Urinary bisphenol A levels in prepubertal children with exogenous obesity according to presence of metabolic syndrome

2021 ◽  
Vol 34 (4) ◽  
pp. 495-502
Author(s):  
Esra Aktağ ◽  
Kadriye Yurdakök ◽  
Siddika Songül Yalçın ◽  
Nurgün Kandemir
Keyword(s):  
Metabolic Syndrome ◽  
Bisphenol A ◽  
High Performance ◽  
Linear Models ◽  
Age Groups ◽  
Control Group ◽  
Healthy Children ◽  
Obese Children ◽  
Potential Link ◽  
Drug Naïve

Abstract Objectives Recent studies have shown a potential link between chronic exposure to Bisphenol A (BPA) and exogenous obesity, the prevalence of which has been increasing dramatically in all age groups and particularly among children in the last decades. In this study, we aimed at comparing BPA exposure levels between controls and otherwise healthy, drug-naive, pre-pubertal children having exogenous obesity with/without metabolic syndrome. Methods A total of 63 pre-pubertal children with exogenous obesity whom 27 of them having metabolic syndrome attending Hacettepe University Ihsan Dogramaci Children’s Hospital were included in this study. The control group consisted of 34 age- and sex-matched healthy children with no significant underlying medical conditions. Urinary BPA levels were measured using LC-MS/MS (high-performance liquid chromatography coupled with tandem mass spectrometry) methodology. Results Urinary BPA levels among obese children were significantly higher than those of the control group (median: 22.9 μg/g-creatinine and 6.9 μg/g-creatinine, respectively; p=0.0001). When adjusted with generalized linear models for age, gender and z scores of body mass index, obese children having metabolic syndrome had significantly higher urinary BPA levels than obese children without metabolic syndrome and both obese groups had considerably elevated levels of urinary BPA than the controls (estimated marginal mean ± standard error: 42.3 ± 7.4 μg/g-creatinine, 22.6 ± 3.5 μg/g-creatinine and 12.1 ± 2.5 μg/g-creatinine, respectively, p=0.0001) Conclusions This study shows much higher BPA exposure among obese children with metabolic syndrome during the prepubertal period.

scholarly journals Aortae of Young Rats with Metabolic Syndrome Exhibit Enhanced Vasoconstrictor Activity Than Older Rats

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
R H Ali ◽  
N M B Gamil ◽  
A M Abdelrahman ◽  
M A Ahmed ◽  
G K Megahed ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Young Adult ◽  
Fasting Blood Glucose ◽  
Age Groups ◽  
Female Rats ◽  
Control Group ◽  
Albino Rats ◽  
Functional Changes ◽  
Vasoconstrictor Response ◽  
Nitrite Content

Abstract Background Metabolic syndrome (MetS) causes pathological remodeling of the heart and adjacent vessels. The functional changes in the big vessels in different age groups had not been fully delineated. Aim of the work The present study was planned to investigate aortic vasodilator and vasoconstrictor reactivity in young, adult and old female rats with MetS. Design: The experimental study was performed on 90 female albino rats randomized into 6 groups: young, adult and old rats with MetS and their respective control groups. Methods MetS was induced by feeding rats 41% fructose -containing diet and giving fructose solution (5 g fructose in 4 ml distilled water/day) by gavage in two sessions (2 ml/session). On the 8th week, all rats were sacrificed and were subjected to determination of body weight (BW), body mass index (BMI), absolute and relative visceral fat weight (VF), fasting blood glucose (FBG), plasma insulin (PI), homeostasis model of insulin resistance (HOMA-IR) and plasma lipid profile. All rats’ aortae were subjected to study of vascular reactivity to Potassium chloride (KCL), phenylephrine (PE) and acetyl choline (A.Ch) as well as estimation of nitrite content. Results On the 8th week of the study, all MetS groups developed criteria of metabolic syndrome as evidenced by the significant increase in final BW, BMI, absolute and relative VF weights, FBG, PI and HOMA-IR compared to their control group values. Also, MetS rat groups exhibited evident dyslipidemia in the form of significant increase in plasma levels of triglycerides, total cholesterol and significant decrease in HDL-cholesterol compared to their control group values. Aortae of young and adult MetS rat groups showed significant increase in their vasoconstrictor response to KCl and PE and decrease in A.Ch/KCL% and A.Ch/PE % compared to their controls, while old MetS rat group showed significantly increased vasoconstrictor response only to KCL compared to their controls. When compared to each other, young age MetS group had significantly higher vasoconstrictor response to PE compared to old MetS group despite comparable nitrite content. Conclusion Met.S causes functional vascular changes in all age groups with unexpectedly enhanced vasoconstrictor response in the young group compared to old.

