CLINICAL CASE: CHRONIC BRONCHITIS AS A RISK FACTOR FOR UNCONTROLLED BRONCHIAL ASTHMA

2020 ◽  
Vol 6 (1) ◽  
pp. 43-47
Author(s):  
M. Gaysaev ◽  
E. Gancgorn
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Chronic Bronchitis ◽  
Bronchial Asthma ◽  
Clinical Case ◽  
Acute Stage

M.O. GAISAEV, E.V. GANTSGORN A clinical case of a 55-year-old patient with persistent moderate uncontrolled bronchial asthma and acute stage of chronic bronchitis is described. In the aspect of etiopathogenetic features and modern approaches to the treatment of this pathology, the tactics of the pharmacotherapy performed are analyzed on the example of this patient. The presented clinical case demonstrates the feasibility of a differentiated approach to the treatment of patients with chronic bronchitis as one of the important risk factors for the progression of bronchial asthma.

scholarly journals Krūtinės ir kitų anatominių sričių sužalojimų gydymo rezultatų įvertinimas

2010 ◽  
Vol 8 (3) ◽  
pp. 0-0
Author(s):  
Paulius Gradauskas ◽  
Stanislovas Maknavičius
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Bronchial Asthma ◽  
Univariate Analysis ◽  
Morbidity And Mortality ◽  
Thoracic Injury ◽  
Morbidity Rate ◽  
Thoracic Injuries ◽  
Polytrauma Patients ◽  
Independent Risk Factors

Paulius Gradauskas, Stanislovas MaknavičiusVilniaus greitosios pagalbos universitetinės ligoninės Krūtinės chirurgijos skyrius, Šiltnamių g. 29, LT-04130 Vilnius El. paštas: [email protected] Įvadas/tikslas: Didelės kinetinės energijos traumas patyrusiems žmonėms neretai yra sužalojami ir krūtinės ląstos organai. Gydant šiuos ligonius dažnai pasitaiko su kvėpavimo sistema susijusių komplikacijų. Darbo tikslas – nustatyti veiksnius, darančius įtaką dauginę traumą patyrusių pacientų gydymo komplikacijų dažniui ir mirštamumui. Ligoniai ir metodai: Retrospektyviai analizuoti 257 ligonių ligos istorijų duomenys. Vertinant vieno ar kelių veiksnių įtaką komplikacijų atsiradimo ar mirties tikimybei, naudota logistinė regresija. Rezultatai: Veiksniais, galinčiais daryti įtaką komplikacijų vystymuisi ar mirštamumui, buvo įvardyti: pacientų amžius; lytis; suminis sužalojimo sunkumas; krūtinės sužalojimo sunkumas pagal AIS; chirurginės intervencijos atlikimo laikas; chirurginės intervencijos apimtis; lėtinės obstrukcinės plaučių ligos arba bronchinės astmos anamnezė, koronarinės širdies ligos anamnezė, cukrinis diabetas, šokas stacionarizavimo metu, hemotransfuzijos poreikis. Nepriklausomu komplikacijų vystimosi veiksniu buvo nustatytas suminis sužalojimo sunkumas (ISS balas). įtakojančių Mirštamumo, veiksnių nenustatyta. Išvados: Iš sužeistųjų, patyrusių krūtinės ir kitų anatominių sričių uždarą traumą, komplikacijų radosi 39,3 %, o mirštamumas siekė 12,5 %. Suminis sužalojimo sunkumas (ISS balas) buvo nepriklausomas komplikacijų vystymosi dažnio veiksnys. Reikšminiai žodžiai: krūtinės sužalojimas, dauginė trauma, ūminių sužalojimų sunkumas, mirštamumas. Assessment of management results of polytraumas, involving the thorax and other anatomical parts Paulius Gradauskas, Stanislovas MaknavičiusVilnius University Emergency Hospital Thoracic Surgery Unit, Šiltnamių str. 29, LT-04130 Vilnius, LithuaniaE-mail: [email protected] Background / oObjective: Thoracic trauma is still one of the leading causes of morbidity and mortality in different countries. The aim of the study was to analyse the results of the management of polytrauma patients suffering from thoracic injuries. Patients and methods: In this retrospective study, the medical charts of 257 patients were reviewed. The risk factors influencing morbidity and mortality were identified. Results: Gender, age, ISS score, AIS score of the thoracic injury, time and invasivness of the surgery, presence of COPD or bronchial asthma, presence of coronary heart disease, diabetes, need of hemotransfusion, and shock at the arrival were analysed as the risk factors. ISS score, need of hemotransfusion and presence of COPD or bronchial asthma were found to be the prognostic factors of morbidity in the univariate analysis. Only the ISS score was found to be an independent risk factor at the multivariate analysis. No risk factors for mortality were identified. Conclusions: The overall morbidity rate was 39.3 %, and the mortality was 12.5 %. The only risk factor independently influencing morbidity was found to be the ISS score. No independent risk factors for mortality were identified. Keywords: thoracic injury, multiple trauma, ISS, mortality.

