scholarly journals Effects of time-of-day on oxidative stress, cardiovascular parameters, biochemical markers, and hormonal response following level-1 Yo-Yo intermittent recovery test

2017 ◽  
Vol 104 (1) ◽  
pp. 77-90 ◽  
Author(s):  
K Aloui ◽  
S Abedelmalek ◽  
H Chtourou ◽  
DP Wong ◽  
N Boussetta ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Muscle Damage ◽  
Biochemical Markers ◽  
Density Lipoprotein ◽  
Time Of Day ◽  
Hormonal Response ◽  
Cardiovascular Parameters ◽  
Recovery Test ◽  
Level 1

The aim of this study was to investigate the effect of time-of-day on oxidative stress, cardiovascular parameters, muscle damage parameters, and hormonal responses following the level-1 Yo-Yo intermittent recovery test (YYIRT). A total of 11 healthy subjects performed an intermittent test (YYIRT) at two times-of-day (i.e., 07:00 h and 17:00 h), with a recovery period of ≥36 h in-between, in a randomized order. Blood samples were taken at the rest (baseline) and immediately (post-YYIRT) after the YYIRT for measuring oxidative stress, biochemical markers, and hormonal response. Data were statistically analyzed using one-way and two-way repeated measures ANOVA and Bonferroni test at p < 0.05. Observed power (α = 0.05) and partial eta-squared were used. Our results showed that oxygen uptake (VO2max), maximal aerobic speed, and the total distance covered tended to be higher in the evening (17:00 h). There was also a main effect of time-of-day for cortisol and testosterone concentration, which were higher after the YYIRT in the morning (p < 0.05). The heart rate peak and the rating of perceived exertion scales were lower in the morning (p < 0.05). However, the plasma glucose (p < 0.01), malondialdehyde, creatine kinase (p < 0.01), lactate dehydrogenase (p < 0.05), high-density lipoprotein (p < 0.01), total cholesterol (p < 0.01), and triglycerides (p < 0.05) were higher after the YYIRT in the evening. Low-density lipoprotein, systolic blood pressure, diastolic blood pressure, and lactate levels (p > 0.05) were similar for the morning and evening test. In conclusion, our findings suggest that aerobic performance presents diurnal variation with great result observed in the evening accompanied by an improvement of hormonal, metabolic, and oxidative responses. These data may help to guide athletes and coaches and contribute to public health recommendations on exercise and muscle damage particularly in the competitive periods.

Biochemical impact of soccer: an analysis of hormonal, muscle damage, and redox markers during the season

2014 ◽  
Vol 39 (4) ◽  
pp. 432-438 ◽  
Author(s):  
João Renato Silva ◽  
António Rebelo ◽  
Franklim Marques ◽  
Laura Pereira ◽  
André Seabra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Glutathione Reductase ◽  
Muscle Damage ◽  
Muscle Function ◽  
Biochemical Markers ◽  
Reductase Activity ◽  
Recovery Period ◽  
Soccer Players ◽  
Professional Soccer ◽  
And Oxidative Stress

This study aimed to analyze changes in performance, muscle function, and stress-related biochemical markers in professional soccer players (n = 14) at 4 timepoints (3 for performance and 4 for stress-related biochemical markers) during the soccer season [Formula: see text] preseason (E1), midseason (E2), end of the season (E3) [Formula: see text] and after the end of the recovery period (E4). Performance in 5- and 30-m sprints, countermovement jump, and agility, and maximal isokinetic knee extension and knee flexion strength were measured (E1 to E3). We observed increased in-season levels of myoglobin (E2 > E1 and E4; p < 0.05), a higher testosterone/cortisol ratio (T/C), and increased levels of creatine kinase (CK), C-reactive protein, superoxide dismutase (SOD), protein sulfhydryls (–SH), and malondialdehyde (E2 and E3 > E1 and E4; p < 0.05). Lower cortisol concentrations (E3 < E1 and E4; p < 0.05) and glutathione reductase activity (E3 < E2 and E4; p < 0.05) were observed at the end of the season. T/C, CK, SOD, –SH, and malondialdehyde decreased during the off-season, and cortisol and glutathione reductase increased (E3 < E4; p < 0.05). Agility increased in E2 and E3 (p < 0.01). Significant correlations were found during the season between hormonal and muscle function parameters (r = 0.56–0.86; p < 0.05). In addition, in E2, significant associations were observed between match-accumulated time (MATE2; minutes played by each player during the competition period), performance, and hormonal and redox parameters (r = 0.456–0.615; p < 0.05). In conclusion, this study shows that soccer players face significant changes in biomarkers of physiologic strain (muscle damage and oxidative stress-related markers) during the season, but values return to normal during the off-season. Additionally, MAT influences physical, hormonal, and oxidative stress-related parameters in professional soccer players.