scholarly journals Exocrine pancreatic dysfunction in children with obesity: characteristics of clinical picture and diagnostics

2020 ◽  
pp. 36-41
Author(s):  
I. S. Lembryk ◽  
O. V. Tymoshchuk
Keyword(s):  
Abdominal Pain ◽  
Clinical Symptoms ◽  
High Density Lipoproteins ◽  
Exocrine Function ◽  
Control Group ◽  
Type I ◽  
Healthy Children ◽  
Obese Children ◽  
Pancreatic Lesion ◽  
Functional Changes

Introduction. During the last twenty-five years the occurrence of obesity in children and teenagers has increased significantly. Materials and methods. 110 adolescents of 12–17 years old, with alimentary-constitutional obesity and involvement of pancreas and without its injury, as compared to the 30 healthy children of control group, were examined. The research provided determination of the sizes and elasticity of pancreas. The detection of the total cholesterol, high density lipoproteins and leptin level was carried out. Intensity of clinical symptoms (spastic pain in epigastrium and left subcostal arc; abdominal pain without localization, vomit without relief, general weakness) have been made accordingly to sum of points (from 0 to 3 points). If sum of points makes from 0 to 2 – intensive character of abdominal pain is low, from 3 to 5 points – it is high, from 5 to 10 points – it is very high. Normal level of amylase in a blood serum (Karavey’s method) is 12–32 g/(hour l), аnd diastase in urine – 20–160 g/(hour l). We made a screening test for elastase-I level by ELISA test. Normal activity of this enzyme in feces is 200 мkg/g. We have used sonographic method for detection of pancreatic diseases in obese children due to echo-structure of parotid gland. The analysis and statistical data processing were made by computer program "Statistica 7.0" and MS Excel XP. Research data. Physical inspection of our patients confirms prevalence of І degree over II degree obesity (52.7 % and 47.3 %, respectively; Р < 0.05). We have confirmed valid risk factor of pancreatic lesion in obese children – presence of diabetes mellitus type I in close relatives (80 % and 65 %, χ2 = 2,05; Р < 0.05). The changes of exocrine function of the pancreas in children with the stage II obesity were established. Echographic signs of the pancreas lesion in teenagers with obesity indicate the presence of functional changes: edema of head or entire edema, partial increase of parenchymal echogenicity, insufficient enlargement of the duct of Wirsung.

scholarly journals Features of immune response in children with varying severity of atopic dermatitis

2021 ◽  
Vol 16 (1) ◽  
pp. 20-26
Author(s):  
S.M. Nedelska ◽  
D.O. Vakula
Keyword(s):  
Immune Response ◽  
Atopic Dermatitis ◽  
Age Groups ◽  
Statistical Processing ◽  
Serum Levels ◽  
Young Age ◽  
Control Group ◽  
Healthy Children ◽  
Th2 Immune Response ◽  
Low Levels

