scholarly journals Razões neutrófilos/linfócitos e plaquetas/linfócitos em pacientes diabéticos com ou sem disfunção renal

2018 ◽  
Vol 28 (3) ◽  
pp. 30376
Author(s):  
Anniely Carvalho Rebouças Oliveira ◽  
Brena Barros Mendes ◽  
Keila Correia De Alcântara
Keyword(s):  
Renal Damage ◽  
Absolute Number ◽  
Diabetic Group ◽  
Control Group ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
And Control

AIMS: To compare the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) between patients with and without type 2 diabetes mellitus and between diabetic patients with and without renal dysfunction.METHODS: A cross-sectional retrospective study was performed at the Laboratory of Clinical Analyzes of the Hospital das Clínicas of the Federal University of Goiás between January and December 2016. Data from patients aged 40 years or older were included in the study. Those with a blood glucose ≥200 mg / dL and/or glycated hemoglobin ≥6.5% formed the diabetic group, and those who did not present these criteria for diabetes formed the control group, being matched by age and sex. The diabetic group was classified in one group with renal damage and another without renal damage, according to the 24-hour microalbuminuria. Calculations for NLR and PLR were performed from the absolute number of neutrophils, lymphocytes and platelets, and the medians were compared.RESULTS: A total of 122 subjects were included in the study, among which 52.5% were between 40 and 64 years of age and 63.9% were male. The median NLR was 2.1 (min 0.8 - max 5.3) in the diabetic group and 1.9 (min 0.6 - max 6.2) in the control group (p=0.16). The median PLR was 120.5 (min 63.5 - max 206.6) in the diabetic group and 119.7 (min 40.4 - max 215.1) in the control group (p=0.19). Considering the age group, there was no difference in the median NLR or PLR among the diabetic group and the control group; however, the NLR was higher for individuals 65 years of age or older, regardless of whether they were diabetic (median 2.2, min 1.0 - max 3.8, p=0.01) or not (median 2.4, min 0.9 - max 3.6, p=0.001). Among the participants, 38 patients presented renal damage, 24 (63.1%) of the diabetic group and 14 (36.9%) of the control group. The median NLR and PLR were similar among diabetic patients with renal damage, diabetics without renal damage and control group.CONCLUSIONS: NLR and PLR were similar between the diabetic group and the control group, as well as among diabetics with or without renal damage. RNL was higher for individuals 65 years of age or older, regardless of whether they were diabetic or not.

scholarly journals Ethnic Foods Diet Program Improve Self-Efficacy and Diet Compliance Among Type 2 Diabetic Patients

Jurnal NERS ◽  
2020 ◽  
Vol 14 (2) ◽  
pp. 155
Author(s):  
Eka Mishbahatul Mar'ah Has ◽  
Amira Aulia ◽  
Tiyas Kusumaningrum ◽  
Ferry Efendi
Keyword(s):  
Treatment Group ◽  
Self Efficacy ◽  
Dietary Guidelines ◽  
Rank Test ◽  
Control Group ◽  
Diabetic Patients ◽  
Post Test ◽  
Diet Compliance ◽  
And Control

A well-balanced diet is one of the four pillars of diabetes self-management. Patient's culture strongly influences intake food. Diabetic dietary guidelines which fit with the patient's culture is expected to improve patient's self-efficacy and diet compliance. This study was aimed to analyze the effect of ethnic foods diet program in improving self-efficacy and diet compliance among Type-2 Diabetes Mellitus (T2DM) patients. This was quasy experiment research with pre and post-test control design. The population was 112 T2DM patients from Sasak Tribes, West Nusa Tenggara. Samples were 36 respondents, divided into intervention (18) and control (18) groups. The independent variable was the ethnic food diet (EFD) program, while the dependent variables were patient's self-efficacy and diet compliance. Data were collected using self-efficacy questionnaire and a 24-hour dietary recall form. Data were then analyzed using Wilcoxon Signed Rank Test and Mann Whitney U Test. The result showed differences in self-efficacy between pre and post-test in the treatment group (p=0,001), but there were no differences in the control group. There were differences in diet compliance in the treatment group (p=0,001), but there were no differences in the control group. There were differences between treatment and control groups on self-efficacy (p=0,000) and diet compliance (p=0,000). Ethnic foods diet program can improve self-efficacy and diet compliance among T2DM patients because more comfortable and easier to be applied. Nurses can apply ethnic foods diet program as an intervention to promote healthy diet for T2DM patients.

