A single-center analysis of initial imaging in multiple myeloma (MM).

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e18554-e18554
Author(s):  
Justin M. Markow ◽  
Amishi Desai ◽  
Harry Staszewski
Keyword(s):  
Limited Data ◽  
Mri Findings ◽  
Data Set ◽  
Exact Test ◽  
Asymptomatic Patients ◽  
Spinal Mri ◽  
Baseline Characteristics ◽  
Initial Imaging ◽  
The Relationship ◽  
Risk Ratios

e18554 Background: Current recommendations for the evaluation of MM include a skeletal survey (SS) and possibly an MRI. The literature documents a discrepancy in the detection of important skeletal lesions between these two techniques. There is limited data on the relationship between symptoms and spinal MRI findings. We analyzed the correlation of symptoms with an abnormal MRI in our patients. Methods: We analyzed 66 unselected,retrospectively identified patients with MM using lab values, ISS scores, the initial SS, and MRI. Skeletal symptoms, interval between studies, discordance between imaging by modality, and interventions were also tabulated. Risk ratios (RR) were calculated for the probability of radiologic abnormalities based on symptoms. Fischer's exact test was applied. Results: The baseline characteristics by age, gender, race, ISS score, and other lab values were similar between groups. 53% (35/66) of patients had an MRI at diagnosis. 51.4% (18/35) of these had different findings from the SS (95% CI, 35.6% - 67.0%). 30.8% (8/26) of patients with an MRI abnormality were asymptomatic or had symptoms in a different location than seen on MRI (95% CI, 16.3% - 50.1%). 15.4% (4/26) of these patients were asymptomatic at presentation (95% CI, 5.5% - 34.2%). (RR) for patients with any reported symptom and abnormal MRI finding is 2.6 (95% CI, 1.1 - 5.6, p< 0.01), while the RR for a symptom corresponding to its anatomic area on MRI is 1.3 (95%CI .8 - 2.1, p = 0.23). Conclusions: 30% of our patients with an abnormal MRI were asymptomatic or reported symptoms in a different area. The RR for an abnormal MRI result in patients with any symptom was significant, but the symptomatic area did not correlate with the anatomic MRI abnormality. This suggests that a significant amount of disease is missed because imaging may be confined to the symptomatic area and asymptomatic patients are less likely to have an MRI. Within this limited data set, there appears to be an advantage to performing routine initial MRI

Effectiveness of daily chlorhexidine bathing for reducing gram-negative infections: A meta-analysis

2019 ◽  
Vol 40 (4) ◽  
pp. 392-399 ◽  
Author(s):  
Aditi Patel ◽  
Parth Parikh ◽  
Aaron N. Dunn ◽  
Jonathan A. Otter ◽  
Priyaleela Thota ◽  
...  
Keyword(s):  
Lower Risk ◽  
Meta Analysis ◽  
Limited Data ◽  
Inclusion Criteria ◽  
Gram Negative ◽  
Adult Intensive Care Unit ◽  
Chlorhexidine Bathing ◽  
Baseline Characteristics ◽  
Risk Ratios ◽  
Adequate Power

AbstractObjective:Multiple studies have demonstrated that daily chlorhexidine gluconate (CHG) bathing is associated with a significant reduction in infections caused by gram-positive pathogens. However, there are limited data on the effectiveness of daily CHG bathing on gram-negative infections. The aim of this study was to determine whether daily CHG bathing is effective in reducing the rate of gram-negative infections in adult intensive care unit (ICU) patients.Design:We searched MEDLINE and 3 other databases for original studies comparing daily bathing with and without CHG. Two investigators extracted data independently on baseline characteristics, study design, form and concentration of CHG, incidence, and outcomes related to gram-negative infections. Data were combined using a random-effects model and pooled relative risk ratios (RRs), and 95% confidence intervals (CIs) were derived.Results:In total, 15 studies (n = 34,895 patients) met inclusion criteria. Daily CHG bathing was not significantly associated with a lower risk of gram-negative infections compared with controls (RR, 0.89; 95% CI, 0.73–1.08; P = .24). Subgroup analysis demonstrated that daily CHG bathing was not effective for reducing the risk of gram-negative infections caused by Acinetobacter, Escherichia coli, Klebsiella, Enterobacter, or Pseudomonas spp.Conclusions:The use of daily CHG bathing was not associated with a lower risk of gram-negative infections. Further, better designed trials with adequate power and with gram-negative infections as the primary end point are needed.