scholarly journals Comparison of the effects of liraglutide and sibutramine in obese patients

2021 ◽  
Vol 18 (2) ◽  
pp. 218-228
Author(s):  
G. A. Matveev ◽  
T. I. Golikova ◽  
A. A. Vasileva ◽  
E. V. Vasilieva ◽  
A. Y. Babenko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Weight Loss ◽  
Side Effects ◽  
Blood Pressure Level ◽  
Density Lipoprotein ◽  
Regulation System ◽  
Positive Trend ◽  
Obese Patients ◽  
Markers Of Inflammation

Background: Obesity is a global noncommunicable pandemic. The low effectiveness of treating obesity is associated with the difficulty of maintaining weight loss due to the reaction of the appetite regulation system. Drugs with central mechanisms of action can help overcome this problem.Aim: The aim of our study was to compare the effects of liraglutide and sibutramine (Reduxin) on the dynamics of weight and cardiometabolic parameters in obese patients without cardiovascular diseases.Materials and methods: We estimated the dynamics of the main metabolic parameters (BMI, glucose, lipid metabolism, blood pressure), the level of hormones involved in the regulation of fat metabolism (leptin, adiponectin, insulin), the ­HOMA-IR index, markers of oxidative stress and inflammation during therapy with liraglutide in comparison with reduxin for 6 months in obese patients.Results: 64 obese patients were included in the study: 25 patients — in the “Liraglutide” group, 39 patients — in the “Sibutramine” group in accordance with the declared inclusion / exclusion criteria. The included patients were young, average body mass index (BMI) (37.92 ± 5.45 kg / m2), average glycemic level was 5.47 ± 0.81 mmol /l, HOMA-IR was 6.01 ± 4.25, blood pressure was at inclusion was within the normal range, but 21.8% of patients received antihypertensive therapy.Both treatment options provided a comparable decrease in body weight (-10.28% vs -9.47%, p = 0.13)., Leptin level (-32.12% vs -41.77%, p = 0.77) and myeloperoxidase (-33.33% vs -19.91%, p = 0.2). The blood pressure level did not change significantly on liraglutide, while on reduxin the level of diastolic blood pressure (dBP) increased significantly (6.87%, p = 0.006). There was a more pronounced decrease in insulin levels compared to the baseline level (-46%, p = 0.005), as well as a decrease in the HOMA-IR index (-50.08, p = 0.005) on liraglutide therapy.An increase in adiponectin levels (+ 45.36% vs 14.01%, p = 0.0045) and a decrease in low density lipoprotein(LDL) cholesterol were significantly more pronounced on reduxin therapy (-15.03% vs -9.4%, p = 0.006).36% of the participants completed their participation in the study ahead of schedule due to the lack of effect in the form of weight loss in the «Liraglutide» group. Side effects in the “Liraglutide” group were observed in 16% of patients. 48% of patients took part in the study within 6 months. In the «Sibutramine» group 33.4% of patients completed the study ahead of schedule for reasons unrelated to the drug intake, the side effects were observed in 20.5% of patients. 46.1% of participants in the «Sibutramine» group received therapy for 6 months.Conclusions: This study confirms the previous findings that both liraglutide and reduxin therapy provide effective weight loss. We found a positive trend in markers of inflammation, atherogenesis and oxidative stress, and leptin levels. Liraglutide therapy was accompanied by a more pronounced effect on the state of carbohydrate metabolism, and reduxin therapy provided a more pronounced dynamics of lipid disorders and adiponexin. Both groups were characterized by a rather low adherence to therapy, but the incidence of side effects requiring stopping therapy was higher in the Sibutramine group.

scholarly journals Evaluation of the Effects ofPinus koraiensisNeedle Extracts on Serum Lipid and Oxidative Stress in Adults with Borderline Dyslipidemia: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial

