scholarly journals Biomechanical behaviours of the bone–implant interface: a review

2019 ◽  
Vol 16 (156) ◽  
pp. 20190259 ◽  
Author(s):  
Xing Gao ◽  
Manon Fraulob ◽  
Guillaume Haïat
Keyword(s):  
Bone Tissue ◽  
Medical Devices ◽  
State Of The Art ◽  
Biomechanical Properties ◽  
Review Article ◽  
Implant Stability ◽  
Bone Implant ◽  
Current State ◽  
Mechanical Methods

In recent decades, cementless implants have been widely used in clinical practice to replace missing organs, to replace damaged or missing bone tissue or to restore joint functionality. However, there remain risks of failure which may have dramatic consequences. The success of an implant depends on its stability, which is determined by the biomechanical properties of the bone–implant interface (BII). The aim of this review article is to provide more insight on the current state of the art concerning the evolution of the biomechanical properties of the BII as a function of the implant's environment. The main characteristics of the BII and the determinants of implant stability are first introduced. Then, the different mechanical methods that have been employed to derive the macroscopic properties of the BII will be described. The experimental multi-modality approaches used to determine the microscopic biomechanical properties of periprosthetic newly formed bone tissue are also reviewed. Eventually, the influence of the implant's properties, in terms of both surface properties and biomaterials, is investigated. A better understanding of the phenomena occurring at the BII will lead to (i) medical devices that help surgeons to determine an implant's stability and (ii) an improvement in the quality of implants.

Modular Prosthetic Design for Transtibial Child Amputees

2017 ◽  
Author(s):  
Brendan M. Hickey ◽  
Samuel T. Woo ◽  
Sally F. Shady
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Lower Limb ◽  
State Of The Art ◽  
Insurance Coverage ◽  
Review Article ◽  
Prosthetic Design ◽  
Current State ◽  
Limb Deficiencies

Lower limb deficiencies and below knee amputations are the most common form of deficiency that may arise from disease or trauma, and returning a patient close to a normal quality-of-life requires prosthetics, which can be quite challenging. Children present even further difficulty to prosthetists and physicians than adults. Although the underlying prosthetic principles for adults are the same for children, additional considerations must be made for practicality, such as downsizing while maintaining its degree of complexity, and frequent appointments to account for the rapid growth of an adolescent. This review article will evaluate the current state-of-the-art in the field of transtibial-amputee prosthetics, review the insurance coverage a typical family would face, and suggest potential improvements to children’s biomimetic prostheses that aid in reducing the frequency of health care provider intervention.

scholarly journals Smoothing additive manufactured parts using ns-pulsed laser radiation

2021 ◽  
Author(s):  
Florian Kuisat ◽  
Fernando Lasagni ◽  
Andrés Fabián Lasagni
Keyword(s):  
Surface Roughness ◽  
Mechanical Performance ◽  
State Of The Art ◽  
Pulsed Laser ◽  
Industrial Applications ◽  
Laser Source ◽  
Pulsed Laser Radiation ◽  
Current State ◽  
The Impact

AbstractIt is well known that the surface topography of a part can affect its mechanical performance, which is typical in additive manufacturing. In this context, we report about the surface modification of additive manufactured components made of Titanium 64 (Ti64) and Scalmalloy®, using a pulsed laser, with the aim of reducing their surface roughness. In our experiments, a nanosecond-pulsed infrared laser source with variable pulse durations between 8 and 200 ns was applied. The impact of varying a large number of parameters on the surface quality of the smoothed areas was investigated. The results demonstrated a reduction of surface roughness Sa by more than 80% for Titanium 64 and by 65% for Scalmalloy® samples. This allows to extend the applicability of additive manufactured components beyond the current state of the art and break new ground for the application in various industrial applications such as in aerospace.

scholarly journals Ensemble-Based Out-of-Distribution Detection

Electronics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 567
Author(s):  
Donghun Yang ◽  
Kien Mai Mai Ngoc ◽  
Iksoo Shin ◽  
Kyong-Ha Lee ◽  
Myunggwon Hwang
Keyword(s):  
Detection Method ◽  
State Of The Art ◽  
Metric Learning ◽  
Feature Space ◽  
Confidence Score ◽  
Distance Metric Learning ◽  
Current State ◽  
Overall Performance ◽  
Deep Learning Model

