scholarly journals Investigation of aspects of the interaction of the indicators of lipid exchange, trombocitarian block of hemostasis, total body reactivity and their influence on the psychosomatic harmonization of the man in chronic inflammatory processes

2019 ◽  
Vol 7 (2) ◽  
pp. 120-137
Author(s):  
Irina Sokolovskaya ◽  
Alla Kutsak ◽  
Valentyna Zarytska ◽  
Valentina Nechiporenko ◽  
Natalia Gordiyenko ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Cellular Mechanisms ◽  
Lipid Exchange ◽  
Inflammatory Processes ◽  
Total Body ◽  
Mechanisms Of Development ◽  
First Time ◽  
Reduced Activity

For the first time on the basis of clinical and laboratory researches were revealed the correlation of indicators of lipid metabolism, platelet level of hemostasis and general reactivity in patients with chronic inflammatory processes of the genital system. The new pathogenetic aspects of the course of inflammatory diseases have been established. It has been shown that chronic inflammatory process is accompanied by disorders of lipid metabolism. The degree of severity of these changes depends on the severity of the inflammatory process, the reduction of phagocytic activity of polymorphonuclear leukocytes and the activation of macrophage and specific cellular mechanisms, accompanied by auto-intoxication. It is established that the frequency of atherogenic dyslipoproteinemias, as well as the intensity of lipid peroxidation increases in accordance with the increase age of the examined patients. Most atherogenic dyslipoproteinemias are found in patients with viral and chlamydial infections. The summarized data of the correlation analysis allow us to establish that the growth of atherogenic properties of blood plasma of patients with chronic inflammatory processes of the reproductive system occurs in accordance with the increase of adhesive-aggregation properties of platelets and damage of the vascular endothelium. These shifts occur in parallel with the predominance of the monocyte-macrophage linkage of phagocytosis against the background of reduced activity of neutrophils and cellular mechanisms of development of immunopathological reactions.

scholarly journals The state of lipid exchange and thrombotic link of hemostasis in patients with chronic non-specific inflammatory diseases of genitals

2019 ◽  
Vol 7 (1) ◽  
pp. 34-45
Author(s):  
Irina Sokolovska ◽  
Nadezhda Maryukhnich ◽  
Valentyna Zarytska ◽  
Olena Kyrpychenko ◽  
Valentina Nechiporenko ◽  
...  
Keyword(s):  
Vascular Endothelium ◽  
Inflammatory Process ◽  
Blood Count ◽  
Inflammatory Diseases ◽  
Full Blood Count ◽  
Complex Treatment ◽  
Lipid Exchange ◽  
Lipid Fractions ◽  
Endothelium Damage ◽  
Blood Characteristics

It has been stated that changes of lipid exchange and increasing of lipid peroxidation are accompanied by the inflammatory process, which show the increase of proatherogenic blood characteristics. In patients with chronic non-specific inflammatory diseases of genitals disorders of phagocytosis mechanisms, increasing of autointoxication and reaction of hypersensitivity of immediate type are revealed after full blood count index. On the basis of analyses results one can conclude that the increase of atherogenic properties of blood plasma in patients with chronic non-specific inflammatory diseases of genitals took place in accordance with vascular endothelium damage. The article is the first to show the effectiveness of complex treatment of different atherosclerotic pathogenesis links by means of correction of proatherogenic lipid fractions and antioxidative complexes.

scholarly journals Mechanisms of benzydamine action against local inflammatory process

2019 ◽  
pp. 78-86 ◽  
Author(s):  
G. V. Poryadin ◽  
J. M. Salmasi ◽  
A. N. Kazimirsky
Keyword(s):  
Immune System ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Local Therapy ◽  
Mechanisms Of Action ◽  
Pharmacological Effects ◽  
Inflammatory Processes ◽  
Antimicrobic Activity ◽  
Acute And Chronic Inflammation ◽  
Inflammatory Action

Local inflammatory diseases caused by various infections are one of the most common pathologies in medical practice. For example, tonsillopharyngitis. This disease is extremely frequent for a physician’s practice. There is a fair amount of drugs, which supposed to be helpful against tonsillopharyngitis, but different drugs are also not the same in their pharmacological effects. In gynecological practice, frequent diseases are specific and non-specific vulvovaginitis, which have inflammatory and infectious components. For administrating local pharmacotherapy in gynecology against inflammation, a large number of drugs with different mechanisms of action are proposed. In this study, we focused on key pathological mechanisms associated with acute and chronic inflammation, for which these drugs should be exposed by their pharmacokinetic and pharmacodynamic properties. The best combination of these properties is available for benzydamine hydrochloride. Benzydamine hydrochloride has a wide antimicrobic activity against bacteria and Candida spices both albicans and non-albicans strains and allows to influence on etiologic cause of the disease. Also benzydamine hydrochloride associated with «cytokine» mechanism of anti-inflammatory action, which means that he does not affect COX enzymes and it allows to avoid gastrotoxic adverse events. Also, in this work showed and discussed aspects of the interaction of benzydamine with local immune system and justification of useful usage the benzydamine for local therapy of acute and chronic inflammatory processes caused by various infections.