2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Hansongyi Lee ◽  
Hyerang Kim ◽  
Ryowon Choue ◽  
Hyunjung Lim
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Superoxide Dismutase ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Cholesterol ◽  
Low Density ◽  
Vldl Cholesterol ◽  
Before And After ◽  
And Oxidative Stress

Background.Dyslipidemia has been well-known as a common metabolic disorder contributing to cardiovascular disease. The aim of this study was to evaluate the effect of thePinus koraiensisneedle extracts (PKE) on the blood cholesterol and oxidative stress.Method.We conducted a 12-week randomized, double-blinded controlled trial to examine the effect of PKE on blood lipid profiles in adults with borderline dyslipidemia. Thirty-three eligible persons were recruited and randomly assigned into PKE (n=20) and placebo groups (n=13). Serum lipids including total cholesterol, low-density lipoprotein- (LDL-) cholesterol, high-density lipoprotein- (HDL-) cholesterol, very low-density lipoprotein- (VLDL-) cholesterol, and triglyceride were measured before and after trial. Serum insulin, glucose, and antioxidant indicators were also analyzed before and after trial and anthropometry and blood pressure were measured every 4 weeks.Results.After 12 weeks, PKE statically significant decreases in systolic blood pressure (p<0.05) and waist circumference (p<0.05) were observed. Also, VLDL-cholesterol significantly decreased (from24.4±10.0 mg/dL at baseline to18.4±4.1 mg/dL after 12 weeks) (p<0.05) and superoxide dismutase (SOD) increased (6.12±0.41 U/mL to9.06±0.62 U/mL) (p<0.01) in PKE group. However, after adjustment with WC, VLDL-cholesterol was not significant between groups (p=0.095) and while SOD remained significant between groups (p=0.013).Conclusion.The results show that PKE was effective in improving the superoxide dismutase in the individuals with borderline dyslipidemia.

scholarly journals Effect of omega-3 fatty acids supplementation on cardio-metabolic and oxidative stress parameters in patients with chronic kidney disease: a systematic review and meta-analysis

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Siavash Fazelian ◽  
Fatemeh Moradi ◽  
Shahram Agah ◽  
Akramsadat Hoseini ◽  
Hafez Heydari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Blood Pressure ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

Abstract Background Omega-3 fatty acids (FAs) have been suggested as a beneficial supplement in chronic kidney disease (CKD) patients, but the results of randomized clinical trials (RCTs) are controversial. We conducted a systematic review and meta-analysis to evaluate all the RCTs about the impact of omega-3 FAs supplementation on cardiometabolic outcomes and oxidative stress parameters in patients with CKD. Methods We performed a systematic database search in PubMed/MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Central, up to May 2020. We included all placebo-controlled randomized trials that assessed the effect of omega-3 FAs supplementation on any cardiometabolic outcomes: blood pressure, total cholesterol (TC), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) or triglycerides (TG) and oxidative stress parameters. Data were pooled using DerSimonian–Laird’s random-effects model. Results Finally, thirteen articles met the inclusion criteria for this review omega-3 FAs supplementation significantly decrease TC (SMD: -0.26; 95% CI: − 0.51, − 0.02; I2 = 52.7%), TG (SMD: -0.22; 95% CI: − 0.43, − 0.02; I2 = 36.0%) and Malondialdehyde (MDA) levels (SMD: -0.91; 95% CI: − 1.29, − 0.54; I2 = 00.0%) and also significantly increase superoxide dismutase (SOD) (SMD: 0.58; 95% CI: 0.27, 0.90; I2 = 00.0%) and Glutathione peroxidase (GPx) (SMD: 0.50; 95% CI: 0.14, 0.86; I2 = 00.0%) activities. However our results show that omega-3 FAs supplementation have no significant effects on HDL, LDL and blood pressure. Conclusion This systematic review and meta-analysis supports current evidence for the clinical benefit of omega-3 FAs intake to improve cardiometabolic parameters in CKD patients. However, well-designed RCTs still needed to provide a conclusive picture in this field.

scholarly journals Effects of pomegranate juice on cardiometabolic risk factors and biomarkers of oxidative stress and inflammation in hemodialysis patients, a crossover controlled trial

2019 ◽  
Author(s):  
Reza Barati Boldaji ◽  
Masoumeh Akhlaghi ◽  
Mohammad Mehdi Sagheb ◽  
Zahra Esmaeilinezhad
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Hemodialysis Patients ◽  
Pomegranate Juice ◽  
Inflammatory Biomarkers ◽  
Dialysis Session ◽  
Significant Difference

