scholarly journals The results of a study of the properties of oral fluid in adolescents with catarrhal gingivitis and chronic gastroduodenitis

2020 ◽  
pp. 70-75
Author(s):  
I.S. Lisetska ◽  
Keyword(s):  
Oral Fluid ◽  
Comparison Group ◽  
Main Group ◽  
The Body ◽  
Social Program ◽  
Control Group ◽  
Special Equipment ◽  
Type Iii ◽  
Stage Of Development ◽  
Somatic Diseases

Today, the most pressing issue in the social program of society is the state of health care of the younger generation, which outlines the future prospects for the development of the nation. Numerous studies by foreign and domestic researchers show that among the dental pathology of periodontal tissue among children in our country remain at a high level, despite the developed treatment regimens. It is known that gingivitis in childhood is often not diagnosed at an early stage of development, due to the absence or mild complaints and signs of the disease, which can lead to chronicity and transition from inflammatory to inflammatory-destructive In recent years in medicine for early diagnosis and prognosis simple, atraumatic, informative methods are used more often, which do not require expensive special equipment and at the same time are sensitive indicators for various diseases. In this regard, the study of the properties of oral fluid remains relevant. Purpose — to study the properties of oral fluid in adolescents with catarrhal gingivitis and chronic gastroduodenitis. Materials and methods. The properties of oral fluid (salivation rate, pH, and microcrystallization) were studied in 173 adolescents aged 12 to 18 years, which was divided into three groups: 86 adolescents with catarrhal gingivitis on the background of chronic gastroduodenitis were included in the main group, and 57 adolescents in the comparison group, gingivitis without somatic pathology and in the control group — 30 adolescents with healthy periodontal disease without somatic diseases. Results. The dependence of oral fluid properties in adolescents on the presence of inflammatory process in the gums and somatic disease was determined, namely in the adolescents of the main group the rate of salivation was 0.27±0.02 ml/min, in the adolescents of the comparison group 0.37±0.03 ml/min (p<0.01) — and in adolescents of the control group 0.49±0.01 ml/min (p<0.001). Determination of the pH of the oral fluid showed that the adolescents of the pH control group averaged 7.15±0.03, then the adolescents of the comparison group and the main group 1.1 times less, respectively 6.48±0.02 and 6.29±0.04 (p<0.001). Conclusions. Тhe study of oral fluid indicates a dependence of the indicators of the overall condition of the body, and dental status. In addition, indicators of oral fluid can serve as a prognostic test assessment of the mouth and course of somatic diseases, the effectiveness of treatment and to justify the prevention of catarrhal gingivitis in adolescents. In the main group revealed predominantly II and III type of microcrystallization in the comparison group — II type, much less individuals with type III and an increase in persons with І аnd II type in the control group, we identified all three types of microcrystallization, and was dominated by type II and greatly increased the number of persons with type І and decreased type III. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the author. Key words: oral fluid, the speed of salivation, pH, microcrystallization, teenagers, catarrhal gingivitis, chronic gastroduodenitis.

scholarly journals Вплив лікувально-профілактичних заходів на показники ротової рідини та клінічний стан тканин пародонта у дітей 6–7 років, хворих на гінгівіт

2017 ◽  
Author(s):  
O. V. Avdeev ◽  
Y. K. Zmarko ◽  
A. B. Boykiv ◽  
R. O. Drevnitska
Keyword(s):  
Clinical Supervision ◽  
Oral Fluid ◽  
Urease Activity ◽  
Comparison Group ◽  
Local Therapy ◽  
Main Group ◽  
Control Group ◽  
Results Of Treatment ◽  
Comparative Group ◽  
Anti Inflammatory

