scholarly journals Incidence and prevalence of nutritional and hereditary rickets in southern Denmark

2009 ◽  
Vol 160 (3) ◽  
pp. 491-497 ◽  
Author(s):  
Signe Sparre Beck-Nielsen ◽  
Bendt Brock-Jacobsen ◽  
Jeppe Gram ◽  
Kim Brixen ◽  
Tina Kold Jensen
Keyword(s):  
Vitamin D ◽  
Medical Records ◽  
Retrospective Cohort ◽  
Population Based ◽  
Immigrant Children ◽  
Hypophosphatemic Rickets ◽  
Age Group ◽  
Common Cause ◽  
Nutritional Rickets

ObjectiveTo estimate the incidence of nutritional rickets and the incidence and prevalence of hereditary rickets.DesignPopulation-based retrospective cohort study based on a review of medical records.MethodsPatients aged 0–14.9 years referred to or discharged from hospitals in southern Denmark from 1985 to 2005 with a diagnosis of rickets were identified by register search, and their medical records were retrieved. Patients fulfilling the diagnostic criteria of primary rickets were included.ResultsWe identified 112 patients with nutritional rickets of whom 74% were immigrants. From 1995 to 2005, the average incidence of nutritional rickets in children aged 0–14.9 and 0–2.9 years was 2.9 and 5.8 per 100 000 per year respectively. Among immigrant children born in Denmark, the average incidence was 60 (0–14.9 years) per 100 000 per year. Ethnic Danish children were only diagnosed in early childhood and the average incidence in the age group 0–2.9 years declined from 5.0 to 2.0 per 100 000 per year during 1985–1994 to 1995–2005. Sixteen cases of hereditary rickets were diagnosed during the study period giving an average incidence of 4.3 per 100 000 (0–0.9 years) per year. The prevalence of hypophosphatemic rickets and vitamin D-dependent rickets type 1 was 4.8 and 0.4 per 100 000 (0–14.9 years) respectively.ConclusionsNutritional rickets is rare in southern Denmark and largely restricted to immigrants, but the incidence among ethnic Danish children was unexpectedly high. Hereditary rickets is the most common cause of rickets in ethnic Danish children, but nutritional rickets is most frequent among all young children.

A major health problem facing immigrant children: nutritional rickets

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Erdal Kurnaz ◽  
Semra Çetinkaya ◽  
Selin Elmaoğulları ◽  
Aslıhan Araslı Yılmaz ◽  
Nursel Muratoğlu Şahin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Immigrant Children ◽  
High Dose ◽  
Pediatric Endocrinology ◽  
Major Health Problem ◽  
Nutritional Rickets ◽  
Increased Risk ◽  
Long Term Follow Up

Abstract Objectives Nutritional rickets (NR) is still an important problem and one which increasing influxes of immigrants are further exacerbating. This study evaluated cases of mostly immigrant children followed up with diagnoses of NR in our pediatric endocrinology clinic. Methods Details of 20 cases diagnosed with NR between 2017 and 2020 were retrieved from file records. Results Twenty (11 male) cases were included in the study. Three (15%) were Turkish nationals and the others (85%) were immigrants. Hypocalcemia and hypophosphatemia were detected in 17 and 13, respectively. Alkaline phosphatase (ALP) values were normal in two cases, while ALP and parathyroid hormone (PTH) values were elevated in all other cases, and PTH levels were very high (473.64 ± 197.05 pg/mL). 25-hydroxyvitamin D levels were below 20 ng/mL in all cases. Patients with NR received high-dose long-term vitamin D or stoss therapy. Six patients failed to attend long-term follow-up, while PTH and ALP levels and clinical findings improved at long-term follow-up in the other 14 cases. Conclusions The elevated PTH levels suggest only the most severe cases of NR presented to our clinic. Clinically evident NR is therefore only the tip of the iceberg, and the true burden of subclinical rickets and osteomalacia remains unidentified. Public health policies should therefore focus on universal vitamin D supplementation and adequate dietary calcium provision, their integration into child surveillance programs, adequate advice and support to ensure normal nutrition, exposure to sunlight, and informing families of the increased risk not only for resident populations but also for refugee and immigrant children.

scholarly journals Postmortem examination protocol and systematic re-evaluation reduce the proportion of unexplained stillbirths

