Phytochemical and Antiulcerogenic Properties of Rhizomes from Simaba ferruginea St. Hill. (Simaroubaceae)

2005 ◽  
Vol 60 (9-10) ◽  
pp. 701-706 ◽  
Author(s):  
Vânia Floriani Noldin ◽  
Domingos Tabajara de Oliveira Martins ◽  
César Marcos Marcello ◽  
Joaquim Corsino da Silva Lima ◽  
Franco Delle Monache ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Medicinal Plant ◽  
Traditional Medicine ◽  
Gastric Lesion ◽  
Indole Alkaloids ◽  
Gastric Ulcers ◽  
Plant Bioassay ◽  
Bioassay Guided Fractionation ◽  
Inflammatory Processes ◽  
Alkaloid Fraction

Abstract Simaba ferruginea (Simaroubaceae) is a Brazilian medicinal plant used in traditional medicine to treat several ailments, including gastric ulcers, fever, diarrhea, and dolorous and inflammatory processes. This study examines the chemical composition and antiulcerogenic effects of rhizomes from this plant. Bioassay-guided fractionation led to the isolation of two bioactive indole alkaloids called canthin-6-one (1) and 4-methoxycanthin-6-one (2). The alkaloid fraction and both alkaloids demonstrated potent antiulcerogenic effects when evaluated in gastric lesion-induced animals, as well as significant antinociceptive activity in mice. These results confirm and justify the popular use of S. ferruginea against gastric ulcers and dolorous processes.

scholarly journals Chemical and Bioactivity Evaluation of the Bark of Neonauclea purpurea

2012 ◽  
Vol 7 (2) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Netiya Karaket ◽  
Kanyaratt Supaibulwatana ◽  
Supatsara Ounsuk ◽  
Valérie Bultel-Poncé ◽  
Van Cuong Pham ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Traditional Medicine ◽  
Resistant Strain ◽  
Antimalarial Activity ◽  
Indole Alkaloids ◽  
Vero Cells ◽  
Stem Bark ◽  
Meoh Extract ◽  
Bioassay Guided Fractionation

Bioassay-guided fractionation of the MeOH extract from the stem bark of Neonauclea purpurea used in traditional medicine, resulted in the isolation of 2 indole alkaloids, cadambine (1) and α-dihydrocadambine (2), as well as a quinolic compound, 2,6-dimethoxy-1,4-benzoquinone (3). Antimalarial activity evaluation showed that compounds 2 and 3 exhibited mild in vitro antimalarial activity against Plasmodium falciparum, the chloroquine-resistant strain K1 with IC50 values of 6.6 and 11.3 μM, respectively. Compounds 1 and 2 showed no cytotoxicity to monkey (Vero) cells, but compound 3 showed weak cytotoxicity with an IC50 value of 1.19 μM.

scholarly journals A Review on Tabernaemontana spp.: Multipotential Medicinal Plant

2018 ◽  
Vol 11 (5) ◽  
pp. 45 ◽  
Author(s):  
Anan Athipornchai
Keyword(s):  
Medicinal Plant ◽  
Traditional Medicine ◽  
Human Health ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Indole Alkaloids ◽  
Great Majority ◽  
Point Of View ◽  
Isolation And Identification

Tabernaemontana is one of the genera that is used in Chinese, Ayurvedic and Thai traditional medicine for the treatment several diseases. From a chemical point of view, the great majority of Tabernaemontana species have already been subjected to isolation and identification of indole alkaloids present in their several parts. Many of indole alkaloids have been shown to exhibit a wide array of biological activities. The biogenesis, classification and biological activities of the indole alkaloids found in Tabernaemontana species were discussed in this review and its brings the research up-to-date on the bioactive compounds produced by Tabernaemontana species, directly or indirectly related to human health.

scholarly journals Zingiber zerumbet(L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
N. J. Yob ◽  
S. Mohd. Jofrry ◽  
M. M. R. Meor. Mohd. Affandi ◽  
L. K. Teh ◽  
M. Z. Salleh ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Traditional Medicine ◽  
Biological Evaluation ◽  
Perennial Herb ◽  
Zingiber Zerumbet ◽  
Tropical Countries ◽  
Traditional Uses ◽  
Worm Infestation