Background. Atopic dermatitis (AD) is the most common allergic disease among children of young age. Severe forms of AD with skin bacterial and fungal overgrowth may be associated with features of the immune response in different age groups. Plenty of studies demonstrated not only polarization of the Th2 immune response in AD patients, but also the Th1 immune dysregulation. The purpose of this study was to investigate the features of the immune response in children with varying severity of atopic dermatitis. Materials and methods. The study included 85 children aged 3 months to 3 years with a verified diagnosis of AD, living in the Zaporozhzhia region. Twenty healthy children without atopy formed a control group. The patients were divided into groups depending on the severity of AD based on the SCORAD scale. The serum levels C3, C4–2, CD3+, CD19–, CD4+, CD8–, CD4–, CD8+, CD3–, CD56+, CD19+, CD14, CD45, IgA, IgM, IgG, IgE, С3, С4–2, phagocytic acti­vity of neutrophils, and proliferative activity of lymphocytes were measured by flow cyto­metry (Synevo). ELISA method was used to detect serum levels of IL-13 (ELISA Kit, Thermo Fisher Scientific, Austria). Statistical processing of the results was performed using the official software package Statistica 13.0. Results. The study revealed eosinophilia in 60 % of the children with a mild and moderate course of AD (Me 5.62 [3.64; 7.81]) and in 56 % of the children with a severe course (Me 6.18 [3.13; 9.42]). The children with a severe course of AD and low levels of IL-13, C3 had transient hypogammaglobulinemia and significantly lower le­vels of the C3 complement, increased levels of CD4+, CD8– with simultaneously decreased levels of CD4–, CD8+ compared with groups of the children with high levels of ­IL-13 (р < 0.05). Conclusion. The results suggest that severe forms of AD in children of the young age were associated with changes in the complement system and low levels of cytotoxic cells, transient hypogammaglobulinemia. It requires deeper research of the cascades of the immune response in children with AD.

Bisphenol A as a risk factor for allergic rhinitis in children

2020 ◽  
pp. 096032712095810
Author(s):  
A Nalbantoğlu ◽  
A Çelikkol ◽  
N Samancı ◽  
NC Günaydın ◽  
B Nalbantoğlu
Keyword(s):  
Allergic Rhinitis ◽  
Bisphenol A ◽  
Disease Severity ◽  
Allergic Diseases ◽  
Nasal Symptom ◽  
Interleukin 4 ◽  
Control Group ◽  
Healthy Children ◽  
Endocrine Disrupting Compound ◽  
Total Nasal Symptom Score

Aim: Bisphenol-A (BPA) is an endocrine disrupting compound and may exacerbate or induce allergic diseases. To the best of our knowledge, there is little evidence regarding the effects of BPA exposure on allergic rhinitis (AR) in children. In the present study, we sought to examine whether exposure to BPA in children is associated with AR. Methods: This study was designed as a case controlled clinical study. 140 children diagnosed as allergic rhinitis and 140 healthy children as control group were recruited. BPA, interleukin-4, interleukin-13, total IgE and interferon-gamma levels were determined. Skin prick tests were performed in patient group. Total nasal symptom score and ARIA classification were used to predict disease severity. Results: Serum IL-4, IgE and BPA levels of children with allergic rhinitis were found to be significantly higher than the control group. BPA and IL-4 levels were significantly higher in moderate to severe-persistent group. There was a positive correlation between total nasal symptom scores and Bisphenol A levels in children with allergic rhinitis. Conclusions: The present study is the first to observe statistically significant relationship between BPA concentrations and allergic rhinitis in children. Also increased levels of BPA are associated with disease severity.