2020 ◽  
Vol 48 (8) ◽  
pp. 771-777
Author(s):  
Maria Pekkola ◽  
Minna Tikkanen ◽  
Mikko Loukovaara ◽  
Jouko Lohi ◽  
Jorma Paavonen ◽  
...  
Keyword(s):  
Cause Of Death ◽  
Medical Records ◽  
Retrospective Cohort ◽  
Causes Of Death ◽  
Postmortem Examination ◽  
University Hospital ◽  
Obstetrics And Gynecology ◽  
Common Cause ◽  
Examination Protocol

AbstractBackgroundStillbirth often remains unexplained, mostly due to a lack of any postmortem examination or one that is incomplete and misinterpreted.MethodsThis retrospective cohort study was conducted at the Department of Obstetrics and Gynecology, Helsinki University Hospital, Finland, and comprised 214 antepartum singleton stillbirths from 2003 to 2015. Maternal and fetal characteristics and the results of the systematic postmortem examination protocol were collected from medical records. Causes of death were divided into 10 specific categories. Re-evaluation of the postmortem examination results followed.ResultsBased on our systematic protocol, the cause of death was originally defined and reported as such to parents in 133 (62.1%) cases. Re-evaluation of the postmortem examination results revealed the cause of death in an additional 43 (20.1%) cases, with only 23 (10.7%) cases remaining truly unexplained. The most common cause of stillbirth was placental insufficiency in 56 (26.2%) cases. A higher proportion of stillbirths that occurred at ≥39 gestational weeks remained unexplained compared to those that occurred earlier (24.1% vs. 8.6%) (P = 0.02).ConclusionA standardized postmortem examination and a re-evaluation of the results reduced the rate of unexplained stillbirth. Better knowledge of causes of death may have a major impact on the follow-up and outcome of subsequent pregnancies. Also, closer examination and better interpretation of postmortem findings is time-consuming but well worth the effort in order to provide better counseling for the grieving parents.

The Effects of Vitamin D Deficiency and Insufficiency on the Endocrine and Paracrine Systems

2007 ◽  
Vol 9 (2) ◽  
pp. 117-129 ◽  
Author(s):  
Patricia T. Alpert ◽  
Ulfat Shaikh
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Sun Exposure ◽  
Vitamin D Insufficiency ◽  
Paracrine Effects ◽  
Breastfed Infants ◽  
Nutritional Rickets ◽  
Disease States

Individuals are capable of producing vitamin D with proper exposure to sunlight. However, several factors can interfere with the effectiveness of this process. Most sunscreens filter out UVB light, thus inhibiting vitamin D production. Individuals with more darkly pigmented skin have greater difficulty producing vitamin D because melanin acts as an effective natural sunscreen, requiring longer sun exposure to produce an adequate daily allotment of vitamin D. Additionally, solely breastfed infants whose mothers suffered from vitamin D deficiency or insufficiency when pregnant have smaller reserves of the nutrient and are at greater risk of developing nutritional rickets. Vitamin D deficiency leads to rickets, osteomalacia, and osteoporosis. Long-term vitamin D insufficiency can lead to paracrine effects such as type 1 diabetes, cancer, and multiple sclerosis. This article reviews the current literature on vitamin D deficiency and insufficiency and their relation to different disease states. Potential areas for research are discussed.

scholarly journals Pola Kasus dan Penatalaksanaan Peritonitis Akut di Bangsal Bedah RSUP Dr. M. Djamil Padang

2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Aiwi Japanesa ◽  
Asril Zahari ◽  
Selfi Renita Rusjdi
Keyword(s):  
Medical Records ◽  
Surgical Procedure ◽  
Sampling Technique ◽  
Exploratory Laparotomy ◽  
Descriptive Study ◽  
Common Type ◽  
Age Group ◽  
Exclusion Criteria ◽  
Common Cause ◽  
Abdominal Emergency