scholarly journals Clinical features of chronic bronchitis and genetic risk factors for the development of chronic obstructive pulmonary disease in adolescent smokers

2019 ◽  
Vol 4 ◽  
Author(s):  
Svitlana Ilchenko ◽  
Anastasiia Fialkovska
Keyword(s):  
Risk Factors ◽  
Chronic Obstructive Pulmonary Disease ◽  
Risk Factor ◽  
Chronic Bronchitis ◽  
Pulmonary Disease ◽  
Genetic Risk ◽  
Chronic Obstructive ◽  
Multifactorial Disease ◽  
Obstructive Pulmonary Disease ◽  
Adolescent Smokers

Chronic bronchitis (CB) is a multifactorial disease with complex internal and external etiological risk factors. One of the main risk factors for the development of CB in adolescence and chronic obstructive pulmonary disease (COPD) in adults is tobacco smoking. It is also known that an important internal risk factor for the development of СB is a genetic predisposition

Hemmkörperentwicklung bei Hämophilie-Patienten nach Präparate wechsel

2012 ◽  
Vol 32 (S 01) ◽  
pp. S39-S42 ◽  
Author(s):  
S. Kocher ◽  
G. Asmelash ◽  
V. Makki ◽  
S. Müller ◽  
S. Krekeler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Observational Study ◽  
Retrospective Observational Study ◽  
Frequent Change ◽  
Patient Age ◽  
Treatment Regimens ◽  
Patient Âgé ◽  
The Relationship ◽  
Observation Period

SummaryThe retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. Results: During the observation period of 12 months none of the patients developed an inhibitor, which was temporally associated with a change of FVIII products. A frequent change of FVIII products didn’t lead to an increase in inhibitor risk. The change between plasmatic and recombinant preparations could not be confirmed as a risk factor. Furthermore, no correlation between treatment regimens, severity, patient age and comorbidities of the patients could be found.

Risk Factors of Collateralized Loan Obligations and Corporate Bonds

2020 ◽  
Vol 32 (6) ◽  
pp. 347-355
Author(s):  
Mark Wahrenburg ◽  
Andreas Barth ◽  
Mohammad Izadi ◽  
Anas Rahhal
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Asset Pricing ◽  
Systemic Risk ◽  
Corporate Bonds ◽  
Risk Exposure ◽  
Expected Returns ◽  
Yield Spreads ◽  
Pricing Factors ◽  
Return Difference

AbstractStructured products like collateralized loan obligations (CLOs) tend to offer significantly higher yield spreads than corporate bonds (CBs) with the same rating. At the same time, empirical evidence does not indicate that this higher yield is reduced by higher default losses of CLOs. The evidence thus suggests that CLOs offer higher expected returns compared to CB with similar credit risk. This study aims to analyze whether this return difference is captured by asset pricing factors. We show that market risk is the predominant risk factor for both CBs and CLOs. CLO investors, however, additionally demand a premium for their risk exposure towards systemic risk. This premium is inversely related to the rating class of the CLO.

MYCOPLASMA AND CHLAMYDIA AS ETHIOLOGICAL FACTORS OF BRONCHIAL ASTHMA IN TERMS OF ETHNOGENESIS

2013 ◽  
Vol 68 (7) ◽  
pp. 57-60
Author(s):  
O. A. Sharavii ◽  
S. V. Smirnova
Keyword(s):  
Immune Response ◽  
Chlamydia Trachomatis ◽  
Blood Serum ◽  
Bronchial Asthma ◽  
Mycoplasma Hominis ◽  
Acute Stage ◽  
Control Group ◽  
Clinical Markers ◽  
Chlamydophila Psittaci ◽  
Asthma Patients