scholarly journals Intermuscular Fat Content in Young Chinese Men With Newly Diagnosed Type 2 Diabetes: Based on MR mDIXON-Quant Quantitative Technique

2021 ◽  
Vol 12 ◽  
Author(s):  
Fuyao Yu ◽  
Bing He ◽  
Li Chen ◽  
Fengzhe Wang ◽  
Haidong Zhu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Fat Content ◽  
Control Group ◽  
Diabetic Patients ◽  
Diabetes Group ◽  
Control Subjects ◽  
Intermuscular Fat ◽  
And Control

ObjectiveSkeletal muscle fat content is one of the important contributors to insulin resistance (IR), but its diagnostic value remains unknown, especially in the Chinese population. Therefore, we aimed to analyze differences in skeletal muscle fat content and various functional MRI parameters between diabetic patients and control subjects to evaluate the early indicators of diabetes. In addition, we aimed to investigate the associations among skeletal muscle fat content, magnetic resonance parameters of skeletal muscle function and IR in type 2 diabetic patients and control subjects.MethodsWe enrolled 12 patients (age:29-38 years, BMI: 25-28 kg/m2) who were newly diagnosed with type 2 diabetes (intravenous plasma glucose concentration≥11.1mmol/l or fasting blood glucose concentration≥7.0mmol/l) together with 12 control subjects as the control group (age: 26-33 years, BMI: 21-28 kg/m2). Fasting blood samples were collected for the measurement of glucose, insulin, 2-hour postprandial blood glucose (PBG2h), and glycated hemoglobin (HbAlc). The magnetic resonance scan of the lower extremity and abdomen was performed, which can evaluate visceral fat content as well as skeletal muscle metabolism and function through transverse relaxation times (T2), fraction anisotropy (FA) and apparent diffusion coefficient (ADC) values.ResultsWe found a significant difference in intermuscular fat (IMAT) between the diabetes group and the control group (p<0.05), the ratio of IMAT in thigh muscles of diabetes group was higher than that of control group. In the entire cohort, IMAT was positively correlated with HOMA-IR, HbAlc, T2, and FA, and the T2 value was correlated with HOMA-IR, PBG2h and HbAlc (p<0.05). There were also significant differences in T2 and FA values between the diabetes group and the control group (p<0.05). According to the ROC, assuming 8.85% of IMAT as the cutoff value, the sensitivity and specificity of IMAT were 100% and 83.3%, respectively. Assuming 39.25ms as the cutoff value, the sensitivity and specificity of T2 value were 66.7% and 91.7%, respectively. All the statistical analyses were adjusted for age, BMI and visceral fat content.ConclusionDeposition of IMAT in skeletal muscles seems to be an important determinant for IR in type 2 diabetes. The skeletal muscle IMAT value greater than 8.85% and the T2 value greater than 39.25ms are suggestive of IR.

scholarly journals Can hematological parameters in type 2 diabetes predict microvascular complication development?

2019 ◽  
Vol 35 (6) ◽  
Author(s):  
Erhan Onalan ◽  
Nevzat Gozel ◽  
Emir Donder
Keyword(s):  
Type 2 Diabetes ◽  
Microvascular Complications ◽  
Hematological Parameters ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
The Mean ◽  
The Difference

