scholarly journals Melatonin, A Promising Therapeutic for Diabetes Mellitus and Its Complications: A Narrative Review

2021 ◽  
Vol 7 (3) ◽  
pp. 138-145
Author(s):  
Yanuarita Tursinawati ◽  
Arum Kartikadewi ◽  
Arum Kartikadewi ◽  
Ari Yuniastuti ◽  
Ari Yuniastuti ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Signaling Pathways ◽  
Animal Studies ◽  
Communicable Disease ◽  
Reproductive Organs ◽  
Diabetes Therapy ◽  
Sugar Levels ◽  
Role Administration ◽  
Non Communicable Disease

Diabetes mellitus (DM) is a non-communicable disease and still a health problem in the world. Melatonin is responsible to metabolize carbohydrate and regulate blood sugar levels. Several studies proved Melatonin is useful in the diabetes therapy and its complication by performing antioxidant activity through various signaling pathways. The role of the melatonin hormone in the pathogenesis of complications of diabetes mellitus is still a lot of controversy. Animal studies are still incomplete to explain the mechanism of action of melatonin. Therefore, this review aims to discuss Melatonin role administration in DM and its complications. This review was started by searching articles using electronic databases such as Google Scholar, Science Direct, SpringerLink and Pubmed between 2009-2019. Melatonin increased respiration within mitochondria; acted as antioxidant that fight free radical production; and reduced oxidative stress. It diminished proinflammatory cytokines in diabetes and prevents various DM complications on eyes, cardiac and male reproductive organs through antioxidant effects. It inhibited proinflammatory within several signaling Pathways, included PI3K/Akt-Nrf2,cGMP-PKG, Nrf-2-HO-1 and MAPK, Syk, p38MAPK pathways. There are various melatonin roles in diabetes and DM complications as a promising new breakthrough of DM treatment. It is necessary to explore Melatonin role in other DM complications. Most of this research is on experimental animals, thus clinical trial studies should be carried out in humans to make melatonin a promising therapeutic or prevention for diabetes and its complications in the future

scholarly journals Pemberdayaan pada Penderita Diabetes Tipe 2 dan Kader Kesehatan dalam Pelaksanaan Program Pos Binaan Terpadu Penyakit Tidak Menular (Posbindu PTM)

2020 ◽  
Vol 4 (1) ◽  
pp. 201-211
Author(s):  
Arief Andriyanto ◽  
Etty Rekawati ◽  
Dwi Cahya Rahmadiyah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Risk Factor ◽  
Communicable Disease ◽  
Control Program ◽  
Community Empowerment ◽  
Risk Factor Control ◽  
Non Communicable Disease

Diabetes mellitus is classified as a non-communicable disease which has been estimated to have increased, so a risk factor control program recommended by the Ministry of Health is required according to the DM management pillar. Health cadre empowerment is also needed to actively support non-communicable diseases programs. The purpose of this community empowerment was to change the behaviour of people with type 2 diabetes in glucose control and improve the health cadres' skills in Posbindu PTM activities. The program was carried out in October 2018 until March 2019. The targets were: 86 type 2 diabetes patients, 24 cadres in Cisalak Pasar Kelurahan, 120 cadres in Cimanggis District, and 293 cadres in Depok City. The results showed that patients could control their glucose and health cadres experienced improved skills. The role of community nurses is continuously needed to provide appropriate interventions to the patients.

scholarly journals Gambaran Pengetahuan dan Upaya Pencegahan Diabetes Melitus: Literatur Review

2021 ◽  
Vol 1 ◽  
pp. 1809-1816
Author(s):  
Novi Aji Lestari ◽  
Dafid Arifiyanto
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Communicable Disease ◽  
Impaired Insulin ◽  
Level Of Knowledge ◽  
Sugar Levels ◽  
Prevention Of Diabetes ◽  
Good Prevention ◽  
Non Communicable Disease ◽  
Diabetes Melitus

