Assessing the impact of antiemetic guideline compliance on prevention of chemotherapy-induced nausea and vomiting (CINV): Results of the Nausea/Emesis Registry in Oncology (NERO).

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 12083-12083
Author(s):  
Matti S. Aapro ◽  
Marika Chrápavá ◽  
Razvan-Ovidiu D. Curca ◽  
Laurentia Gales ◽  
Alexandru Calim Grigorescu ◽  
...  
Keyword(s):  
Complete Response ◽  
Emetogenic Chemotherapy ◽  
Absolute Difference ◽  
Test Results ◽  
Efficacy Evaluation ◽  
Chi Square ◽  
Recommended Treatment ◽  
Antiemetic Guidelines ◽  
Chi Square Test ◽  
The Impact

12083 Background: Evidence-based antiemetic guidelines offer predominantly consistent recommendations for CINV prophylaxis. However, studies and surveys suggest that adherence to these recommendations is suboptimal. We explored potential inconsistencies between clinical practice and guideline-recommended treatment with a registry evaluating the effect of guideline-consistent CINV prophylaxis (GCCP) on patient outcomes. Methods: This was a prospective, non-interventional, observational, multicenter study designed to assess overall (0-120 h) complete response (CR: no emesis/no rescue use) rates in patients who received GCCP or guideline inconsistent CINV prophylaxis (GICP) using diaries for 5 days following chemotherapy. Cycle 1 results are presented in patients who received either 1) anthracycline/cyclosphosphamide (AC) highly emetogenic chemotherapy (HEC), non-AC HEC or carboplatin, with GCCP for all these groups consisting of prophylaxis with an NK1 receptor antagonist (RA), 5-HT3RA, and dexamethasone (DEX) prior to chemotherapy or 2) moderately emetogenic chemotherapy (MEC), with GCCP consisting of a 5-HT3RA and DEX prior to chemotherapy as per MASCC 2016 guidelines. CR rates for cohorts deemed to be GCCP and GICP were compared using a chi-square test. Results: A total of 1,089 patients were part of the cycle 1 efficacy evaluation. Overall GCCP was 23% for all patients. CR rates were significantly higher in patients receiving GCCP versus GICP (Table). Conclusions: Consistent with prior studies, GCCP was very low. The primary endpoint of the study was achieved as there was a significant benefit of almost 10% improved prevention of CINV when administering GCCP. As per MASCC/ESMO guidelines such an absolute difference should be practice changing. Comprehensive multifaceted strategies are needed to achieve better adherence to antiemetic guidelines. [Table: see text]

Single-day regimen of palonosetron (PALO) and dexamethasone (DEX) for the prevention of emesis associated with moderately emetogenic chemotherapy (MEC): Subgroup analysis from a randomized phase III trial

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 9620-9620
Author(s):  
L. Celio ◽  
E. Bajetta ◽  
A. Denaro ◽  
E. Bichisao ◽  
S. Frustaci ◽  
...  
Keyword(s):  
Complete Response ◽  
Phase Iii ◽  
Test Results ◽  
Effective Protection ◽  
Chi Square ◽  
Phase Iii Trial ◽  
Protocol Population ◽  
Delayed Nausea ◽  
Chi Square Test ◽  
To Receive

