scholarly journals Paradoxical GH response to TRH during status epilepticus in man

1999 ◽  
pp. 307-314 ◽  
Author(s):  
U Lindbom ◽  
AL Hulting ◽  
T Tomson
Keyword(s):  
Status Epilepticus ◽  
Epileptic Activity ◽  
Control Group ◽  
Fisher Exact Probability Test ◽  
Exact Probability ◽  
Paradoxical Response ◽  
Before And After ◽  
The Status ◽  
Altered Regulation ◽  
Patients With Epilepsy

Information on GH in relation to epilepsy is sparse, and to our knowledge there is no information on GH levels during status epilepticus in man. We studied GH in serum in six patients during status epilepticus, and in a control group of six seizure-free patients with epilepsy, before and after injection of TRH. The baseline GH values before TRH administration were within the normal range in all patients. After injection of TRH all patients with status epilepticus showed a paradoxical peak-shaped increase of GH to at least twice their baseline levels within 45 min after the injection (median basal GH value 1.5 mU/l and median peak GH value 6. 5 mU/l, mean increase 330%). No uniform reaction to TRH was observed in the control group (median basal GH value 2.7 U/l and median of the highest value within 45 min 5.2mU/l). A paradoxical peak reaction of GH to TRH was significantly more frequent in the status epilepticus group compared with the control group (P=0.008, Fisher exact probability test). TRH is not considered a GH-releasing hormone in humans during normal conditions, but a paradoxical response of GH to TRH, similar to that observed during status epilepticus, has been reported in various other pathological conditions, such as acromegaly, liver cirrhosis, mental depression and hypothyroidism. Our results of GH release after TRH administration in patients with status epilepticus suggest an altered regulation of GH as a result of the long-standing epileptic activity.

How Different Are the Patients With Bilateral Hippocampal Sclerosis From the Unilateral Ones Clinically?

2016 ◽  
Vol 48 (3) ◽  
pp. 209-216 ◽  
Author(s):  
Ebru Nur Vanli-Yavuz ◽  
Betul Baykan ◽  
Serra Sencer ◽  
Altay Sencer ◽  
Isin Baral-Kulaksizoglu ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Status Epilepticus ◽  
Epilepsy Surgery ◽  
Hippocampal Sclerosis ◽  
Control Group ◽  
High Signal ◽  
Binary Logistic Regression Analysis ◽  
Laboratory Findings ◽  
Patients With Epilepsy ◽  
Febrile Status Epilepticus

Purpose. There is a lack of knowledge on consecutive patients with epilepsy associated with bilateral hippocampal sclerosis (BHS). We aimed to investigate the differentiating features of BHS in comparison with unilateral HS (UHS). Method. We investigated our database for patients with epilepsy fulfilling the major magnetic resonance imaging criteria for BHS; namely, presence of bilateral atrophy and high signal changes on T2 and FLAIR series in the hippocampi. UHS patients seen in past 2 years were included as the control group. Clinical, EEG, and other laboratory findings, data on treatment response and epilepsy surgery were investigated from their files. Results. A total of 124 patients (31 with BHS and 93 with UHS; 49 right-sided and 44 left-sided) were included. We found that 16.1% of the BHS and 18.3% of the UHS groups were not drug-refractory. A binary logistic regression analysis performed with significant clinical features disclosed that history of febrile status epilepticus, mental retardation, and status epilepticus were statistically more common in BHS group. Moreover, diagnosis of psychosis established by an experienced psychiatrist and slowing of the EEG background activity were both found significantly more frequent in BHS. 66.67% of the operated BHS patients showed benefit from epilepsy surgery. Conclusions. BHS is a heterogeneous group, showing significant differences such as increased frequencies of mental retardation, status epilepticus, febrile status epilepticus and psychosis, in comparison to UHS. In all, 16.1% of the BHS cases showed a benign course similar to the UHS group and some patients with drug-resistant epilepsy may show benefit from epilepsy surgery.