AbstractDiabetes Mellitus ia a non-communicable disease characterized by high blood sugar levels due to impaired insulin function. Diabetes prevention encompassed modified and unmodifie factors. Age and heredity are the ummodified factors, whereas diet, pack of physical activity, drugs, stress, and pack of knowledge are the modified factors. Education and family support Van influence the level of knowledge that can affect a person both towards the environment and particular objects. To identify the level of knowledge, physical activity, and other prevention efforts to prevent diabetes. A Literature review was used on this study, The article was selected from the Pubmeed, Portal Garuda, and Scilit database. Five studies where selected based on inclusion criteria. This study showed that people with diabetes mellitus had good knowledge 377 respondents, 161 respondents gas suffcient knowledge, and 131 respondents lacked knowledge. While the prevention of diabetes mellitus had good prevention as many as 322 respondents, adequate prevention as 166 respondents, lack of prevention was 141 respondents. Physical activity gas a level of mild as many as 30 respondents, moderate as right respondents, high as two respondents. Many people had a lack of knowledge and prevention of diabetes mellitus, Nurse are expected to provide education or nursing care as well as phychological aspects. Keywords : Diabetes Melitus; Prevention; Knowledge. AbstrakDiabetes Melitus suatu penyakit tidak menular yakni gangguan metabolisme kronis yang disebabkan oleh banyak faktor dengan ditandai tingginya kadar gula darah sebagian dari akibat gangguan fungsi insulin, upaya pencegahan diabetes memiliki faktor risiko meliputi faktor yang tidak dapat diubah yakni umur dan keturunan dan faktor yang dapat diubah yakni makanan, aktifitas fisik yang kurang, obat- obatan,stress dan kurangnya pengetahuan. Tingkat pengetahuan dapat dipengaruhi oleh pendidikan dan dukungan keluarga yang dapat mempengaruhi seseorang baik terhadap lingkungan maupun objek tertentu. Mengetahui gambaran pengetahuan dan upaya pencegahan dan juga pencegahan dengan melakukan aktivitas fisik. Penelitian ini merupakan penelitian sekunder berjenis literatur review. Metode yang digunakan dalam pemilihan artikel yaitu dengan melakukan penelusuran literatur dari sumber database Pubmed, Portal Garuda, dan Scilit dan didapatkan 5 artikel yang sesuai dengan kriteria inklusi penelitian. Hasil analisis literatur review menunjukkan bahwa masyarakat dengan pengetahuan dan upaya pencegahan diabetes melitus memiliki pengetahuan baik dengan hasil sebanyak 377 responden, pengetahuan cukup sebanyak 161 responden, pengetahuan kurang sebanyak 131 responden. Sedangkan pencegahan diabetes melitus memiliki pencegahan baik sebanyak 322 responden, pencegahan cukup sebanyak 166 respondnen, pencegahan kurang baik sebanyak 141 responden. Dan pencegahan aktivitas fisik memiliki tingkat pencegahan ringan sebanyak 30 responden, pencegahan sedang sebanyak 8 responden, pencegahan tinggi sebanyak 2 responden. Masyarakat yang mengalami kurang pengetahuan dan pencegahan diabetes melitus paling banyak mengalami tingkat pengetahuan dan pencegahan baik. Diharapkan perawat dapat memberikan edukasi atau asuhan keperawatan dengan tetap memperhatikan aspek psikologi. Kata kunci : Diabetes Melitus; Pencegahan; Pengetahuan.

scholarly journals Pengaruh Diabetes Mellitus Terhadap Kejadian Disfungsi Ereksi

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Alpacino J. Wowor ◽  
Lydia E. N. Tendean ◽  
Janette M. Rumbajan
Keyword(s):  
Diabetes Mellitus ◽  
Erectile Dysfunction ◽  
Literature Review ◽  
Sexual Health ◽  
Erectile Function ◽  
Communicable Disease ◽  
The Elderly ◽  
Exclusion Criteria ◽  
Sugar Levels ◽  
Non Communicable Disease

Abstract: Diabetes Mellitus (DM) is a non-communicable disease that can be found at all ages, especially in adults and the elderly. Erectile Dysfunction (ED) is the inability to maintain an erection. Like DM, DE is still a problem facing the world, including Indonesia. Blood vessels can be damaged by various factors, one of which is uncontrolled blood sugar levels that can lead to Erectile Dysfunction. The International Index of Erectile Function (IIEF-5) or Sexual Health Inventory for Men (SHIM) is a tool for diagnosing ED. The purpose of this study was to determine the effect of Diabetes Mellitus on the incidence of Erectile Dysfunction. This study took the form of a literature review with data searches using three databases, namely Pubmed, ScienceDirect and Google Scholar. The keywords used were Diabetes Mellitus "AND" Erectile Dysfunction. 10 literature was obtained after being selected based on inclusion and exclusion criteria.  According to the ten literature selected in this study, all found an effect of Diabetes Mellitus on the incidence of Erectile Dysfunction. In Conclusion, Diabetes Mellitus affects the occurrence of Erectile Dysfunction.Keywords: Diabetes Mellitus, Erectile Dysfunction.  Abstrak: Diabetes Mellitus (DM) merupakan penyakit tidak menular yang dijumpai pada segala usia terutama pada dewasa dan lansia. Disfungsi Ereksi (DE) merupakan ketidakmampuan dalam mempertahankan ereksi. Seperti halnya DM, DE juga masih menjadi masalah yang dihadapi dunia termasuk Indonesia. Pembuluh darah dapat mengalami kerusakan oleh berbagai faktor, salah satunya adalah kadar gula darah yang tidak terkontrol sehingga dapat memicu terjadinya Disfungsi Ereksi. International Index of Erectile Function (IIEF-5) atau Sexual Health Inventory for Men (SHIM) merupakan alat bantu dalam penegakan diagnosis DE. Tujuan penelitian ini adalah untuk mengetahui pengaruh Diabetes Mellitus terhadap kejadian Disfungsi Ereksi. Penelitian ini berbentuk literature review dengan pencarian data menggunakan tiga database, yaitu Pubmed, ScienceDirect dan Google Cendekia. Kata kunci yang digunakan yaitu Diabetes Mellitus “DAN” Erectile Dysfunction. Didapatkan 10 literatur setelah diseleksi berdasarkan kriteria inklusi dan eksklusi. Berdasarkan dari sepuluh literatur yang dipilih dalam penelitian ini, seluruhnya mendapati adanya pengaruh Diabetes Mellitus terhadap kejadian Disfungsi Ereksi. Sebagai simpulan, Diabetes Mellitus berpengaruh terhadap terjadinya Disfungsi Ereksi.Kata kunci: Diabetes Mellitus, Disfungsi Ereksi.