The high prevalence of inflammatory processes in the periodontitis of children, the ineffective effectiveness of preventive and curative measures can contribute to the development of generalized periodontitis, therefore it remains urgent to develop pathogenetic effects in the treatment of chronic catarrhal gingivitis.The aim of the study – a comparative assessment of the traditional treatment of chronic catarrhal gingivitis in children aged 6–7 years with therapy using an anti-inflammatory gel with neovitin.Materials and Methods. 61 children aged 6–7 years, suffering from chronic catarrhal gingivitis, were taken under clinical supervision and divided into groups: the main (30 children) and the comparative (31 children). All children underwent conventional therapy in accordance with the protocols for the provision of medical care – basic therapy. In the main group, for a month, pathogenetic agents were used: an anti-inflammatory gel with neovitin, hygiene products were recommended. In the comparative group, 3 % hydrogen peroxide solution was used for local therapy, for rinsing of the mouth (during the first week of treatment) – Rotokan, a therapeutic and prophylactic toothpaste.Examination and control examinations were carried out with the hygienic state of the mouth determined by the hygienic index of Yu. A. Fedorov and V. V. Volodkina, prevalence and intensity of the inflammatory process in the gums with the help of the Schiller-Pisarev test and the PMA index, oral fluid index (lysozyme content, formation of oxydradicals, urease activity, degree of dysbiosis, pH and viscosity).Results and Discussion. After the treatment, elimination of gum inflammation in patients of the main group was accompanied by a decrease in the PMA index by 3.8 times; formation of oxyradicals decreased in children of the main group by 6.35 %; in the comparative group – by 6.15 %. Urease activity decreased in children of the main group by 16.37 % (p<0.05), the viscosity of the oral fluid of children decreased in 2.65 times in the main group and in 2.13 times in the comparative group (p<0.05). The lysozyme content increased in children of the main group by 15.61 % (p<0.05) in the comparison group – by 9.63% (p<0.05). The treatment after 0.5 years caused an increase in the lysozyme content in the oral fluid of the children of the main group to the level of the control group. The degree of dysbiosis decreased in the main group, in the comparison group tended to increase.Conclusions. The use of the proposed therapy with gel with neovitin contributed to the best results of treatment: reducing the degree of inflammation of the gums, the number of visits to the doctor, improving the indices of nonspecific protection in the oral fluid of 6-7 years-old children and, to a greater extent, six months after the treatment.

Correction of antioxidant protection of the oral mucosa in chronic pancreatitis

2019 ◽  
Vol 24 (3) ◽  
pp. 274-279
Author(s):  
Ya. A. Lavrovskaya ◽  
I. G. Romanenko ◽  
O. M. Lavrovskaya
Keyword(s):  
Chronic Pancreatitis ◽  
Oral Mucosa ◽  
Catalase Activity ◽  
Oral Fluid ◽  
Comparison Group ◽  
Malonic Dialdehyde ◽  
Main Group ◽  
Laboratory Research ◽  
Control Group ◽  
Inflammatory Processes

Relevance: inflammatory processes in the oral mucosa are often found in diseases of the gastrointestinal tract, which is explained by the common functions and unity of all parts of the digestive system.Purpose – to study the effect of the studied drugs on the state of antioxidant-prooxidant systems of the oral mucosa in patients with chronic pancreatitis.Materials and methods: we examined 118 patients, of whom 62 were men (mean age 39.6 ± 16.4 years) and 56 women (mean age 40.3 ± 15.7 years); of these, 34 patients (control group) are practically healthy people without somatic pathology and 84 patients with chronic pancreatitis who were divided into two groups. The first (main) group - 46 people who, in addition to the drug therapy prescribed by the gastroenterologist, were prescribed the drug “Multiflora” 1 tablet 1 time per day with meals for 30 days. Also, the patients of the main group, after each meal, rinsed their mouths with “Enoant” food concentrate at a dilution of 1: 5 and applied it inside with 1 tablespoon 2 times a day, diluted with water in a ratio of 1: 5. The second (comparison group) - 38 people who, in addition to treatment of chronic pancreatitis, were treated with the oral mucosa according to the generally accepted method - prescribed fluconazole 150 mg 1 time a day, rinsing with 2% borax solution in glycerol after eating for 14 days. Unstimulated oral fluid of the examined patients served as the material for the study. In all groups, the activity of the catalase enzyme was determined by the method of S.V. Girina (1999), the level of malonic dialdehyde (MDA activity by reaction with thiobarbiturate acid to form a trimethine complex) and antioxidant-prooxidant index of unstimulated oral fluid by the method of А.P. Levitsky (2010). Laboratory research was carried out at the time of the initial examination before the start and on the 30th day of treatment.Results: in the comparison group after treatment, an increased concentration of malondialdehyde in the oral fluid, as well as reduced indicators of the API index and catalase activity confirm the presence of inflammatory processes in the oral mucosa. The application of the proposed therapeutic complex to patients of the main group significantly reduces the concentration of malondialdehyde in the oral fluid, proving its anti-inflammatory effect on the oral mucosa. An increase in the antioxidant-prooxidant index and an increase in catalase activity indicates an increase in the body’s defenses in patients of the main group.Conclusion: the use of the proposed therapeutic complex in patients with inflammatory diseases of the oral mucosa suffering from chronic pancreatitis contributes to the elimination of inflammatory and degenerative processes and the restoration of the normal level of protective systems in the oral mucosa.