Zingiber zerumbetSm., locally known to the Malay as “Lempoyang,” is a perennial herb found in many tropical countries, including Malaysia. The rhizomes ofZ. zerumbet, particularly, have been regularly used as food flavouring and appetizer in various Malays' cuisines while the rhizomes extracts have been used in Malay traditional medicine to treat various types of ailments (e.g., inflammatory- and pain-mediated diseases, worm infestation and diarrhea). Research carried out using differentin vitroandin vivoassays of biological evaluation support most of these claims. The active pharmacological component ofZ. zerumbetrhizomes most widely studied is zerumbone. This paper presents the botany, traditional uses, chemistry, and pharmacology of this medicinal plant.

Cytoprotective and antisecretory properties of methanolic extract of Distemonanthus benthamianus (Caesalpiniaceae) stem bark on acute gastric ulcer in rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Vanessa Mba Matah Marthe ◽  
Gilbert Ateufack ◽  
Marius Mbiantcha ◽  
William Yousseu Nana ◽  
Albert Donatien Atsamo ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Gastric Lesion ◽  
Stem Bark ◽  
Male Rats ◽  
Gastric Ulcers ◽  
Gastric Lesions ◽  
Mucus Production ◽  
Antisecretory Activity ◽  
Antisecretory Effect ◽  
Pylorus Ligation

AbstractObjectivesIn African traditional medicine, Distemonanthus benthamianus (Caesalpiniaceae) is used to treat many diseases including gastric ulcers. We evaluated in this study, the cytoprotective and antisecretory properties of the methanolic extract of the stem bark of this plant using different technics of gastric lesion induction.MethodsCytoprotective and antisecretory activity of the methanolic extract of D. benthamianus stem bark was evolved through six methods of gastric lesion induction in experimental Wistar male rats (150–200 g): (1) gastric lesions induced by HCl/ethanol, (2) gastric lesions induced by Indomethacin- HCl/ethanol, (3) gastric lesion induced by Indomethacin, (4) gastric lesions induced by Pylorus ligation, (5) gastric lesions induced by histamine-Pylorus ligation, (6) gastric lesions induced by carbachol-Pylorus ligation. Mucus and gastric mucosal ulceration were evaluated. pH, gastric volume, and acidity were quantified in all pylorus ligation induction technics. Nitric oxide (NO) level was determined in indomethacin induced gastric ulcers.ResultsAt different doses (125, 250 and 500 mg/kg), extract reduced significantly the ulcer index. In all models used, that is 100.00% with HCl/ethanol; 100.00% with HCl/ethanol/indomethacin; 95.70% with Indomethacin; 74.79% with pylorus ligation, 95.94% histamine-Pylorus ligation, 99.54% carbachol-Pylorus ligation at the highest dose of 500 mg/kg. The lesion formation reduces in all the methods used followed by a significant increase of mucus production. The pylorus ligation technic revealed that the extract has an antisecretory activity.ConclusionsThe methanolic extract of D. benthamianus stem bark has both cytoprotective and antisecretory effects. This extract exerts its antisecretory effect trough cholinergic and histaminergic pathways.

Review on pharmacological and phytochemical prospects of traditional medicinal plant: Persicaria hydropiper (Smartweed)

2021 ◽  
Vol 21 ◽  
Author(s):  
Abdul Nasir ◽  
Atif Ali Khan Khalil ◽  
Muhammad Zeeshan Bhatti ◽  
Ashfaq Ur Rehman ◽  
Jiayi Li ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Traditional Medicine ◽  
Northern Hemisphere ◽  
Biological Activities ◽  
Folk Medicine ◽  
Present Review ◽  
Polygonum Hydropiper ◽  
Wide Range ◽  
Pharmacological Data ◽  
Different Parts

