scholarly journals Circulating inflammatory biomarkers and academic performance in adolescents: DADOS study

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242016
Author(s):  
Mireia Adelantado-Renau ◽  
Maria Reyes Beltran-Valls ◽  
Jorge Mota ◽  
Diego Moliner-Urdiales
Keyword(s):  
Academic Performance ◽  
Verbal Ability ◽  
Roc Curves ◽  
Science Research ◽  
Inflammatory Biomarkers ◽  
Grade Point ◽  
Tnf Α ◽  
Academic Grades ◽  
Wbc Count ◽  
Factor Α

Objective The present study aimed (1) to examine the association between circulating inflammatory biomarkers and academic performance in adolescents, and (2) to identify the ability of circulating inflammatory biomarkers to predict low academic performance. Methods A total of 244 adolescents (13.9±0.3 years, 112 girls) from the DADOS study were included in the analysis. Four inflammatory biomarkers were quantified: white blood cell (WBC) count, interleukin-6, tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP). Academic performance was assessed through academic grades and the Spanish version of the Science Research Associates Test of Educational Abilities. Results TNF-α was inversely associated with math, Spanish and grade point average (β ranging from -0.166 to -0.124; all p<0.05), while CRP was inversely associated with verbal ability (β = -0.128; p<0.05). Overall, receiver operating characteristic (ROC) curves analyses showed discriminatory ability of WBC and TNF-α in identifying low academic performance (all p<0.05). Moreover, logistic regression analyses indicated that students with levels of WBC and TNF-α above the ROC cut-offs values showed between 78% to 87% increased likelihood of lower academic performance (p<0.05). Conclusions Our findings suggested that some circulating inflammatory biomarkers were associated with academic performance in adolescents. Further larger longitudinal and interventional studies are needed to clarify the short-term and long-term relationship between inflammation and academic performance in youths.

scholarly journals Acute Effect of a Single Dose of Tomato Sofrito on Plasmatic Inflammatory Biomarkers in Healthy Men

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 851 ◽  
Author(s):  
Sara Hurtado-Barroso ◽  
Miriam Martínez-Huélamo ◽  
Jose Fernando Rinaldi de Alvarenga ◽  
Paola Quifer-Rada ◽  
Anna Vallverdú-Queralt ◽  
...  
Keyword(s):  
Single Dose ◽  
Bioactive Compounds ◽  
Acute Effect ◽  
Inflammatory Biomarkers ◽  
Positive Health ◽  
Reactive Protein ◽  
Inflammatory Status ◽  
Tnf Α ◽  
Factor Α ◽  
Antioxidant Diet

Sofrito is a Mediterranean tomato-based sauce that typically also contains olive oil, onion, and garlic. The preparation of sofrito modifies the bioactive compounds (carotenoids and polyphenols) in the ingredients to more bioavailable forms, promoting cis-lycopene formation and polyphenol bioaccessibility. To evaluate the health benefits of this cooking technique, the effect of consuming an acute dose of sofrito on the inflammatory status was studied. In a clinical trial, 22 healthy male subjects consumed a single dose of sofrito (240 g/70 kg) after three days without ingesting any tomato products and following a low-antioxidant diet the day before the intervention. Plasma carotenoids and total polyphenol excretion (TPE) were evaluated, as well as the inflammatory biomarkers C-reactive protein (CRP), interleukin-6 (IL-6), interleukin 1β (IL-1β) and tumor necrosis factor-α (TNF-α). After the sofrito intake, a significant decrease in CRP (p = 0.010) and TNF-α (p = 0.011) was observed, but only TNF-α was inversely correlated with an increase in TPE and plasma β-carotene (not the major carotenoid, lycopene). The positive health effects of this tomato-based product may be attributed not only to lycopene, but to the bioactive compounds of all the ingredients.