Thromboembolic complications prevention in the obstetric practice

2017 ◽  
pp. 19-24
Author(s):  
O.V. Grishchenko ◽  
◽  
V.V. Bobrytska ◽  
Keyword(s):  
Pulmonary Embolism ◽  
Comparison Group ◽  
Main Group ◽  
Control Group ◽  
Efficacy And Safety ◽  
Thromboembolic Complications ◽  
Moderate Risk ◽  
Obstetric Practice ◽  
Thrombotic Complications ◽  
And Control

The objective: To evaluate the clinical efficacy and safety of Enoxaparin-Pharmex for the prevention of thrombotic complications (pulmonary embolism) in the postoperative period in patients with moderate risk of these complications. Patients and methods. The study included 50 women after a caesarean section had an average degree of risk of pulmonary embolism. Patients were divided into the main group (n=25) and control group (n=25) in accordance with the treatment: patients of the main group received postoperative Еnoxaparin- Pharmex, group comparisons enoxaparin sodium (brand foreign manufacturer’s). Patients in both groups received the drug at a dose of 20 mg for 5 days, 1 time per day subcutaneously. Results. The research data analysis showed identity results of hemostasiogram of patients in the main group and the comparison group, no side effects after treatment in both groups. Conclusion. The clinical studies suggest the drug Enoxaparin-Pharmex is effective, safe LMWH, which can be used to prevent troboembolic complications, including post-operative treatment in obstetric practice. Spectrum of Enoxaparin-Pharmex can be extended to the prevention and treatment of thromboembolic conditions of varying severity with appropriate doses of the drug. Key words: Enoxaparin-Pharmex, prevention of pulmonary embolism.

scholarly journals BIOMARKERS OF OSTEO-DEFFICIENCY IN THE COURSE OF SECONDARY OSTEOPOROSIS IN PATIENTS WITH COMORBID CHRONIC PANCREATITIS AND ARTERIAL HYPERTENSION

2020 ◽  
Vol 20 (4) ◽  
pp. 16-20
Author(s):  
T.I. Viun ◽  
L.M. Pasieshvili ◽  
S.V. Viun ◽  
A.S. Marchenko ◽  
O.V. Karaya
Keyword(s):  
Chronic Pancreatitis ◽  
Acid Phosphatase ◽  
Arterial Hypertension ◽  
Comparison Group ◽  
Practical Importance ◽  
Main Group ◽  
Secondary Osteoporosis ◽  
Control Group ◽  
Tartrate Resistant Acid Phosphatase ◽  
Detection Of Biomarkers

The prevalence of comorbidities has been growing for the last decades. Therefore, the detection of biomarkers for diagnostic and prognostic purposes is of great practical importance. The aim of this study was to assess the biomarkers of osteo-defficiency in the course of secondary osteoporosis in patients with comorbid chronic pancreatitis and arterial hypertension. We examined 110 patients with chronic pancreatitis: 70 of them had comorbid hypertension, and 40 patients were found as having no comorbidities. The age of patients ranged from 33.2 ± 2.1 (main group) and 32.9 ± 3.1 years (comparison group); women predominated (72.9% and 70%, respectively). The control group includes 78 healthy individuals of the same age and sex. Diagnostic investigation included studying clinical and anamnestic characteristics of patients (duration of the disease, manifestations of the course, frequency of recrudescence, fractures) and biochemical parameters of bone metabolism: osteocalcin, total bone phosphatase and tartrate-resistant acid phosphatase and the establishment of correlations between these parameters and incidence of complications. It was found that in the isolated course of chronic pancreatitis there is a high (R = 0.60) statistically significant (p <0.01) correlation between the levels of osteocalcin and pancreatic elastase-1. A negative statistically significant (p <0.01) mean correlation (R = -0.49) was found between the content of tartrate-resistant acid phosphatase and age of the patients having comorbidity of chronic pancreatitis and hypertension, as well as there is a moderate correlation between the content of tartrate-resistant acid phosphatase and the duration of hypertension, which is statistically significant (R = 0.36, p <0.01). The levels of total bone phosphatase and tartrate-resistant acid phosphatase in the main group exceeded the reference values in 2.5 and 1.9 times respectively (CMU; U = 866.0; p <0.01), while in the comparison group were 2 times (total bone phosphatase) and 1.3 times higher (tartrate-resistant acid phosphatase) times, respectively (CMU; U = 821.0; p <0.01) that enables to diagnose the development of osteopenic conditions. That is, the combined course of chronic pancreatitis and hypertension should be considered as unfavourable tandem in the development of secondary osteoporosis and requires early osteoporotic screening.