scholarly journals Functional Lipids in Autoimmune Inflammatory Diseases

2020 ◽  
Vol 21 (9) ◽  
pp. 3074
Author(s):  
Michele Dei Cas ◽  
Gabriella Roda ◽  
Feng Li ◽  
Francesco Secundo
Keyword(s):  
Immune Responses ◽  
Small Molecules ◽  
Lupus Erythematosus ◽  
Inflammatory Process ◽  
Recent Literature ◽  
Inflammatory Diseases ◽  
Biological Functions ◽  
Bioactive Lipids ◽  
Inflammatory Processes

Lipids are apolar small molecules known not only as components of cell membranes but also, in recent literature, as modulators of different biological functions. Herein, we focused on the bioactive lipids that can influence the immune responses and inflammatory processes regulating vascular hyperreactivity, pain, leukocyte trafficking, and clearance. In the case of excessive pro-inflammatory lipid activity, these lipids also contribute to the transition from acute to chronic inflammation. Based on their biochemical function, these lipids can be divided into different families, including eicosanoids, specialized pro-resolving mediators, lysoglycerophospholipids, sphingolipids, and endocannabinoids. These bioactive lipids are involved in all phases of the inflammatory process and the pathophysiology of different chronic autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, type-1 diabetes, and systemic lupus erythematosus.

EXPERIMENTAL ESTIMATION OF THE EFFICIENCY OF COMPLEX TREATMENT OF PERIODONTAL DISEASES USING AN ADAPTOGEN

2021 ◽  
pp. 18-21
Author(s):  
Алик Эдикович Петросян ◽  
Наталия Владимировна Чиркова ◽  
Арпине Бронислави Антонян ◽  
Жанна Владимировна Вечеркина
Keyword(s):  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Histological Study ◽  
Scientific Data ◽  
New Drugs ◽  
Complex Treatment ◽  
Comparative Aspect ◽  
Male Wistar Rats ◽  
Inflammatory Processes

Заболевания пародонта представляют собой серьезное воспалительное заболевание, которое с прогрессированием постепенно разрушает опорный аппарат зуба. Чаще всего, в практической стоматологии встречаются такие воспалительные заболевания как гингивит и пародонтит, тяжесть которых обусловлена степенью выраженности воспалительных процессов. Профилактика, диагностика и лечение данных состояний являются актуальной проблемой современной стоматологии. Научные данные подтверждают, что современные лекарственные средства оказывают влияние на все звенья этиологии и патогенеза, но тем не менее переход данных заболеваний в хроническую форму, а также неполноценный терапевтический эффект обуславливает актуальность поиска новых препаратов и комбинаций для профилактики и лечения воспалительных заболеваний пародонта. Анализ научной литературы показал, что в медицине широко используется комплексное лечение различных заболеваний органов и систем с применением адаптогенов, которые обладают не только богатым аминокислотным и витаминным составом, но и оказывают противовоспалительное, иммуномодулирующее, вяжущее и седативное действие. В данной статье представлены результаты гистологического исследования биоматериала слизистой губы крыс-самцов линии Вистар при экспериментальном моделировании воспалительного процесса в нем. Было проведено дифференцированное исследование влияния комплексного лечения с применением геля «Асепта с прополисом», модифицированного пантогематогеном на течение воспалительного процесса в сравнительном аспекте Periodontal diseases are a serious inflammatory disease that gradually destroys the supporting apparatus of the tooth as it progresses. Most often, in practical dentistry, there are such inflammatory diseases as gingivitis and periodontitis, the severity of which is due to the degree of severity of inflammatory processes. Prevention, diagnosis and treatment of these conditions are an urgent problem of modern dentistry. Scientific data confirm that modern medicines have an impact on all parts of the etiology and pathogenesis, but nevertheless, the transition of these diseases to a chronic form, as well as an incomplete therapeutic effect, determines the urgency of the search for new drugs and combinations for the prevention and treatment of inflammatory periodontal diseases. The analysis of scientific literature has shown that in medicine, complex treatment of various diseases of organs and systems is widely used with the use of adaptogens, which have not only a rich amino acid and vitamin composition, but also have anti-inflammatory, immunomodulatory, astringent and sedative effects. This article presents the results of a histological study of the biomaterial of the lip mucosa of male Wistar rats with experimental modeling of the inflammatory process in it. A differentiated study of the effect of complex treatment with the use of "Asepta with propolis" gel modified with pantohematogen on the course of the inflammatory process in a comparative aspect was conducted

scholarly journals Mutant Glucocorticoid Receptor Binding Elements on the Interleukin-6 Promoter Regulate Dexamethasone Effects