 Aim. The study of the prevalence and clinical peculiarities of Mycoplasmosis and Chlamydiosis in patients with different pathogenic forms of bronchial asthma (BA) taking into account ethnicity of a patient. Subjects and Methods. The research covered 239 subjects – both the Europeoids and the Mongoloids in the city of Krasnoyarsk and the town of Kyzyl, all of them being BA patients of different stages, including acute stage and practically healthy. We had determined antigens Mycoplasma pneumoniae, Mycoplasma hominis, Chlamydophila pneumoniae, Chlamydophila psittaci and Chlamydia trachomatis in smears of mucosa of pharynx and antibodies to these antigens in peripheral blood serum. Results.  We found high frequency of Mycoplasmosis and Chlamydiosis in the inhabitants of Eastern Siberia, BA patients with different pathogenic forms as compared to control group. We had determined ethnic peculiarities of specific immune response: IgM to М. pneumoniae was revealed in the Europoids more frequently than in the Mongoloids, but IgM to С. pneumoniae and to C. trachomatis, C. trachomatis antigens had been revealed more often in the Mongoloids than in the Europoids. We accepted as clinical equivalents of Mycoplasmosis and Chlamydiosis diagnostics the following signs: temperature around 37C (subfebrile temperature), non-intensive but stable coughing with scanty mucous and muco-purulent sputum, dyspnea of mixed character. Conclusions. Mycoplasma and Chlamydia are meaningful etiologic factors of bronchial asthma. We have found the peculiarities of immune response depending on ethnicity of a patient (ethnic belonging). Clinical markers of Mycoplasmosis and Chlamydiosis should be taken into account in bronchial asthma in order to provide diagnostics timely as well as eradication of infection agents. Because of insufficient knowledge of problem of bronchial asthma related to contamination with Мycoplasma and Chlamydia we put the goal to study the frequency of Mycoplasmosis and Chlamydiosis occurrence in bronchial asthma patients and determine the characteristics clinical course of diseases. We defined antigens Мycoplasma pneumoniae, Мycoplasma hominis, Chlamydophila pneumoniaе, Chlamydophila psittaci, Chlamydia trachomatis in smears of oropharynx mucosa and antibodies to them in blood serum. 

Clinical case of a comorbid patient with arterial hypertension

2020 ◽  
pp. 31-39
Author(s):  
Ella Polozova ◽  
Vsevolod Skvortsov ◽  
Olga Radaykina ◽  
Mariya Narvatkina ◽  
Anastasiya Seskina ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Arterial Hypertension ◽  
Clinical Picture ◽  
Clinical Case ◽  
Diagnosis And Treatment ◽  
The Moment

The widespread prevalence of comorbid pathology determines the relevance of this problem. Comorbid pathology due to the interaction of diseases, drug pathomorphism, age characteristics of the patient, significantly changes clinical picture and course of the main nosology, affects severity of complications and their nature, significantly affects quality of life and prognosis of patients. Diagnosis and treatment of many diseases is complicated in the conditions of comorbidity. The article presents a clinical case of a comorbid patient with arterial hypertension from the moment of exposure to risk factors and ending with the formation of many concomitant diseases, as an example of trans-nosological comorbidity.

Cardiovascular Risk in Perimenopausal Women

2019 ◽  
Vol 17 (6) ◽  
pp. 591-594 ◽  
Author(s):  
John C. Stevenson ◽  
Sophia Tsiligiannis ◽  
Nick Panay
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Ovarian Function ◽  
Density Lipoprotein ◽  
Premenopausal Women ◽  
Therapeutic Interventions ◽  
Additional Risk Factor ◽  
Chd Risk ◽  
Perimenopausal Women ◽  
Chd Risk Factors

Cardiovascular disease, and particularly coronary heart disease (CHD), has a low incidence in premenopausal women. Loss of ovarian hormones during the perimenopause and menopause leads to a sharp increase in incidence. Although most CHD risk factors are common to both men and women, the menopause is a unique additional risk factor for women. Sex steroids have profound effects on many CHD risk factors. Their loss leads to adverse changes in lipids and lipoproteins, with increases being seen in low density lipoprotein (LDL) cholesterol and triglycerides, and decreases in high density lipoprotein (HDL) cholesterol. There is a reduction in insulin secretion and elimination, but increases in insulin resistance eventually result in increasing circulating insulin levels. There are changes in body fat distribution with accumulation in central and visceral fat which links to the other adverse metabolic changes. There is an increase in the incidence of hypertension and of type 2 diabetes mellitus, both major risk factors for CHD. Oestrogens have potent effects on blood vessels and their loss leads to dysfunction of the vascular endothelium. All of these changes result from loss of ovarian function contributing to the increased development of CHD. Risk factor assessment in perimenopausal women is recommended, thereby permitting the timely introduction of lifestyle, hormonal and therapeutic interventions to modify or reverse these adverse changes.