Obesity Prevention Program in Childcare Centers: Two-Year Follow-Up

2016 ◽  
Vol 31 (6) ◽  
pp. 502-510 ◽  
Author(s):  
Ruby A. Natale ◽  
Sarah E. Messiah ◽  
Lila S. Asfour ◽  
Susan B. Uhlhorn ◽  
Nicole E. Englebert ◽  
...  
Keyword(s):  
Obesity Prevention ◽  
Low Income ◽  
Negative Slope ◽  
Control Group ◽  
Healthy Children ◽  
Unhealthy Food ◽  
Healthy Weight ◽  
Obese Children ◽  
Childcare Centers ◽  
The Impact

Purpose: To assess the impact of an early childhood obesity prevention intervention “Healthy Caregivers–Healthy Children” (HC2) on dietary patterns and body mass index percentile (PBMI) over 2 school years. Design: Randomized controlled trial. Setting: Childcare centers. Participants: Low-income families. Intervention: Intervention centers (N = 12) received HC2 which consisted of (1) menu modifications, (2) a healthy eating and physical activity curriculum for children, and (3) a parent curriculum for healthy meal preparation, reinforced through a role-modeling curriculum. Control centers (N = 16) received an injury prevention/safety intervention. Measures: Child PBMI and parent report of child’s consumption of fruits/vegetables and unhealthy food. Analysis: Confirmatory factor analysis verified the psychometric properties of factor scores for children’s consumption of fruits/vegetables and unhealthy food. Growth curve analysis assessed the impact of HC2 on change in consumption of fruits/vegetables and unhealthy food and PBMI over 2 school years. Results: Children in the intervention group (n = 754) had a negative slope (β = −1.95, standard error [SE] = 0.97, P = .04), indicating less increase in PBMI versus control children (n = 457). Stratified analyses showed that obese children in the intervention arm had a significantly higher increase in fruit/vegetable consumption versus control group obese children (β = 0.24, SE = 0.08, P = .003). Conclusion: The HC2 intervention resulted in the maintenance of healthy PBMI over 2 preschool years among low-income multiethnic children. These findings support efforts to implement healthy weight programs in the childcare setting.

Investigation of ischemia modified albumin and coenzyme Q10 levels in obese children with metabolic syndrome

2016 ◽  
Vol 41 (6) ◽  
Author(s):  
Sabahattin Muhtaroğlu ◽  
Selda Özkan Koçak ◽  
İhsan Çetin ◽  
Didem Barlak Keti ◽  
Mustafa Kendirci
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Colorimetric Method ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Healthy Children ◽  
Model Assessment ◽  
Obese Children ◽  
Ischemia Modified Albumin

AbstractIntroduction:The aim of this study was to analyze serum ischemia modified albumin (IMA) and plasma CoQ10 levels and to evaluate their correlation with insulin resistance (homeostatic model assessment, HOMA) and lipid profile in obese children with and without metabolic syndrome (MS).Methods:Thirty-one obese with MS, 30 obese without MS and 34 healthy children aged 6–18 years were included in the study. Serum IMA was measured by colorimetric method, plasma CoQ10 levels were measured by HPLC. Serum glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and insulin were analyzed.Results:IMA levels were found to be significantly higher (p<0.001) while the CoQ10 levels were significantly lower (p<0.001) in obese children with and without MS compared to controls. IMA and CoQ10 significantly correlated with each other and metabolic parameters. Furthermore, IMA and CoQ10 levels did not significantly differ between obese children with and without MS, while glucose, insulin levels and HOMA were significantly higher (p<0.001) in obese children with MS than obese without MS and controls.Conclusions:Based on the high levels of IMA, low CoQ10 and association with HOMA and lipid profile; we suggest that obese children may have oxidative damage, lipid peroxidation and cardiometabolic risk.

The effect of lifestyle change and metformin therapy on serum arylesterase and paraoxonase activity in obese children

2015 ◽  
Vol 28 (5-6) ◽  
Author(s):  
Atilla Çayır ◽  
Mehmet İbrahim Turan ◽  
Fatih Gurbuz ◽  
Nezahat Kurt ◽  
Abdulkadir Yildirim
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Control Group ◽  
Morbidly Obese ◽  
Low Density ◽  
Activity Levels ◽  
Obese Children ◽  
Metformin Therapy ◽  
Diet And Exercise ◽  
Serum Paraoxonase

