Nucleoli migration coupled with cytomixis

Biologia ◽  
2016 ◽  
Vol 71 (6) ◽  
Author(s):  
Puneet Kumar ◽  
Vijay Kumar Singhal
Keyword(s):  
Mother Cell ◽  
Vital Role ◽  
Wild Plants ◽  
Cold Desert ◽  
North West ◽  
Desert Region ◽  
Cellular Processes ◽  
The Past ◽  
Nuclear Domain ◽  
Chromatin Material

AbstractNucleolus was regarded as a mere ribosome-producing factory for many decades however, in the past two decades; this has come to the light that it is a plurifunctional nuclear domain which plays vital role in many cellular processes. Despite many advances, much remains to be revealed about the nucleolus association with cellular processes. While exploring the chromosomal diversity in the high altitude plants of the Indian cold desert region in North West Himalayas we came across 140 wild plants, out of these, pollen mother cell (PMC) in 31 plants showed the occurrence of additional nucleoli. Coincidently, all these plants also depicted the phenomenon of cytomixis i.e. inter-PMC chromatin material extrusion/transfer among/between adjacent meiocytes. Interestingly, it was noticed that nucleolus accompanied the chromatin material during process of cytomixis. During, and after the migration of nucleolus, change in its shape, size and number has also been discussed. So the current paper here in correlated the inter-PMC migration of nucleolus to the occurrence of cytomixis.

TOXIC PROPERTIES AND INTAKE SYMPTOMS OF SOME WILD PLANTS IN RELATION TO REPORTED FROM THE FOREST OF NORTH WEST SATPUDA REGION OF MAHARASTRA, INDIA

2017 ◽  
Vol 23 (2) ◽  
Author(s):  
SANJAY A. KHAIRNAR
Keyword(s):  
Secondary Phase ◽  
Wild Plants ◽  
Chemical Components ◽  
World Population ◽  
Poisonous Plants ◽  
North West ◽  
Toxic Plants ◽  
Datura Metel ◽  
Croton Tiglium ◽  
Modern Era

In modern era about 80% of the world population depends on herbal alternative system of medicine. Seventy thousand plants are used in medicine and about 2000 plants are used in Indian Ayurveda. The activities of the curative plants are evaluated by their chemical components. Few of them are important as a medicine but also posses poisonous or toxic properties. The toxicity is produced in them due to the synthesis of toxic chemical compounds may be in primary or secondary phase of their life. Most of the users of such medicinal plants in crude form are tribal and peoples living in the forests and their domestic stock . Most of the time these peoples may not aware about the toxicity of such plants used by them and probably get affected sometimes even leads to death. In the study area during the field survey of poisonous plants, information are gathered from the traditional practicing persons, cow boy and from shepherds. About 20 plant species belonging to 17 families are reported as a medicinal as well as toxic. From the available literature, nature of toxic compound and symptoms of their intake on human being are recorded. In the study area the plants like, Abrus precatorious commonly known as a Gunj or Gunjpala, Jatropha curcas , (Biodiesel plant), Croton tiglium (Jamalgota), Citrullus colocynthis (Kadu Indrawan, Girardinia diversifolia (Agya), Mucuna purriens (Khajkuairi), Euphorbia tirucali (Sher), E. ligularia (Sabarkand), Datura metel ( Kala Dhotara), Datura inoxia (Pandhara Dhotara) and Asparagus racemo-sus (Shatavari) etc . are some of the toxic plants used as a medicine and harmful also.

MiRNA-145 and Its Direct Downstream Targets in Digestive System Cancers: A Promising Therapeutic Target

2020 ◽  
Vol 26 ◽  
Author(s):  
Yini Ma ◽  
Xiu Cao ◽  
Guojuan Shi ◽  
Tianlu Shi
Keyword(s):  
Digestive System ◽  
Target Genes ◽  
Malignant Neoplasm ◽  
Vital Role ◽  
Diagnostic Biomarkers ◽  
Cellular Processes ◽  
Promising Therapeutic Target ◽  
Direct Target ◽  
Potential Strategy

: MicroRNAs (miRNAs) play a vital role in the onset and development of many diseases, including cancers. Emerging evidence shows that numerous miRNAs have the potential to be used as diagnostic biomarkers for cancers, and miRNA-based therapy may be a promising therapy for the treatment of malignant neoplasm. MicroRNA-145 (miR-145) has been considered to play certain roles in various cellular processes, such as proliferation, differentiation and apoptosis, via modulating expression of direct target genes. Recent reports show that miR-145 participates in the progression of digestive system cancers, and plays crucial and novel roles for cancer treatment. In this review, we summarize the recent knowledge concerning the function of miR-145 and its direct targets in digestive system cancers. We discuss the potential role of miR-145 as valuable biomarkers for digestive system cancers and how miR-145 regulates these digestive system cancers via different targets to explore the potential strategy of targeting miR-145.