Surviving “Risk Factor Frenzy”: The Perils of Incorrectly Applying Epidemiological Research in Health Education and Promotion

2002 ◽  
Vol 21 (1) ◽  
pp. 83-100 ◽  
Author(s):  
Jonathan I. Robison ◽  
Gregory Kline
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Health Education ◽  
Health Professionals ◽  
Lifestyle Change ◽  
Negative Consequences ◽  
Epidemiological Research ◽  
Health Practitioners ◽  
Health Education And Promotion

In health education and promotion, “risk factors” for disease gathered from epidemiological research form the basis from which the majority of recommendations to individuals for lifestyle change are made. Unfortunately, many health practitioners are unaware that this type of research was never intended to be applied to individuals. The result is ongoing public confusion and anxiety concerning health recommendations and a loss of credibility for health professionals. This article: 1) briefly reviews the most commonly encountered limitations inherent in epidemiological research; 2) explores the problems and potential negative consequences of incorrectly applying epidemiological research in health education and promotion; and 3) makes recommendations to help health practitioners more skillfully interpret and incorporate into their work findings from epidemiological research.

Knowledge, awareness and perceptions of diabetes mellitus among the Saudi population

2020 ◽  
Vol 9 (6) ◽  
pp. 413-422
Author(s):  
Muhammad H Mujammami ◽  
Abdulaziz A Alodhayani ◽  
Mohammad Ibrahim AlJabri ◽  
Ahmad Alhumaidi Alanazi ◽  
Sultan Sayyaf Alanazi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Social Media ◽  
Risk Factor ◽  
Healthcare Workers ◽  
Health Workers ◽  
Saudi Population ◽  
Limited Data ◽  
High Prevalence ◽  
Associated Risk Factors

Background: High prevalence of undiagnosed cases of diabetes mellitus (DM) has increased over the last two decades, most patients with DM only become aware of their condition once they develop a complication. Limited data are available regarding the knowledge and awareness about DM and the associated risk factors, complications and management in Saudi society. Aim: This study aimed to assess knowledge of DM in general Saudi society and among Saudi healthcare workers. Results: Only 37.3% of the participants were aware of the current DM prevalence. Obesity was the most frequently identified risk factor for DM. Most comparisons indicated better awareness among health workers. Conclusion: A significant lack of knowledge about DM in Saudi society was identified. Social media and educational curriculum can improve knowledge and awareness of DM.

scholarly journals A-126 Clinical Utility of Risk Factors to Predict Self-reported Neurobehavioral Outcome Following Traumatic Brain Injury: PTSD, Sleep, Resilience, and Lifetime Blast Exposure

2020 ◽  
Vol 35 (6) ◽  
pp. 919-919
Author(s):  
Lange R ◽  
Lippa S ◽  
Hungerford L ◽  
Bailie J ◽  
French L ◽  
...  
Keyword(s):  
Risk Factors ◽  
Traumatic Brain Injury ◽  
Risk Factor ◽  
Brain Injury ◽  
Clinical Utility ◽  
Poor Sleep ◽  
Post Injury ◽  
Poor Outcome ◽  
Blast Exposure ◽  
Neurobehavioral Outcome

Abstract Objective To examine the clinical utility of PTSD, Sleep, Resilience, and Lifetime Blast Exposure as ‘Risk Factors’ for predicting poor neurobehavioral outcome following traumatic brain injury (TBI). Methods Participants were 993 service members/veterans evaluated following an uncomplicated mild TBI (MTBI), moderate–severe TBI (ModSevTBI), or injury without TBI (Injured Controls; IC); divided into three cohorts: (1) < 12 months post-injury, n = 237 [107 MTBI, 71 ModSevTBI, 59 IC]; (2) 3-years post-injury, n = 370 [162 MTBI, 80 ModSevTBI, 128 IC]; and (3) 10-years post-injury, n = 386 [182 MTBI, 85 ModSevTBI, 119 IC]. Participants completed a 2-hour neurobehavioral test battery. Odds Ratios (OR) were calculated to determine whether the ‘Risk Factors’ could predict ‘Poor Outcome’ in each cohort separately. Sixteen Risk Factors were examined using all possible combinations of the four risk factor variables. Poor Outcome was defined as three or more low scores (< 1SD) on five TBI-QOL scales (e.g., Fatigue, Depression). Results In all cohorts, the vast majority of risk factor combinations resulted in ORs that were ‘clinically meaningful’ (ORs > 3.00; range = 3.15 to 32.63, all p’s < .001). Risk factor combinations with the highest ORs in each cohort were PTSD (Cohort 1 & 2, ORs = 17.76 and 25.31), PTSD+Sleep (Cohort 1 & 2, ORs = 18.44 and 21.18), PTSD+Sleep+Resilience (Cohort 1, 2, & 3, ORs = 13.56, 14.04, and 20.08), Resilience (Cohort 3, OR = 32.63), and PTSD+Resilience (Cohort 3, OR = 24.74). Conclusions Singularly, or in combination, PTSD, Poor Sleep, and Low Resilience were strong predictors of poor outcome following TBI of all severities and injury without TBI. These variables may be valuable risk factors for targeted early interventions following injury.

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