To design an efficient deep learning model that can be used in the real-world, it is important to detect out-of-distribution (OOD) data well. Various studies have been conducted to solve the OOD problem. The current state-of-the-art approach uses a confidence score based on the Mahalanobis distance in a feature space. Although it outperformed the previous approaches, the results were sensitive to the quality of the trained model and the dataset complexity. Herein, we propose a novel OOD detection method that can train more efficient feature space for OOD detection. The proposed method uses an ensemble of the features trained using the softmax-based classifier and the network based on distance metric learning (DML). Through the complementary interaction of these two networks, the trained feature space has a more clumped distribution and can fit well on the Gaussian distribution by class. Therefore, OOD data can be efficiently detected by setting a threshold in the trained feature space. To evaluate the proposed method, we applied our method to various combinations of image datasets. The results show that the overall performance of the proposed approach is superior to those of other methods, including the state-of-the-art approach, on any combination of datasets.

scholarly journals A review on the use of additive manufacturing to produce lower limb orthoses

2019 ◽  
Vol 5 (2) ◽  
pp. 85-94 ◽  
Author(s):  
Mohammed S. Alqahtani ◽  
Abdulsalam Al-Tamimi ◽  
Henrique Almeida ◽  
Glen Cooper ◽  
Paulo Bartolo
Keyword(s):  
Additive Manufacturing ◽  
Lower Limb ◽  
State Of The Art ◽  
Production Costs ◽  
Current State ◽  
Research Challenges ◽  
Fixation Devices ◽  
Alignment Correction ◽  
And Performance

Abstract Orthoses (exoskeletons and fracture fixation devices) enhance users’ ability to function and improve their quality of life by supporting alignment correction, restoring mobility, providing protection, immobilisation and stabilisation. Ideally, these devices should be personalised to each patient to improve comfort and performance. Production costs have been one of the main constraints for the production of personalised orthoses. However, customisation and personalisation of orthoses are now possible through the use of additive manufacturing. This paper presents the current state of the art of additive manufacturing for the fabrication of orthoses, providing several examples, and discusses key research challenges to be addressed to further develop this field.

What Every Therapist Needs to Know About Couple Therapy

2019 ◽  
Vol 36 (3) ◽  
pp. 121-142 ◽  
Author(s):  
W. Kim Halford ◽  
Christopher A. Pepping
Keyword(s):  
Couple Therapy ◽  
State Of The Art ◽  
Couple Relationship ◽  
Couple Relationships ◽  
Art And Science ◽  
Relationship Distress ◽  
Relationship Problems ◽  
Current State ◽  
The Relationship

AbstractThis invited paper is a review of the significance of couple relationships to the practice of all therapists. The article begins with a summary of the evidence on the centrality of committed couple relationships to the lives and wellbeing of adults, and the association of the quality of the parents’ couple relationship on the wellbeing of children. We argue that the well-established reciprocal association between individual problems and couple relationship problems means that all therapists need to pay attention to how a couple relationship might be influencing a client's functioning, even if the relationship is not the presenting problem. There is an outline the evolution of current approaches to behavioural couple therapy, and the current state of the art and science of couple therapy. We present an analysis of the evidence for couple therapy as a treatment for relationship distress, as well as couple-based treatments for individual problems. This is followed by a description of the distinctive challenges in working with couples and how to address those challenges, and recommendations about how to address the needs of diverse couple relationships. Finally, we propose some core therapist competencies needed to work effectively with couples.

scholarly journals Host-Directed Therapies and Anti-Virulence Compounds to Address Anti-Microbial Resistant Tuberculosis Infection

2020 ◽  
Vol 10 (8) ◽  
pp. 2688 ◽  
Author(s):  
Raphael Gries ◽  
Claudia Sala ◽  
Jan Rybniker
Keyword(s):  
Immune Cells ◽  
State Of The Art ◽  
Research Community ◽  
Review Article ◽  
Drug Resistant ◽  
Resistant Tuberculosis ◽  
Current State ◽  
Major Virulence Factor ◽  
Emerging Therapies ◽  
Active Research

