Alexithymia and its relation with eating disorders and obesity

This manuscript provides a review of current literature on the relationship between overweight and alexithymia as a psychological factor associated with obesity, as well as the role of alexithymia in the development of various abnormalities and eating disorders (ED). Obesity is a multifactorial disease, and lifestyle characteristics are the most important pathogenetic links on its development, as well as a complex of genetic, epigenetic, biological and psychological factors that cause accumulation of excessive fat and prevent effective reduction and retention of body weight. One possible reason for the increased prevalence of obesity in adults is poor emotional management, which can affect healthy eating behavior and lifestyle. It was found that overweight and obese people have a high prevalence of alexithymia, and also the study shows its prognostic role in the development of ED. Alexithymia is a factor that not only predisposes to weight gain, but is also a significant predictor of inefficiency and premature termination of programs for the treatment of obesity and ED. Timely diagnosis and correction of alexithymic syndrome can help in developing the effective treatment strategies for obese patients.

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Intestinal microbiota, obesity and prebiotics

Polish Journal of Microbiology ◽

10.33073/pjm-2015-014 ◽

2015 ◽

Vol 64 (2) ◽

pp. 93-100 ◽

Cited By ~ 21

Author(s):

R. BARCZYNSKA ◽

K. BANDURSKA ◽

K. SLIZEWSKA ◽

M. LITWIN ◽

M. SZALECKI ◽

...

Keyword(s):

Body Weight ◽

Gut Microbiota ◽

Disease Risk ◽

Global Scale ◽

Weight One ◽

Prevalence Of Obesity ◽

Normal Body Weight ◽

Healthy Body Weight ◽

Treatment Of Obesity

Over the past few decades there has been a significant increase in the prevalence of obesity in both children and adults. Obesity is a disease that has reached epidemic levels on a global scale. The development of obesity is associated with both environmental and genetic factors. Recent studies indicate that intestinal microorganisms play an important function in maintaining normal body weight. One of the objectives in the gut microbiota research is to determine the role it plays and can it be a reliable biomarker of disease risk, including the predisposition to obesity. This article discusses (1) the role of prebiotics and gut microbiota in maintaining a healthy body weight and (2) potential influence on the gut microbiota in the prevention and treatment of obesity.

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Role of Phytomolecules in the Treatment of Obesity: Targets, Mechanisms and Limitations

Current Topics in Medicinal Chemistry ◽

10.2174/1568026621666210305101804 ◽

2021 ◽

Vol 21 ◽

Author(s):

Shampa Ghosh ◽

Srividya Manchala ◽

Manchala Raghunath ◽

Gaurav Sharma ◽

Abhishek Kumar Singh ◽

...

Keyword(s):

Management Strategies ◽

Epigallocatechin Gallate ◽

Therapeutic Interventions ◽

Public Health Issue ◽

Gastrointestinal Problems ◽

High Prevalence ◽

Prevalence Of Obesity ◽

Treatment Of Obesity ◽

The Right

: Obesity has become a worldwide health problem. It triggers additional co-morbidities like cardiovascular diseases, cancer, depression, sleep disorders, gastrointestinal problems and many more. Excess accumulation of fat in obesity could be caused by many factors like sedentary lifestyle, consumption of high fat diet, genetic predisposition, etc. Imbalanced energy metabolism i.e., greater energy consumption than utilisation, invariably underlies obesity. Considering the high prevalence and continuous, uncontrolled increase of this major public health issue, there is an urgent need to find appropriate therapeutic agents with minimal or no side effects. The high prevalence of obesity in recent years has led to a surge in the number of drugs available in the market that claim to control obesity. Although there is a long list of medicines and management strategies that are available, selecting the right therapeutic intervention and feasible management of obesity is a challenge. Several phytochemicals like hydroxycitric acid, flavonoids, tannins, anthocyanins, phytohaemagglutins, thymoquinone and epigallocatechin gallate have been shown to possess promising anti-obesity properties. However, studies providing information on how various phytochemicals exert their anti-obesity effects are inadequate. This calls for more experimentation in this less explored area of research. Additionally, the complication of obesity arises when it is a result of multiple factors and associated with a number of co-morbidities. In order to handle such complexities combinatorial therapeutic interventions become effective. In this review, we have described the medicinal chemistry of different highly effective phytochemicals which can be used in the effective treatment and management of obesity.

