scholarly journals Features of cytokine spectrum in chronic urticarial

2021 ◽  
Vol 23 (6) ◽  
pp. 1347-1356
Author(s):  
Т. P. Оspelnikova ◽  
A. A. Denisov ◽  
N. A. Cherevko ◽  
V. V. Кuzmina ◽  
V. S. Dmitruk ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Blood Serum ◽  
Chronic Urticaria ◽  
Sleep Disturbances ◽  
Well Being ◽  
The Body ◽  
Biologically Active ◽  
Present Moment ◽  
Intercellular Interaction ◽  
Blood Leukocytes

Urticaria is a serious medical and social problem due to its high prevalence, lack of unified approaches to diagnosis and treatment, with high financial costs for therapy and rehabilitation. Long-term recurrent course of the disease, resistance to traditional methods of therapy lead to a significant decrease in the quality of life of patients with chronic urticaria. Itching accompanying this disease leads to deterioration in the patient’s general well-being, frequent sleep disturbances and, as a result, significant decrease in working capacity. Up to the present moment, etiopathogenesis of urticaria is a complex challenge due to the multivector nature of cytokine response, interference of protides of the complement system, patterns of kininbradykinin interference, peculiar expression of the immune response. The problem of current population is lipotrophy – chronic, heterogeneous, cytokine mediating, progressive inflammatory disease attributed by abnormal accumulation of excessive adipose tissue. Adipose tissue, being a sporadic organ of endocrine system secretes multiple hormone-like substances, mediators, cytokines and chemokines which have been given a common name, i.e., adipokines or adipocytokines. True signs of destructive parenchymal changes of liver in the form of increasing bilirubin and AST, decreasing level of vitamin D in patients with chronic recurrent urticarial in presence of obesity have been revealed during the study performed. The action of cytokines, as mediators of intercellular interaction is closely related to the physiological and pathophysiological responses of the body with modulation of both local and systemic defense mechanisms. It is assumed that the cytokine status of patients with chronic urticaria is dominated by cytokines that increase allergic inflammation of the skin. Analysis of 12 T regulatory biomarker concentrations revealed increased concentrations of IL-10, IL-19, IL-20, IL-27, IL-35, IFNλ2 and IFNλ1 in blood serum of patients with chronic urticaria. It was found that in the group of patients with chronic urticaria and increased body mass index (BMI), the level of all investigated T regulatory cytokines is lower than in the patients with normal BMI, except for IL-10. Decreased levels of biologically active IFN I (α/β) and, especially, IFN II (γ) types of blood leukocytes in patients with chronic urticaria were revealed. The levels of 12 Treg cytokines were determined in blood serum of patients with chronic urticaria, showing trend for imbalance of Treg cytokines: IL-10, IL-19, IL-20, IL-27, IL-35, IFNλ2 and IFNλ1.

scholarly journals Obesity – a closer look to cell mechanisms disfunction

2021 ◽  
Vol 16 (2) ◽  
pp. 129-134
Author(s):  
Elena BĂLĂȘESCU ◽  
◽  
Larisa Diana PANDIA ◽  
Roxana Ioana NEDELCU ◽  
Daniela Adriana ION ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Public Health Problem ◽  
Overweight And Obesity ◽  
The Body ◽  
Biologically Active ◽  
Major Public Health Problem ◽  
Cellular Mechanisms ◽  
Functional Changes ◽  
Long Term Impact ◽  
Visceral Adipose

Obesity is a complex, multifactorial condition, a major public health problem with an increasing prevalence worldwide. Obesity is characterized by an excess of adipose tissue, a low degree of chronic inflammation and disorders in the synthesis of biologically active hormones and peptides which intervene in regulating appetite and energy balance, immunity, insulin sensitivity, angiogenesis, blood pressure, lipid metabolism and homeostasis of the body. The visceral adipose tissue accumulation is accompanied by metabolic disorders that have as a substrate subclinical inflammation and signaling by intracellular pathways that lead to irreversible cellular structural and functional changes. The long-term impact of overweight and obesity translates into shortening life expectancy and disability, due to association with severe comorbidities, such as cardiovascular diseases, diabetes, oncological conditions. Therefore, understanding the cellular mechanisms involved in obesity may facilitate the highlighting of new possible therapeutic targets.