Abstract Background: Pomegranate has antioxidant, cardioprotective, and anti-inflammatory properties. We questioned if pomegranate juice (PJ) benefits lipid profile and oxidative and inflammatory biomarkers of hemodialysis patients. Methods: The study had a crossover design. Hemodialysis patients (n=41) were divided into two groups: PJ-treated group who received 100 ml natural PJ immediately after their dialysis session three times a week and the control group who received the usual care. After 8 weeks, a 4-week washout period was established and afterwards the role of the groups was exchanged. Lipid profile, blood pressure, and oxidative and inflammatory biomarkers were measured before and after each sequence. Comparisons between the two conditions were performed by ANCOVA with adjustments for potential confounders. Results: Based on results of intention-to-treat analysis, triglycerides were decreased in PJ condition and increased in the control. Conversely, high-density lipoprotein (HDL)-cholesterol was increased in PJ and decreased in control. There was a significant between-condition difference for both triglycerides and HDL-cholesterol (P<0.001). Total and low-density lipoprotein (LDL)-cholesterol did not significantly change in either condition. Systolic and diastolic blood pressure significantly decreased in PJ condition and caused a significant difference between two conditions (P<0.001). Total antioxidant capacity increased in PJ condition (P<0.001) and decreased in control (P<0.001). Conversely, malondialdehyde and interleukin-6 decreased in PJ (P<0.001) and increased in the control (P≤0.001). The changes of these biomarkers were significantly different between two conditions. Conclusions: In conclusion, 8-week PJ consumption showed beneficial effects on blood pressure, serum triglycerides, HDL cholesterol, oxidative stress, and inflammation in hemodialysis patients. The trial was registered at Iranian Registry of Clinical Trials (ID number: IRCT 2016070428797N1). Keywords: Pomegranate, hemodialysis, hypertension, oxidative stress, inflammation, lipid profile.

scholarly journals Metabolic Syndrome and Periodontitis: Is Oxidative Stress a Common Link?

2009 ◽  
Vol 88 (6) ◽  
pp. 503-518 ◽  
Author(s):  
P. Bullon ◽  
J.M. Morillo ◽  
M.C. Ramirez-Tortosa ◽  
J.L. Quiles ◽  
H.N. Newman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Inflammatory State ◽  
Anti Oxidant ◽  
Obesity Hypertension ◽  
The Relationship

A review of pathological mechanisms that can explain the relationship between periodontitis and cardiovascular disease (CVD) is necessary to improve the management of both conditions. Metabolic syndrome is a combination of obesity, hypertension, impaired glucose tolerance or diabetes, hyperinsulinemia, and dyslipidemia. All these have been examined in recent years in terms of their relationship to periodontitis. Reviewed data indicate an association between some of them (body mass index, high-density lipoprotein-cholesterol [HDL-C], triglycerides, high blood pressure, among others) and periodontitis. Oxidative stress may act as a potential common link to explain relationships between each component of metabolic syndrome and periodontitis. Both conditions show increased serum levels of products derived from oxidative damage, with a pro-inflammatory state likely influencing each other bidirectionally. Adipocytokines might modulate the oxidant/anti-oxidant balance in this relationship.

scholarly journals gp91phox, a Novel Biomarker Evaluating Oxidative Stress, Is Elevated in Subclinical Hypothyroidism

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Xiaochun Ma ◽  
Furong Wang ◽  
Xiaowen Zhen ◽  
Lifang Zhao ◽  
Li Fang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Normal Level ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Thyroid Stimulating Hormone ◽  
Low Density ◽  
Healthy Controls ◽  
Main Effect ◽  
High Level