β-Carotene Concentration and Its Association with Inflammatory Biomarkers in Spanish Schoolchildren

2017 ◽  
Vol 71 (1-2) ◽  
pp. 80-87 ◽  
Author(s):  
Elena Rodríguez-Rodríguez ◽  
Ana M. López-Sobaler ◽  
Beatriz Navia ◽  
Pedro Andrés ◽  
Ana I. Jiménez-Ortega ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Inflammatory Biomarkers ◽  
Reactive Protein ◽  
Inflammatory Status ◽  
Tnf Α ◽  
Hs Crp ◽  
Α Level ◽  
Factor Α ◽  
Β Carotene ◽  
Necrosis Factor

Aim: To examine the correlation between inflammatory biomarkers and plasma β-carotene levels in children. Methods: A total of 564 Spanish schoolchildren aged 9-12 were observed and studied. Plasma β-carotene levels were assessed by HPLC. A β-carotene level <4.83 µg/dL (0.09 µmol/L) was considered deficient. Plasma tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were measured by immunoenzyme assays. Serum high-sensitivity C-reactive protein (hs-CRP) was tested by immunonephelometry. Results: Subjects who were β-carotene-deficient (23.1% of the studied children) had higher IL-6 levels than subjects with normal β-carotene concentrations. The log-IL-6 and log-hs-CRP concentrations, but not the log-TNF-α level, were strongly and inversely related to the plasma log-β-carotene level (taking into account log-age, energy intake, log-triglycerides, gender, log-body mass index, log-β-carotene intake, energy from lipids and cholesterol as covariables). When the 3 inflammatory biomarkers were introduced into the regression model along with the corresponding covariables, only the log-IL-6 level was related to the plasma log-β-carotene level (β = -0.505 ± 0.078; p < 0.001). Conclusions: Inflammatory status, in particular IL-6 levels, appears to be negatively associated with plasma β-carotene levels in schoolchildren.

Employment Characteristics, Course Satisfaction and Academic Performance of College Students

1984 ◽  
Vol 54 (3) ◽  
pp. 943-946 ◽  
Author(s):  
Li-Chen Ma
Keyword(s):  
Academic Performance ◽  
Employment Status ◽  
Sampling Technique ◽  
Working Hours ◽  
Course Satisfaction ◽  
Full Time ◽  
Grade Point ◽  
Academic Grades ◽  
Perceived Relevance ◽  
Employment Characteristics

This study examined the role of course satisfaction in correlations between academic performance and three characteristics of employment: employment status, kind of employment, and job's relevance to major. Data were obtained from 320 students by questionnaires. A stratified (by sex, major and class standing), random-sampling technique was used to obtain data from junior and senior full-time students at a state university. Academic performance was measured by semester's grade point average, employment status by working hours per week, kind of employment by reported job title, job's relevance to major by perceived relevance of the present job to academic major, and course satisfaction by self-evaluation of general feeling toward course work. Analysis indicates that satisfaction exerts differential effects on the academic grades of students with differing employment characteristics.

scholarly journals COMPERISON OF “OLD” AND “NEW” ACUTE PHASE REACTANTS IN PATIENTS WITH COMMUNITY ACQUIRED PNEUMONIA AND DIABETS MELLITUS 2 TYPE AS INFLAMMATORY CHANGES MARKERS

InterConf ◽  
2021 ◽  
pp. 208-216
Author(s):  
Olena Makharynska ◽  
Ievgeniia Tokareva
Keyword(s):  
Immune System ◽  
Complete Blood Count ◽  
Community Acquired Pneumonia ◽  
Inflammatory Biomarkers ◽  
Acute Phase Reactants ◽  
Markers Of Inflammation ◽  
Tnf Α ◽  
Significant Difference ◽  
Severe Community Acquired Pneumonia ◽  
Wbc Count

The aim of the study was to evaluate “old” (WBC count) and “new” inflammatory biomarkers in hospitalized patients with non-severe community-acquired pneumonia in patients with\without Diabetes Mellitus 2 type. Materials and methods. At inclusion, clinical and laboratory parameters of pneumonia were recorded and the CRB-65 was evaluated. A total of 131 adult patients hospitalized with non-severe CAP were included in this prospective study. Levels of pro-inflammatory (IL-1β, IL-8, TNF-α), anti-inflammatory (IL-10) cytokines and markers of inflammation (CRP, complete blood count) were determined at the beginning of the disease (day O) and in 48-72 hours. Results. The level of leukocytes in CBC was significantly higher in the main group at the beginning of the disease, as well after 10 ± 2 days from day 0 the number of episodes of leukocytosis > 10 · 109 / l was higher (8.5% vs. 2%, respectively, p <0,05). There was no statistically significant difference between the studied inflammatory biomarkers levels in the both groups of patients with and without concomitant diabetes. There was a tendency to a higher number of cases of "recovery" after CAP in the group with CRP levels during hospitalization ≥ 21.8 pg / ml (22% vs. 48%, p <0.1). Conclusion. It can be assumed that such a low dynamics of inflammatory markers is associated with involutive changes in the immune system due to older age of the patients included in the study and the influence of DM on the immune system reactivity in the CAP with concomitant DM 2 type with immune response suppression can also explain absence of significant difference in inflammatory biomarkers concentration in the groups compered in this study.