Objective: To examine potential associations between neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet volume (MPV), HbA1c and microvascular complications in diabetic patients from a cost-effectiveness perspective. Methods: One hundred patients with type 2 diabetes attending our outpatient unit between May 2018 and October 2018 were included, and 100 healthy individuals served as the control group. A retrospective file search was performed to collect information on hemoglobin, mean platelet volume (MPV), glycosylated haemoglobin (HbA1c), hematocrit (Hct), neutrophil and lymphocyte count, neutrophil/lymphocyte ratio (NLR), platelets (Plt), platelet/lymphocyte ratio (PLR), and microvascular complications (neuropathy, retinopathy, nephropathy). Results: Demographic and laboratory data were retrospectively controlled between diabetes (n=100) and healthy control (n=100) groups. The mean age in diabetic patients and healthy controls was 56.34 and 36.68 years, respectively. The mean NLR in diabetics and healthy controls was 2.48 and 2.11, the difference in NLR being significant (p=0.002). MPV in diabetics and controls was 8.54 and 8.53, respectively, and the difference was not significant (p=0.93). PLR was also similar, i.e. 149.7 and 145.3 in diabetics and healthy controls (p=0.067). With respect to microvascular complications, retinopathy was found to be significantly associated with MPV and NLR (p=0.015, and p=0.051), and nephropathy showed a significant association with NLR (p=0.027) among diabetics. In contrast with the two other microvascular complications, no significant association between neuropathy and NLR could be detected, while PLR and neuropathy was significantly associated (p=0.003). Conclusion: Microvascular complications may be associated with certain hematologic parameters, as suggested by comparisons both between diabetics and healthy individuals and within the group of diabetic individuals. We believe that hematologic parameters such as hematocrit, MPV, NLR, and PLR, which can be obtained through a simple complete blood count, may be utilized as cost-effective predictors of diabetic microvascular complications. Further prospective studies with larger sample size are required to better delineate these associations. doi: https://doi.org/10.12669/pjms.35.6.1150 How to cite this:Onalan E, Gozel N, Donder E. Can hematological parameters in type 2 diabetes predict microvascular complication development? Pak J Med Sci. 2019;35(6):1511-1515. doi: https://doi.org/10.12669/pjms.35.6.1150 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Prevalence of Comorbidities in Individuals Diagnosed and Undiagnosed with Alzheimer’s Disease in León, Spain and a Proposal for Contingency Procedures to Follow in the Case of Emergencies Involving People with Alzheimer’s Disease

2020 ◽  
Vol 17 (10) ◽  
pp. 3398
Author(s):  
Macrina Tortajada-Soler ◽  
Leticia Sánchez-Valdeón ◽  
Marta Blanco-Nistal ◽  
José Alberto Benítez-Andrades ◽  
Cristina Liébana-Presa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Disorders ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Emergency Procedures ◽  
And Control ◽  
Similar Incidence

Background: Alzheimer’s disease (AD) which is the most common type of dementia is characterized by mental or cognitive disorders. People suffering with this condition find it inherently difficult to communicate and describe symptoms. As a consequence, both detection and treatment of comorbidities associated with Alzheimer’s disease are substantially impaired. Equally, action protocols in the case of emergencies must be clearly formulated and stated. Methods: We performed a bibliography search followed by an observational and cross-sectional study involving a thorough review of medical records. A group of AD patients was compared with a control group. Each group consisted of 100 people and were all León residents aged ≥65 years. Results: The following comorbidities were found to be associated with AD: cataracts, urinary incontinence, osteoarthritis, hearing loss, osteoporosis, and personality disorders. The most frequent comorbidities in the control group were the following: eye strain, stroke, vertigo, as well as circulatory and respiratory disorders. Comorbidities with a similar incidence in both groups included type 2 diabetes mellitus, glaucoma, depression, obesity, arthritis, and anxiety. We also reviewed emergency procedures employed in the case of an emergency involving an AD patient. Conclusions: Some comorbidities were present in both the AD and control groups, while others were found in the AD group and not in the control group, and vice versa.

scholarly journals Exposure to Chinese Famine in Fetal Life and the Risk of Dysglycemiain Adulthood

2020 ◽  
Vol 17 (7) ◽  
pp. 2210
Author(s):  
Yan Zhang ◽  
Chao Song ◽  
Meng Wang ◽  
Weiyan Gong ◽  
Yanning Ma ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Exposed Group ◽  
Control Group ◽  
Fetal Life ◽  
Cross Sectional ◽  
Affected Area ◽  
Famine Exposure ◽  
And Control ◽  
The Relationship