The Oxford History of Historical Writing

2018 ◽  
Keyword(s):  
Early Modern ◽  
Korean Peninsula ◽  
Comparative Approach ◽  
Modern World ◽  
Historical Writing ◽  
North West ◽  
The Past ◽  
History Of

How was history written in Europe and Asia between 400–1400? How was the past understood in religious, social, and political terms? And in what ways does the diversity of historical writing in this period mask underlying commonalities in narrating the past? The volume tackles these and other questions. Part I provides comprehensive overviews of the development of historical writing in societies that range from the Korean Peninsula to north-west Europe, which together highlight regional and cultural distinctiveness. Part II complements the first part by taking a thematic and comparative approach; it includes chapters on genre, warfare, and religion (amongst others) which address common concerns of historians working in this liminal period before the globalizing forces of the early modern world.

scholarly journals Use of PRP, PRF and CGF in Periodontal Regeneration and Facial Rejuvenation—A Narrative Review

Biology ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 317
Author(s):  
Eitan Mijiritsky ◽  
Haya Drora Assaf ◽  
Oren Peleg ◽  
Maayan Shacham ◽  
Loredana Cerroni ◽  
...  
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Periodontal Regeneration ◽  
Clinical Work ◽  
Gingival Recession ◽  
Vital Role ◽  
Facial Rejuvenation ◽  
Cochrane Library ◽  
The Past ◽  
Autologous Platelet

Growth factors (GFs) play a vital role in cell proliferation, migration, differentiation and angiogenesis. Autologous platelet concentrates (APCs) which contain high levels of GFs make them especially suitable for periodontal regeneration and facial rejuvenation. The main generations of APCs presented are platelet-rich plasma (PRP), platelet-rich fibrin (PRF) and concentrated growth factor (CGF) techniques. The purpose of this review is to provide the clinician with an overview of APCs’ evolution over the past decade in order to give reliable and useful information to be used in clinical work. This review summarizes the most interesting and novel articles published between 1997 and 2020. Electronic and manual searches were conducted in the following databases: Pubmed, Scopus, Cochrane Library and Embase. The following keywords were used: growth factors, VEGF, TGF-b1, PRP, PRF, CGF and periodontal regeneration and/or facial rejuvenation. A total of 73 articles were finally included. The review then addresses the uses of the three different techniques in the two disciplines, as well as the advantages and limitations of each technique. Overall, PRP is mainly used in cases of hard and soft tissue procedures, while PRF is used in gingival recession and the treatment of furcation and intrabony defects; CGF is mainly used in bone regeneration.

scholarly journals A Response of Snow Cover to the Climate in the Northwest Himalaya (NWH) Using Satellite Products

2021 ◽  
Vol 13 (4) ◽  
pp. 655
Author(s):  
Animesh Choudhury ◽  
Avinash Chand Yadav ◽  
Stefania Bonafoni
Keyword(s):  
Snow Cover ◽  
Land Surface ◽  
Significant Negative Correlation ◽  
Shuttle Radar Topography Mission ◽  
Vital Role ◽  
Snow Cover Area ◽  
Study Region ◽  
Northwest Himalaya ◽  
The Past ◽  
Average Annual Temperature

