In Reply: Heparinization of Alimentation Solutions

PEDIATRICS ◽  
1985 ◽  
Vol 75 (6) ◽  
pp. 1167-1168
Author(s):  
G. ALPAN ◽  
F. EYAL

We thank Poland and Bedard for their interest in our findings and for pointing out an error of omission in our reporting of the data. The infants in the heparinized group did indeed receive intravenous alimentation for a longer (mean) duration. The difference is due to skewing ofthe data by a subgroup of infants who required intravenous treatment for prolonged periods. Bronchopulmonary dysplasia developed in three infants in the heparmnized group v one infant in the nonheparinized group.

2021 ◽  
Vol 9 (T4) ◽  
pp. 87-91
Author(s):  
Titiek Hidayati ◽  
Akrom Akrom ◽  
Indrayanti Indrayanti ◽  
Suny Sun

BACKGROUND: The carcinogen dimethylbenzanthracene (DMBA) is immunotoxic. Thymoquinone, meanwhile, is known to have antioxidant and anti-inflammatory effects. AIM: This study aims to determine the effect of thymoquinone and tamoxifen on the CD4CD25Treg count in Sprague-Dawley (SD) rats induced by DMBA. METHODS: The 50 SD rats were divided into five groups. Group I (normal control) was given standard drinking and food. Group II was given thymoquinone, Group III was given tamoxifen, Group IV was given DMBA, and Group V was given solvent control. Thymoquinone, tamoxifen, and solvent control administration started 2 weeks before DMBA administration and continued during DMBA induction. In the 3rd week, except for the normal group, all groups were created to be induced with 10 × 20 mg/kg body weight of DMBA for 5 weeks. In the 21st week, surgery and data collection were performed. The hematology profile and CD4CD25Treg number were carried out employing a flow cytometer. The difference in the average number of CD4CD25Treg and blood cells between groups was analyzed with one-way analysis of variance RESULTS: The results revealed that DMBA induction reduced the number of erythrocytes, HB levels, platelet counts, and leukocyte counts (p < 0.05). The administration of thymoquinone and tamoxifen reduced the hematopoiesis effect of DMBA. The thymoquinone and tamoxifen group had a higher number of CD4CD25Treg and leukocytes than the DMBA group (p < 0.05). CONCLUSION: There was no difference in the average CD4CD25Treg, leukocyte count, lymphocyte count, and monocyte count between the thymoquinone and the tamoxifen groups (p > 0.05).


2015 ◽  
Vol 27 (1) ◽  
pp. 169
Author(s):  
M. Maturana Filho ◽  
K. M. Lemes ◽  
J. R. Naves ◽  
T. Santin ◽  
T. K. Nishimura ◽  
...  

The aim of this study was to investigate and determine which metabolic predictors measured during the transition period, have a better association with health and fertility parameters in dairy cows in winter (W) and summer (S).The experiment was conducted with 235 multiparous Holstein dairy cows. The animals were divided, retrospectively into the experimental groups [High Production (AP), ≥45.9 to 65 kg of milk during peak lactation; Medium production (MP), between 30 and 45.8 kg of milk during peak lactation]. Blood samples and evaluations occurred during the transition period and during the timed fixed artificial insemination (TAI). Data were analysed for the main effects of group, day, and their interaction using the PROC MIXED procedure of SAS software (SAS 9.3, SAS Institute, Inc., Cary, NC, USA). Creatine kinase (CK) plasmatic concentrations increased during peak lactation in all groups, but the difference was not significant. Variations in superoxide dismutase (SOD) concentrations were observed in HP cows in both seasons (HPW and HPS). These cows had higher levels of superoxide dismutase (SOD) when compared of MP cows (MPW and MPS), with significant changes since 7 days before calving and remained higher until 104 days of lactation. The differences were observed in lipid profile, particularly in NEFA concentration. For this variable, there were group (P < 0.001) and day (P < 0.001) effects and also double interactions (day v. season, P < 0.001) and triple interactions (group v. day v. season, P = 0.009). The HPS cows had higher values, as well as a variation pattern of urea concentration (P < 0.05), different from the other groups until 100 days in milk (DEL). No differences were observed in diseases incidences between group or periods (P > 0.05). There was a statistical tendency to all groups in the summer season for earlier calving (P = 0.1), less calf weight (P = 0.07), and retained placenta (P = 0.09) and metritis incidence (P = 0.08). These parameters were strongly correlated with metritis disease incidence and the significant parameters: Earlier calving (P = 0.03), dystocia (P = 0.05), and retained placenta (P = 0.009). The NEFA (0.4 mmol L–1) and BHBA concentrations (0.7 mmol L–1) were highly correlated with the occurrence of uterine diseases. We observed high levels of AST (around 128 U/L) pre calving in ketotic and in cows with displacement of abomasum. According to these results, we concluded that milk production was not a risk factor for fertility in the first three services. Also, metabolic changes in the transition period were determinant in milk yield and health diseases. Research was supported by FAPESP, CNPq, CAPES, Fazenda Colorado, and Ourofino animal health.


