 30 mg twice daily or enoxaparin 40 mg once daily for venous thromboembolism prophylaxis. Patients classified based on their body mass index into three groups, Group 1 (non-obese: body mass index < 25 kg/m2), Group 2 (overweight: body mass index ≥ 25 kg/m2 but < 30 kg/m2), and Group 3 (obese: body mass index ≥ 30 kg/m2). The primary endpoint was venous thromboembolism occurrence within 90 days, considering day 1 of hospitalization as day 1. Results Of the 428 patients included, 8 cases of venous thromboembolism (1.9%) were identified; 3 in the non-obese group, 2 in the overweight group, and 3 in the obese group, no statistically significant differences were found between the three groups, p = 0.81. When venous thromboembolism incidence was adjusted for age and sex, no statistically significant differences were found between overweight (OR = 0.685; 95% CI 0.115–4.095), obese (OR = 0.797; 95% CI 0.353–1.796), and combined overweight and obese (OR = 0.656; 95% CI 0.154–2.799) groups compared to patients with normal body weight. Conclusion This study did not find a statistically significant difference in venous thromboembolism incidence between obese, overweight, and non-obese hospitalized patients receiving approved enoxaparin prophylaxis doses.

Sign in / Sign up

Export Citation Format

Share Document