ID: 98: EFFECTIVENESS OF DAILY CHLORHEXIDINE BATHING FOR REDUCING GRAM NEGATIVE INFECTIONS: A META-ANALYSIS

2016 ◽  
Vol 64 (4) ◽  
pp. 951.2-952
Author(s):  
A Patel ◽  
P Parikh ◽  
A Deshpande ◽  
JA Otter ◽  
P Thota ◽  
...  
Keyword(s):  
Lower Risk ◽  
Meta Analysis ◽  
Limited Data ◽  
Inclusion Criteria ◽  
Gram Negative ◽  
E Coli ◽  
Chlorhexidine Bathing ◽  
Baseline Characteristics ◽  
Risk Ratios ◽  
Adequate Power

BackgroundMultiple studies have demonstrated that daily chlorhexidine gluconate (CHG) bathing is associated with a significant reduction in infections caused by Gram positive pathogens. However, there is limited data on the effectiveness of daily CHG bathing on gram negative infections. The aim of this study was to determine if daily CHG bathing is effective in controlling and preventing gram negative infections in adult ICU patients.MethodsWe searched MEDLINE and 3 other databases for original studies comparing daily CHG bathing to soap and water bathing. All studies investigating the effectiveness of daily CHG bathing on gram negative infections were eligible. Two investigators extracted data independently on baseline characteristics, study design, form and concentration of CHG, incidence and outcomes related to gram negative infections. Data were combined by means of a random-effects model and pooled relative risk ratios (RRs) and 95% confidence intervals (CIs) were derived for overall gram negative infections and individual gram negative pathogens.ResultsEleven studies (n=27,793 patients) met the inclusion criteria. Of these, 13,852 patients received daily CHG bathing, and 13,941 patients daily bathing with soap and water. Daily CHG bathing was not associated with a lower risk of gram negative infections (2.03% vs. 2.38%; RR 0.84; 95%CI: 0.64–1.09, P=.19). Subgroup analysis demonstrated that daily CHG bathing significantly reduced the risk of gram negative infections caused by Acinetobacter (RR, 0.33; 95% CI: 0.17–0.66, P<.00001) but was not effective for E. coli, Klebsiella, Enterobacter and Pseudomonas associated gram negative infections.ConclusionsIn a meta-analysis of 11 studies, the use of daily CHG was not associated with a lower risk of gram negative infections. However, daily CHG bathing appears to be effective for Acinetobacter associated gram negative infections. There is a need for larger and better designed trials with adequate power with gram negative infections as the primary endpoint to determine the effectiveness of daily CHG bathing.Abstract ID: 98 Figure 1

A comparison of the relationship between measured acoustic response and porosity in carbonates across different geologic periods, depositional basins, and with variable mineral composition

2018 ◽  
Vol 6 (2) ◽  
pp. T245-T256
Author(s):  
Beth Vanden Berg ◽  
Christophe Nussbaumer ◽  
Amy Noack ◽  
John Thornton ◽  
Ralf J. Weger ◽  
...  
Keyword(s):  
Carbonate Platform ◽  
Order Estimate ◽  
Michigan Basin ◽  
Limited Data ◽  
Data Set ◽  
Paradox Basin ◽  
Great Bahama Bank ◽  
Wide Range ◽  
Basic Relationship ◽  
The Relationship

Recent work has shown that there is a predictable inverse relationship between laboratory-measured sonic velocity response and porosity in carbonates, which can be reasonably approximated using the empirical Wyllie time-average equation (WTA). The relationship was initially identified in late Cretaceous to Cenozoic age samples collected from the Great Bahama Bank and the Maiella Platform, an exhumed Cretaceous carbonate platform in Italy. We have compared older carbonate samples from different basins and different geologic ages to determine the applicability of this relationship and subsequent correlations to key petrophysical properties to other carbonate basins and other geologic time periods. The data set used for the comparison shows this relationship to be relatively consistent in other depositional basins (Michigan Basin, Paradox Basin) and with samples from older geologic periods (Pennsylvanian, Ordovician, and Mississippian). However, this basic relationship is also observed to vary significantly within a reservoir system and within a depositional basin in samples from different geologic periods (e.g., Silurian- versus Ordovician-age rocks in the Michigan Basin). Although the empirical WTA can generally be applied as a first-order estimate across a wide range of sample ages in carbonates, limited data suggest the relationship between velocity and porosity to be moderately more complex. For instance, in unconventional carbonate reservoirs characterized by predominantly micro- to nanoscale porosity, it is observed that the WTA should be applied as an upper data boundary. In addition, this study has shown that the relationship to the dominant pore type is less direct than in a macropore system in which it can be assumed that the dominant pore type also has the greatest effect on the effective permeability.