Treatment Methods for Different Variations Syndrome Mirizzi

2021 ◽  
Vol 04 (04) ◽  
Author(s):  
Omarov N.B., Aimagambetov M. Zh. ◽  
◽  
◽  
Keyword(s):  
Surgical Treatment ◽  
Bile Ducts ◽  
Gallstone Disease ◽  
Main Group ◽  
Mirizzi Syndrome ◽  
Long Term Results ◽  
Control Group ◽  
Type Iii ◽  
Type Iv ◽  
Number Of Patients

The number of patients with complicated forms of cholelithiasis of cholelithiasis is progressively growing. One of the complications of gallstone disease is Mirizzi syndrome (SM). The reason for the development of which is the spread of the inflammatory - destructive process from the gallbladder to the bile ducts with the formation of pressure ulcers in the common bile duct, as a result of which the formation of a cholecystobiliary fistula occurs, through which stones from the gallbladder enter the main bile ducts. The analysis of the surgical treatment of patients with cholelithiasis (GSD) treated in the UH NJSC "MUS" was carried out. There were 3842 patients in total, Patients were in the period from January 2012. to July 2018 The analysis revealed that of all these patients with gallstones, Mirizzi SM type III and IV syndrome was diagnosed in 25 (0.7%). In 14 (56%) patients with type III SM and type IV SM, 11 (44%). The main group consisted of 10 (40%) patients and 15 (60%) patients included in the control group. The main group completed: 1) In type III SM (only 4 (40%) patients). One patient underwent hepaticojejunostomy according to the clinic method (2017/0423.1). In 3 patients, cholecystohepaticocholedochoplasty was performed with U-shaped interrupted sutures on the drainage according to Vishnevsky (2017 / 0980.1); 2) In type IV SM (a total of 6 (60%) patients). 4 patients underwent hepaticojejunostomy according to the clinic method (2017/0423.1). In 2 patients, cholecystohepaticocholedochoplasty was performed with U-shaped interrupted sutures on the drainage according to Vishnevsky (2017 / 0980.1). The developed and tested methods of surgical treatment of Mirizzi syndrome of types III and IV make it possible to improve the immediate and long-term results of surgical treatment of patients with this pathology. These methods of surgical treatment allow preserving the physiology of the bile outflow without postoperative complications typical for traditional hepaticojejunostomy (incompetence of the anastomotic sutures, stricture of hepaticojejunostomy).

The optimization of reparative processes after cesarean section (clinical-experimental research)

2015 ◽  
Vol 64 (4) ◽  
pp. 4-12 ◽  
Author(s):  
Edvard Karpovich Aylamazyan ◽  
Victoriya Yuryevna Andreeva ◽  
Tatiana Ulyanovna Kuzminykh ◽  
Dmitriy Igorevich Sokolov ◽  
Sergey Alekseevich Selkov ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
Cesarean Section ◽  
Comparison Group ◽  
Main Group ◽  
Control Group ◽  
Collagen Membrane ◽  
Vascular Endothelial ◽  
Actual Direction ◽  
Uterine Scar ◽  
Endothelial Growth Factor