9620 Background: We have recently shown non-inferiority in preventing acute and delayed nausea and vomiting associated with MEC between the PALO plus 1-day DEX and PALO plus 3-day DEX regimens. Planned analysis stratified by type of chemotherapy (anthracycline + cyclophosphamide [AC] group or patients receiving at least one moderately emetogenic agent according to modified Hesketh classification) has been performed. Methods: A total of 332 chemo-naïve patients with solid tumors were randomized to receive a single IV dose of PALO 0.25 mg plus DEX 8 mg IV on day 1 of chemotherapy (arm A; n=166) or the same regimen followed by DEX 8 mg orally on days 2 and 3 (arm B; n=166). Endpoints included complete response rates (CR: no emetic episodes [EE], no rescue antiemetics; primary endpoint) and proportion of patients with no EE throughout the 5 days after the first cycle of chemotherapy. Subgroups were analyzed by two-sided chi-square test. Results: Per-protocol population included 324 patients (65% women; median age 57.5 years); 35% received AC regimens, and 65% other MEC regimens. There were no significant differences between arms in CR rates according to the type of chemotherapy: 1) CR rates on AC regimens (arm A, 55.8% versus arm B, 60.7%; p=0.599); and 2) CR rates on other MEC regimens (arm A, 68.5% versus arm B, 72%; p=0.576). No significant differences between arms were also observed in the rates of patients with no EE: 1) emesis-free patients on AC regimens (arm A, 78.8% versus arm B, 73.8%; p=0.528); 2) emesis-free patients on other MEC regimens (arm A, 83.8% versus arm B, 90%; p=0.184); 3) nausea-free patients on AC regimens (arm A, 38.5% versus arm B, 44.3%; p=0.533); and 4) nausea-free patients on other MEC regimens (arm A, 58.6% versus arm B, 64%; p=0.418). Conclusions: The single-day regimen of PALO and DEX can provide effective protection against acute and delayed emesis from AC- and MEC-based regimens while avoiding to unnecessarily prolong treatment with DEX. No significant financial relationships to disclose.

scholarly journals Profile of nursing graduates: competencies and professional insertion

2019 ◽  
Vol 27 ◽  
Author(s):  
Amanda Conrado Silva Barbosa ◽  
Franciane Silva Luiz ◽  
Denise Barbosa de Castro Friedrich ◽  
Vilanice Alves de Araújo Püschel ◽  
Beatriz Francisco Farah ◽  
...  
Keyword(s):  
Electronic Mail ◽  
Educational Institution ◽  
Nursing Graduates ◽  
Test Results ◽  
Chi Square ◽  
Public College ◽  
Validated Questionnaire ◽  
Insertion Method ◽  
Chi Square Test ◽  
The Impact

Objective: evaluate the profile of the graduates of Nursing a public college from the perception of skills developed during graduation and the process of professional insertion. Method: quantitative, exploratory and descriptive study. The sample was composed of 216 graduates. The data was collected by a validated questionnaire and sent to a population of 470 egresses via electronic mail. For the analysis of the data, frequencies, mean and standard deviation were applied and, for the correlation, the chi-square test. Results: the majority of the participants were female (88%) and the mean age was 29.62 years. The majority (65%) had an employment relationship, 14% worked in a single institution and 48% started working six months after graduation. Regarding the form of work, 56% work in care, with an average of 4.5 minimum wages and a weekly workload between 37 and 44 hours. The majority reported competence acquisition to practice the profession, assisting the patient in his integrality with ethics and applying technical and scientific concepts in care. Conclusion: the study made it possible to describe the singularities of nurses’ education, their insertion in the world of work and the impact on the educational institution, as well as the presentation of specific competences from the perspective of the graduates themselves.

FAKTOR PERSONAL YANG BERHUBUNGAN DENGAN KOMITMEN ORGANISASI PERAWAT RSUD EMBUNG FATIMAH BATAM

2020 ◽  
Vol 5 (3) ◽  
pp. 875
Author(s):  
Asfri Sri Rahmadeni
Keyword(s):  
Organizational Commitment ◽  
Turnover Rate ◽  
Sampling Technique ◽  
Hospital Nurses ◽  
Test Results ◽  
Personal Factors ◽  
High Turnover ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

<p class="Normal1"><em>Commitment is the attitude or behavior of likes or dislikes shown by someone against the organization at work. Indonesia is recorded as a nurse who has a low organizational commitment (76%) so it harms services. This phenomenon in the hospital can be seen from the indicator of the high turnover rate of nurses which reaches 30.9% which exceeds the standard &lt;5%. Many factors affect organizational commitment. The purpose of this study was to analyze the Personal Factors Associated with Organizational Commitment of Hospital Nurses. This study is a cross-sectional analytic study and purposive sampling technique with a sample of 59 nurses. Chi-Square test results obtained personal factors that have a relationship with organizational commitment Nurse Hospital is age with p = 0,000 and education with p = 0,000, personal factors not related to organizational commitment are gender p = 1,053 and years of service with p = 1,147. Hospitals should conduct research/surveys on Organizational Commitment periodically as an evaluation material in the context of the organization's development and development in the future</em>.</p>