Modern concepts of the adipose tissue effect on bone metabolism regulation

2020 ◽  
Vol 18 (6) ◽  
pp. 69-72
Author(s):  
N. Yu. KRUTIKOVA ◽  
◽  
A. S. EFREMENKOVA ◽  
Keyword(s):  
Adipose Tissue ◽  
Bone Metabolism ◽  
General Circulation ◽  
The Body ◽  
Biologically Active ◽  
Metabolic Effects ◽  
Published Data ◽  
Internal Environment ◽  
Metabolism Regulation ◽  
Active Substances

At present, it has been proved that adipose tissue, in addition to storing energy, is a complex hormonally active organ. Biological active substances secreted by adipose tissue, entering the general circulation, have a variety of metabolic effects, interact with various organs and systems, in particular with bone tissue, and participate in maintaining the constancy of the body internal environment. A number of hormones secreted by adipose tissue are well studied, such as leptin, adiponectin, interleukin-6, etc., others require further research in order to study their effects on various organs and systems. The published data suggest the multidirectional effect of biologically active substances on bone metabolism. The biological activity of hormones can be increased or decreased when interacting with receptors and/or binding proteins. Lack or excess of adipose tissue leads to various metabolic disorders and a shift in the dynamic balance of the constancy of the internal environment of the body.

scholarly journals Influence of mass and distribution of adipose tissue on the content of leptin in pregnant women at different periods gestations

2019 ◽  
Vol 16 (1) ◽  
pp. 55-61
Author(s):  
Natalya B. Chabanova ◽  
Tatiana N. Vasilkova ◽  
Valentina A. Polyakova ◽  
Sergey I. Mataev
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Blood Serum ◽  
Body Mass ◽  
Fat Mass ◽  
First Trimester ◽  
Fat Deposition ◽  
The Body ◽  
Normal Body ◽  
Increased Risk

BACKGROUND: Currently, obesity is one of the most global problem in the world. Redundant accumulation of adipose tissue accompanied by metabolic disorders including high secretion of leptin may lead to an increased risk of gestational complications. AIMS: To assess the level of leptin in pregnant womens blood serum depending on their body weight and the character of content of adipose tissue in different terms of gestation. MATERIALS AND METHODS: We investigated 211 women with single pregnancies, which came in natural cycles and finished with urgent parturitions. All of them got anthropometric study, assessment of adipose tissues weight by bioimpedanceometry, character of fat deposition by ultrasound investigation of adipose tissue, determination of the level of whey leptin at 1014, 2428, 3638 weeks of pregnancy. RESULTS: Established, that the level of leptin increases in proportion to pregestational body mass index from the first trimester. Women with excess body mass and with obesity had higher concentrations of leptin all over gestation, than women with normal body mass (р0.001). The higher term of pregnancy was, the higher the level of whey leptin was in all groups, independently of character of fat deposition. In the end of third trimester, women with normal body mass had the largest value of absolute and relative increase of body mass and fatty mass, what accompanied by enlargement of the concentration of leptin more than in 3 times for the pregestational level. CONCLUSIONS: In this way, high content of leptin in pregnant womens (with excess body mass and obesity) blood serum in the first trimester is explained by redundant accumulation of the adipose tissue. The largest value of gestational increase of body mass and fat mass in group where women had normal initial weight is accompanied by the great increase of the level of leptin on the body weight unit and fat mass. These data indicate, that control and limitation of excessive weight gain while pregnancy can be a measure of prevention of the redundant leptins secretion and different gestational complications related with it.

scholarly journals Use of Lipocavitation in the Treatment of Localized Adiposity: a Review

2021 ◽  
Vol 6 (3) ◽  
pp. 01-10
Author(s):  
Emerson Barbosa da Silva ◽  
Carla Bianca de Freitas Bozo ◽  
Patrick Gabriel dos Santos Pessini
Keyword(s):  
Adipose Tissue ◽  
Mechanism Of Action ◽  
Exploratory Study ◽  
Body Contouring ◽  
Well Being ◽  
The Body ◽  
Non Invasive ◽  
Selective Destruction ◽  
Technological Advances ◽  
Localized Adiposity

With the growing demand for body, contouring, non-invasive devices for reducing localized fat have become increasingly popular and have grown exponentially in the last decade. The Lipocavitation technique has been used recently for this purpose and has been evaluated as a method for the selective destruction of adipose tissue. This work has as main objective, to bring up the practice, the mechanism of action in the body and the effects of the use of lipocavitation in the treatment of localized adiposity. This is an exploratory study of bibliographic review, with consultation in the databases of the VHL (Virtual Health Library), PUBMED and MEDLINE and SciELO. The results showed that the lipocavitation technique used in aesthetics to reduce adipocytes allows the destruction of localized fat, facilitating its elimination and contributing to the reduction of localized measures. With the current technological advances, a variety of techniques can be used, or even combined, allowing innovation to professionals, bringing improvement and well-being to each individual.