Development and introduction of materials influenced on reparation process in a myometrium is actual direction of modern obstetrics in connection with the increase of cesarean section rate. One of such preparation is «Collost», it stimulates the processes of neoangio- and myogenesis and excludes the disorderly growth of scars tissue. Aim: To study the influence of bioplastic material «Collost» on the reparation process in myometrium after cesarean section. Objectives: to estimate the morpho-functional state of scar on uterus after cesarean sections depending on implantation of collagen membrane. Material and methods: There were included 13 female rabbits in experimental part of the study. In clinical part of the study there were included 20 pregnant woman with intraoperative application of «Collost» (main group), 30 pregnant woman without «Collost» implantation (comparison group) and 10 pregnant with vaginal delivery (control group). Results: histological, immunohistological and immunological findings of postoperative uterine scars of female rabbits showed significant differences of expressions of miosin, vascular endothelial growth factor and collagen I type. The myometrium was significantly thicker in the area of uterine scar in main group (with collagen membrane implantation) than in comparison group. Conclusions: bioplastic material «Collost» leads to full formation of muscular wall and vascular ture in the area of postoperative uterine scar.

scholarly journals The role of a balanced diet in the metabolism of nutrients

2021 ◽  
Vol 100 (4) ◽  
pp. 333-338
Author(s):  
Zoya I. Zholdakova ◽  
Rofail S. Rakhmanov ◽  
Elena S. Bogomolova ◽  
Rashid Sh. Khayrov ◽  
Ekaterina A. Olyushina
Keyword(s):  
Uric Acid ◽  
Total Cholesterol ◽  
Comparison Group ◽  
Density Lipoprotein ◽  
Food Products ◽  
Main Group ◽  
The Body ◽  
Metabolic Status ◽  
Low Density ◽  
Blood Indices

The purpose of the study was to assess the metabolic status of the body when correcting the diet with a concentrated natural product. Materials and methods. The diet of athletes was analyzed. The leading group (n = 15) received concentrated food products (CNP) for 20 days: No. 1 - 30.0 g and No. 2 - 20 g each. Blood indices including (total protein, uric acid, urea, creatinine, total cholesterol, high and low-density lipoprotein cholesterol, triglycerides, glucose, amylase) were assessed metabolic status: taken before, after, and in one month of taking CNP Results. The diet’s calorie content was 5953.2-6494.4 kcal/day in the main and the comparison group corresponding to this cohort’s physiological need. The proportions of protein and fat exceeded the recommended ones; deficiency of carbohydrates accounted for 8.7%. The inclusion of CNP increased the ratio of slow carbohydrates, vitamins, minerals, and minor food components. In the leading group, the increase in urea and uric acid was less significant in terms of average indices, and the proportion of such people increased. Creatinine was significantly higher than baseline within one month after CNP administration. The increase in the proportion of people with increased total cholesterol is 2.9 times less; the share with a borderline high level decreased by 15.5%, in the comparison group, it increased by 5.6%. The proportion with low-density lipoproteins exceeding the reference value decreased from 61.5% to 30.0% in the comparison group - without dynamics (55.6%) and signs of dyslipidemia increased. In the main group, within the normal range, 76.9% of individuals had an increase in glucose, amylase by 5.7% (p = 0.049). Conclusion. The diet is not macronutrient balanced. The use of CNP affected the metabolism of proteins, fats, and carbohydrates. It proved a more adequate energy supply for the activities of the persons of the main group. There has been shown the possibility of correcting the body’s metabolic processes with food products that reduces the risk of developing prenosological conditions during physical exertion, particularly fatigue and cardiovascular pathology.

scholarly journals Optimization of rehabilitation measures after artificial abortion as the result of immunomodulator aminodihydrophthalasindione sodium apply in comprehensive therapy

2019 ◽  
pp. 156-161
Author(s):  
E. A. Voroshilova
Keyword(s):  
Marked Reduction ◽  
Clinical Effect ◽  
Comparison Group ◽  
Clinical Symptoms ◽  
Randomized Study ◽  
Main Group ◽  
Control Group ◽  
Comprehensive Therapy ◽  
Effect Of Treatment ◽  
Artificial Abortion