Undernutrition in early life may have a long consequence of type 2 diabetes in adulthood. The current study was aimed to explore the association between famine exposure in fetal life during China’s Great Famine (1959–1961) and dysglycemia in adulthood. The cross-sectional data from 7830 adults from the 2010–2012 China National Nutrition and Health Surveillance was utilized. Participants who were born between 1960 and 1961 were selected as the exposed group, while the participants who were born in 1963 were selected as the unexposed group. Logistic regression was utilized to examine the relationship between fetal famine exposure and dysglycemia in adulthood. The prevalence of type 2 diabetes in the exposed and control group was 6.4% and 5.1%, respectively, and the risk of type 2 diabetes in the exposed group was 1.23 times higher than that of the control group (95%CI, 1.01–1.50; P = 0.042) in adulthood, and 1.40 times in the severely affected area (95%CI, 1.11–1.76; P = 0.004). The fasting plasma glucose of the exposed group was higher than that of the control group, which was only found in the severely affected area (P = 0.014) and females (P = 0.037). The association between famine and impaired fasting glucose was observed only in females (OR 1.31, 95%CI, 1.01–1.70; P = 0.040). Our results suggested that fetal exposure to Chinese famine increased the risk of dysglycemia in adulthood. This association was stronger in the severely affected area and females.

scholarly journals Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control Group

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Parisa Behzadi ◽  
Firouzeh Torabi ◽  
Massoud Amini ◽  
Ashraf Aminorroaya
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Control Group ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
First Degree Relatives ◽  
Significant Difference ◽  
Healthy Control ◽  
And Control

Oxidized low density lipoprotein (ox-LDL) is a product of oxidative stress. In this cross-sectional study, we compared the ox-LDL concentrations in diabetic patients with normoalbuminuria (n=28), microalbuminuria (n=28), and macroalbuminuria (n=28) with their first degree relatives (n=28) and healthy control people (n=31). They were selected by consecutive patient selection method. The ox-LDL level was assayed using ELISA. We measured blood pressure, lipid profile, fasting plasma glucose (FPG), and HbA1c in all groups. There was no significant difference in ox-LDL concentrations among normoalbuminuric, microalbuminuric, and macroalbuminuric diabetic groups. In diabetic patients with micro- and macroalbuminuria, ox-LDL concentration was higher than their first degree relatives (P=0.04andP=0.03) and control group (P=0.001andP=0.03, resp.). In normoalbuminuric diabetic persons, ox-LDL concentration was just higher than that of healthy people (P=0.02). There was no statistically significant difference in ox-LDL levels between normoalbuminuric diabetic patients and their first degree relatives. In conclusion, the presence and progression of albuminuria in diabetic patients are not related to ox-LDL concentration and genetic predisposition influences the plasma OX-LDL level. Larger sample size is needed to confirm this conclusion in future studies.

scholarly journals SERUM MAGNESIUM LEVEL IN DIABETIC RETINOPATHY - A CROSS SECTIONAL STUDY

2019 ◽  
Vol 3 (5) ◽  
Author(s):  
Dr. I. Vijayapriya ◽  
Dr. Prakash. S ◽  
Dr. S. Hemadharshini
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Serum Magnesium ◽  
Study Groups ◽  
Control Group ◽  
P Value ◽  
Cross Sectional ◽  
The Difference ◽  
And Control

Background: Among different complications of diabetes, ddiabetic retinopathy is one of the leading causes of blindness in the world. Increase in the frequency of lower serum magnesium levels have been reported among patients with diabetes. Materials and methods: A total of 120 subjects were included in this study and divided into 3 groups. The study groups consisted of 40 patients that are type 2 diabetes with retinopathy and 40 patients with type 2 diabetes without retinopathy and control group consisted of 40 healthy subjects respectively. Both cases and controls were subjected to estimation of biochemical parameters. Results: Among the study population, (80) 66.67% participants were cases and another (40) 33.33% participants were controls. Among the people who had mild NPDR, the median Mg was 1.90 (IQR 1.80, 2.00). It was 1.90 (1.70, 2.00), 1.75 (1.67, 1.92), 1.8 (1.69, 2.0) and 2.10 (1.90, 2.20) among people with DM retinopathy moderate NPDR, severe NPDR, Proliferative retinopathy and no retinopathy respectively. The difference in the Mg across DM retinopathy was statistically significant (P Value 0.008). The difference between the values among both the case and control groups for certain parameters such as SBP, FBG, PPBG, HbA1c, Magnesium, Urea, and Creatinine were found to be statistically significant. Conclusion: Serum magnesium levels were significantly lower in patients with diabetic retinopathy compared to diabetics without complications and control group. Keywords:  Diabetes mellitus, Diabetic retinopathy, Magnesium

scholarly journals To study association of Neutrophil- Lymphocyte ratio with vascular complications in Type-2 Diabetes