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Vitamin D Deficiency: Consequence or Cause of Obesity?

Medicina ◽

10.3390/medicina55090541 ◽

2019 ◽

Vol 55 (9) ◽

pp. 541 ◽

Cited By ~ 11

Author(s):

Luka Vranić ◽

Ivana Mikolašević ◽

Sandra Milić

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Treatment Option ◽

Obese People ◽

Diet And Exercise ◽

High Prevalence ◽

Excess Amount ◽

Obese Subjects ◽

Significant Health

Obesity is defined as an excess amount of body fat and represents a significant health problem worldwide. High prevalence of vitamin D (VD) deficiency in obese subjects is a well-documented finding, most probably due to volumetric dilution into the greater volumes of fat, serum, liver, and muscle, even though other mechanisms could not completely be excluded, as they may contribute concurrently. Low VD could not yet be excluded as a cause of obesity, due to its still incompletely explored effects through VD receptors found in adipose tissue (AT). VD deficiency in obese people does not seem to have consequences for bone tissue, but may affect other organs, even though studies have shown inconsistent results and VD supplementation has not yet been clearly shown to benefit the dysmetabolic state. Hence, more studies are needed to determine the actual role of VD deficiency in development of those disorders. Thus, targeting lifestyle through healthy diet and exercise should be the first treatment option that will affect both obesity-related dysmetabolic state and vitamin D deficiency, killing two birds with one stone. However, VD supplementation remains a treatment option in individuals with residual VD deficiency after weight loss.

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Obesity and Polypharmacy among African American Older Adults: Gender as the Moderator and Multimorbidity as the Mediator

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16122181 ◽

2019 ◽

Vol 16 (12) ◽

pp. 2181 ◽

Cited By ~ 8

Author(s):

Shervin Assari ◽

Cheryl Wisseh ◽

Mohsen Bazargan

Keyword(s):

Older Adults ◽

African American ◽

Los Angeles ◽

Older Women ◽

Urban Areas ◽

South Los Angeles ◽

High Prevalence ◽

Prevalence Of Obesity ◽

Independent Variable

Despite high prevalence of obesity and polypharmacy among African American (AA) older adults, little information exists on the associations between the two in this population. This study explored the association between obesity and polypharmacy among AA older adults who were residing in poor urban areas of South Los Angeles. We also investigated role of gender as the moderator and multimorbidity as the mediator of this association. In a community-based study in South Los Angeles, 308 AA older adults (age ≥ 55 years) were entered into this study. From this number, 112 (36.4%) were AA men and 196 (63.6%) were AA women. Polypharmacy (taking 5+ medications) was the dependent variable, obesity was the independent variable, gender was the moderator, and multimorbidity (number of chronic medical conditions) was the mediator. Age, educational attainment, financial difficulty (difficulty paying bills, etc.), income, marital status, self-rated health (SRH), and depression were the covariates. Logistic regressions were used for data analyses. In the absence of multimorbidity in the model, obesity was associated with higher odds of polypharmacy in the pooled sample. This association was not significant when we controlled for multimorbidity, suggesting that multimorbidity mediates the obesity-polypharmacy link. We found significant association between obesity and polypharmacy in AA women not AA men, suggesting that gender moderates such association. AA older women with obesity are at a higher risk of polypharmacy, an association which is mainly due to multimorbidity. There is a need for screening for inappropriate polypharmacy in AA older women with obesity and associated multimorbidity.

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The gut microbiota changes in obese people: a new perspective for the modern medicine

The International Journal of Gastroenterology and Hepatology Diseases ◽

10.2174/2666290601666211018120831 ◽

2021 ◽

Vol 01 ◽

Author(s):

Ludovico Abenavoli ◽

Anna Caterina Procopio ◽

Emidio Scarpellini

Keyword(s):

Gut Microbiota ◽

Modern Medicine ◽

Age Group ◽

Obese People ◽

Major Health ◽

Prevention And Treatment ◽

Treatment Of Obesity ◽

New Perspective ◽

Modern Era

: Obesity is one of the major health problems of the modern era. Obesity has been associated with rapidly rising growth rates that affect every age group of the population indiscriminately, particularly the younger ones. Undoubtedly, it is necessary to identify increasingly effective therapies in order to avoid the possible complications of the syndrome. In this context, the microbota can represent one of the therapeutic targets for prevention and treatment of obesity. We highlight the role of the microbiota as a therapeutic target in obesity.