scholarly journals Fractal Dimension Estimation in Diagnosing Alzheimer’s Disease

10.14311/1785 ◽  
2013 ◽  
Vol 53 (2) ◽  
Author(s):  
Václav Hubata-Vacek ◽  
Jaromír Kukal ◽  
Robert Rusina ◽  
Marie Buncová
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fractal Dimension ◽  
Taylor Series ◽  
Fractal Dimensions ◽  
Limited Data ◽  
Data Set ◽  
Brain Scans ◽  
Definition Of ◽  
The Relationship

Estimated entropies from a limited data set are always biased. Consequently, it is not a trivial task to calculate the entropy in real tasks. In this paper, we used a generalized definition of entropy to evaluate the Hartley, Shannon, and Collision entropies. Moreover, we applied the Miller and Harris estimations of Shannon entropy, which are well known bias approaches based on Taylor series. Finally, these estimates were improved by Bayesian estimation of individual probabilities. These methods were tested and used for recognizing Alzheimer’s disease, using the relationship between entropy and the fractal dimension to obtain fractal dimensions of 3D brain scans.

Component resolved diagnostics in peanut sensitized children with and without a history of clinical reaction

2020 ◽  
Vol 41 (5) ◽  
pp. 336-340
Author(s):  
Yasmin Hamzavi Abedi ◽  
Cristina P. Sison ◽  
Punita Ponda
Keyword(s):  
Retrospective Chart Review ◽  
Clinical History ◽  
Specific Ige ◽  
Exact Test ◽  
Ara H 1 ◽  
Sige Level ◽  
History Of ◽  
Laboratory Procedures ◽  
Ige Mediated ◽  
The Relationship

Background: Serum Peanut-specific-IgE (PN-sIgE) and peanut-component-resolved-diagnostics (CRD) are often ordered simultaneously in the evaluation for peanut allergy. Results often guide the plans for peanut oral challenge. However, the clinical utility of CRD at different total PN-sIgE levels is unclear. A commonly used predefined CRD Ara h2 cutoff value in the literature predicting probability of peanut challenge outcomes is 0.35kUA/L. Objective: To examine the utility of CRD in patients with and without a history of clinical reactivity to peanut (PN). Methods: This was a retrospective chart review of 196 children with PN-sIgE and CRD testing, of which, 98 patients had a clinical history of an IgE-mediated reaction when exposed to PN and 98 did not. The Fisher's exact test was used to assess the relationship between CRD and PN-sIgE at different cutoff levels, McNemar test and Gwet’s approach (AC1 statistic) were used to examine agreement between CRD and PN-sIgE, and logistic regression was used to assess differences in the findings between patients with and without reaction history. Results: Ara h 1, 2, 3, or 9 (ARAH) levels ≤0.35 kUA/L were significantly associated with PN-sIgE levels <2 kUA/L rather than ≥2 kUA/L (p < 0.0001). When the ARAH threshold was increased to 1 kUA/L and 2 kUA/L, these thresholds were still significantly associated with PN-sIgE levels of <2, <5, and <14 kUA/L. These findings were not significantly different in patients with and without a history of clinical reactivity. Conclusion: ARAH values correlated with PN-sIgE. Regardless of clinical history, ARAH levels are unlikely to be below 0.35, 1, or 2 kUA/L if the PN-sIgE level is >2 kUA/L. Thus, if possible, practitioners should consider PN-sIgE rather than automatically ordering CRD with PN-sIgE every time. Laboratory procedures that allow automatically and reflexively adding CRD when the PN-sIgE level is ≤5 kUA/L can be helpful. However, further studies are needed in subjects with challenge-proven PN allergy.