scholarly journals The Preparation of Breastfeeding Lowers the Incidence of Nipple Blisters of Postpartum Mother in Sub-district Health Centers Gandusari Kec. Gandusari Kab. Blitar

2016 ◽  
Vol 3 (3) ◽  
pp. 242-246
Author(s):  
Maria Ulfa
Keyword(s):  
Breast Feeding ◽  
Health Centers ◽  
Control Group ◽  
Fisher Exact Probability Test ◽  
District Health ◽  
Exact Probability ◽  
Control Group Design ◽  
Group Design ◽  
Independent Variable ◽  
Feeding Techniques

Breastmilk has advantages and privilages as a source of nutrients compared to other nutrientsources. However, the breastfeeding process often fail. The main cause of the failure is a problem in thebreast. One of them are blisters on the nipples. Nipple blisters dominantly caused by breast feedingpreparationespecially on breast feeding techniques and breastcare. The purpose of this study was todetermine how is the preparation of breastfeeding lowers the incidence of nipple blisters of postpartummother in Sub-district Health CentersGandusari Kec.GandusariKab. Blitar. Methods: with posttestonly control group design. The population in this study was 50 postpartum mother in Health Centers.Thesample was 16 respondents by using purposive sampling. The independent variable was the preparationof breastfeeding, the dependent variable was the sore nipple blisters. The instrument used SOP.Result: the statistical Fisher Exact Probability Test showed p=0,003 (a=0,05). It could be concludedthat the preparation of brestfeeding could reduce the incidence of nipple blisters postpartum mother inSub-district Health Centers Gandusari. By this research, it was expected the respondents to activelyask, observing carefully about breasfeeding preparation especially breaastfeeding techniques andtreatments given. So, breastfeeding in infants couldbe succeed. As for the profession of midwifery resultsof this study could be used as the input in motivating postpartum mother, so that it could perform theappropriate techniques of breastfeeding and breastcareto avoid nipple blisters.

scholarly journals The intervention of maternal nutrition literacy has the potential to prevent childhood stunting: Randomized control trials

2021 ◽  
Vol 10 (2) ◽  
Author(s):  
Sirajuddin Sirajuddin ◽  
Saifuddin Sirajuddin ◽  
Amran Razak ◽  
Ansariadi Ansariadi ◽  
Ridwan M Thaha ◽  
...  
Keyword(s):  
Maternal Nutrition ◽  
Stress Test ◽  
Intervention Group ◽  
Control Group ◽  
Normal Children ◽  
Before And After ◽  
The Status ◽  
Randomized Control ◽  
Families With Children ◽  
The Impact

Background: Stunting is the impaired growth and development of children due to poor nutrition, repeated infection, and inadequate psychological stimulation. This research aims to examine the impact of maternal nutrition literacy (MNL) in increasing the height or score of a stunted child.Design and Methods: This study is a randomized control trial, which uses a sample size of 85 participants, 43 interventions and 42 controls, an 80% stress test and a 95% confidence level. The intervention group of the MNL consists of families with children under the age of five, focused on the mother's ability to perform breastfeeding, hygiene activities, care, and intervention for 3 months.Result: The status of stunting was determined by the different distribution of stunting before and after the intervention in both the intervention and control groups. There was a decrease of about 9.3% of MNL in the intervention group, while in the control group it decreased by just 2.4% (p<0.05).Conclusions: It can be concluded that MNL has an effect in preventing stunting, and it is recommended that preventive measures should focus more on normal children, while stunted children should be provided with breastfeeding as the core of MNL.

scholarly journals Effect of Acupuncture on Functional Connectivity of Anterior Cingulate Cortex for Bell’s Palsy Patients with Different Clinical Duration

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Hongli Wu ◽  
Hongxing Kan ◽  
Chuanfu Li ◽  
Kyungmo Park ◽  
Yifang Zhu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Physiological Mechanism ◽  
Bell’S Palsy ◽  
Anterior Cingulate ◽  
Control Group ◽  
Bell's Palsy ◽  
Brain Response ◽  
Before And After ◽  
The Status ◽  
Healthy Control