scholarly journals The role of oat products in the prevention and therapy of type 2 diabetes, hypercholesterolemia and obesity*

2019 ◽  
Vol 65 (4) ◽  
Author(s):  
Katarzyna Janda ◽  
Anna Orłowska ◽  
Katarzyna Watychowicz ◽  
Karolina Jakubczyk
Keyword(s):  
Type 2 Diabetes ◽  
Essential Element ◽  
Well Being ◽  
Overweight And Obesity ◽  
The Body ◽  
Water Soluble ◽  
Biologically Active ◽  
Blood Cholesterol ◽  
Excess Body Weight

A healthy diet, of which unrefined grain products are an essential element, is crucial to maintaining health and well-being. Both oats and oat products have been used for centuries and are a widely popular dietary component. They are rich in nutrients, vitamins and minerals, as well as other biologically active compounds, which gives them many health-promoting properties. Because of their high nutritional value, these products are widely used in many branches of industry.The aim of this article is to present the current body of knowledge about the influence of oat products on human health, and also their industrial applications. A special emphasis is placed on the relationship between the intake of products made from oats and the development and treatment of such disorders as type 2 diabetes, cardiovascular diseases and excess body weight. There are many scientific reports indicating that the incorporation of oat products into the diet is associated with beneficial effects in the context of the above conditions, notably due to the high content of water-soluble dietary fibre, particularly β-glucans, which deserve special recognition. According to the body of academic literature, high consumption of the latter is linked to enhanced glycemic control, reduction in blood cholesterol and may also contribute to weight loss in overweight and obesity. For these reasons, oat products deserve special attention and should be recommended for both prophylactic and therapeutic use in metabolic disorders.

scholarly journals The influence of biologically active additives on the morpho-biochemical parameters of the blood of broiler chickens

2021 ◽  
Vol 207 (04) ◽  
pp. 93-98
Author(s):  
Elena Shackih ◽  
Dar'ya Korol'kova-Subbotkina ◽  
D. Galiev
Keyword(s):  
Blood Serum ◽  
Biochemical Parameters ◽  
Blood Test ◽  
Broiler Chickens ◽  
Feed Additives ◽  
The Body ◽  
Biologically Active ◽  
Morphological Examination ◽  
Protein Nitrogen ◽  
Diagnostic Center

Abstract. The introduction of synbiotics and phytobiotics into the diet allows us to optimize metabolism, increase the level of use of feed components, and activate immune processes in the body. The purpose of the work is to determine the effect of “GerbaStor” and “ProStor” feed additives, including probiotic, prebiotic and phytobiotic components, on the morphological and biochemical parameters of the blood of broiler chickens of the “Ross-308” cross. Methods. In the course of a scientific and economic experiment at the age of 29 days, blood was taken from 5 medium-sized broilers by decapitation to determine morphological and biochemical parameters. The blood test was carried out at the Clinical and Diagnostic Center in Ekaterinburg. The morphological examination of blood was carried out in the hemostasis laboratory, on an automatic analyzer ADVIA 120, manufactured by BAYER, as well as by manual counting of formed elements in the Goryaev chamber. A biochemical blood test was performed in a clinical diagnostic laboratory using a Vitros 350 analyzer. Results. The inclusion of “GerbaStor” and “ProStor” in the diet did not adversely affect the metabolic processes of the bird. Morpho-biochemical blood parameters were within physiological values. In the experimental groups was observed an improvement in the assimilation of protein nitrogen, it is evidenced by a decrease in uric acid in the blood serum. In addition, the use of the studied feed was accompanied by the activation of lipid metabolism in the body of birds, which was characterized by a tendency to reduce the amount of triglycerides in the blood serum in individuals of the 1st and 2nd experimental groups. The results of the study showed that when “ProStor” is introduced into the feed concentrate, there is a tendency of decreasing in the activity of transaminases in the body of broilers, which demonstrates a higher resistance of their internal organs, in particular the liver and heart, to unfavorable exogenous and endogenous influences. The academic novelty lies in the fact that new data were obtained on the influence of the studied feed factors, including probiotic, prebiotic and phytobiotic components, on the morpho-biochemical parameters of the blood of broiler chickens.

scholarly journals Adipose Tissue and Biological Factors. Possible Link between Lymphatic System Dysfunction and Obesity