2020 ◽  
Author(s):  
Wen-Teng Chang ◽  
Ming-Yuan Hong ◽  
Chien-Liang Chen ◽  
Chi-Yuan Hwang ◽  
Cheng-Chieh Tsai ◽  
...  
Keyword(s):  
Binding Sites ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Inducible Promoter ◽  
Transcriptional Factor ◽  
Factor Binding ◽  
Inflammatory Processes ◽  
Nuclear Receptor Family ◽  
Receptor Family ◽  
Pro Inflammatory Cytokines

Abstract BackgroundGlucocorticoids (GCs) have been extensively used as essential modulators in clinical infectious and inflammatory diseases. The GC receptor (GR) is a transcription factor belonging to the nuclear receptor family that regulates anti-inflammatory processes and releases pro-inflammatory cytokines. ResultsFive putative GR binding sites and other transcriptional factor binding sites were identified on the interleukin (IL)-6 promoter, and dexamethasone (DEX) was noted to reduce the lipopolysaccharide (LPS)-induced IL-6 production. Among mutant transcriptional factor binding sites, NF-κB, AP-1, and Sp1-2 sites reduced basal and LPS-induced IL-6 promoter activities through various responses. The first and third GR binding sites (GR2 and GR3) were noted to play a crucial role in both basal and inducible promoter activities in LPS-induced inflammation. ConclusionsWe concluded that selective GR2 and GR3 modulators might exert agonistic and antagonistic effects and could activate crucial signaling pathways during the LPS-stimulated inflammatory process.

RADIOTHERAPY FOR LYMPHOMAS: A 40-YEAR EXPERIENCE OF ONE CENTER

2018 ◽  
Vol 64 (4) ◽  
pp. 539-543
Author(s):  
Yuliya Vinogradova ◽  
Anastasiya Chumachenko ◽  
Nikolay Ilin
Keyword(s):  
Radiation Treatment ◽  
Allogeneic Transplantation ◽  
Original Method ◽  
Hematopoietic Stem ◽  
Sequential Development ◽  
Radio Therapy ◽  
Local Lesions ◽  
Total Body ◽  
First Time ◽  
Medium Dose

The 40-year experience of the department of radiotherapy for lymphoma of the «RRCRST named after. ac. A.M. Granov» of the Ministry of Health of Russia from the standpoint of today is discussed in the article. Modern methods of radiation treatment of Hodgkin's lymphoma at the stages of their sequential development, unique methods of local and total skin radio-therapy with electrons in skin lymphomas, the experience of radiotherapy in patients with lymphomas of various structures of the organ of vision, and the features of fractionation in radiotherapy for patients with plasma-cell tumors are considered. The department developed an original method of medium-dose total body radiotherapy in terms of the conditioning regime before allogeneic transplantation of hematopoietic stem cells for patients with leukemia and lymphomas, for the first time the experience of radiation therapy of patients with acute leukemia with local lesions of various organs and tissues was accumulated.

Natural Products for Regulating Macrophages M2 Polarization

2020 ◽  
Vol 15 (7) ◽  
pp. 559-569 ◽  
Author(s):  
Zhen Chang ◽  
Youhan Wang ◽  
Chang Liu ◽  
Wanli Smith ◽  
Lingbo Kong
Keyword(s):  
Molecular Mechanisms ◽  
Inflammatory Diseases ◽  
Therapeutic Strategies ◽  
Research Progress ◽  
Cellular Mechanisms ◽  
Pharmacological Activities ◽  
Current Review ◽  
M2 Polarization ◽  
Macrophages Polarization ◽  
Herbal Plants

Macrophages M2 polarization have been taken as an anti-inflammatory progression during inflammation. Natural plant-derived products, with potential therapeutic and preventive activities against inflammatory diseases, have received increasing attention in recent years because of their whole regulative effects and specific pharmacological activities. However, the molecular mechanisms about how different kinds of natural compounds regulate macrophages polarization still unclear. Therefore, in the current review, we summarized the detailed research progress on the active compounds derived from herbal plants with regulating effects on macrophages, especially M2 polarization. These natural occurring compounds including flavonoids, terpenoids, glycosides, lignans, coumarins, alkaloids, polyphenols and quinones. In addition, we extensively discussed the cellular mechanisms underlying the M2 polarization for each compound, which could provide potential therapeutic strategies aiming macrophages M2 polarization.

scholarly journals Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines

2019 ◽  
Vol 20 (3) ◽  
pp. 459 ◽  
Author(s):  
Leila Kheirandish-Gozal ◽  
David Gozal
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Inflammatory Diseases ◽  
Sleep Apnea Syndrome ◽  
Special Focus ◽  
Normal Body Mass Index ◽  
Low Grade ◽  
Obstructive Sleep ◽  
Inflammatory Processes ◽  
Factor Α