AbstractObesity is known to be associated with many diseases in the long and short terms. Elevated oxidative stress contributes to the development of such obesity-related diseases as dyslipidemia, diabetes mellitus and hypertension. Levels of the endogenous antioxidants paraoxonase and arylesterase have been shown to decrease in such diseases. The purpose of this study was to investigate whether or not changes in lifestyle and metformin therapy would affect serum paraoxonase and arylesterase levels.The study was performed with 25 overweight, 26 obese and 25 morbidly obese patients aged 6–15 years as well as 27 healthy children. Serum paraoxonase (PON1) and arylesterase (ARE) activity levels and total cholesterol, triglyceride, low-density protein, high-density protein, very low-density protein, glucose, aspartate amino transferase and alanine amino transferase levels were measured. Enrolled patients were assessed at initial presentation and again at 6 months. No procedure was performed in the control group, while the overweight, obese and morbidly obese groups were recommended diet and exercise and given metformin therapy (insulin-resistant subjects only).Serum PON1 activity levels in patients with metabolic syndrome were significantly lower than those in individuals without metabolic syndrome (p<0.05), while lipid concentrations were significantly higher (p<0.05). Metabolic syndrome patients had higher serum glucose, total cholesterol, low-density protein, very low-density protein and triglyceride values compared to those of the control group but significantly lower high-density protein values (p<0.05). No difference was determined between the groups in terms of PON1 and ARE levels following diet and exercise and metformin therapy.Measurement of PON1 and ARE enzyme levels may be useful in monitoring the effectiveness of treatment aimed at reducing oxidative stress in obese children.

scholarly journals The Association of Hypertension with Obesity and Metabolic Abnormalities among Chinese Children

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Haiquan Xu ◽  
Xiaoqi Hu ◽  
Qian Zhang ◽  
Songming Du ◽  
Hongyun Fang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Odds Ratio ◽  
Serum Lipid ◽  
Education Level ◽  
Chinese Children ◽  
Healthy Children ◽  
Metabolic Abnormalities ◽  
Obese Children

A total of 8898 Chinese children (4580 boys and 4318 girls) aged 7–13 years in 6 cities of east China were recruited. Data on height, weight, waist circumference, blood pressure, serum lipid profiles, glucose, and insulin were collected. The overall prevalence of hypertension was 11.1%. Overweight and obese children had a higher risk of developing hypertension than their counterparts (29.1%, 17.4%, and 7.8%, resp.) (P=0.0001). The means levels of triglycerides, glucose, insulin, and HOMA-IR (1.0 mmol/L, 4.5 mmol/L, 8.4 mU/mL and 1.7, resp.) among hypertensive children were all significantly higher than their normotensive counterparts (0.8 mmol/L, 4.5 mmol/L, 5.9 mU/mL, and 1.2, resp.) (P=0.0001). Compared with the healthy children, the risk (odds ratio, OR) of having hypertension among children with high triglycerides, hyperglycemia, and metabolic syndrome was 1.4 (95% confidence interval (CI): 1.0–2.0,P=0.0334), 1.5 (95% CI: 0.9–2.5,P=0.0890), and 2.8 (95%CI: 1.5–5.4,P=0.0014), respectively, after controlling for age, gender, BMI, income level, parents' education level and puberty. In conclusion, overweight and obese children have higher risk of having hypertension and children with dyslipidemia, hyperglycemia, and metabolic syndrome and higher HOMA-IR have higher risk of developing hypertension.

scholarly journals Acylated and nonacylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome

2009 ◽  
Vol 161 (6) ◽  
pp. 861-870 ◽  
Author(s):  
Lucia Pacifico ◽  
Eleonora Poggiogalle ◽  
Francesco Costantino ◽  
Caterina Anania ◽  
Flavia Ferraro ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Fasting Blood Glucose ◽  
Tanner Stage ◽  
Normal Subjects ◽  
Normal Weight ◽  
Healthy Children ◽  
Model Assessment ◽  
Obese Children ◽  
The Impact