2003 ◽  
Vol 1 (2) ◽  
pp. 50-57 ◽  
Author(s):  
HESTI PUSPITASARI ◽  
SHANTI LISTYAWATI ◽  
TETRI WIDIYANI

The objectives of the research were to find out the effect of giving sedges root extract orally on the number of writhing after chemical pain induction and time reaction after thermal pain induction of mice and also to find out the extract dosage which had an influence on decreasing number of writhing after chemical pain induction and length of reaction time after thermal pain induction of mice. The Complete Random Design (CRD) with 6 treatment groups and each treatment used 5 repetitions were used in this study. The groups were: Group I , control group, treated with sedges root extract of 0 mg/ 20 g BW , 0,5 ml; Group II treated with sedges root extract of 1 mg/ 20 g BW, 0,5 ml; Group III treated with sedges root extract of 3 mg/ 20 g BW, 0,5 ml; Group IV treated with sedges root extract of 5 mg/ 20 g BW, 0,5 ml; Group V treated with sedges root extract of 7 mg/ 20 g BW, 0,5 ml; Group VI treated with asetosal 200 mg/ kg BW , 0,5 ml/ 20 g BW and for the activity test, the sedges root extract was suspended in CMC 1%. Induction of chemical pain was done according to Witkin et al. (1965) in Pudjiastuti et al. (2000), in which 0,1 ml 3% of Acetic Acid/ 20 g BB was injected intraperitoneally 30 minutes after giving oral-material test. The mouse gave a respond in the way of writhing. Thermal pain induction was done by placing the mouse on hot plate with constant temperature of 55oC. The mouse gave a respond in the way of lick its back foot or even jumping. The data collected was analyzed using one direction ANOVA model and it was continued with LSD test in order to find out the difference every treatment group. The result of the analysis showed that the sedges root extract dosage of 7 mg/ 20 g BB decreased the number of writhing after chemical pain induction and length of mouse time reaction after thermal pain induction, so that sedges root extract dosage 7 mg/ 20 g BB had an analgetic function.


1995 ◽  
Vol 378 ◽  
Author(s):  
X. Liu ◽  
E. R. Weber ◽  
D. F. Ogletree ◽  
M. Salmeron ◽  
T. Slupinski

AbstractWe report cross-sectional scanning tunneling microscopy studies of GaAsP single crystals grown by the Liquid Encapsulated Czochralski technique. We show that the two group-V elements can be clearly distinguished, which is attributed to the difference in energies of surface dangling bond states of As and P. Our atomic scale imaging results show alloy composition in agreement with spectroscopic studies. They also provide valuable information about atomic scale alloy fluctuations and clustering effects.


2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Emma E. Williams ◽  
Theodore Dassios ◽  
Mikhaela Mann ◽  
Anne Greenough