HUBUNGAN UMUR DAN PARITAS DENGAN PEMILIHAN ALAT KONTRASEPSI METODE OPERASI WANITA (MOW) DI POLIKLINIK KEBIDANAN RS BHAYANGKARA PALEMBANG TAHUN 2012

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Y. Widyastuti Y. Widyastuti
Keyword(s):  
Family Planning ◽  
Medical Records ◽  
Test Results ◽  
Family Planning Services ◽  
Chi Square ◽  
Cross Sectional ◽  
Planning Methods ◽  
Chi Square Test ◽  
Family Planning Methods ◽  
Selection Of

  ABSTRACT [In advanced countries the number of permanent contraception option ( kontap ) approximately 10 % of all national family planning methods , while in Indonesia reached approximately 5.7 % . Based on data obtained from medical records Bhayangkara Hospital Palembang in 2010 the number of achievement when seen from the percentage of contraceptive use is only 9.10 % The purpose of this study is known age and parity relationship with the selection of contraceptive methods Surgery Women ( MOW ) in Palembang RS.Bhayangkara obstetrics clinic in 2012 . This study uses the analytic survey with cross sectional approach . The population in this study were women who become new acceptors were recorded in medical records at the hospital . Palembang Bhayangkara Hospitals January 1, 2012 to December 31 in 2012 . The sample in this study is part of a whole number of new acceptors ( either using contraception methods MOW and other family planning methods ) were registered in the hospital . Palembang Police Hospitals of January 1, 2012 to December 31 years of data 2012.Analisa univariate and bivariate statistical Chi - Square test with significance level α = 0.05 . The results showed there were 80 respondents ( 46.3 % ) who became MOW contraceptive acceptors , acceptors who have old age by 45 respondents ( 56.3 % ) and who has a young age by 35 respondents ( 43.8 % ) . acceptors which have high parity were 44 respondents ( 55 % ) who had low parity and a total of 36 respondents ( 45 % ) . From the results of Chi-square test value obtained ρ = 0.00 is smaller than α = 0.05 . There is a significant correlation between age and the selection of MOW Chi square test results obtained ρ value = 0.00 and there was a significant association between parity with the election MOW Chi square test results obtained ρ value = 0 , . From these results , it is expected to power health, especially family planning services at the hospital . Palembang Police Hospitals in order to improve the quality of family planning services in an effective, efficient , and safe are considered particularly suitable for users of contraception OperatingMethodWomen(MOW).                                      ABSTRAK Di negara sudah maju jumlah pilihan kontrasepsi mantap (kontap) sekitar 10% dari semua metode KB nasional, sedangkan di Indonesia baru mencapai sekitar 5,7 %. Berdasarkan data yang diperoleh dari Rekam medik  Rumah Sakit Bhayangkara Palembang tahun 2010 Jumlah pencapain tersebut jika dilihat dari persentasi penggunaan kontrasepsi MOW hanya  9,10% Tujuan penelitian ini adalah diketahuinya hubungan umur dan paritas dengan pemilihan alat kontrasepsi Metode Operasi Wanita (MOW) di poliklinik kebidanan RS.Bhayangkara Palembang Tahun 2012. Penelitian ini menggunakan metode survey analitik dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah wanita yang menjadi akseptor KB Baru yang tercatat di rekam medik  di RS. Bhayangkara Palembang tanggal 1 januari 2012 sampai dengan 31 Desember  tahun 2012. Sampel dalam penelitian ini adalah sebagian dari seluruh jumlah akseptor KB Baru (baik yang menggunakan alat kontrasepsi Metode MOW maupun Metode KB lain) yang teregister di RS. Bhayangkara Palembang dari tanggal 1 januari 2012 sampai dengan 31 Desember  tahun 2012.Analisa data dilakukan secara univariat dan bivariat dengan uji statistik Chi-Square dengan tingkat kemaknaan α = 0,05. Hasil penelitian menunjukkan dari 80 responden terdapat (46,3%) yang menjadi akseptor kontrasepsi MOW, akseptor yang memiliki umur tua sebanyak 45 responden (56,3%) dan yang memiliki  umur muda sebanyak 35 responden (43,8%). akseptor yang memiliki paritas tinggi sebanyak 44 responden  (55%) dan yang memiliki  paritas rendah sebanyak 36 responden (45%). Dari hasil uji Chi square didapatkan ρ value = 0,00 lebih kecil dari α = 0,05. Ada hubungan yang bermakna antara umur dengan pemilihan MOW dari hasil uji Chi square didapatkan ρ value = 0,00 dan ada hubungan yang bermakna antara paritas dengan pemilihan MOW hasil uji Chi square didapatkan ρ value = 0,.Dari hasil penelitian ini, diharapkan kepada tenaga kesehatan khususnya pelayanan KB  di RS. Bhayangkara Palembang  agar dapat meningkatkan kualitas pelayanan KB secara efektif, efisien, dan aman yang dianggap cocok bagi penggunanya khususnya mengenai kontrasepsi Metode Operasi Wanita (MOW).    