scholarly journals Randomized Controlled Trial for Promotion of Healthy Eating in Older Adults by Increasing Consumption of Plant-Based Foods: Effect on Inflammatory Biomarkers

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3753
Author(s):  
Andreas Nilsson ◽  
Antonio Cano ◽  
Oscar Bergens ◽  
Fawzi Kadi
Keyword(s):  
Older Adults ◽  
Controlled Trial ◽  
Activity Level ◽  
Inflammatory Biomarkers ◽  
Reactive Protein ◽  
Inflammatory Status ◽  
Inflammatory Protein ◽  
Tnf Α ◽  
Chemokine Ligand ◽  
Factor Α

To what extent the intake of fruit and vegetables (FV) influences inflammatory status remains elusive, particularly in older populations. The aim of the present study was to determine the effect of increased FV intake for 16 weeks on circulating biomarkers of inflammation in a population of older men and women. Sixty-six participants (65–70 years) randomly assigned to either FV or control (CON) groups were instructed to increase FV intake to five servings per day through nutritional counseling (FV) or to maintain habitual diet (CON). Dietary intake and physical activity level (PA) were determined using food frequency questionnaire and accelerometers, respectively, at the start and end of the intervention. C-reactive protein (CRP), interleukin 6 (IL-6), IL-18, macrophage inflammatory protein-1α (MIP-1α), MIP-1β, tumor necrosis factor-α (TNF-α), TNF-related apoptosis-inducing ligand (TRAIL), TNF-related activation-induced cytokine (TRANCE), and C-X3-C motif chemokine ligand-1 (CX3CL1, or fractalkine) were analyzed. The FV group significantly increased daily FV intake (from 2.2 ± 1.3 to 4.2 ± 1.8 servings/day), with no change in CON. Waist circumference and PA level were unchanged by the intervention. Interaction effects (time × group, p < 0.05) for TRAIL, TRANCE, and CX3CL1 denoting a significant decrease (p < 0.05) in FV but not in CON were observed. No corresponding effects on CRP, IL6, TNF-α, MIP-1α, and β and IL-18 were observed. The present study demonstrates the influence of increased FV consumption on levels of some inflammatory biomarkers in a population of older adults. Future work is warranted to examine the clinical implications of FV-induced alterations in these inflammatory biomarkers.

scholarly journals Relationship of Extroversion Dimension with Academic Performance of Medical Students

2016 ◽  
Vol 3 (2) ◽  
Author(s):  
Dr. Ramyashilpa. D. Nayak
Keyword(s):  
Academic Performance ◽  
Medical Students ◽  
Sampling Technique ◽  
Personality Factors ◽  
Personality Factor ◽  
School Students ◽  
Personality Dimension ◽  
Grade Point ◽  
Study Results ◽  
Academic Grades

Most people know that academic performance generally refers to how well a student is accomplishing his or her tasks and studies, but there are quite a number of factors that determine the level and quality of students’ academic performance. Certainly the most well-known indicator of academic performance, grades is the student’s “score” for their classes and overall tenure. Grades are most often a tallying or average of assignment and test scores and may often be affected by factors such as attendance and instructor opinion of the student as well. Grading systems vary greatly by country and school; common scales include a percentage from 1-100, lettering systems from A-F, and grade point averages (GPA) from 0-4.0 or above. Academic Performance of medical school students is predisposed by personality dimension extroversion has been concentrated in the present study. The main objective of the study was to determine the extroversion score among the medical students and find out the correlation between extroversion and their academic performance. Participants for this study were 70 Phase-I year 1Medical Students of USM-KLE International Medical Programme Belgaum, Karnataka, India. They were selected by purposive sampling technique. Eysanck personality Inventory was administered to find out the extroversion scores among the students and these scores were compared with academic grades. For this process Carl Pearson’s Correlation coefficient method was carried out. The results reveal that there is no significant correlation between academic performance and extroversion (‘t’ Value 0.23 which is not Significant at 0.05 level of significance). Even though the personality factor extroversion has relation with the academic performance which many previous scientific researches show but the present study results of negative correlation nullifies the significance. The implication of this study was to develop an understanding and thoughtfulness among the medical students that the personality factors have an influence on their academic performance.