scholarly journals Precision Medicine, Developmental Plasticity and Prevention of Non-Communicable Disease

2020 ◽  
Author(s):  
Carol Wang ◽  
John Attia ◽  
Stephen Lye ◽  
Wendy Oddy ◽  
Lawrence Beilin ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Early Life ◽  
Developmental Plasticity ◽  
Communicable Disease ◽  
Adult Health ◽  
Lower Systolic Blood Pressure ◽  
Adult Disease ◽  
Healthy Nutrition ◽  
Non Communicable Disease

Abstract Background: It is well established that genetics, environment, and interplay between them play crucial roles in adult disease. We aimed to evaluate the role of genetics, early life nutrition, and interaction between them, on optimal adult health. Methods: As part of a large international consortium (n~154,000), we identified 60 SNPs associated with both birthweight and adult disease. Utilising the Raine Study, we developed a birthweight polygenic score (BW-PGS) based the 60 SNPs and examined relationships between BW-PGS and adulthood cardiovascular risk factors, specifically evaluating interactions with early life nutrition. Findings: Healthy nutrition was beneficial for all individuals; longer duration of any breastfeeding was associated with lower BMI and lower Systolic Blood Pressure in those with higher BW-PGS. Interpretation: Optimal breastfeeding offers the greatest benefit to reduce adult obesity and hypertension in those genetically predisposed to high birthweight. This provides an example of how precision medicine in early life can improve adult health.

scholarly journals Beliefs and practices in diabetes care

Duazary ◽  
2020 ◽  
Vol 17 (1) ◽  
pp. 74-86
Author(s):  
Juan Pablo Álvarez-Najar ◽  
Mery Luz Valderrama-Sanabria ◽  
Amalia Priscila Peña-Pita
Keyword(s):  
Diabetes Mellitus ◽  
Health Beliefs ◽  
Eating Habits ◽  
Communicable Disease ◽  
High Morbidity ◽  
Economic Costs ◽  
Beliefs And Practices ◽  
Life Style Changes ◽  
High Prevalence ◽  
Non Communicable Disease

Diabetes mellitus is considered a chronic non-communicable disease with high morbidity, presents to its high prevalence, social, family, and economic costs. Interventions aimed at life-style changes are fundamental in managing; due to this, patients must receive education. The aim of the study was to identify the beliefs and practices of the persons with diabetes mellitus, to propose nurse care according to these precepts. This was a descriptive study of systematic literature review, searching for articles in databases, Springer Science, Elsevier, ProQuest, Science Direct, Index, Pubmed, SciELO, Medigraphic, and Medline during 2016 to 2018, published between 2001 and 2018, in Spanish, English, and Portuguese. A total of 49 studies were contributing to fulfilling the objective. Within the beliefs for the management of disease, is the use of herbs, some consider as cause "fright"; Others take into account risk factors such as heredity, obesity, poor eating habits. Various beliefs are presented in relation to insulin treatment. Spirituality is emphasized; seeking refuge in God and prayer. Is important to understand the person, from their values, beliefs, customs and feelings. Education is a fundamental tool to control the disease, but health beliefs must be taken into account in order to achieve favorable results.

scholarly journals Gerakan Siaga Masyarakat Anti-Diabetes Mellitus (SIMANIS) Melalui Kartu SIDIA (Skrining Pre-Diabetes) di Kabupaten Semarang