Despite global efforts to contain tuberculosis (TB), the disease remains a leading cause of morbidity and mortality worldwide, further exacerbated by the increased resistance to antibiotics displayed by the tubercle bacillus Mycobacterium tuberculosis. In order to treat drug-resistant TB, alternative or complementary approaches to standard anti-TB regimens are being explored. An area of active research is represented by host-directed therapies which aim to modulate the host immune response by mitigating inflammation and by promoting the antimicrobial activity of immune cells. Additionally, compounds that reduce the virulence of M. tuberculosis, for instance by targeting the major virulence factor ESX-1, are being given increased attention by the TB research community. This review article summarizes the current state of the art in the development of these emerging therapies against TB.

scholarly journals Advances in Analysis of Milk Proteases Activity at Surfaces and in a Volume by Acoustic Methods

Sensors ◽  
2020 ◽  
Vol 20 (19) ◽  
pp. 5594 ◽  
Author(s):  
Mark Dizon ◽  
Marek Tatarko ◽  
Tibor Hianik
Keyword(s):  
State Of The Art ◽  
Enzyme Reaction ◽  
Ultrasonic Spectroscopy ◽  
Basic Principles ◽  
Current State ◽  
Acoustic Methods ◽  
Milk Gelation ◽  
Kinetics Of ◽  
Increased Activity

This review is focused on the application of surface and volume-sensitive acoustic methods for the detection of milk proteases such as trypsin and plasmin. While trypsin is an important protein of human milk, plasmin is a protease that plays an important role in the quality of bovine, sheep and goat milks. The increased activity of plasmin can cause an extensive cleavage of β-casein and, thus, affect the milk gelation and taste. The basic principles of surface-sensitive acoustic methods, as well as high-resolution ultrasonic spectroscopy (HR-US), are presented. The current state-of-the-art examples of the application of acoustic sensors for protease detection in real time are discussed. The application of the HR-US method for studying the kinetics of the enzyme reaction is demonstrated. The sensitivity of the acoustics biosensors and HR-US methods for protease detection are compared.

Online Social Exergames for Seniors

2020 ◽  
pp. 1599-1631
Author(s):  
Stathis Th. Konstantinidis ◽  
Ellen Brox ◽  
Per Egil Kummervold ◽  
Josef Hallberg ◽  
Gunn Evertsen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Physical Training ◽  
State Of The Art ◽  
Social Contact ◽  
High Quality ◽  
Current State ◽  
The Future ◽  
The Impact

The population is getting older, and the resources for care will be even more limited in the future than they are now. There is thus an aim for the society that the seniors can manage themselves as long as possible, while at the same time keeping a high quality of life. Physical activity is important to stay fit, and social contact is important for the quality of life. The aim of this chapter is to provide a state-of-the-art of online social exergames for seniors, providing glimpses of senior users' opinions and games limitations. The importance of the motivational techniques is emphasized, as well as the impact that the exergames have to seniors. It contributes to the book objectives focusing on current state and practice in health games for physical training and rehabilitation and the use of gamification, exploring future opportunities and uses of gamification in eHealth and discussing the respective challenges and limitations.

You Need Teachers

PEDIATRICS ◽  
1979 ◽  
Vol 64 (1) ◽  
pp. 125-125
Author(s):  
Miles Weinberger
Keyword(s):  
State Of The Art ◽  
Review Article ◽  
Current State ◽  
Children With Asthma ◽  
Degree Of Control ◽  
Considerable Morbidity ◽  
High Degree ◽  
Changing Role ◽  
Excellent Review Article

The excellent review article by Leffert1 and the accompanying commentary by Bergner2 made important points regarding the changing role of the pediatric allergist and the broad requirements for knowledge of any physicians who are to provide specialty care for children with asthma. While the current state of the art allows a high degree of control for this disease,3 considerable morbidity from inadequately treated asthma persists. This situation is unlikely to change rapidly unless departments of pediatrics place a high priority on ensuring that the modern allergist described by Dr. Bergner is on their faculty to teach the current housestaff and provide continuing education for the practitioner; only then will most general pediatricians be able to assume the role envisioned by Dr. Leffert.

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