AbstrakPeritonitis menjadi salah satu penyebab tersering akut abdomen yang merupakan suatu kegawatan abdomen. Peritonitis biasanya disertai dengan bakterisemia atau sepsis yang dapat menimbulkan kematian. Tujuan penelitian ini adalah untuk mengetahui hal-hal yang berkaitan dengan peritonitis agar dapat mencegah dan melakukan penanganan secepatnya terhadap kasus ini. Penelitian deskriptif retrospektif ini telah dilakukan dari September 2014 sampai Oktober 2014 dengan teknik total sampling. Data yang diambil merupakan kasus pasien peritonitis yang dirawat inap di Bagian Bedah RSUP Dr. M. Djamil Padang, kemudian dilakukan seleksi berdasarkan kriteria inklusi dan eksklusi sehingga didapatkan 98 data rekam medik periode 01 Januari 2013 sampai 31 Desember 2013.  Prevalensi peritonitis pada laki-laki (68,4%) lebih tinggi dibandingkan perempuan (31,6%). Kelompok usia terbanyak adalah 10-19 tahun (24,5%). Peritonitis sekunder umum akibat perforasi apendiks merupakan jenis peritonitis yang terbanyak (53,1%). Sebagian besar pasien peritonitis mendapatkan tatalaksana bedah berupa laparatomi eksplorasi dan apendektomi (64,3%). Lama rawatan terbanyak pada 4-7 hari (45,9%). Frekuensi pasien peritonitis menurut kondisi keluar sebagian besar dalam keadaan hidup (85,7%). Kesimpulan yang dapat diambil dari penelitian ini adalah bahwa peritonitis dapat dipengaruhi oleh faktor usia, jenis kelamin, penyebab peritonitis, tatalaksana, lama rawatan dan kondisi saat keluar dari rumah sakit.Kata kunci: peritonitis, bedah, pola AbstractPeritonitis is one of the most common cause of acute abdomen, which is an abdominal emergency. Peritonitis is usually accompanied by bacteremia or sepsis that can cause mortality. The objective of this study was to know something that associated with peritonitis in order to prevent and to respond immediately to this case. This retrospective descriptive study was conducted from September 2014 to October 2014 using a total sampling technique. Data was taken from cases of hospitalized patients with peritonitis in Surgery Ward of RSUP Dr. M. Djamil Padang, selected by on inclusion and exclusion criteria. There were 98 medical records by the period from 1st of January 2013 to 31th of December 2013. Peritonitis prevalence in men (68,4%) was higher than women (31,6%). Most common age group is 10-19 years old (24,5%). Secondary peritonitis due to perforation of the appendix is the most common type of peritonitis (53,1%). Most patients with peritonitis get a surgical procedure of exploratory laparotomy and appendectomy (64,3%). Most hospitalization length was 4-7 days (45,9%). The frequency of peritonitis patients based on conditions when discharged from hospital is mostly alive (85,7%).Conclusion from this study is that peritonitis may be influenced by age, sex, cause of peritonitis, the surgical procedure, hospitalization, and condition when discharged from hospital.Keywords: peritonitis, surgical, pattern

scholarly journals INDIKASI FOTOKOAGULASI LASER PADA PASIEN RETINOPATI DIABETIK DI BALAI KESEHATAN MATA PROPINSI SULAWESI UTARA PERIODE JANUARI – DESEMBER 2012

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Renta Tappang ◽  
Harry Sumual ◽  
Laya Rares
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Retrospective Study ◽  
Proliferative Diabetic Retinopathy ◽  
Medical Records ◽  
Laser Photocoagulation ◽  
Age Group ◽  
North Sulawesi ◽  
Diabetes Melitus

Abstract: Diabetic retinopathy is one of the vascular disorders that can occur in type 1 and 2 diabetes mellitus cases after 10-15 years. Treatment of diabetic retinopathy is based on its severity; one of the treatment is laser photocoagulation.This study aimed to find out the indication of laser photocoagulation procedure among diabetic retinopathy cases at BKMM North Sulawesi Province. This was a descriptive retrospective study using the medical records of diabetic retinopathy cases who underwent laser photocoagulation. There were 35 cases as samples who underwent laser photocoagulation during January– December 2012. The results showed that most cases were proliferative diabetic retinopathy (86,6%).  The most frequent age group was 41-60 years (68.6%),  predominantly females (60%). Moreover, there were 80% cases who underwent one time of laser photocoagulation meanwhile the others 20% underwent more than one photocoagulation during  January– December 2012. Conclusion: The most frequent indication of laser photocoagulation among diabetic retinophaty cases at BKMM North Sulawesi Province was proliferative diabetic retinopathy. Keywords: indication of laser photocoagulation, retinopathy    Abstrak: Retinopati diabetik adalah suatu kelainan vaskular yang terjadi pada kasus diabetes melitus tipe 1 dan 2 setelah 10 – 15 tahun. Penatalaksanaan retinopati diabetik dibuat berdasarkan pada tingkat kelainan penyakitnya; salah satu cara ialah dengan menggunakan terapi fotokoagulasi laser. Penelitian ini bertujuan untuk mengetahui indikasi fotokoagulasi laser pada kasus retinopati diabetik di Balai Kesehatan Mata Masyarakat (BKMM) Propinsi Sulawesi Utara. Metode penelitian ini deskriptif retrospektif dengan menggunakan catatan rekam medik kasus retinopati diabetik yang telah dilakukan fotokoagulasi laser. Sampel berjumlah 35 kasus retinopati diabetik yang menjalani fotokoagulasi laser pada periode Januari – Desember 2012 dengan persentase terbanyak retinopati diabetik proliferatif (88,6%). Kelompok usia tersering 41-60 tahun (68,6%), sedangkan jenis kelamin  didominasi oleh perempuan (60%). Kasus yang terbanyak (80%) ialah yang menjalani hanya satu kali fotokoagulasi laser sedangkan sisanya (20%) menjalani tindakan tersebut lebih dari satu kali. Simpulan: Pada kasus retinopati diabetik di BKMM Propinsi Sulawesi Utara indikasi tersering untuk dilakukan fotokoagulasi laser ialah retinopati diabetik proliferatif. Kata kunci: indikasi fotokoagulasi laser, retinopati