2021 ◽  
Vol 12 (8) ◽  
pp. 16-22
Author(s):  
Shilpa Tumkur Andane Gowda ◽  
Shahari Hegde Kusumakar ◽  
Raveendra Kodur Ramamurthy ◽  
Rohith Maraludevanapura Govindaiah
Keyword(s):  
Type 2 Diabetes ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Medical College ◽  
Increased Risk ◽  
Significant Difference

Background: Diabetes is a pro-thrombotic state associated with increased risk of atherosclerosis and inflammation. Neutrophil lymphocyte ratio (NLR) provides information about early and subclinical inflammation and thus may act as a prognostic marker for vascular complications in type 2 diabetes. Aims and Objective: To analyze the correlation between Neutrophil- Lymphocyte ratio in diabetics with and without vascular complications. Materials and Methods: A total of 111 patients admitted in Victoria hospital and Bowring & Lady Curzon hospital attached to Bangalore Medical College and Research Institute from NOV 2018 to MAY 2020 were studied. The data was collected according to the proforma in terms of history, clinical examination and the necessary investigations. NLR was observed in type 2 diabetic patients and was compared in those with complications and without complications. Results: The NLR was higher in diabetics with vascular complications compared to those without complications, 2.8 ± 0.7 fl versus 6.8 ± 3.1 fl (P< 0.001), respectively. In this study, Mean N (%), In No Vascular Complications was 61.7 ± 10.6 and with vascular complications was 79.9 ± 9.5. Mean L (%) in No Vascular Complications was 23.7 ± 5.8. Mean N (%), In No Vascular Complications was 61.7 ± 10.6 and with vascular complications was 79.9 ± 9.5. There was a significant difference in mean N (%) mean L (%) and NLR in comparison with respect to Complications. Conclusion: This study showed significantly higher NLR in diabetic patients with vascular complications. Hence, NLR can be used as a simple parameter to assess the vascular complications in diabetes.

Serum Cystatin C in Type 2 Diabetic Patients with Early Renal Damage

2019 ◽  
Vol 31 (2) ◽  
pp. 137-142
Keyword(s):  
Cystatin C ◽  
Renal Damage ◽  
Diabetic Patients ◽  
Serum Cystatin C ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Female Ratio ◽  
Mean Values ◽  
Type 2 Diabetic

Diabetic nephropathy is one of the most common complications in diabetes mellitus (DM). The ability to assess renal function in diabetes patients rapidly and early is of major importance. Nowadays, cystatin C (cys C) is introduced as a new marker for diagnosis of early renal damage. The purpose of this study was to study serum cys C in type 2 diabetic patients with early renal damage. This is a hospital-based, cross-sectional analytical study involving 50 cases of type 2 diabetic patients attending the Diabetic Clinic of Mandalay General Hospital. In this study, most cases were females with male to female ratio of 1:2. Mean age was 59±11.9. Mean values of serum cys C, albumim creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) were 0.89±0.37 mg/l, 18.46±16.47 mg/g and 92.34±22.63 ml/min, respectively. In this study, 60% of cases were eGFR 60-90 ml/min and 40% of cases were eGFR >90 ml/min. And then, 82% of cases were normoalbuminuria and 18% of cases were microalbuminuria. Serum cys C was negatively correlated with eGFR (r=-0.0235, p=0.1) and positively correlated with urine for ACR (r=0.177, p=0.219). In addition, serum cys C was positively correlated with normoalbuminuria (r=0.188, p=0.238) and negatively correlated with microalbuminuria (r=-0.008, p=0.984). But these are not statistically significant. Therefore, this study is concluded that serum cys C was higher in both normoalbuminuric and microalbuminuric type 2 diabetic patients. The correlations of serum cys C with microalbuminuria and normoalbuminuria were not statistically significant. Therefore, it is controversial to say that serum cys C can be used as early detection marker of renal damage in type 2 diabetic patients in this study.

Sign in / Sign up

Export Citation Format

Share Document