The Himalayan region is one of the most crucial mountain systems across the globe, which has significant importance in terms of the largest depository of snow and glaciers for fresh water supply, river runoff, hydropower, rich biodiversity, climate, and many more socioeconomic developments. This region directly or indirectly affects millions of lives and their livelihoods but has been considered one of the most climatically sensitive parts of the world. This study investigates the spatiotemporal variation in maximum extent of snow cover area (SCA) and its response to temperature, precipitation, and elevation over the northwest Himalaya (NWH) during 2000–2019. The analysis uses Moderate Resolution Imaging Spectroradiometer (MODIS)/Terra 8-day composite snow Cover product (MOD10A2), MODIS/Terra/V6 daily land surface temperature product (MOD11A1), Climate Hazards Infrared Precipitation with Station data (CHIRPS) precipitation product, and Shuttle Radar Topography Mission (SRTM) DEM product for the investigation. Modified Mann-Kendall (mMK) test and Spearman’s correlation methods were employed to examine the trends and the interrelationships between SCA and climatic parameters. Results indicate a significant increasing trend in annual mean SCA (663.88 km2/year) between 2000 and 2019. The seasonal and monthly analyses were also carried out for the study region. The Zone-wise analysis showed that the lower Himalaya (184.5 km2/year) and the middle Himalaya (232.1 km2/year) revealed significant increasing mean annual SCA trends. In contrast, the upper Himalaya showed no trend during the study period over the NWH region. Statistically significant negative correlation (−0.81) was observed between annual SCA and temperature, whereas a nonsignificant positive correlation (0.47) existed between annual SCA and precipitation in the past 20 years. It was also noticed that the SCA variability over the past 20 years has mainly been driven by temperature, whereas the influence of precipitation has been limited. A decline in average annual temperature (−0.039 °C/year) and a rise in precipitation (24.56 mm/year) was detected over the region. The results indicate that climate plays a vital role in controlling the SCA over the NWH region. The maximum and minimum snow cover frequency (SCF) was observed during the winter (74.42%) and monsoon (46.01%) season, respectively, while the average SCF was recorded to be 59.11% during the study period. Of the SCA, 54.81% had a SCF above 60% and could be considered as the perennial snow. The elevation-based analysis showed that 84% of the upper Himalaya (UH) experienced perennial snow, while the seasonal snow mostly dominated over the lower Himalaya (LH) and the middle Himalaya (MH).

scholarly journals Ensemble models on palaeoclimate to predict India's groundwater challenge

2013 ◽  
Vol 2 (3) ◽  
Author(s):  
Partha Sarathi Datta
Keyword(s):  
Climate Change ◽  
Climate Models ◽  
Global Climate ◽  
Global Climate Models ◽  
Humid Climate ◽  
Ensemble Models ◽  
North West ◽  
The Past ◽  
The North ◽  
14C Age

In many parts of the world, freshwater crisis is largely due to increasing water consumption and pollution by rapidly growing population and aspirations for economic development, but, ascribed usually to the climate. However, limited understanding and knowledge gaps in the factors controlling climate and uncertainties in the climate models are unable to assess the probable impacts on water availability in tropical regions. In this context, review of ensemble models on δ18O and δD in rainfall and groundwater, 3H- and 14C- ages of groundwater and 14C- age of lakes sediments helped to reconstruct palaeoclimate and long-term recharge in the North-west India; and predict future groundwater challenge. The annual mean temperature trend indicates both warming/cooling in different parts of India in the past and during 1901–2010. Neither the GCMs (Global Climate Models) nor the observational record indicates any significant change/increase in temperature and rainfall over the last century, and climate change during the last 1200 yrs BP. In much of the North-West region, deep groundwater renewal occurred from past humid climate, and shallow groundwater renewal from limited modern recharge over the past decades. To make water management to be more responsive to climate change, the gaps in the science of climate change need to be bridged.

At the Still Point of the Turning World: Freud's Reception of Winckelmann's Greece

2014 ◽  
Vol 16 (2) ◽  
pp. 137-152
Author(s):  
Sharon Kool
Keyword(s):  
Vital Role ◽  
Classical Literature ◽  
German Culture ◽  
Classical Greece ◽  
Cultural Ideal ◽  
The Past ◽  
Greco Roman ◽  
Late Nineteenth ◽  
With Memory ◽  
Of Greece

Freud's theory is primarily concerned with memory, about the present contained within the past. It is also rooted to the past in another way; Freud's reception of the Greek classical tradition played a vital role in the genesis of his oeuvre. Winckelmann's revival of ‘Greece’ dominated German culture up to the late nineteenth and early twentieth century, yet besides the importance of Bildung in shaping Freud's early Gymnasium experience, his influence upon Freud is often neglected. While Freud's debt to German Hellenism is clearly demonstrated in his library of classical literature and his collection of Greco-Roman antiquities, the afterlife of Winckelmann's legacy is more subtly inscribed upon psychoanalysis. This paper focuses on Winckelmann's aesthetic reconstruction of classical Greece which made beauty, self-restraint and repression a cultural ideal to be imitated and admired. It is argued that hysteria provided one of the most powerful challenges to this ideal. Psychoanalysis can thus be seen as developing out of a milieu that was still overshadowed by Winckelmann's idealization of Greece. Further, it is argued that Winckelmann advanced a homoerotic tradition in German culture and the sedimentation of this tradition can be discerned in Freud's response to hysteria, his privileging of the masculine and his theory of bisexuality.

