scholarly journals Association of prenatal sex steroid exposure estimated by the digit ratio (2D:4D) with birth weight, BMI and muscle strength in 6- to 13-year-old Polish children

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258179
Author(s):  
Magdalena Kobus ◽  
Aneta Sitek ◽  
Iwona Rosset ◽  
Paulina Pruszkowska–Przybylska ◽  
Elżbieta Żądzińska
Keyword(s):  
Body Weight ◽  
Body Size ◽  
Birth Weight ◽  
Muscle Strength ◽  
Grip Strength ◽  
Overweight And Obesity ◽  
Digit Ratio ◽  
Sex Steroid ◽  
Fetal Life ◽  
Hip Circumference

Objectives The aim of this paper was to provide evidence for the impact of prenatal sex steroid exposure on prenatal and postnatal body size parameters, and muscle strength in children. Methods The following anthropometric data were studied in a group of 1148 children (536 boys and 612 girls) aged 6–13 years: the 2D:4D digit ratio, birth weight and length, and birth head and chest circumference. Postnatal parameters (6–13 years) included body weight and height, BMI, waist and hip circumference, WHR, as well as grip strength in both hands. All parameters that required it were adjusted for sex and gestational or chronological age. A general linear model, Pearson’s correlation, t-statistics and Cohen’s Δ were used in statistical analysis. Results Among birth size parameters, only birth weight was significantly negatively correlated with the 2D:4D digit ratio in children. Higher (feminized) digit ratios were significantly correlated with postnatal parameters such as body weight, BMI, and waist and hip circumference (positively), as well as hand grip strength–a proxy for muscular strength (negatively). Conclusion Problems with maintaining adequate body size parameters and muscle strength may be programmed in fetal life and predicted on the basis of the 2D:4D digit ratio. Body weight at birth and in early ontogenesis are additive correlates of the 2D:4D ratio. The present findings suggest that the 2D:4D digit ratio is related to postnatal phenotypes such as birth weight, overweight, and obesity as well as muscle strength in 6–13-year-old children of both sexes.

scholarly journals Relationship between Children’s Birth Weight and Birth Length and a Risk of Overweight and Obesity in 4–15-Year-Old Children

Medicina ◽  
2019 ◽  
Vol 55 (8) ◽  
pp. 487
Author(s):  
Joanna Baran ◽  
Aneta Weres ◽  
Ewelina Czenczek-Lewandowska ◽  
Justyna Leszczak ◽  
Katarzyna Kalandyk-Osinko ◽  
...  
Keyword(s):  
Body Weight ◽  
Birth Weight ◽  
Body Mass ◽  
Overweight And Obesity ◽  
Birth Length ◽  
Significant Difference ◽  
The Family ◽  
Normal Body Weight ◽  
The Relationship ◽  
Birth Body Weight

Background and Objectives. The purpose of the study was to investigate the relationship between children’s birth weight/length and a risk of overweight and obesity. Materials and Methods. The study involved 747 children from kindergartens, as well as primary and middle schools from southeastern Poland. All the subjects were examined on fasting status. Each child was examined for body mass and height, in order to calculate their body mass index (BMI), and BMI centile. The parents completed a questionnaire related to basic information about the child and the family. Results. In the study group, the male infants presented greater birth body weight and birth body length. A comparison of the distribution of birth weights and lengths between the children with normal BMI and with high BMI showed statistically significant differences only in the case of birth length of 12–15-year-old children and in the group of boys aged 12–15 years. In the case of the female children and the group of 7–11-year-olds a statistically significant difference was found in the BMI centile at a later age—a higher centile was found in the girls and in the children aged 7–11 years classified as adequate for gestational age (AGA). Conclusions. Birth body weight is positively related to BMI centile; however, no significant differences were found in birth weight between children with overweight/obesity and children with normal body weight. Birth length is associated with a lower BMI centile only in boys aged 12–15 years, and lower birth length is found in boys with overweight and obesity.

scholarly journals Developmental pathways and programming of diabetes: epidemiological aspects

2019 ◽  
Vol 242 (1) ◽  
pp. T95-T104 ◽  
Author(s):  
Johan G Eriksson
Keyword(s):  
Public Health ◽  
Birth Weight ◽  
Paradigm Shift ◽  
Adult Life ◽  
Overweight And Obesity ◽  
Life Course Perspective ◽  
Fetal Life ◽  
Global Public Health ◽  
Related Factors ◽  
Increased Risk