Acupuncture is widely used in the treatment of Bell’s palsy (BP) in many countries, but its underlying physiological mechanism remained controversial. In order to explore the potential mechanism, changes of functional connectivity (FC) of anterior cingulate gyrus (ACC) were investigated. We collected 20 healthy (control group) participants and 28 BP patients with different clinical duration accepted resting state functional MRI (rfMRI) scans before and after acupuncture, respectively. The FC of ACC before and after acupuncture was compared with pairedt-test and the detailed results are presented in the paper. Our results showed that effects of the acupuncture on FC were closely related to clinical duration in patients with BP, which suggested that brain response to acupuncture was closely connected with the status of brain functional connectivity and implied that acupuncture plays a homeostatic role in the BP treatment.

Acetylation Phenotype and Hepatotoxicity in the Treatment of Tuberculosis in Children

PEDIATRICS ◽  
1986 ◽  
Vol 77 (6) ◽  
pp. 912-915 ◽  
Author(s):  
A. Martinez-Roíg ◽  
J. Camí ◽  
J. Llorens-Terol ◽  
R. de la Torre ◽  
F. Perich
Keyword(s):  
Liver Damage ◽  
Clinical Signs ◽  
Control Group ◽  
Fisher Exact Probability Test ◽  
Acetylation Phenotype ◽  
Exact Probability ◽  
Tuberculosis In Children ◽  
The Relationship

We studied the relationship between acetylation phenotype and the appearance of biochemical and clinical signs of liver damage in 73 tuberculous children treated with isoniazid and rifampin. No significant differences were found with respect to the distribution of acetylation phenotype between tuberculous patients and a control group consisting of 256 children. Hepatotoxicity manifested in 27 cases (37%), of which only five (7%) had clinical signs. Application of the Fisher exact probability test did not show a relationship between acetylation phenotype and hepatotoxicity.

Effect of Peritoneal Dialysis and a Single Hemodialysis on Erythrocyte Membrane Atpase Activity of Uremic Subjects

1985 ◽  
Vol 5 (1) ◽  
pp. 31-32 ◽  
Author(s):  
Ozdogu Hakan ◽  
Gurcay Ali ◽  
Akoglu Tevfik ◽  
Akoglu Emel
Keyword(s):  
Peritoneal Dialysis ◽  
Normal Subjects ◽  
Acute Effect ◽  
Clinical Findings ◽  
Control Group ◽  
Significant Difference ◽  
Before And After ◽  
The Status ◽  
Unknown Structure ◽  
Comparison Of The Results

In this study erythrocytic A TPase activities were studied in 21 patients before and after six hours of hemodialysis. In another group of 20 patients A TPase activities were also studied before and after 48 72 hours of peritoneal dialysis. As a control group 20 healthy normal subjects were used. Comparison of the results revealed that all three (Na+/k+, Mg++, Ca++/Mg++) ATPase activities were lower in the chronic renal failure patients than normal controls (p < 0.001). Both peritoneal and hemodialysis increased significantly all three A TPase activities. When peritoneal and hemodialysis results were compared no significant difference was noted. It is concluded that the increase in A TPase activites observed by both dialysis methods is due to removal from the plasma of substances which are responsible for the decrease in A TPase activities before dialysis. In uremia numerous substances alone or together have been held responsible for various clinical findings. In addition some other metabolic wastes of unknown structure act upon important enzyme systems resulting to an altered cellular function. A TPase enzymes are a group of enzymes responsible for the maintenance of the ionic and osmotic balance of the cells. In this study we studied the status of these enzymes in ESRD patients undergoing dialysis and also the acute effect of peritoneal dialysis and hemodialysis on them.

scholarly journals Anticonvulsant Effects of Topiramate and Lacosamide on Pilocarpine-Induced Status Epilepticus in Rats: A Role of Reactive Oxygen Species and Inflammation