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Role of Herbal Supplements in the Treatment of Obesity and Diabetes

Treating Endocrine and Metabolic Disorders With Herbal Medicines - Advances in Medical Diagnosis, Treatment, and Care ◽

10.4018/978-1-7998-4808-0.ch004 ◽

2021 ◽

pp. 74-103

Author(s):

Sonia Singh ◽

Bhupesh C. Semwal ◽

Yogesh Murti

Keyword(s):

Heart Diseases ◽

The Body ◽

Herbal Supplements ◽

Herbal Products ◽

Obesity And Diabetes ◽

Uncontrolled Diabetes ◽

Prevalence Of Obesity ◽

The Common ◽

Treatment Of Obesity

Around the world, the prevalence of obesity and diabetes are high raising multiple severe diseases. Some of the common disorders associated with obesity are diabetes, heart diseases, and hypertension. These disorders have a tremendous effect on social lifestyles of every individual. However, another lifestyle disorder is diabetes, which can also be called hyperglycemia. Uncontrolled diabetes has the potential to cause serious complications in the body including kidney disease, loss of vision, and cardiovascular disease, which contribute towards morbidity and mortality. Though various allopathic drugs are available in the market, the herbal products and their derivatives have enough potential to treat such diseases with little or no side effects. This chapter is concerned and focuses on the application of herbal drugs along with proven mechanisms of action.

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The Complex Context of the Involvement of Vitamin D Deficiency in Obesity

Revista de Chimie ◽

10.37358/rc.19.10.3654 ◽

2019 ◽

Vol 70 (10) ◽

pp. 3654-3656

Keyword(s):

Vitamin D ◽

Weight Loss ◽

Obese People ◽

Overweight People ◽

Keywords Obesity ◽

Mortality Increase ◽

Prevalence Of Obesity ◽

Treatment Of Obesity ◽

New Perspective ◽

Exact Relationship

The prevalence of obesity is increasing and morbidity and mortality increase with it. Vitamin D plays an important role in obesity. Determining the exact relationship between obesity and vitamin D may represent a new perspective in the approach and treatment of obesity. Clarifying whether supplementation with vitamin D in overweight people can prevent obesity and whether supplementation in obese people can help weight loss are essential. Keywords: obesity, vitamin D, treatment

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Elevated body fat increases amphetamine accumulation in brain: evidence from genetic and diet-induced forms of adiposity

Translational Psychiatry ◽

10.1038/s41398-021-01547-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Xiuping Fu ◽

Aparna P. Shah ◽

Jacqueline Keighron ◽

Ta-Chung M. Mou ◽

Bruce Ladenheim ◽

...

Keyword(s):

Attention Deficit Disorder ◽

High Fat Diet ◽

Wild Type ◽

High Prevalence ◽

Prevalence Of Obesity ◽

Normal Body Weight ◽

Mice Brain ◽

Potential Impact ◽

The Impact

AbstractDespite the high prevalence of obesity, little is known about its potential impact on the pharmacokinetics of psychotropic drugs. In the course of investigating the role of the microRNA system on neuronal signaling, we found that mice lacking the translin/trax microRNA-degrading enzyme display an exaggerated locomotor response to amphetamine. As these mice display robust adiposity in the context of normal body weight, we checked whether this phenotype might reflect elevated brain levels of amphetamine. To assess this hypothesis, we compared plasma and brain amphetamine levels of wild type and Tsn KO mice. Furthermore, we checked the effect of diet-induced increases in adiposity on plasma and brain amphetamine levels in wild type mice. Brain amphetamine levels were higher in Tsn KO mice than in wild type littermates and correlated with adiposity. Analysis of the effect of diet-induced increases in adiposity in wild type mice on brain amphetamine levels also demonstrated that brain amphetamine levels correlate with adiposity. Increased adiposity displayed by Tsn KO mice or by wild type mice fed a high-fat diet correlates with elevated brain amphetamine levels. As amphetamine and its analogues are widely used to treat attention deficit disorder, which is associated with obesity, further studies are warranted to assess the impact of adiposity on amphetamine levels in these patients.

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