scholarly journals The impact of COVID-19 related national lockdown on ophthalmic emergency in Italy: A multicenter study

2021 ◽  
pp. 112067212110280
Author(s):  
Maria L Salvetat ◽  
Carlo Salati ◽  
Patrizia Busatto ◽  
Marco Zeppieri
Keyword(s):  
Gender Bias ◽  
Tertiary Care ◽  
Lower Number ◽  
Electronic Records ◽  
Chi Square ◽  
Efficient Access ◽  
Chi Square Test ◽  
Unpaired Student ◽  
The Impact ◽  
Wet Amd

Purpose: To assess ocular pathologies admitted to Italian Emergency Eye Departments (EEDs) during the COVID-19 pandemic national lockdown in 2020 in comparison with the same period in 2019. Methods: Electronic records of all patients presenting at EEDs of two tertiary-care Eye Centers during the COVID-19 national lockdown in Italy (March 10–May 3, 2020) were compared with the equivalent period in 2019. Main outcomes were patient age, gender, and diagnoses. Statistical analysis included unpaired Student t-tests, Poisson regression, and chi-square test. Results: Overall EED visits significantly decreased by 54.1% during the 2020 lockdown compared to 2019 (851 vs 1854, p < 0.001). During lockdown, patients showed comparable mean age (52.8 years in 2020 vs 53.3 years in 2019, p = 0.52) and significant male gender bias (61.1% in 2020 vs 55.8% in 2019, p < 0.0001). The most frequent pathologies were eye inflammations, trauma-related incidents, and spontaneous acute vitreous detachment. Patients with inflammation, headache/hemicrania, and spontaneous subconjunctival hemorrhages were significantly less, whereas those with trauma-related diagnoses were significantly higher during the lockdown as compared with 2019 ( p < 0.05). The proportion of non-urgent visits decreased from 17% in 2019 to 8% in 2020 ( p < 0.001). Conclusions: During the 2020 lockdown, there was a significant reduction of accesses to EED, especially for non-urgent pathologies. Potentially visual function threatening conditions, such as trauma-related pathologies, retinal detachment or ruptures, and wet AMD, showed lower number of cases but higher or stable proportion relative to the total caseload, suggesting a correct and efficient access to ophthalmic health care during the pandemic period.

KORELASI ANTARA HASIL TES MIKROSKOPIS DENGAN TES CEPAT MOLEKULER PADA PASIEN TUBERCULOSIS DAN MULTIDRUG RESISTEN TUBERCULOSIS DI RSUD Dr. H CHASAN BOESOIRIE TERNATE

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Andi Sitti Nur Afiah ◽  
Fera The
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Disease ◽  
Program Analysis ◽  
Rifampicin Resistance ◽  
Test Results ◽  
Chi Square ◽  
Significant Difference ◽  
Mdr Tb ◽  
Chi Square Test ◽  
Analytical Research