scholarly journals Students’ Housing in Private Universities in Nigeria: Influencing Factors and Effect on Academic Performance

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Joshua Ugbede Adama ◽  
Douglas Omoregie Aghimien ◽  
Christopher Odunmorayo Fabunmi
Keyword(s):  
Academic Performance ◽  
Private Institutions ◽  
Item Score ◽  
Grade Point ◽  
Cumulative Grade Point Average ◽  
Academic Level ◽  
Factors Influencing ◽  
Essential Facility ◽  
Academic Grades ◽  
Major Factors

Student housing plays an essential role in the attainment of quality education. However, there has been significant evidence as regards the inadequacy of this essential facility among public universities in Nigeria. It was further observed that there is a paucity of information as regards this situation within the private institutions in the country. Based on this background this research was conducted to assess the students’ housing in private institutions, by determining the factors influencing students’ choice of residence and its effect on their academic performance. The study adopted a survey approach, with 216 students sampled through a structured questionnaire. Data gathered were analyzed using frequency, mean item score, and Mann-Whitney U-Test. Results revealed that although gender has no relationship with students’ choice of residence, age and academic level does. The major factors influencing students’ choice of residence are: accommodation fee, quality of the environment, need for privacy, influence of friends/desire to be close to friends, and number of students within the building. The study also revealed that students’ on-campus rarely miss classes due to distance of their residence from their lecture halls, unlike their mates staying off-campus. However, they tend to miss classes as a result of inadequacy of needed facilities; a situation that is uncommon among those staying off-campus. As regards students Cumulative Grade Point Average (CGPA) as a measure of their performance, the residence of students does not have any statistical relationship with their academic grades.

Genetic Variation in TNF-α, its Relation with Inflammatory Biomarkers and Susceptibility to Rheumatoid Arthritis

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Khadiga Ahmed Ismail
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Level ◽  
Functional Disability ◽  
Serum Levels ◽  
Amplification Refractory Mutation System ◽  
Reactive Protein ◽  
Tnf Α ◽  
Mutation System ◽  
Potential Factor ◽  
Factor Α

Background: Tumor necrosis Factor-α (TNF-α) is encoded and controlled by TNF-α gene, which is involved in rheumatoid arthritis (RA) susceptibility. This research aimed to identify genetic variations of TNF-α (G308A) and to establish its association with inflammatory markers in Rheumatoid Arthritis predisposition. Methods: In the present study, fifty RA patients and fifty volunteers were involved and evaluated for the C-reactive protein, rheumatoid factor, and TNF-α were estimated by ELISA, Erythrocyte Sedimentation Rate (ESR) by Wintergreen method and for TNF-α-308 G>A polymorphism by polymerase chain reaction with amplification refractory mutation system (PCR-ARMS). Results: The CRP, RF, ESR and TNF-α were significantly elevated in RA patients relative to controls. The serum level TNF-α was also significantly elevated in female patients and in patients ≥50 years. Analysis of TNF-308 gene polymorphism revealed that GG genotypes were more prevalent in RA patients than in the healthy individuals and that GG genotype may be a potential factor to RA. The G allele was more common in RA than in the control. Elevated TNF-α serum levels were significantly associated the GG genotype and functional disability in RA patients. Conclusion: TNF-α promoter 308polymorphism GG genotype may be considered as a risk factor for RA and the TNF-α serum level was significantly related to the functional disability in the disease.