PSVI-8 Meta-regression Analysis to Determine the Relationship Between Growing Pig Body Weight and Variation

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 218-219
Author(s):  
Andres Fernando T Russi ◽  
Mike D Tokach ◽  
Jason C Woodworth ◽  
Joel M DeRouchey ◽  
Robert D Goodband ◽  
...  
Keyword(s):  
Body Weight ◽  
Regression Analysis ◽  
Sample Size ◽  
Polynomial Regression ◽  
Data Sets ◽  
Regression Equations ◽  
Prediction Equations ◽  
Data Set ◽  
Rate Of Increase ◽  
The Relationship

Abstract The swine industry has been constantly evolving to select animals with improved performance traits and to minimize variation in body weight (BW) in order to meet packer specifications. Therefore, understanding variation presents an opportunity for producers to find strategies that could help reduce, manage, or deal with variation of pigs in a barn. A systematic review and meta-analysis was conducted by collecting data from multiple studies and available data sets in order to develop prediction equations for coefficient of variation (CV) and standard deviation (SD) as a function of BW. Information regarding BW variation from 16 papers was recorded to provide approximately 204 data points. Together, these data included 117,268 individually weighed pigs with a sample size that ranged from 104 to 4,108 pigs. A random-effects model with study used as a random effect was developed. Observations were weighted using sample size as an estimate for precision on the analysis, where larger data sets accounted for increased accuracy in the model. Regression equations were developed using the nlme package of R to determine the relationship between BW and its variation. Polynomial regression analysis was conducted separately for each variation measurement. When CV was reported in the data set, SD was calculated and vice versa. The resulting prediction equations were: CV (%) = 20.04 – 0.135 × (BW) + 0.00043 × (BW)2, R2=0.79; SD = 0.41 + 0.150 × (BW) - 0.00041 × (BW)2, R2 = 0.95. These equations suggest that there is evidence for a decreasing quadratic relationship between mean CV of a population and BW of pigs whereby the rate of decrease is smaller as mean pig BW increases from birth to market. Conversely, the rate of increase of SD of a population of pigs is smaller as mean pig BW increases from birth to market.

Railroad Integration and Uneven Development on the European Periphery, 1870–1910

2021 ◽  
Vol 45 (2) ◽  
pp. 261-289
Author(s):  
Eduard J. Alvarez-Palau ◽  
Alfonso Díez-Minguela ◽  
Jordi Martí-Henneberg
Keyword(s):  
Economic Development ◽  
Positive Impact ◽  
Data Set ◽  
Per Capita Gdp ◽  
Catching Up ◽  
Nation States ◽  
Railroad Network ◽  
Per Capita ◽  
European Periphery ◽  
The Relationship

AbstractThis study explores the relationship between railroad integration and regional development on the European periphery between 1870 and 1910, based on a regional data set including 291 spatial units. Railroad integration is proxied by railroad density, while per capita GDP is used as an indicator of economic development. The period under study is of particular relevance as it has been associated with the second wave of railroad construction in Europe and also coincides with the industrialization of most of the continent. Overall, we found that railroads had a significant and positive impact on the growth of per capita GDP across Europe. The magnitude of this relationship appears to be relatively modest, but the results obtained are robust with respect to a number of different specifications. From a geographical perspective, we found that railroads had a significantly greater influence on regions located in countries on the northern periphery of Europe than in other outlying areas. They also helped the economies of these areas to begin the process of catching up with the continent’s industrialized core. In contrast, the regions on the southern periphery showed lower levels of economic growth, with this exacerbating the preexisting divergence in economic development. The expansion of the railroad network in them was unable to homogenize the diffusion of economic development and tended to further benefit the regions that were already industrialized. In most of the cases, the capital effect was magnified, and this contributed to the consolidation of newly created nation-states.

scholarly journals The Effect of Sex and Age on Bone Morphology and Strength in the Metacarpus and Humerus in Beef-Cross-Dairy Cattle

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 694
Author(s):  
Michaela Gibson ◽  
Rebecca Hickson ◽  
Penny Back ◽  
Keren Dittmer ◽  
Nicola Schreurs ◽  
...  
Keyword(s):  
Dairy Cattle ◽  
Quantitative Computed Tomography ◽  
Live Weight ◽  
Peripheral Quantitative Computed Tomography ◽  
Bone Size ◽  
Limited Data ◽  
Bone Morphology ◽  
Relationship Of ◽  
The Relationship ◽  
Effect Of Age