Obstructive sleep apnea syndrome (OSAS) is a markedly prevalent condition across the lifespan, particularly in overweight and obese individuals, which has been associated with an independent risk for neurocognitive, behavioral, and mood problems as well as cardiovascular and metabolic morbidities, ultimately fostering increases in overall mortality rates. In adult patients, excessive daytime sleepiness (EDS) is the most frequent symptom leading to clinical referral for evaluation and treatment, but classic EDS features are less likely to be reported in children, particularly among those with normal body-mass index. The cumulative evidence collected over the last two decades supports a conceptual framework, whereby sleep-disordered breathing in general and more particularly OSAS should be viewed as low-grade chronic inflammatory diseases. Accordingly, it is assumed that a proportion of the morbid phenotypic signature in OSAS is causally explained by underlying inflammatory processes inducing end-organ dysfunction. Here, the published links between OSAS and systemic inflammation will be critically reviewed, with special focus on the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), since these constitute classical prototypes of the large spectrum of inflammatory molecules that have been explored in OSAS patients.

scholarly journals How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?

2021 ◽  
Vol 15 (1) ◽  
pp. 21-35
Author(s):  
Yana Geng ◽  
Klaas Nico Faber ◽  
Vincent E. de Meijer ◽  
Hans Blokzijl ◽  
Han Moshage
Keyword(s):  
Lipid Metabolism ◽  
Liver Disease ◽  
Fatty Liver ◽  
Lipid Accumulation ◽  
Fatty Liver Disease ◽  
Lipid Uptake ◽  
Cellular Mechanisms ◽  
Alcoholic Fatty Liver ◽  
Lipid Species ◽  
Alcoholic Fatty Liver Disease

Abstract Background Non-alcoholic fatty liver disease (NAFLD), characterized as excess lipid accumulation in the liver which is not due to alcohol use, has emerged as one of the major health problems around the world. The dysregulated lipid metabolism creates a lipotoxic environment which promotes the development of NAFLD, especially the progression from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH). Purposeand Aim This review focuses on the mechanisms of lipid accumulation in the liver, with an emphasis on the metabolic fate of free fatty acids (FFAs) in NAFLD and presents an update on the relevant cellular processes/mechanisms that are involved in lipotoxicity. The changes in the levels of various lipid species that result from the imbalance between lipolysis/lipid uptake/lipogenesis and lipid oxidation/secretion can cause organellar dysfunction, e.g. ER stress, mitochondrial dysfunction, lysosomal dysfunction, JNK activation, secretion of extracellular vesicles (EVs) and aggravate (or be exacerbated by) hypoxia which ultimately lead to cell death. The aim of this review is to provide an overview of how abnormal lipid metabolism leads to lipotoxicity and the cellular mechanisms of lipotoxicity in the context of NAFLD.

scholarly journals Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein

2021 ◽  
Vol 43 (2) ◽  
pp. 767-781
Author(s):  
Vanessa Pinatto Gaspar ◽  
Anelise Cardoso Ramos ◽  
Philippe Cloutier ◽  
José Renato Pattaro Junior ◽  
Francisco Ferreira Duarte Junior ◽  
...  
Keyword(s):  
Dna Replication ◽  
Protein Interactions ◽  
Ribosome Biogenesis ◽  
Cell Metabolism ◽  
Cell Types ◽  
Protein Protein Interactions ◽  
Cellular Mechanisms ◽  
Cancerous Cell ◽  
First Time

KIN (Kin17) protein is overexpressed in a number of cancerous cell lines, and is therefore considered a possible cancer biomarker. It is a well-conserved protein across eukaryotes and is ubiquitously expressed in all cell types studied, suggesting an important role in the maintenance of basic cellular function which is yet to be well determined. Early studies on KIN suggested that this nuclear protein plays a role in cellular mechanisms such as DNA replication and/or repair; however, its association with chromatin depends on its methylation state. In order to provide a better understanding of the cellular role of this protein, we investigated its interactome by proximity-dependent biotin identification coupled to mass spectrometry (BioID-MS), used for identification of protein–protein interactions. Our analyses detected interaction with a novel set of proteins and reinforced previous observations linking KIN to factors involved in RNA processing, notably pre-mRNA splicing and ribosome biogenesis. However, little evidence supports that this protein is directly coupled to DNA replication and/or repair processes, as previously suggested. Furthermore, a novel interaction was observed with PRMT7 (protein arginine methyltransferase 7) and we demonstrated that KIN is modified by this enzyme. This interactome analysis indicates that KIN is associated with several cell metabolism functions, and shows for the first time an association with ribosome biogenesis, suggesting that KIN is likely a moonlight protein.

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