2021 ◽  
Vol 22 (5) ◽  
pp. 2264
Author(s):  
Michaela Shishmanova-Doseva ◽  
Lyudmil Peychev ◽  
Lyubka Yoanidu ◽  
Yordanka Uzunova ◽  
Milena Atanasova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Status Epilepticus ◽  
Control Level ◽  
Epileptic Activity ◽  
Control Group ◽  
Anticonvulsant Effect ◽  
Sod Activity ◽  
Inflammatory Damage ◽  
Male Wistar Rats ◽  
Early Effects

Background: Status epilepticus (SE) is a neurological disorder characterized by a prolonged epileptic activity followed by subsequent epileptogenic processes. The aim of the present study was to evaluate the early effects of topiramate (TPM) and lacosamide (LCM) treatment on oxidative stress and inflammatory damage in a model of pilocarpine-induced SE. Methods: Male Wistar rats were randomly divided into six groups and the two antiepileptic drugs (AEDs), TPM (40 and 80 mg/kg, i.p.) and LCM (10 and 30 mg/kg, i.p.), were injected three times repeatedly after pilocarpine administration. Rats were sacrificed 24 h post-SE and several parameters of oxidative stress and inflammatory response have been explored in the hippocampus. Results: The two drugs TPM and LCM, in both doses used, succeeded in attenuating the number of motor seizures compared to the SE-veh group 30 min after administration. Pilocarpine-induced SE decreased the superoxide dismutase (SOD) activity and reduced glutathione (GSH) levels while increasing the catalase (CAT) activity, malondialdehyde (MDA), and IL-1β levels compared to the control group. Groups with SE did not affect the TNF-α levels. The treatment with a higher dose of 30 mg/kg LCM restored to control level the SOD activity in the SE group. The two AEDs, in both doses applied, also normalized the CAT activity and MDA levels to control values. In conclusion, we suggest that the antioxidant effect of TPM and LCM might contribute to their anticonvulsant effect against pilocarpine-induced SE, whereas their weak anti-inflammatory effect in the hippocampus is a consequence of reduced SE severity.

scholarly journals The Effectiveness of Giving Cold Compress in Pain Reduction Intensity of Perineal Wound of Postpartum Mother

2020 ◽  
Vol 7 (3) ◽  
pp. 398-403
Author(s):  
Maria Ulfa ◽  
Laily Prima Monica
Keyword(s):  
Perineal Wound ◽  
Health Centers ◽  
Control Group ◽  
Fisher Exact Probability Test ◽  
Exact Probability ◽  
Control Group Design ◽  
Perineal Repair ◽  
Wound Pain ◽  
Independent Variable ◽  
Postpartum Mothers

Perineal wound pain is very likely to cause problems for the postpartum mothers. In the process of childbirth often occurs perineal wound, for some cases, it will heal permanently, but if the wound is wide enough can be sutured to the perineum. Perineal repair not only giving some benefits, but also can cause pain. One way to deal is by applying non-pharmacological pain management, the way is by giving cold compresses in the form of ice bags, it will result smaller risk. The purpose of this study was to provide cold compress therapy in scars to reduce pain. Methods: Posttest only control group design. The population in this study was 30 postpartum mothers in Kanigoro Health Centers by using purposive sampling. The sample was 16 respondents. The independent variable was cold compress, while the dependent variable was pain in the perineal wound. The instrument used Standart Operating Prosedure.  Results: Fisher Exact Probability Test shows p = 0.003 (a = 0.05).  It could be concluded that giving cold compress could reduce the problem in perineal wound for postpartum mothers in the Kanigoro Health Center area. Along with this study, respondents are expected to actively ask questions, learn about problems during and after giving birth, especially not only learn about the technique of giving cold compresses to the perineum, but also about the provided comments.