Tuberculosis (TB) is a pulmonary disease caused by Mycobacterium tuberculosis. Globally in 2018 theestimated number of people affected by TB was estimated at 10.0 million population and 484,000 cases ofmultidrug-resistant TB (MDR-TB). This study aims to determine the correlation between microscopic testresults with RMT on TB and MDR-TB patients at RSUD Dr. H Chasan Boesoirie Ternate. This type of researchis analytical research using a retrospective approach. The sample in this study were patients with suspected TBand MDR-TB who had performed microscopic tests and TCM in February – April at 2020 in the ClinicalPathology Laboratory of RSUD Dr. H Chasan Boesoirie Ternate, who met the inclusion and exclusion criteria.Data were analyzed using the SPSS program analysis was carried out in stages, namely by univariate andbivariate using chi-square test. From 100 samples, the results of RMT examination with TB suspects were 30rifampicin sensitive samples with 2 rifampicin resistance and 5 rifampin sensitive samples for TB MDR-TBsuspects RMT examination results. Chi-square test results obtained the value of p = 000 (p <0.05). There is stilla significant difference between the microscopic test results with RMT in TB and MDR-TB suspect patients atRSUD Dr. H Chasan Boesoirie Ternate.

Evaluation of the effect of cetrimide with edta on Microhardness and surface changes in root dentin – An invitro study

2019 ◽  
Vol 11 (1) ◽  
pp. 3-11
Author(s):  
Dr. Swarooparanil Patil ◽  
Dr. B.S. Keshava Prasad
Keyword(s):  
Surface Erosion ◽  
Distilled Water ◽  
Test Results ◽  
Chi Square ◽  
Chi Square Test ◽  
Root Dentin ◽  
Group 3 ◽  
Post Hoc ◽  
Hardness Values ◽  
Surface Changes

The aim of the study was to evaluate the effect of different concentrations of cetrimide with or without EDTA solution on the microhardness and surface changes in root dentin. Single rooted human mandibular premolar teeth were decoronated and sectioned longitudinally. The root segments were horizontally embedded in autopolymerizing resin. These specimens were randomly divided into 6 experimental groups according to the irrigating solution used. The irrigating solutions used were 5% EDTA, 5%EDTA + 0.25% Cetrimide, 5%EDTA + 0.50% Cetrimide, 0.25% Cetrimide, 0.50% Cetrimide and distilled water. Each group was further divided into two subgroups. First subgroup specimens were employed for microhardness testing using vicker’s indenter. Second subgroup specimens were used to evaluate the surface changes of root dentin under stereomicroscope. Comparison of the mean microhardness of test groups was done using ANOVA followed by post hoc Tukey’s test. Pre- and post- treatment hardness values were compared using student paired t test. The data obtained from surface erosion scoring was subjected to statistical analysis using Chi square test. Results of this study showed significant reduction in the microhardness of dentin for all the groups except for the distilled water (p<0.001). The greatest reduction in dentin microhardness was observed with Group-3 (5% EDTA + 0.50% CTR). Specimens in 5% EDTA group showed greater erosion than other groups. Within the limitations of this study it was concluded that all the tested irrigating solutions reduced the microhardness of root dentin except distilled water. Maximum reduction in microhardness was observed with addition of 0.50% cetrimide to EDTA. EDTA increased the surface roughness of root dentin irrespective of cetrimide association. Use of cetrimide at concentrations higher than 0.25% would be detrimental to the microhardness of dentin.

Relationship between new farming practices and chemical use and the consumption of giant cricket (Brachytrupes membranaceus Drury, 1770)

2018 ◽  
Vol 4 (4) ◽  
pp. 295-300 ◽  
Author(s):  
F.O. Miantsia ◽  
F. Meutchieye ◽  
S. Niassy
Keyword(s):  
Food Source ◽  
Farming Practices ◽  
Smallholder Farming ◽  
Chi Square ◽  
Pesticides Residues ◽  
Intensive Use ◽  
Chi Square Test ◽  
Dependence Relationship ◽  
The Impact ◽  
Persistent Pesticides