Abstract Objectives Corticosteroids are administered to ventilator dependent infants with bronchopulmonary dysplasia (BPD) to improve respiratory function and facilitating extubation. Acutely, however, growth impairment can occur as a side effect of such therapy. We aimed to determine the effect of corticosteroids on postnatal growth during the entire neonatal intensive care unit (NICU) admission. Methods A whole population study of extremely preterm infants with BPD was undertaken. Corticosteroid therapy was classified as treatment with dexamethasone or hydrocortisone for a least five consecutive days. Growth was calculated as the difference in weight and head circumference z-score from birth to discharge. Results Six thousand, one hundred and four infants with BPD were included of whom 28.3% received postnatal corticosteroids. Infants receiving corticosteroids were less mature (GA 25.0 vs. 26.3 weeks) and of lower birthweight (0.70 vs. 0.84 kg) than those not receiving treatment. There were no significant differences between those who did and did not receive corticosteroids in weight gain (p=0.61) or head circumference growth (p=0.33) from birth to discharge. Single vs. multiple courses of postnatal corticosteroids did not result in significant differences in weight (p=0.62) or head circumference (p=0.13) growth. Conclusions Postnatal corticosteroid treatment did not affect the longer term growth of preterm infants with BPD.


Author(s):  
M. S. Gabaev ◽  
N. V. Berbekova

Milk production and live weight of queens in mountain meat-coarse-wool sheep breeding, as one of the main quantitative traits in postnatal ontogenesis, are more susceptible to the influence of paratypical factors, that is, they have a large “rate of reaction” to the conditions of feeding and maintenance.In order to resolve the question * how to select, what animals to leave for the tribe in the mountain meat coarse-wool sheep breeding *? We at OOO Dargan, a mountainous zone of the Kabardino-Balkarian Republic (KBR), according to the methodology, formed five groups of queens, with a class interval of 5 kg.It was found that the milk production of the queens had a certain relationship with their live weight, and was 32.4 kg in group V, which exceeds the same indicator of group IV by 1.4 kg; III - by 3.0; II - by 7.6; I - by 8.5 kg, the difference between IV and III groups is 0.6 kg.At 4 months of age, the rams of group V in live weight exceeded rams of groups IV and III by 0.7 and 0.4 kg, II - by 2.5 kg, I - by 5.3 kg, at 6 months of age - I at 7.9 kg, II - at 4.0 kg, III - 1.5 kg. There were no significant differences between IV and V groups - 0.7 kg.Along with this, it should be noted that with an increase in the vertical zoning of pastures above sea level (above sea level), with steep slopes, the higher milk production potential of large queens is leveled.The obtained research results indicate that in mountain meat and coarse-wool sheep breeding, selection for increasing the milk yield of ewes, in combination with the optimal live weight, is an effective method of increasing the live weight of young animals.


2019 ◽  
Vol 25 (3) ◽  
pp. 173-179
Author(s):  
Youstina Hanna ◽  
Corinne Laliberté ◽  
Nadya Ben Fadel ◽  
Brigitte Lemyre ◽  
Bernard Thébaud ◽  
...  

Abstract Background Recent clinical practice changes in neonatal care resulted in higher, narrower oxygen saturation target ranges for preterm infants. The effect of targeting higher or lower oxygen saturations on respiratory outcomes of preterm infants and duration of hospitalization has not been extensively reviewed in the context of current care, but could have significant implications. Methods A multicentre retrospective cohort of 145 preterm infants was conducted; 105 had lower oxygen saturation targets (88 to 92%), 40 had higher targets (90 to 95%). The primary outcome was bronchopulmonary dysplasia (BPD). Secondary outcomes included duration of invasive/noninvasive respiratory support, oxygen therapy, and hospitalization. The primary outcome was compared using Fisher’s exact test. Secondary outcomes were evaluated with survival analysis and Wilcoxon rank sum test. Results The difference in incidence of BPD in the lower (N=56, 53.3%) and higher saturation groups (N=14, 35.0%) was not statistically significant (relative risk [RR]=0.66 [0.41, 1.04], P=0.06). The difference in duration of mechanical ventilation in the lower (median 7.8 days, interquartile range [IQR] 3.7 to 15.9) and higher saturation groups (median 4.5, IQR 1.9 to 12.3) approached statistical significance (P=0.05). There were no statistically significant differences in the durations of other respiratory supports or hospital stay between the two groups. Conclusions The results of this study approached statistical significance and suggest that higher, narrower oxygen saturation targets may result in a clinically important reduction in BPD incidence and duration of mechanical ventilation. These results require validation in a larger sample to refine optimal targets.