Type 2 diabetes (T2D) is a major, rapidly increasing global public health challenge. The major risk factors for T2D include overweight and obesity, lifestyle-related factors and genetic factors. Early life exposures shape the developmental trajectories and alter susceptibility to T2D. Based on epidemiological studies it has been suggested that fetal undernutrition plays a role in the etiology of T2D. A low birth weight has been considered a proxy for fetal undernutrition. A meta-analysis reported that a 1 kg increase in birth weight is associated with a roughly 20% lower risk of T2D. Although fetal life is of major importance for future health, the period spanning the first 1000 days of life, is characterized by great plasticity and largely influencing later health. Different growth trajectories during this time period have also been associated with an increased risk of T2D. Studies assessing the association between age at BMI rebound in childhood and later risk for T2D have reported a fivefold difference in T2D according to age at BMI rebound. Developmental and epidemiological cohort studies focusing on T2D have major public health implications supporting a paradigm shift; a shift from focusing upon risk factor modification in adult life to adopting a life course perspective when studying T2D. This paradigm shift will not only help us in getting a better understanding of the pathophysiology underlying T2D, but it will also open new possibilities and opportunities in the prevention of T2D and related disorders.

Effects of growth hormone overproduction on grip strength of transgenic mice

1995 ◽  
Vol 133 (6) ◽  
pp. 735-740 ◽  
Author(s):  
Eckhard Wolf ◽  
Rüdiger Wanke ◽  
Emanuel Schenck ◽  
Walter Hermanns ◽  
Gottfried Brem
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Muscle Strength ◽  
Transgenic Mice ◽  
Least Squares ◽  
Grip Strength ◽  
Long Term Effects ◽  
Muscle Weight ◽  
Significant Difference

Wolf E, Wanke R, Schenck E, Hermanns W, Brem G. Effects of growth hormone overproduction on grip strength of transgenic mice. Eur J Endocrinol 1995;133:735–40. ISSN 0804–4643 Growth hormone (GH) is used by athletes like bodybuilders to increase muscle strength and weight gain. On the other hand, chronic hypersecretion of GH in active acromegaly may result in outwardly hypertrophied but functionally weaker muscles. As a model for studying long-term effects of GH on muscle strength, we analysed transgenic mice (TM) carrying rat phosphoenolpyruvate carboxykinasebovine GH (PEPCKbGH) fusion genes, which are expressed in liver and kidney but not in skeletal muscle. Circulating GH levels in TM ranged between 0.5 and 3 μg/ml, resulting in increased (p <0.001) body weight (wt) as well as increased (p <0.01) weights of forelimb and hindlimb muscles. However, muscle weight/body wt ratios of TM were 16–20% smaller than in controls (p<0.05), Forelimb grip strength of hemizygous TM (16 males, 132 ± 45 days old, body wt = 56.8 ± 8.3 g; 32 females, 146 ± 38 days old, body wt = 54.9 ± 6.1 g) and non-transgenic controls (28 males, 127 ± days old, body wt = 40.5±2.9 g; 33 females, 126 ±47 days old, body wt = 32.1 ± 3.6 g) was determined using an automated grip strength meter. Data were computed by analysis of variance, taking into account effects of group, sex and age. Least-squares means estimated for the grip strength (N) of male TM (1.91) and controls (1.92) were significantly (p<0.05) greater than those of female TM (1.78) and controls (1.61). A significant difference between groups was only seen in females (p <0.01). Least-squares means estimated for grip strength/body wt ratios (N/10 g) of male (0.34) and female TM (0.33) were 29% and 35% lower than those of male (0.48) and female controls (0.51), respectively (p <0.001). In summary, long-term elevated GH levels in TM increased muscle weight less efficiently than body weight, and muscle strength did not increase proportionally with muscle weight. Eckhard Wolf, Lehrstuhl für Molekulare Tierzucht und Haustiergenetik, Ludwig-Maximilians-Universität München, Würmtalstraβe 221, 81375 München, Germany

Excessive body weight versus physical fitness in adults with moderate and severe intellectual disabilities

2020 ◽  
Vol LXXXI (1) ◽  
pp. 28-36
Author(s):  
Krystyna Gawlik ◽  
Anna Zwierzchowska ◽  
Barbara Rosołek ◽  
Diana Celebańska ◽  
Georgina Franusz
Keyword(s):  
Body Weight ◽  
Muscle Strength ◽  
Lower Extremity ◽  
Physical Fitness ◽  
Intellectual Disabilities ◽  
Body Height ◽  
Overweight And Obesity ◽  
Lower Extremity Muscle ◽  
Severe Intellectual Disabilities ◽  
The Impact