Background. gp91phox, the catalytic core of NADPH oxidase (NOX) and biomarker of NOX activation, has been recently recognized as a parameter of systemic oxidative stress in several studies. Subclinical hypothyroidism (SH) is characteristic of elevated level of serum thyroid stimulating hormone (TSH) and is frequently accompanied with cholesterolemia. In this study, the levels of serum soluble gp91phox were measured to assess the oxidative stress in patients with SH. And the relationship among gp91phox, low-density lipoprotein-C (LDL-C), and TSH was also investigated. Methods. A total of 51 subjects were enrolled and categorized into four groups: the healthy controls subjects (n = 13), controls with high level of LDL-C alone (n = 12), SH with normal level of LDL-C (n = 11), and SH with high level of LDL-C (n = 15). The related clinical and laboratory data were collected for statistical analysis. All the patients were newly diagnosed and did not take any medication. The information of lipid profile and thyroid function was extracted, and the concentrations of gp91phox were obtained with ELISA. Results. The levels of serum soluble gp91phox evidently increased in the patients with SH with a high level of LDL-C (81.52 ± 37.00 ug/mL) as compared to the healthy controls (54.98 ± 1.83ug/mL, p<0.001), controls with high level of LDL-C (61.21 ± 4.48 ug/mL, p=0.038) and SH with a normal level of LDL-C (62.82 ± 11.67ug/mL, p=0.027). Additionally, the levels of gp91phox showed a significant positive correlation with both the levels of LDL-C (r = 0.595, p<0.001) and TSH (r = 0.346, p=0.013) by the Spearman correlation analyses. The correlation remained significant even when the effect of another factor was controlled (TSH: when the effect of LDL-C was controlled, r = 0.453, p=0.001; LDL-C: when the effect of TSH was controlled, r = 0.291, p=0.040). The main effect analysis showed an independent main effect of either LDL-C (p = 0.041) or TSH (p=0.022) on gp91phox without interaction (p=0.299). Conclusions. Our work demonstrated that the levels of gp91phox, a novel biomarker for measuring the oxidative stress, were significantly elevated in the patients with SH. And LDL-C and TSH were both independent predictors of gp91phox. Abbreviations. BMI : Body mass index; TC : Total cholesterol; LDL-C : Low-density lipoprotein cholesterol; HDL-C : High-density lipoprotein cholesterol; TG : Triglyceride; FBG : Fasting blood glucose; FT3 : Free triiodothyronine; FT4 : Free thyroxine; TSH: Thyroid stimulating hormone; SBP : Systolic blood pressure; DBP : Diastolic blood pressure; SD : Standard deviation; LSD: Least significant difference.

scholarly journals Assessment of the Levels of Oxidative Stress, Muscle Damage, and Psychomotor Abilities of Special Force Soldiers during Military Survival Training

2020 ◽  
Vol 17 (13) ◽  
pp. 4886
Author(s):  
Paweł Różański ◽  
Ewa Jówko ◽  
Andrzej Tomczak
Keyword(s):  
Oxidative Stress ◽  
Motor Control ◽  
Sleep Deprivation ◽  
Muscle Damage ◽  
Divided Attention ◽  
Biochemical Markers ◽  
Maximum Strength ◽  
Lipid Hydroperoxides ◽  
Special Unit

The aim of this study was to analyze the changes in biochemical markers of oxidative stress and muscle damage, as well as psychomotor abilities during a military survival training. The study included 15 soldiers of special unit (SU), that completed 48 h military survival training combined with sleep deprivation. Before the training (P1), after 24 h (P2), and after 48 h of training (P3), blood samples were taken to measure biochemical markers. At the same time points, the measurements of divided attention and handgrip strength were conducted. Glutathione peroxidase activity decreased significantly at P3, in comparison with P1 and P2 (p < 0.0001), however, no changes were observed in other biochemical markers (i.e., lipid hydroperoxides, creatine kinase and superoxide dismutase activity) throughout the survival training (p > 0.05). The divided attention index was improved significantly at P2 and P3, as compared to P1 (p < 0.05). A tendency to change in maximum strength was found during the training period (main time effect; p = 0.08). Moreover, the strength differentiation (i.e., 50% maximum strength; 50%max) was higher at P3 than at P1 and P2 (p < 0.05). In conclusion, the 48 h survival training in the SU soldiers does not cause oxidative stress or muscle tissue damage, as well as any deterioration, and even improvement in psychomotor abilities. However, the change in strength differentiation (i.e., the production above 60%max instead of target 50%max) after the training may point to deterioration in motor control. Although it should be confirmed in further study with a more numerous group of soldiers, our findings indicate that the special unit soldiers will be able to perform, in a correct manner, specialized tasks related to their long-term activities, especially those which require divided attention. However, participation in long-term survival training, even with low workload, combined with sleep deprivation, results in a deterioration in motor control which may indicate the relevance of monitoring coordination motor abilities/skills in the training process of special unit soldiers.

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