The current work is aimed at generating information on giant crickets and the impact of commonly used pesticides on the natural population of these crickets. Data was collected based on interviews and complemented with field observations. Out of 319 respondents surveyed, 290 were aware of the use of the giant cricket as a food source, and 161 were active consumers. Regarding the availability of the giant cricket, respondents reported that the crickets’ populations were diminishing because of farming practices. About 219 persons reported that commonly used herbicides harm giant crickets at different stages. This could be attributed to the scarcity of this species, as mentioned by 233 respondents. The results showed that 130 respondents were engaged in gathering giant crickets for consumption. This insect gathering is related to soil tilling. Chi-square test showed a significant dependence relationship between herbicides use and cricket scarcity. Although less than a majority (129) of respondents are making regular use of persistent pesticides (herbicides), it has been observed that intensive use of pesticides could become a popular practice in smallholder farming categories. This paper thus suggests the need for training and surveillance concerning the trade of pesticides in the region and proposes further investigations into pesticides residues or traces in collected giant crickets consumed in the study site and in all areas with similar conditions.

scholarly journals Perceived Level of Burden of Care and Its Association with Socio-Demographic Profile of Patients with Schizophrenia and Their Caregivers

2017 ◽  
Vol 4 (2) ◽  
Author(s):  
Dr. Shubhangi S. Dere ◽  
Dr. Bindoo S. Jadhav ◽  
Dr. Dipak C. Patil ◽  
Dr. Hemangi S. Dhavale
Keyword(s):  
Mental Health Problems ◽  
Clinical Syndrome ◽  
Older Age ◽  
Test Results ◽  
Chi Square ◽  
Demographic Profile ◽  
Perceived Burden ◽  
Chi Square Test ◽  
Male Patients ◽  
Spss Software

Background: Schizophrenia is a clinical syndrome of variable, but profoundly disruptive, psychopathology that involves cognition, emotion, perception and behaviour. Caregiver burden refers to negative response that occurs when the caregiver assumes an unpaid and unanticipated responsibility for the person with disabling mental health problems. The burden varies with socio-demographic parameters of patients and caregivers. Aims & Objectives: To study socio demographic details of schizophrenia patients and caregivers. To assess perceived level of burden in caregivers and it’s association with socio demographic profile of patients and caregivers. Materials & Methods: Ethics committee approval and informed consent was taken. 100 consecutive patients with their primary caregiver, presenting to psychiatry OPD of general hospital, satisfying inclusion criteria, were included in the study. Socio-demographic details of caregiver were collected using semi-structured proforma. Caregiver’s perceived burden was assessed with Burden Assessment Schedule. Data thus obtained, was pooled & analyzed by using SPSS software, descriptive statistics, mean, percentage, Chi- Square test. Results: The sample consisted of 52 female & 48 male patients. Prevalence of burden in caregivers was found to be 52%. The perceived burden was found to be high in caregivers of female patients, patients of older age, less educated, single, and unemployed patients. Majority of caregivers were female and of older age. The burden perceived was found to be significantly high in female caregivers, especially mother.

scholarly journals Suicide, the main cause of referral of patients from a general hospital for psychiatric evaluation

2021 ◽  
Vol 5 (1) ◽  
pp. 018-021
Author(s):  
Gómez Elena ◽  
Guzmán Marianela ◽  
Torres Oriol Yuguero
Keyword(s):  
Suicide Attempts ◽  
Hospital Admissions ◽  
Cross Sectional Study ◽  
Psychiatric Evaluation ◽  
Outpatient Basis ◽  
Test Results ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test ◽  
Life Threatening

Introduction: Psychiatric emergencies constitute between 1% - 10% of general emergencies in Spain, of which a quarter will end up being hospital admissions. There is little literature on patients who are referred from general to specialized hospitals. Methods: Cross-Sectional study of all the patients referred in 2018. Sociodemographic variables and clinical variables, such as diagnosis and discharge destination, were analyzed. An analysis was performed by comparing means with the Chi Square test. Results: 433 derived emergencies were analyzed. Most of the patients were women. The main reason for derivation were suicide attempts. Of those patients, 40% required hospitalizations. More than 50% of the derived emergencies were referred to the home and followed up on an outpatient basis. Conclusion: Most derived emergencies are referred to the home after evaluation. This implies that most are not life-threatening and that with adequate tools for evaluating suicide risk, we could avoid transfers and improve the resolution of these cases.

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