An increasing number of people with intellectual disabilities (ID) are characterized by an excess of body weight. The impact of overweight and obesity on motor skills in this population is ambiguous. The study aimed to review the impact of overweight and obesity on the physical fitness of adults with intellectual disabilities. The study covered 128 people with ID: 70 women (W) and 58 men (M); 62 people with moderate intellectual disabilities and 66 people with severe intellectual disabilities. The following measurements were taken: body mass (BM), body height (BH), and waist circumference (WC). BMI was calculated. The physical fitness level was assessed with the Eurofit Special test. Obesity and overweight were found in 37% and 24% of W and 39% and 22% of M respectively; in 40% and 17% of people with moderate ID and 36% and 28% of people with severe ID respectively. Significant negative correlations between speed and BMI and WC, and between core muscle strength and WC were found in women. In men, negative correlations were found: between core muscle strength and BM, BMI, and WC; between flexibility and BM, BMI, and WC; between lower extremity muscle strength and BMI and WC; and between balance and BMI. Further, obese men had significantly lower scores compared to the normal weight sample in the following tests: balance (T1), lower extremity muscle strength (T2), speed (T4), and core muscle strength (T6). The study showed a relationship between obesity and scores in physical fitness tests. More relationships were found in men than women and in people with severe ID than moderate ID.

scholarly journals Penampilan Produksi Sapi Aceh Umur Satu Hari, Umur Sapih, dan Umur Satu Tahun

2018 ◽  
Vol 5 (2) ◽  
pp. 67
Author(s):  
Ikhsanuddin Ikhsanuddin ◽  
V.M. Ani Nurgiartiningsih ◽  
Kuswati Kuswati ◽  
Mukhtar Mukhtar
Keyword(s):  
Body Weight ◽  
Body Size ◽  
Birth Weight ◽  
Body Length ◽  
Chest Circumference ◽  
Productive Performance ◽  
Weaning Weight ◽  
Breeding Center ◽  
Cattle Performance

ABSTRAKPenelitian ini bertujuan untuk mengetahui penampilan produksi sapi aceh di BPTU-HPT Indrapuri Aceh. Materi penelitian yaitu sapi aceh umur satu hari, umur sapih, dan umur satu tahun sebanyak 159 ekor. Metode penelitian adalah studi kasus berdasarkan data bobot lahir, bobot sapih, bobot satu tahun beserta ukuran tubuhnya. Data dianalisis menunjukkan bahwa sapi jantan memiliki bobot lahir 13,66±1,08 kg, bobot umur 205 hari 71,60±7,92 kg dan bobot  umur 365 hari 104,66±11,72 kg.  Sapi betina memiliki bobot lahir 13,88±1,32 kg, bobot umur 205 hari 64,38 ± 10,36 kg dan bobot umur 365 hari 90,29±11,95 kg. Sapi Aceh umur satu hari memiliki lingkar dada, panjang badan dan tinggi pundak berturut-turut  55,41 cm, 46,16 cm  dan 55,22 cm pada sapi jantan serta 55,87 cm, 46,83 cm, dan 55,74 cm pada sapi betina. Sapi aceh umur 365 hari memiliki ukuran lingkar dada, panjang badan dan tinggi pundak berturut-turut 114,32 cm, 94,31 cm dan 92,93 cm pada sapi jantan serta 104,25 cm, 85,06 dan 87,71 cm pada sapi betina. Rata-rata penampilan produksi sapi aceh di BPTU Indrapuri  berpotensi menjadi ternak unggul berdasarkan kriteria SNI.Kata Kunci: sapi aceh, penampilan produksi, bobot badan, ukuran tubuhABSTRACTThis study aimed to evaluate the productive performance of aceh cattle at Indrapuri Breeding Center for Superior Livestock and Forage. A total of 159 heads of aceh cattle were used in this study. The method used was a case study based on the data of birth weight, weaning weight, yearling weight, and body size. The results showed that the birth weight, weaning weight at 205 days of age, and yearling weight at 365 days of age of male aceh cattle were 13.66±1.08 kg, 71.60±7.92 kg, and 104.66±11.72 kg, respectively. Whereas, female aceh cattle had the birth weight, weaning weight at 205 days of age, and yearling weight at 365 days of age of 13.88±1.32 kg, 64.38±10.36 kg, and 90.29±11.95 kg, respectively. At birth, male Aceh cattle had the chest circumference, body length, and shoulder height of 55.41 cm, 46.16 cm, and 55.22 cm, respectively, while female aceh cattle were 55.87 cm, 46.83 cm, and 55.74 cm, respectively. At 365 days of age, male aceh cattle had the chest circumference, body length, and shoulder height of 114.32 cm, 94.31 cm, and 92.93 cm, respectively, while female aceh cattle were 104.25 cm, 85.06 cm, and 87.71 cm, respectively. The average productive performance of aceh cattle at Indrapuri Breeding Center for Superior Livestock and Forage has the potential to become superior cattle based on the criteria of Indonesian National Standard.Keywords: aceh cattle, performance, body weight, body size

scholarly journals Intake of ruminanttrans-fatty acids, assessed by diet history interview, and changes in measured body size, shape and composition

2015 ◽  
Vol 19 (3) ◽  
pp. 494-502 ◽  
Author(s):  
Camilla P Hansen ◽  
Berit L Heitmann ◽  
Thorkild IA Sørensen ◽  
Kim Overvad ◽  
Marianne U Jakobsen
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Body Size ◽  
Waist Circumference ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Hip Circumference ◽  
Diet History