Synthesis of Novel 8-Hydroxyquinoline Derivatives through Mannich Reaction and their Biological Evaluation as Potential Immunomodulatory Agents

2020 ◽  
Vol 16 (4) ◽  
pp. 531-543
Author(s):  
Shaheen Faizi ◽  
Tahira Sarfaraz ◽  
Saima Sumbul ◽  
Almas Jabeen ◽  
Sobia A. Halim ◽  
...  
Keyword(s):  
Mannich Reaction ◽  
Aromatic Aldehydes ◽  
Mannich Bases ◽  
Biological Evaluation ◽  
Mechanism Of Inhibition ◽  
Potent Inhibition ◽  
Tnf Α ◽  
Elisa Technique ◽  
Factor Α ◽  
New Compounds

Background: In continuation of our work on Mannich reaction on 8-hydroxyquinoline, fifteen different combinations of aromatic aldehydes and aniline were subjected to Mannich reaction from which twelve products (eight Mannich bases, two imines and two intramolecularly cyclized products with benzofuranone skeleton) were obtained. Among them six compounds (1, 2, 6, 8, 9 and 12) are the new compounds. The structures of the compounds were characterized by UV, IR, MS and 1H NMR. Method: The compounds were tested for the inhibition of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β) at a concentration of 25 µg/mL. The cytokines were produced by THP-1 cells differentiated with PMA for 24hrs and stimulated with LPS for 4 hrs and supernatant were analyzed through ELISA technique. Results and Discussion: Compounds 1-5, 8 and 9 inhibited the production of TNF-α and IL-1β. Compounds 1, 3, and 8 exerted potent inhibitions of TNF-α with 71%, 71%, and 83% inhibition, respectively. Compounds 1 and 8 significantly inhibited the production of IL-1β with 64% and 78% inhibition, respectively. Conclusion: Compounds 1 and 8 significantly inhibited the production of IL-1β with 64% and 78% inhibition, respectively. Notably compound 8 showed the most potent inhibition of these cytokines. Additionally, the effect of compounds on viability of THP-1 cells was also evaluated. Moreover, molecular docking was carried out to study the mechanism of inhibition of TNF-α production.

Molecular Mechanisms of Curcumin in Neuroinflammatory Disorders: A Mini Review of Current Evidences

2019 ◽  
Vol 19 (3) ◽  
pp. 247-258 ◽  
Author(s):  
Mahsa Hatami ◽  
Mina Abdolahi ◽  
Neda Soveyd ◽  
Mahmoud Djalali ◽  
Mansoureh Togha ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
English Language ◽  
Molecular Mechanisms ◽  
Randomized Clinical Trials ◽  
Mitochondrial Dynamics ◽  
Nuclear Factor Κb ◽  
General Term ◽  
Neuroinflammatory Disease ◽  
Tnf Α ◽  
Factor Α

Objective: Neuroinflammatory disease is a general term used to denote the progressive loss of neuronal function or structure. Many neuroinflammatory diseases, including Alzheimer’s, Parkinson’s, and multiple sclerosis (MS), occur due to neuroinflammation. Neuroinflammation increases nuclear factor-κB (NF-κB) levels, cyclooxygenase-2 enzymes and inducible nitric oxide synthase, resulting in the release of inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). It could also lead to cellular deterioration and symptoms of neuroinflammatory diseases. Recent studies have suggested that curcumin (the active ingredient in turmeric) could alleviate the process of neuroinflammatory disease. Thus, the present mini-review was conducted to summarize studies regarding cellular and molecular targets of curcumin relevant to neuroinflammatory disorders. Methods: A literature search strategy was conducted for all English-language literature. Studies that assessed the various properties of curcuminoids in respect of neuroinflammatory disorders were included in this review. Results: The studies have suggested that curcuminoids have significant anti- neuroinflammatory, antioxidant and neuroprotective properties that could attenuate the development and symptom of neuroinflammatory disorders. Curcumin can alleviate neurodegeneration and neuroinflammation through multiple mechanisms, by reducing inflammatory mediators (such as TNF-α, IL-1β, nitric oxide and NF-κB gene expression), and affect mitochondrial dynamics and even epigenetic changes. Conclusion: It is a promising subject of study in the prevention and management of the neuroinflammatory disease. However, controlled, randomized clinical trials are needed to fully evaluate its clinical potential.

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