: Persicaria hydropiper (L.) Delarbre (family Polygonacea), commonly known as Polygonum hydropiper, is a popular medicinal plant used in traditional medicine. The plant is indigenous to the tropical northern hemisphere and temperate zone including China, Bangladesh, India, and Japan. The plant is used in folk medicine for numerous ailments such as hemorrhoids, antifertility, diarrhea, and dyspepsia. Its medicinal usage in Unani, Ayurveda, Siddha, and other traditional medicine is well-recognized. So far, a wide range of active phytochemicals of this plant has been identified, such as flavonoids, sulphated flavonoids, terpenoids, anthraquinones, steroids, coumarin, simple phenolics, and others. Pharmacological data reported in the literature suggest that various parts of P. hydropiper exhibit antimicrobial, antioxidant, hypoglycemic, antidepressant, cardioprotective, hepatoprotective, anticancer, and antifertility effects. The present review aim is to compile the coherently document research on the phytochemical, pharmacological, and biological activities of P. hydropiper from different parts of the globe.

scholarly journals Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Anna Aiello ◽  
Ernesto Fattorusso ◽  
Marialuisa Menna ◽  
Rocco Vitalone ◽  
Heinz C. Schröder ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Traditional Medicine ◽  
Cortical Neurons ◽  
Neuroprotective Effect ◽  
Amyloid Peptide ◽  
Neuroprotective Activity ◽  
Antiallergic Activity ◽  
Neuronal Pc12 Cells ◽  
Biomedical Potential

Mumijo is a widely used traditional medicine, especially in Russia, Altai Mountains, Mongolia, Iran Kasachstan and in Kirgistan. Mumijo preparations have been successfully used for the prevention and treatment of infectious diseases; they display immune-stimulating and antiallergic activity as well. In the present study, we investigate the chemical composition and the biomedical potential of a Mumijo(-related) product collected from the Antarctica. The yellow material originates from the snow petrels,Pagodroma nivea. Extensive purification and chemical analysis revealed that the fossil samples are a mixture of glycerol derivatives.In vitroexperiments showed that the Mumijo extract caused in cortical neurons a strong neuroprotective effect against the apoptosis-inducing amyloid peptide fragmentβ-fragment 25–35 (Aβ25–35). In addition, the fraction rich in glycerol ethers/wax esters displayed a significant growth-promoting activity in permanent neuronal PC12 cells. It is concluded that this new Mumijo preparation has distinct and marked neuroprotective activity, very likely due to the content of glycerol ether derivatives.

scholarly journals Pemulihan Kerusakan Jaringan Hati Mencit yang Diberi Ekstrak Butanol Buah Tua Mahkota Dewa

2018 ◽  
Vol 10 (1) ◽  
pp. 53
Author(s):  
Arif Soeksmanto
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Medicinal Plant ◽  
Traditional Medicine ◽  
Tissue Damage ◽  
Liver Tissue ◽  
Butanol Extract ◽  
Phaleria Macrocarpa ◽  
Almost All

Mahkota dewa (Phaleria macrocarpa [Scheff.] Boerl.) is an Indonesians traditional medicinal plant used to treat various diseases, such as diabetes mellitus, hemorrhoid, impotency and cancer. Almost all parts of the plants canbe used as traditional medicine, but if directly consumed, it can cause swollen, sprue, numb at tongue, fever, even unconsciousness. This research was carried out to find out recovery of liver tissue damage of mice administered intraperitoneally with subchronic dosage of butanol extract 170 mg/kg body weight. Observation on first week showed that there is light degeneration (vacuolization) which is getting better on second week and apparentlynormal on forth week.

scholarly journals Effects of a dietary supplement on gastric ulcer number and severity in exercising horses1

2018 ◽  
Vol 2 (2) ◽  
pp. 119-124
Author(s):  
Alysia L Conner ◽  
Amanda J Davis ◽  
Cheryl A Porr
Keyword(s):  
Gastric Ulcer ◽  
Dietary Supplement ◽  
Fixed Effects ◽  
Gastric Lesion ◽  
Gastric Ulcers ◽  
Experimental Unit ◽  
Adaptation Period ◽  
Feeding Period ◽  
Gastric Lesions ◽  
Dependent Variables

