scholarly journals Effect of spray dryer settings on the morphology of illite clay granules

2015 ◽  
Vol 1 ◽  
pp. 216 ◽  
Author(s):  
A. Stunda-Zujeva ◽  
V. Stepanova ◽  
L. Bērziņa-Cimdiņa
Keyword(s):  
Surface Area ◽  
Clay Fraction ◽  
Inlet Temperature ◽  
Outlet Temperature ◽  
Spray Dryer ◽  
Operational Conditions ◽  
The Mean ◽  
Size And Morphology ◽  
Two Fluid ◽  
Spray Dried

<p class="R-AbstractKeywords"><span lang="X-NONE">Spray drying is an effective and common method for powder drying, e.g. clay. The morphology and properties of spray dried granules depend on properties of slurry and operational conditions of spray dryer. The aim of this study was to investigate the effect of spray dryer settings on the morphology of illite clay granules. </span></p><p class="R-AbstractKeywords"><span lang="X-NONE">Laboratory scale spray dryer was used. Operational conditions: inlet temperature 190-220˚C, outlet temperature 70-96˚C, spray dispersion is obtained using two-fluid nozzle where the slurry feed was varied from 4.5 to 15 ml/min and gas pressure 15-40 mm. Slurry was prepared from clay fraction under 2 µm without additives. Latvian illite clay from Iecava, Pavāri and Laža deposits was studied. Slurries with concentration 1, 8 and 15 mass% was used.The size and morphology was investigated by scanning electron microscopy, surface area and porosity by liquid nitrogen sorption.</span></p><p class="R-AbstractKeywords"><span lang="X-NONE">All obtained granules irrespective of </span><span lang="X-NONE">spray dryer settings</span><span lang="X-NONE"> were well-rounded and dense without large pores or holes, however the surface was rough. The mean diameter of granules was in range of 2.6-5.4 µm, depending on slurry feed rate. The surface area of produced granules mostly depended on clay composition and was in a range of 70-92 m2/g. Inlet temperature in a range of 190-220 °C was found to be appropriate to produce well dried clay granules (moisture content &lt;10 wt%).   </span></p>

Droplet-Particle Agglomeration of Maltodextrin and Salt in a Small-Scale Spray Dryer

2008 ◽  
Vol 4 (6) ◽  
Author(s):  
Tim Langrish ◽  
D. Ali ◽  
M. Asplet
Keyword(s):  
Small Scale ◽  
Inlet Temperature ◽  
Scanning Electron Micrographs ◽  
Spray Dryer ◽  
Particle Agglomeration ◽  
Collision Efficiency ◽  
Flow Rates ◽  
Air Inlet ◽  
Two Fluid ◽  
Scanning Electron

The technique of in-chamber blending in practice has been investigated, by altering the configuration of a Buchi B290 small-scale spray dryer having a two-fluid nozzle, through adding an extra pipe into the chamber to agglomerate maltodextrin (DE18) particles with 20% salt solution sprayed through the atomizer. Scanning Electron Micrographs showed the importance of splash impacts between salt droplets and maltodextrin particles in this geometry, suggesting that the collision efficiency is strongly affected by whether or not the salt droplets completely surround the dry maltodextrin particles. Changing the air inlet temperature did not affect the measured amount of collisions (from Atomic Absorption Spectroscopy) significantly, but both the main air and the nozzle air flow rates had significant effects on the collision outcomes.

scholarly journals Comparison of a Novel Miniaturized Screening Device with Büchi B290 Mini Spray-Dryer for the Development of Spray-Dried Solid Dispersions (SDSDs)

Processes ◽  
2018 ◽  
Vol 6 (8) ◽  
pp. 129 ◽  
Author(s):  
Aymeric Ousset ◽  
Joke Meeus ◽  
Florent Robin ◽  
Martin Schubert ◽  
Pascal Somville ◽  
...  
Keyword(s):  
Drug Loading ◽  
Solid Dispersions ◽  
Morphological Properties ◽  
Similar Process ◽  
Process Conditions ◽  
Outlet Temperature ◽  
Spray Dryer ◽  
Residual Solvent ◽  
Screening Device ◽  
Spray Dried

Spray-drying is an increasingly popular technology for the production of amorphous solid dispersions (ASDs) in the pharmaceutical industry that is used in the early evaluation and industrial production of formulations. Efficient screening of ASD in the earliest phase of drug development is therefore critical. A novel miniaturized atomization equipment for screening spray-dried solid dispersions (SDSDs) in early formulation and process development was developed. An in-depth comparison between the equipment/process parameters and performance of our novel screening device and a laboratory Büchi B290 mini spray-dryer was performed. Equipment qualification was conducted by comparing the particle/powder attributes, i.e., miscibility/solid state, residual solvent, and morphological properties of binary SDSDs of itraconazole prepared at both screening and laboratory scales. The operating mode of the miniaturized device was able to reproduce similar process conditions/parameters (e.g., outlet temperature (Tout)) and to provide particles with similar drug–polymer miscibility and morphology as laboratory-scale SDSDs. These findings confirm that the design and operation of this novel screening equipment mimic the microscale evaporation mechanism of a larger spray-dryer. The miniaturized spray-dryer was therefore able to provide a rational prediction of adequate polymer and drug loading (DL) for SDSD development while reducing active pharmaceutical ingredient (API) consumption by a factor of 120 and cycle time by a factor of 4.