The article presents the results of a comparative randomized study, the purpose of which was to evaluate the effectiveness of the use of aminodihydrophthalasindione sodium (Galavit, LLC SELVIM, Russia) in the treatment of patients undergoing an abortion. Included in the study, 48 women were divided into two groups, 24 patients of the main group in addition to the standard rehabilitation were treated with aminodihydrophthalasindione sodium in the comparison group – 24 patients underwent only standard rehabilitation. In this study, all patients (100%) of the main group who were treated with aminodihydrophthalasindione sodium in addition to the standard therapy marked reduction of the clinical symptoms of the disease and positive dynamics was observed at ultrasound. In the control group, the full clinical effect of treatment was observed only in 10 patients (52.6%). 9 women (47,4%) required repeated therapy. Ultrasound studies in 12 patients (63.2%) showed changes equivalent to endometritis.

scholarly journals THE STATE OF HYGIENE AND LOCAL IMMUNITY OF THE ORAL CAVITY IN PATIENTS WITH ANOREXIA NERVOSA

2019 ◽  
pp. 10-13
Author(s):  
M. Yu. Antonenko ◽  
L. L. Reshetnyk ◽  
E. V. Moskalenko ◽  
N. A. Zelinska ◽  
O. A. Znachkova
Keyword(s):  
Oral Hygiene ◽  
Oral Fluid ◽  
Mirror Image ◽  
The State ◽  
The Body ◽  
Immunological Methods ◽  
Control Group ◽  
Poor Oral Hygiene ◽  
Local Immunity ◽  
Group I

Aim: to study the state of local immunity and oral hygiene in patients with GP suffering from AN.Materials and methods: 35 patients with AN were examined at the age of 19-35 years. In the study we used immunological methods, an index assessment of the state of oral hygiene (PMA, API, GI).Results and discussion: in patients of I group poor oral hygiene was established. The amount of lysozyme in the oral fluid in I group was 0.014 ± 0.07 g/l. A decrease SIgA (11SIgA) was established in patients of I group: I, II and control (135.31 ± 23.17, 130.26 ± 24.21 and 300.34 ± 27.38 mg/l, respectively). A tendency to an increase in the level of IgG in the oral fluid in patients of group II compared with I and the control group (5.35 ± 0.36, vs. 4.57 ± 0.04 and 4.98 ± 0.23 g/l, respectively) was established.Conclusions: poor oral hygiene is an objective indicator which reflects low motivation to maintain oral health. The observed immunodeficiency (11SIgA) in patients with GP is a mirror image of changes occurring in the body of patients with AN.

scholarly journals Biochemical indices of urine in children with allergic diseases of airways

2020 ◽  
Vol 23 (4) ◽  
pp. 223-228
Author(s):  
Elena V. Tush ◽  
Anna N. Obuhova ◽  
Ivan I. Balabolkin ◽  
Olga V. Haletskaya ◽  
Andrey B. Stroganov ◽  
...  
Keyword(s):  
Comparison Group ◽  
Biochemical Study ◽  
Allergic Diseases ◽  
Main Group ◽  
The Body ◽  
Daily Urine ◽  
Daily Excretion ◽  
Biochemical Indices ◽  
Excretion Of Urates ◽  
Oxalate Metabolism

Currently, unsatisfactory control of the course of allergic diseases of airways (ADA) remains. There is data on the potential involvement of urate and oxalate metabolism in the pathogenesis of ADA, which determines the need to study the corresponding biomarkers. Aim of the work - to evaluate the daily urinary excretion of urates and oxalates in ADA children. Materials and methods. We examined 100 children aged 2 to 9 years, boys - 22, girls - 78, with symptoms of crystalluria. The children were divided into the main group (42 children) and the comparison group (58 people). The main group included patients with established diagnoses of ADA, and the comparison group included patients without ADA. A biochemical study of daily urine was performed in all cases. Results. It was found that the daily excretion of oxalates in ADA patients was significantly increased compared to the control, 26.5 [22.1; 32.6] mg/day and 23.3 [20.1; 27.6] mg/day, respectively. Daily urate excretion in patients of the main group was also significantly increased compared to the control, both in absolute numbers - 1.45 [1.13; 2.13] mmol/day and 1.17 [0.89; 1.5] mmol/day, respectively (p = 0.005), and in normalized to the body surface area units. Conclusion. A statistically significant increase in daily urate excretion was found in ADA children. The clinical and pathogenetic significance of this phenomenon in children with ADA requires further study.

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