Abstract This study evaluated the effect of a dietary supplement on the treatment of equine gastric ulcer syndrome (EGUS). Gastroscopy was performed on university riding horses of mixed breeds at two locations and only horses exhibiting gastric ulcers were selected to participate in this study (location A, n = 13; location B, n = 15). Gastric ulcer severity was assessed using two different methods depending on location before treatment (Pre). After gastroscopy, horses were fed the supplement in addition to their regular diet for 44 d (14-d adaptation period followed by 30-d feeding period). All horses were subjected to gastroscopy again at the end of the feeding period (Post) to evaluate changes in gastric lesions. Statistical analysis was performed using SAS. Individual horses were the experimental unit with dependent variables including severity and number of gastric ulcers. At location A, dependent variable included severity of gastric lesions with fixed effects of time (Pre and Post) and location (stall or pasture). For location B, dependent variables included severity and number of gastric lesions with fixed effects of time. Severity of gastric ulcers decreased at both locations in horses following the feeding period. Gastric lesion scores decreased from 2.2990 to 1.3760 (P = 0.0015) at location A and gastric lesion severity from 3.8000 to 2.5667 (P = 0.0322) at location B. No differences were found in gastric lesion scores at location A between horses housed in stalls or pastures (1.8750 and 1.8000; P = 0.7783). The number of gastric ulcers observed at location B were similar Pre and Post treatment (3.4667 and 3.5333; P = 0.8363). There were no changes in body condition score (P ≥ 0.2607), BW (P ≥ 0.4551), or behavior at either location. Results suggest that oral supplementation may decrease severity of gastric ulcers in horses participating in university riding programs.

scholarly journals Medicinally Important Herbal Flowers in Sri Lanka

2019 ◽  
Vol 2019 ◽  
pp. 1-18 ◽  
Author(s):  
S. L. A. Gunawardana ◽  
W. J. A. B. N. Jayasuriya
Keyword(s):  
Chemical Composition ◽  
Sri Lanka ◽  
Traditional Medicine ◽  
Therapeutic Effects ◽  
Syzygium Aromaticum ◽  
Human Beings ◽  
Plant Resources ◽  
Plant Parts ◽  
Anticancer Properties ◽  
Medical Issues

Background. The plant kingdom is rich with a numerous number of plants with various medical properties which can be used to treat various medical issues. Sri Lanka is a country full of biodiversity which is gifted with many plant resources. It has a rich history of traditional medicine systems consisting of Ayurveda, Unani, and Deshiya Chikitsa, where these plant resources are used as remedies for the diseases. In the traditional medicine system, various plant parts such as leaves, roots, fruits, flowers, and bark are used to treat disease conditions. Although less attention is paid to the medicinal importance of the flowers, some of them have been used to treat many diseases from the ancient time. Some properties of the flowers may differ from the properties of the other plant parts. For example, Sesbania grandiflora (Katuru murunga) flowers have shown anticancer properties against various cell models whereas some flowers have shown antispermatogenic properties. Flowers of Woodfordia floribunda (Militta) are added as fermenting agents in the preparation of Arishtas in Ayurveda. Also the most popular Clove oil is obtained from the flower buds of Syzygium aromaticum (Karabu-neti) which is used to treat toothaches since it has antibiotic and antiseptic properties. This article gives an overview of herbal flowers used in the traditional medicine system of Sri Lanka and their pharmacological importance. Method. A comprehensive literature survey was done on the medicinally important flowers in Sri Lanka. Data was collected from Libraries of Ayurveda in Sri Lanka and from scientific databases. Results. According to the survey many flowers are used as astringent, cardiac tonic, and febrifuge. Also some flowers are used to treat dysentery, diarrhoea, and indigestion. Some flowers are useful in the treatment of bleeding piles while some are useful in the treatment of asthma and bronchitis. Conclusion. It was revealed that there are many flowers with valuable therapeutic effects. Traditional medicine systems prevailing in Sri Lanka have made use of these flowers with therapeutic effects to cure so many diseases. The review of medicinally important herbal flowers provides knowledge and pharmacological leads which will help for the wellbeing of the human beings. Although there are phytochemical studies done to identify the chemical compounds on some flowers, chemical composition of many flowers remains unrevealed. So further studies need to be done to identify the chemical composition of these flowers.

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