2020 ◽  
Vol 27 (3) ◽  
Author(s):  
Selen İnce Yusufoğlu ◽  
◽  
Esma Saricam ◽  

Many root canal preparation techniques and instruments produce apically extruded materials to a certain extent depending on the preparation system adopted. The extrusion of debris from the apical foramen during chemomechanical preparation may cause postoperative pain and failure of endodontic treatment. Objective: This study evaluates the differences in the apical extrusion of debris and calcium hydroxide (CH) during endodontic instrumentation by using Reciproc Blue (RB), WaveOne Gold (WOG), and F6 Skytaper (F6). Methods: Six experimental study groups (n = 13) were established. The root canal procedures for all groups were prepared with different methods: Group I: One Shape (OS) instrumentation, CH filling for 21 days, removal of CH using RB; Group II: OS instrumentation, CH filling for 21 days, removal of CH using WOG; Group III: OS, CaOH filling for 21 days, removal of CH using F6; Group IV: root canal instrumentation using RB; Group V: root canal instrumentation using WOG; Group VI: root canal instrumentation using F6. Apically extruded debris was collected into preweighed Eppendorf tubes by using the Myers and Montgomery method. Data were statistically analyzed with one-way ANOVA and Kruskal–Wallis tests. Results: All the tested instruments caused the extrusion of debris and irrigant from the apical foramen. The difference among the six groups was not statistically significant (p > 0.05). Conclusions: The tested instruments caused similar apical extrusions of debris and irrigant during CH removal or instrumentation procedures.


2021 ◽  
Vol 104 (9) ◽  
pp. 1549-1556

Background: Additional media during the pre-anesthetic visit may improve knowledge of anesthetic information, reduce anxiety, and increase patient satisfaction. Objective: To compare three of the pre-anesthetic visit conducting methods in knowledge score of anesthetic information, anxiety, and satisfaction in patients undergoing elective general anesthesia. Materials and Methods: The authors randomized 225 patients into three groups, the animated video plus face-to-face interview group, which included 76 patients (group V), the brochure plus face-to-face interview group, which included 73 patients (group B), and the face-to-face interview only group, which included 76 patients (group F). The patients were asked to complete the same self-evaluation questionnaires at three different times, which were before, immediately after, and on the day of surgery after the pre-anesthetic visit, to evaluate for the knowledge of anesthetic information, anxiety, and satisfaction level. Results: At all times, the knowledge scores of anesthetic information were statistically different among the three groups (p=0.002). V and B group had higher knowledge scores when compared with F group. The mean difference between the V and F groups were 1.36 (95% CI 0.41 to 2.32, p=0.005), and between the B and F groups were 1.99 (95% CI 1.02 to 2.96, p<0.001). However, there was no difference in knowledge score between the V and B group after the visit (p>0.999 and 0.559, respectively). The anxiety scores were never statistically different between the three groups (p=0.365). While the patients had high satisfaction scores on the day of surgery, there were no statistically significant differences between the three groups (p=0.220). Conclusion: The use of medias either animated video or brochure added to the routine face-to-face interview can improve anesthetic knowledge, but animated video was not more effective than the brochure in elective surgical patients undergoing general anesthesia. The difference in methods did not affect patient anxiety and satisfaction. Keywords: Knowledge; Pre-anesthetic visit; General anesthesia; Video; Brochure


Author(s):  
C. Ballesteros ◽  
J. Piqueras ◽  
H. Laknerb ◽  
B. Bollig ◽  
A. Ruiz ◽  
...  

In the epitaxial growth of superlattice (SL) structures composed of non lattice-matched materials a large difference in the lattice constants of the components could result in the formation of misfit dislocations at the interfaces. However, high quality structures can be obtained when the thickness of the layers are kept below a critical value and the difference is elastically accomodated by strain. In particular GaAs-GaP short period superlattices (3.7% mismatch) constitute an interesting case of strained SLS because the stress related shifts of the electronic levels can result in novel optical and electronic properties. In the present work the quality of GaAs-GaP SLS is studied by STEM.Short period GaAs-GaP superlattices were grown on SI (001) GaAs substrates by Atomic Layer Molecular Beam Epitaxy a new modification of the MBE technique capable of a sharp modulation of both group III and group V sources. To study the possibility of using the GaAs-GaP system for SL and Quantum Well structures a 18 monolayer thick GaAs quantum well was confined by two GaAs-GaP superlattices.


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