Editorial

2016 ◽  
Vol 15 (1) ◽  
pp. 2-2
Author(s):  
Chris Roseveare ◽  
Keyword(s):  
The Netherlands ◽  
Editorial Team ◽  
Patient Specific ◽  
Service Improvement ◽  
Single Individual ◽  
National Goal ◽  
Acute Medicine ◽  
North West ◽  
The Past

Clinicians working in acute medicine will be familiar with change. The speciality and the environment we work in has changed continually over the past 15 years – I often reflect that no two years have been the same since I started working in the field back in 1999. Change is important, in order to achieve best practice, but sustaining such improvements can be an enormous challenge. The regular turnover of medical staff, local management restructuring and the constantly shifting National goal posts often conspire against us. It is easy for ‘changefatigue’ to set in. Submissions to this journal often describe local audits and service improvement projects which have raised standards: a low baseline may result in a statistically significant improvement from a relatively small intervention – often an education programme or poster campaign to raise awareness of the problem. However, what happens next is far more important: can the improvement be sustained when the key driver behind the project – the enthusiast – moves on, after their 4 month block of acute medicine comes to an end? One year on, we are often back where we started. Two articles in this edition appear to have achieved the Holy Grail of sustainability. In the paper by Joanne Botten from Musgrove Park, door to antibiotic time was improved for patients with neutopaenic sepsis by introducing a system whereby the antibiotics could be administered without waiting for a prescription to be written. The combination of a neutropaenic sepsis alert card and a patient-specific direction empowered the nurses and patients to ensure administration within an hour of arrival in over 90% of cases, a figure which has been sustained for over a year. Sustainable change is often facilitated by modifications in paperwork, but crucially the project’s success was not reliant on a single individual. The value of engaging with the wider team is also shown in Gary Misselbook’s paper describing sustained improvement in the layout and utility of an AMU procedure room. The authors describe how repeated attempts by different registrars had failed to achieve more than temporary reorganisation; the change was only sustained when nursing, infection control and administrative staff became involved in the process. The multiprofessional nature of the AMU is one of its greatest assets – we would all do well to remember this when instigating change. On a similar note, observant readers may have noticed some changes to the editorial board of this journal – I am delighted to welcome Dr Tim Cooksley, acute physician from Manchester and Dr Prabath Nanayakkara from the VUMC in the Netherlands. Tim came through the acute medicine training programme in the North West and his role in the acute oncology service at the Christie Hospital as well as his active involvement in the SAMBA project over recent years brings an important perspective to the editorial team. Prabath has been heavily involved with the development of acute medicine in the Netherlands and co-hosted the successful SAMSTERDAM meeting in 2014. His international perspective will be welcome as we attempt to extend the reach of Acute Medicine to our European neighbours over the coming years. I am very grateful to Nik Patel, Mark Jackson and Ashwin Pinto for their help and support during the past decade and wish them well for the future.

The development of biomedical gerontology in Ukraine – a historical priority

2021 ◽  
Vol 2021 (2b) ◽  
pp. 35-40
Author(s):  
I. Stambler ◽  
Keyword(s):  
Academic Discipline ◽  
National Development ◽  
Global Scale ◽  
Vital Role ◽  
Social Significance ◽  
International Growth ◽  
The Past ◽  
The Future ◽  
History Of ◽  
Further Development

Celebrating the 30th anniversary of Ukraine's independence, it is important to remember the historical achievements of Ukrainian science, to honor the heroes of the science of the past and to draw inspiration from their achievements for the development of science of the future. In this regard, the history of medicine, as a special academic discipline, plays a vital role an important academic and civic role, as it helps to trace the medical scientific achievements of the past and draw conclusions about their strengths and priorities for future national and international growth and development. Analyzing the scientific strengths and priorities of science and medicine in Ukraine, it is safe to say that biomedical gerontology is one of the most important scientific and historical values and priorities of Ukraine on a global scale. There are good reasons to continue and develop this tradition, building on the strengths that exist, drawing inspiration from the past and looking to the future. Currently, the development of biomedical gerontology is becoming increasingly important for Ukraine, given the rapid aging of the country's population. The resulting economic and social problems are related to the aging population, which puts biomedical gerontology as a discipline that seeks solutions to achieve healthy and productive longevity, at the forefront of social significance, demanding further development and support of this field for the sake of internal national stability, and to preserve the country's international contribution. It is hoped that the outstanding history of biomedical gerontology in Ukraine, its honorable historical place in national development and international cooperation, will inspire further growing support and development of this field in Ukraine and abroad.

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