2020 ◽  
Vol 6 (1) ◽  
pp. 84-89
Author(s):  
Lukman Fauzi ◽  
R.R. Sri Ratna Rahayu ◽  
Lindra Anggorowati ◽  
Hendri Hariyanto ◽  
Trinita Septi Mentari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Early Detection ◽  
Communicable Disease ◽  
Public Awareness ◽  
Knowledge Score ◽  
Case Finding ◽  
Attitude Score ◽  
Active Case Finding ◽  
Active Case ◽  
Non Communicable Disease

Diabetes Mellitus (DM) is a non-communicable disease that contributes to the cause of death. Based on the analysis of the situation in Kawengen Village, Semarang Regency, there were several problems related to the incidence of DM, including the Non-Communicable Disease Integrated Guidance Post Program (Posbindu PTM), which was not running optimally. Based on these problems, it is necessary to form a movement called the Anti-Diabetes Mellitus Community Alert Movement (SIMANIS). Active case finding and detection of pre-DM cases aim to capture people who already have pre-DM symptoms, but they do not know. Furthermore, if caught, they can be followed up so that they are willing to go to the health service unit before complications occur. The implementation of this community service activity is carried out in four stages, namely the formation of SIMANIS cadres, education on prevention and control of DM to SIMANIS cadres and the community, ToT on how to fill in and use the SIDIA Card (pre-diabetes screening) to SIMANIS cadres, and use of the SIDIA Card for early detection active case finding pre-DM. There was an increase in the pre-post education knowledge score from 7.59 + 1.5 to 8.93 + 0.9 and an increase in the pre-post education attitude score from 7.96 + 1.22 to 9.07 + 0.78. SIMANIS through the use of the SIDIA Card can be used to increase public awareness in prevention, early detection, and case finding of DM.

scholarly journals The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Joshua A. David ◽  
William J. Rifkin ◽  
Piul S. Rabbani ◽  
Daniel J. Ceradini
Keyword(s):  
Diabetes Mellitus ◽  
Oxidative Damage ◽  
Therapeutic Target ◽  
Type Ii Diabetes ◽  
Animal Studies ◽  
Cell Types ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
And Oxidative Stress

Despite improvements in awareness and treatment of type II diabetes mellitus (TIIDM), this disease remains a major source of morbidity and mortality worldwide, and prevalence continues to rise. Oxidative damage caused by free radicals has long been known to contribute to the pathogenesis and progression of TIIDM and its complications. Only recently, however, has the role of the Nrf2/Keap1/ARE master antioxidant pathway in diabetic dysfunction begun to be elucidated. There is accumulating evidence that this pathway is implicated in diabetic damage to the pancreas, heart, and skin, among other cell types and tissues. Animal studies and clinical trials have shown promising results suggesting that activation of this pathway can delay or reverse some of these impairments in TIIDM. In this review, we outline the role of oxidative damage and the Nrf2/Keap1/ARE pathway in TIIDM, focusing on current and future efforts to utilize this relationship as a therapeutic target for prevention, prognosis, and treatment of TIID.

scholarly journals Gestational Diabetes Mellitus—Innovative Approach to Prediction, Diagnosis, Management, and Prevention of Future NCD—Mother and Offspring

2020 ◽  
Vol 11 ◽  
Author(s):  
H. David McIntyre ◽  
Anil Kapur ◽  
Hema Divakar ◽  
Moshe Hod
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Communicable Disease ◽  
Critical Evaluation ◽  
Medical Complication ◽  
Diagnostic Approaches ◽  
Non Communicable Disease ◽  
Subsequent Risk

Gestational diabetes mellitus (GDM) is the commonest medical complication of pregnancy. The association of GDM with immediate pregnancy complications including excess fetal growth and adiposity with subsequent risk of birth trauma and with hypertensive disorders of pregnancy is well recognized. However, the associations with wide ranges of longer-term health outcomes for mother and baby, including the lifetime risks of obesity, pre-diabetes, and diabetes and cardiovascular disease have received less attention and few health systems address these important issues in a systematic way. This article reviews historical and recent data regarding prediction of GDM using demographic, clinical, and biochemical parameters. We evaluate current and potential future diagnostic approaches designed to most effectively identify GDM and extend this analysis into a critical evaluation of lifestyle and nutritional/pharmacologic interventions designed to prevent the development of GDM. The general approach to management of GDM during pregnancy is then discussed and the major final focus of the article revolves around the importance of a GDM diagnosis as a future marker of the risk of non-communicable disease (NCD), in particular pre-diabetes, diabetes, and cardiovascular disease, both in mother and offspring.

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