In cattle, limited data have been reported about the relationship between live weight, bone size, and strength and how this relationship can be altered by factors such as sex and age. The aim of this study was to describe the relationship of peripheral quantitative computed tomography (pQCT)-derived parameters of bone strength and morphology with live weight, age and sex in beef-cross-dairy cattle. All animals were weighed the day before slaughter. The metacarpus and humerus were collected at slaughter and scanned at the mid-diaphysis using pQCT. Live weight was the primary explanatory variable for bone size and strength in all cohorts. However, the effect of age was significant, such that magnitude of response to liveweight was less in the 24-month-old cohort. Sex was significant within cohorts in that bulls had a shorter metacarpus than steers and heifers had a shorter metacarpus than steers at age of slaughter.

scholarly journals Extreme geomagnetic activities: a statistical study

2020 ◽  
Vol 72 (1) ◽  
Author(s):  
Ryuho Kataoka
Keyword(s):  
Magnetic Storms ◽  
Magnetic Observatory ◽  
Statistical Distributions ◽  
Limited Data ◽  
Data Set ◽  
Sudden Commencements ◽  
The One ◽  
Log Normal ◽  
Geomagnetic Activities ◽  
Log Normal Distribution

Abstract Statistical distributions are investigated for magnetic storms, sudden commencements (SCs), and substorms to identify the possible amplitude of the one in 100-year and 1000-year events from a limited data set of less than 100 years. The lists of magnetic storms and SCs are provided from Kakioka Magnetic Observatory, while the lists of substorms are obtained from SuperMAG. It is found that majorities of events essentially follow the log-normal distribution, as expected from the random output from a complex system. However, it is uncertain that large-amplitude events follow the same log-normal distributions, and rather follow the power-law distributions. Based on the statistical distributions, the probable amplitudes of the 100-year (1000-year) events can be estimated for magnetic storms, SCs, and substorms as approximately 750 nT (1100 nT), 230 nT (450 nT), and 5000 nT (6200 nT), respectively. The possible origin to cause the statistical distributions is also discussed, consulting the other space weather phenomena such as solar flares, coronal mass ejections, and solar energetic particles.

scholarly journals RESTING HEART RATE MODERATES THE RELATIONSHIP BETWEEN NEUROPSYCHIATRIC SYMPTOMS, MCI, AND ALZHEIMER’S DISEASE

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S641-S641
Author(s):  
Shanna L Burke
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Heart Rate ◽  
Relative Risk ◽  
Neuropsychiatric Symptoms ◽  
Cognitive Status ◽  
Resting Heart Rate ◽  
Data Set ◽  
Increased Risk ◽  
The Relationship

Abstract Little is known about how resting heart rate moderates the relationship between neuropsychiatric symptoms and cognitive status. This study examined the relative risk of NPS on increasingly severe cognitive statuses and examined the extent to which resting heart rate moderates this relationship. A secondary analysis of the National Alzheimer’s Coordinating Center Uniform Data Set was undertaken, using observations from participants with normal cognition at baseline (13,470). The relative risk of diagnosis with a more severe cognitive status at a future visit was examined using log-binomial regression for each neuropsychiatric symptom. The moderating effect of resting heart rate among those who are later diagnosed with mild cognitive impairment (MCI) or Alzheimer’s disease (AD) was assessed. Delusions, hallucinations, agitation, depression, anxiety, elation, apathy, disinhibition, irritability, motor disturbance, nighttime behaviors, and appetite disturbance were all significantly associated (p&lt;.001) with an increased risk of AD, and a reduced risk of MCI. Resting heart rate increased the risk of AD but reduced the relative risk of MCI. Depression significantly interacted with resting heart rate to increase the relative risk of MCI (RR: 1.07 (95% CI: 1.00-1.01), p&lt;.001), but not AD. Neuropsychiatric symptoms increase the relative risk of AD but not MCI, which may mean that the deleterious effect of NPS is delayed until later and more severe stages of the disease course. Resting heart rate increases the relative risk of MCI among those with depression. Practitioners considering early intervention in neuropsychiatric symptomology may consider the downstream benefits of treatment considering the long-term effects of NPS.

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