BackgroundGhrelin, a peptide mainly derived from the stomach, plays a pivotal role in the regulation of food intake, energy metabolism, and storage, as well as in insulin sensitivity. Ghrelin circulates in acylated (A-Ghr) and nonacylated (NA-Ghr) forms, and their potential differential associations with insulin resistance (IR) in childhood obesity remain undefined.ObjectiveWe investigated the associations of ghrelin forms with IR in normal weight and obese children and the impact of metabolic syndrome (MS) on their plasma values.DesignA total of 210 children in four subgroups of normal weight/obese children with and without components of MS were studied. Fasting blood glucose, insulin, lipid profile, and acylated and total ghrelin were examined. IR was determined by a homeostasis model assessment (HOMA) of IR.ResultsIn the entire population, plasma insulin and HOMA-IR were associated negatively with T-Ghr and NA-Ghr, but positively with the ratio of A/NA-Ghr after adjustment for age, gender, and Tanner stage. Obese metabolically abnormal children had lower T-Ghr and NA-Ghr, but comparable A-Ghr and a higher A/NA-Ghr ratio than obese metabolically normal subjects. Compared with lean healthy children, lean metabolically abnormal subjects had higher A-Ghr and the A/NA-Ghr ratio, but comparable T-Ghr and NA-Ghr. A multiple regression analysis showed that A-Ghr and the A/NA-Ghr ratios were positively associated with HOMA-IR, independent of age, gender, Tanner stage, and body mass index (or waist circumference) and other components of MS.ConclusionsA-Ghr excess may negatively modulate insulin action in obese and nonobese children, and may contribute to the association of IR and MS.

Does obesity influence ventricular repolarisation in children?

2020 ◽  
pp. 1-9
Author(s):  
Nihan Yıldırım Yıldız ◽  
Tayfun Uçar ◽  
Mehmet G. Ramoğlu ◽  
Merih Berberoğlu ◽  
Zeynep Şıklar ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Wall Thickness ◽  
Left Ventricular ◽  
Normal Weight ◽  
Qtc Interval ◽  
Healthy Children ◽  
Obese Children ◽  
Ventricular Repolarisation

Abstract Objective: Ventricular repolarisation changes may lead to sudden cardiac death in obese individuals. We aimed to investigate the relationship between ventricular repolarisation changes, echocardiographic parameters, anthropometric measures, and metabolic syndrome laboratory parameters in obese children. Methods: The study involved 81 obese and 82 normal-weight healthy children with a mean age of 12.3 ± 2.7 years. Anthropometric measurements of participants were evaluated according to nomograms. Obese patients were subdivided into two groups; metabolic syndrome and non-metabolic syndrome obese. Fasting plasma glucose, fasting insulin, and lipid profile were measured. QT/QTc interval, QT/QTc dispersions were measured, and left ventricular systolic and diastolic measurements were performed. Results: Body weight, body mass index, relative body mass index, waist/hip circumference ratio, and systolic and diastolic blood pressures were significantly higher in obese children. QT and QTc dispersions were significantly higher in obese children and also obese children with metabolic syndrome had significantly higher QT and QTc dispersions compared to non-metabolic syndrome obese children (p < 0.001) and normal-weight healthy children (p < 0.001). Waist/hip circumference ratio, body mass index, and relative body mass index were the most important determinant of QT and QTc dispersions. Left ventricular wall thickness (left ventricular posterior wall thickness at end-diastole, left ventricular posterior wall thickness at end-systole, interventricular septal thickness at end-diastole) and left ventricular mass index were significantly higher and ejection fraction was lower in obese children. Left ventricular mass index and interventricular septal thickness at end-diastole were positively correlated with QT and QTc dispersions. Conclusions: Our study demonstrated that QT/ QTc interval prolongation and increase in QT and QTc dispersion on electrocardiogram may be found at an early age in obese children.

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