Metabolites ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 617
Author(s):  
Klaudia Antoniak ◽  
Rita Hansdorfer-Korzon ◽  
Małgorzata Mrugacz ◽  
Katarzyna Zorena
Keyword(s):  
Adipose Tissue ◽  
Lymphatic System ◽  
Polycystic Ovary ◽  
Experimental Studies ◽  
The Body ◽  
Biologically Active ◽  
World Health ◽  
Biological Factors ◽  
Active Metabolites ◽  
Venous Circulation

The World Health Organization (WHO) has recognised obesity as one of the top ten threats to human health. Obesity is not only a state of abnormally increased adipose tissue in the body, but also of an increased release of biologically active metabolites. Moreover, obesity predisposes the development of metabolic syndrome and increases the incidence of type 2 diabetes (T2DM), increases the risk of developing insulin resistance, atherosclerosis, ischemic heart disease, polycystic ovary syndrome, hypertension and cancer. The lymphatic system is a one-directional network of thin-walled capillaries and larger vessels covered by a continuous layer of endothelial cells that provides a unidirectional conduit to return filtered arterial and tissue metabolites towards the venous circulation. Recent studies have shown that obesity can markedly impair lymphatic function. Conversely, dysfunction in the lymphatic system may also be involved in the pathogenesis of obesity. This review highlights the important findings regarding obesity related to lymphatic system dysfunction, including clinical implications and experimental studies. Moreover, we present the role of biological factors in the pathophysiology of the lymphatic system and we propose the possibility of a therapy supporting the function of the lymphatic system in the course of obesity.

scholarly journals The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Ali Jangjou ◽  
Amir Hossein Meisami ◽  
Kazem Jamali ◽  
Mohammad Hadi Niakan ◽  
Milad Abbasi ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Drug Carrier ◽  
Well Being ◽  
The Body ◽  
Biologically Active ◽  
Medicinal Uses ◽  
Medication Delivery ◽  
Effective Care ◽  
Wide Range ◽  
Area Of Concern

AbstractMicrobubbles are typically 0.5–10 μm in size. Their size tends to make it easier for medication delivery mechanisms to navigate the body by allowing them to be swallowed more easily. The gas included in the microbubble is surrounded by a membrane that may consist of biocompatible biopolymers, polymers, surfactants, proteins, lipids, or a combination thereof. One of the most effective implementation techniques for tiny bubbles is to apply them as a drug carrier that has the potential to activate ultrasound (US); this allows the drug to be released by US. Microbubbles are often designed to preserve and secure medicines or substances before they have reached a certain area of concern and, finally, US is used to disintegrate microbubbles, triggering site-specific leakage/release of biologically active drugs. They have excellent therapeutic potential in a wide range of common diseases. In this article, we discussed microbubbles and their advantageous medicinal uses in the treatment of certain prevalent disorders, including Parkinson's disease, Alzheimer's disease, cardiovascular disease, diabetic condition, renal defects, and finally, their use in the treatment of various forms of cancer as well as their incorporation with nanoparticles. Using microbubble technology as a novel carrier, the ability to prevent and eradicate prevalent diseases has strengthened the promise of effective care to improve patient well-being and life expectancy.

Neutral Lipids of Oats Fruit (Avena Sativa L.)

2020 ◽  
Vol 9 (4) ◽  
pp. 40-43
Author(s):  
N. K. Yuldasheva ◽  
S. D. Gusakova ◽  
D. Kh. Nurullaeva ◽  
N. T. Farmanova ◽  
R. P. Zakirova ◽  
...  
Keyword(s):  
Avena Sativa ◽  
Neutral Lipids ◽  
The Body ◽  
Biologically Active ◽  
Absorption Bands ◽  
Vital Functions ◽  
The Republic ◽  
Living Organisms ◽  
Main Components ◽  
Active Substances

Introduction. Lipids are a widespread group of biologically active substances in nature, making up the bulk of the organic substances of all living organisms. They accumulate in plants in seeds, as well as in fruits and perform a number of vital functions: they are the main components of cell membranes and the energy reserve for the body.Aim. Study of neutral lipids of sown oats (Avena sativa L.).Materials and methods. The objects of the study were fruits (grains) of oats of the sown variety "Tashkent 1," harvested in the Republic of Uzbekistan. Results and discussions. Neutral lipids of oat grains have been found to contain 13 fatty acids with a predominance of the sum of oleic, linolenic and linoleic acids. The total degree of unsaturation was almost 78%. Absorption bands characteristic of these substances were observed in the IR spectrum of MEGC.Conclusion. According to the results of the NL analysis, oat grains consisted of triacylglycerides and free LCDs, which were accompanied by hydrocarbons, phytosterols, triterpenoids and tocopherols.

Sign in / Sign up

Export Citation Format

Share Document