Modifications of urato-oxalate exchange in patients with diabetes mellitus after maloinvasive treatment with ureterolytiaase induction

2017 ◽  
pp. 51-56
Author(s):  
A.Yu. Gurzhenko ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Healthy Volunteers ◽  
Complete Recovery ◽  
Urinary Stones ◽  
Control Group ◽  
Urine Ph ◽  
Noninvasive Methods ◽  
Before And After ◽  
Patients With Diabetes ◽  
The Status

The objective: of the study was to study the status of urate-oxalate exchange in peple with ureterolithiasis and concomitant diabetes mellitus undergoing various methods of non-invasive surgical treatment of urinary stones. Patients and methods. The study involved 164 patients and 12 healthy volunteers, of whom men accounted for 93 (56.7%), women – 71 (43.3%) persons. The age range of patients is 19–53 years, on average – 34.6±5.5 years. The average age of women is 30.1±2.9 years, and men are 37.6±3.1 years. Patients were divided into IV clinical groups: I – patients with ureterolithiasis and diabetes, which were performed by TUKL (n=34); II – patients with ureterolithiasis and diabetes, which were conducted by the EWHL (n=32); III – patients with ureterolithiasis without diabetes, which was performed by TUKL (n=41); IV – patients with ureterolithiasis without diabetes, which was performed by ESWL (n=57). The control group consisted of healthy volunteers with no signs of pathology (n=12). The studies were performed before and after disintegration of stones by the method of transurethral contact lithotripsy (TUKL) and ESWL. The diagnosis of SCH was verified using clinical, anamnestic, laboratory and instrumental research methods in accordance with the MOH protocols, before and after the disintegration of stones by the method of transurethral contact lithotripsy (TUCL) and ESWL. Results.The analysis of the above-mentioned data found that in the presence of ureterolithiasis in people with diabetes, there were significant changes in daily pH indices in the form of monotony of the indicator curve, with a rather high shift towards acidification. Constant urine pH is an important marker for excretory renal function in the presence of urinary tract, diabetes, and diabetes. Strongly sour urine reflects the peculiarities of the flow of uratogenic urolithiasis in the conditions of the DN, indicating the absence of isolated violation by the GKO and outlines this state as a two-way. Conclusion. Hypocytarturia was established in all cases of CKD, but in urine subjects with diabetes, excrement rates of citrate were as low as possible. In patients with diabetes mellitus and concomitant ureterolithiasis, there are significant disturbances in the metabolism of uric acid and oxalate, with the possibility of correction in case of rapid and complete recovery of urodynamics by noninvasive methods (TUKL). Key words: ureterolithiasis, diabetes mellitus, urates, oxalates, minimally invasive methods of lithotripsy.

scholarly journals Use of Levetiracetam in Epileptic Dogs with Chronic Kidney Disease: A Retrospective Study

2021 ◽  
Vol 8 (11) ◽  
pp. 263
Author(s):  
So-Yeon Gim ◽  
Woo-Jin Song ◽  
Hwa-Young Youn
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Side Effects ◽  
Kidney Disease ◽  
Dose Adjustment ◽  
Laboratory Evaluation ◽  
Individualized Dosing ◽  
Before And After ◽  
The Status ◽  
Patients With Epilepsy

In human medicine, doses of levetiracetam (LEV) are individualized for patients with epilepsy, depending on the status of the patient’s renal function. However, there are not reports on the individualized dosing of LEV for small animals. The aim of this study is to investigate whether a dose adjustment of LEV is needed in dogs with chronic kidney disease (CKD). Patient databases were searched, and 37 dogs with seizures or epilepsy were retrospectively included in this study. Based on pre-existing CKD, patients were divided into a CKD group (n = 20) and a non-CKD group (n = 17). We collected kidney panels before and after LEV treatment. Side-effects were monitored for 1 month after the start of LEV administration. In the CKD group, more dogs developed adverse effects (85%) than in the non-CKD group (52.94%). After LEV administration, an increase in blood urea nitrogen and/or serum creatinine was more often reported in the CKD group than it was in the non-CKD group. Our data indicate that in dogs with seizures or epilepsy with pre-existing CKD, an LEV dose-adjustment is needed. During LEV treatment, CKD patients should be monitored for side-effects and may require laboratory evaluation of renal function.

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