AbstractObjectiveStudies have suggested that total intake oftrans-fatty acids (TFA) is positively associated with changes in body weight and waist circumference, whereas intake of TFA from ruminant dairy and meat products (R-TFA) has not been associated with weight gain. However, these previous studies are limited by self-reported measures of body weight and waist circumference or by a cross-sectional design. The objective of the present study was to investigate if R-TFA intake was associated with subsequent changes in anthropometry (body weight, waist and hip circumference) measured by technicians and body composition (body fat percentage).DesignA 6-year follow-up study. Information on dietary intake was collected through diet history interviews, and anthropometric and bioelectrical impedance measurements were obtained by trained technicians at baseline (1987–1988) and at follow-up (1993–1994). Multiple regression with cubic spline modelling was used to analyse the data.SettingCopenhagen County, Denmark.SubjectsTwo hundred and sixty-seven men and women aged 35–65 years from the Danish MONICA (MONItoring of trends and determinants in CArdiovascular diseases) cohort.ResultsThe median R-TFA intake was 1·3 g/d (5th, 95th percentile: 0·4, 2·7 g/d) or 0·6 % of the total energy intake (5th, 95th percentile: 0·2, 1·1 %). No significant associations were observed between R-TFA intake and changes in body weight, waist and hip circumference or body fat percentage.ConclusionsR-TFA intake within the range present in the Danish population was not significantly associated with subsequent changes in body size, shape or composition and the 95 % confidence intervals indicate that any relevant associations are unlikely to have produced these observations.

scholarly journals Normalization of Muscle Strength Measurements in the Assessment of Cardiometabolic Risk Factors in Adolescents

2021 ◽  
Vol 18 (16) ◽  
pp. 8428
Author(s):  
Tiago Rodrigues de Lima ◽  
Xuemei Sui ◽  
Diego Augusto Santos Silva
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Body Size ◽  
Muscle Strength ◽  
Fat Mass ◽  
Cardiometabolic Risk ◽  
Cross Sectional Study ◽  
Cardiometabolic Risk Factors ◽  
Cross Sectional ◽  
The Impact

Muscle strength (MS) has been associated with cardiometabolic risk factors (CMR) in adolescents, however, the impact attributed to body size in determining muscle strength or whether body size acts as a confounder in this relationship remains controversial. We investigated the association between absolute MS and MS normalized for body size with CMR in adolescents. This was a cross-sectional study comprising 351 adolescents (44.4% male; 16.6 ± 1.0 years) from Brazil. MS was assessed by handgrip and normalized for body weight, body mass index (BMI), height, and fat mass. CMR included obesity, high blood pressure, dyslipidemia, glucose imbalance, and high inflammation marker. When normalized for body weight, BMI, and fat mass, MS was inversely associated with the presence of two or more CMR among females. Absolute MS and MS normalized for height was directly associated with the presence of two or more CMR among males. This study suggests that MS normalized for body weight, BMI, and fat mass can be superior to absolute MS and MS normalized for height in representing lower CMR among females. Absolute MS and MS normalized for height were related to higher CMR among males.

scholarly journals Rangifer population ecology: a Scandinavian perspective

Rangifer ◽  
1997 ◽  
Vol 17 (3) ◽  
pp. 105 ◽  
Author(s):  
Eigil Reimers
Keyword(s):  
Body Weight ◽  
Body Size ◽  
Birth Weight ◽  
Neonatal Mortality ◽  
Population Ecology ◽  
Reproductive Performance ◽  
Rangifer Tarandus ◽  
Postnatal Growth ◽  
Strongly Correlated ◽  
Maternal Weight

Population ecology is concerned with measuring changes in population size and composition, and identifying the causes of these fluctuations. Important driving variables include animal body size and growth rate, and their relationship to reproduction and mortality. Among wild and domestic reindeer (Rangifer tarandus tarandus), reproductive performance, calving time, calf birth weight and neonatal mortality are strongly correlated to maternal weight. Heavy females enjoy higher pregnancy rates, calve earlier, and give birth to heavier calves which have a higher neonatal survival rate than light females. Most studies indicate that both weaning weight of a calf and mature body weight correlate to its birth weight. Calf body weight and composition influence the rate of attainment of sexual maturity. Females which breed as calves suffer reduced growth and give birth to smaller calves, which suffer higher neonatal mortality and lower rates of postnatal growth. A yet unresolved question is whether reindeer body weight, and hence reproductive performance and neonatal mortality, are more strongly influenced by winter than by summer grazing conditions. This paper reviews population ecology studies on wild and domestic reindeer and promotes the view that body size in Rangifer is determined primarily by grazing conditions during the summer.

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