scholarly journals The correlation between progesterone/MII oocyte ratio on the day of trigger and ICSI outcome

2020 ◽  
Vol 11 (1) ◽  
pp. 1104-1108
Author(s):  
Nassrin Malik Aubead
Keyword(s):  
Embryo Transfer ◽  
Retrospective Cohort ◽  
Implantation Rate ◽  
Endometrial Receptivity ◽  
World Health ◽  
Age Group ◽  
Serum Progesterone ◽  
Common Cause ◽  
The World ◽  
Health Organization

The World Health Organization (WHO) defines subfertility as the inability to get pregnant in couples who have more than 12 months maintaining frequent sexual intercourse without the use of contraceptives methods. Subfertility affects approximately 10-15% of couples in fertile age and this figure is increasing. Assess the level of serum progesterone\MII oocyte ratio at the day of a trigger is to determine that if associated with poor ICSI-embryo transfer outcome. A retrospective cohort study carried in the period from Nov.1, 2018 to the end of Nov. 2019, when 50 patients were enrolled within the age between 20-35 years old with mean age (29±5)years and the main age group were in between (25-30) years. The most common cause of subfertility was oligospermia (48.0%) and the HCG was positive in (20.0%) of the patients and negative in (80.0%), Significant association were found between implantation rate and P/MII oocyte ratio (P=0.008), while highly significant association were noticed between pregnancy rate and P/MII oocyte ratio (P<0.001). Progesterone increase should be avoided that lead to advance maturation of the endometrium and impaired endometrial receptivity, so from these results, we concluded that raised serum progesterone\MII oocyte ratio at the day of the trigger is related with reduced ICSI-embryo transfer outcome.

scholarly journals Incidence of Type 1 Diabetes May Be Underestimated in the Chinese Population: Evidence From 21.7 Million People Between 2007 and 2017

2021 ◽  
Author(s):  
Chang Liu ◽  
Ying-Chao Yuan ◽  
Mo-Ning Guo ◽  
Zhong Xin ◽  
Guan-Jie Chen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Chinese Population ◽  
Age Groups ◽  
Population Based ◽  
Annual Incidence ◽  
Age Group ◽  
And Gender ◽  
Population Based Registry ◽  
Design And Methods

OBJECTIVE─ Previous reports of the annual incidence of type 1 diabetes (T1D) in China were conducted using retrospective hospital cases, which may not reflect the reality. This longitudinal study estimated T1D incidence in a 21.7-million Chinese population during 2007-2017. <p>RESEARCH DESIGN AND METHODS─ A population-based registry of T1D was performed by the Beijing Municipal Health Commission Information Center. Annual incidence and 95% confidence intervals (CI) were calculated by age group and gender. The association of gender with T1D incidence and predicted new T1D cases were assessed using Poisson regression models. Annual percentage change and average annual percentage of change were assessed using Joinpoint regression. </p> <p>RESULTS─ Overall, there were 6,875 individuals who developed T1D from 2007 to 2017 in this population. T1D incidence [95% CI] (/100,000 persons) significantly increased from 2.72 [2.51, 2.93] in 2007 to 3.60 [3.38, 3.78] in 2017 (p<0.001). The T1D onset peak was in the 10-14 age group. While no significant trend was found in the 0-14 and 15-29 age groups, T1D incidence markedly increased from 1.87 to 3.52 in ≥30 age group (p<0.05). The prevalence of diabetic ketoacidosis at diagnosis was highest in 0-4 age group. We predicted T1D new cases will increase to 1.57-fold over the next decade. </p> CONCLUSIONS─ T1D incidence in this large Chinese population is higher than has been reported previously. During 2007-2017, although the incidence peak was in the 10-14 age group, the T1D incidence increased sharply in adults but not in youth.

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