scholarly journals Phenolic Analysis and Characterization of Palm Sugar (Arenga pinnata) Produced by The Spray dryer

2019 ◽  
Vol 35 (1) ◽  
pp. 150-156
Author(s):  
Jayanudin Jayanudin ◽  
Teguh Kurniawan ◽  
Indar Kustiningsih
Keyword(s):  
Phenolic Content ◽  
Operating Conditions ◽  
Total Phenolic ◽  
Inlet Temperature ◽  
Outlet Temperature ◽  
Spray Dryer ◽  
Phenolic Analysis ◽  
Palm Sugar ◽  
Increasing Temperature

The effect of spray dryer inlet temperature on characterization and total phenolic content of palm sugar has been studied. The spray dryer operating conditions used were 160 ̶ 220°C inlet temperature with a feed flow rate of 2 L/hour, while for outlet temperature was 85°C. The high inlet temperature produced a higher crystallinity of sucrose and did not agglomerate and not sticky. However, the high temperature of the spray dryer inlet produced palm sugar that was browner than the low temperature one. The effect of increasing temperature of spray dryer produced irregular total phenolic. The total phenolic at 220°C was higher than 200°C. Likewise, the temperature of 180°C generated total phenolic was higher than the temperature of 160°C. The total phenolic of palm sugar analyzed in this study was quite large within the range of 49 ± 0.01 to 63.6 ± 0.01 mg of GAE/100 g samples.

scholarly journals The Use of a Three-Fluid Atomising Nozzle in the Production of Spray-Dried Theophylline/Salbutamol Sulphate Powders Intended for Pulmonary Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1116
Author(s):  
Stefano Focaroli ◽  
Guannan Jiang ◽  
Peter O'Connell ◽  
John V. Fahy ◽  
Anne-Marie Healy
Keyword(s):  
Dry Powder Inhaler ◽  
Pulmonary Delivery ◽  
Spray Dryer ◽  
Equivalent Formulation ◽  
Dry Powders ◽  
Salbutamol Sulphate ◽  
Pharmaceutical Ingredients ◽  
Low Solubility ◽  
Two Fluid ◽  
Spray Dried

The aim of this study was to investigate the use of a three-fluid atomising nozzle in a lab-scale spray dryer for the production of dry powders intended for pulmonary delivery. Powders were composed of salbutamol sulphate and theophylline in different weight ratios. The three-fluid nozzle technology enabled powders containing a high theophylline content to be obtained, overcoming the problems associated with its relatively low solubility, by pumping two separate feed solutions (containing the two different active pharmaceutical ingredients (APIs)) into the spray dryer via two separate nozzle channels at different feed rates. The final spray-dried products were characterized in terms of morphology, solid-state properties and aerosolization performance, and were compared with an equivalent formulation prepared using a standard two-fluid atomising nozzle. Results confirmed that most of the powders made using the three-fluid atomising nozzle met the required standards for a dry powder inhaler formulation in terms of physical characteristics; however, aerosolization characteristics require improvement if the powders are to be considered suitable for pulmonary delivery.

scholarly journals ENCAPSULATION OF RED GINGER OLEORESIN (ZINGIBER OFFICINALE VAR RUBRUM) WITH CHITOSAN AS WALL MATERIAL

2017 ◽  
Vol 9 (8) ◽  
pp. 29 ◽  
Author(s):  
Jayanudin . ◽  
Rochmadi .
Keyword(s):  
Infrared Spectroscopy ◽  
Spray Drying ◽  
Encapsulation Efficiency ◽  
Weight Ratio ◽  
Wall Material ◽  
Inlet Temperature ◽  
Outlet Temperature ◽  
Spray Dryer ◽  
Red Ginger ◽  
Scanning Electron

Objective: This research aims to determine the effect of the spray drying condition against encapsulation efficiency and characterization microcapsules of red ginger oleoresin.Methods: Preparation of encapsulation begun with the formation of emulsions by mixing red ginger oleoresin with chitosan solution which was dissolved with acetic acid 2% (v/v). The weight ratio of chitosan with red ginger oleoresin was 1: 1, 2: 1 and 3: 1 and then stirred using a homogenizer while added 2 ml tween 80 for 10 min. The size of emulsion droplet was measured using nanoparticle analyzer (NPA). The emulsion is formed and then inserted into the feed tank of a spray dryer. Inlet temperature of the spray dryer used in the 180 °C, 190 °C and 200 °C; and the spray dryer outlet temperature was 85 °C, feed rate at 2 L/h. The microcapsules formed were then analyzed encapsulation efficiency and characterization using scanning electron microscopy (SEM) and fourier transform infrared spectroscopy (FTIR).Results: Based on the research that has been done, the smallest effective diameter of the emulsion droplets was 216.4±1.5 nm and the largest was 2109.2±46.1 nm. The value of encapsulation efficiency ranged between 83.33±0.42%-99.15±0.02%. Increasing the weight ratio of chitosan with red ginger oleoresin and increase the spray drying inlet temperature, the encapsulation efficiency is also increased. The highest encapsulation efficiency was 99.15±0.02% occurred at 200 °C of spray drying inlet temperature and the weight ratio of chitosan with red ginger oleoresin of 3:1. Morphology analysis of the surface of microcapsules using scanning electron microscope (SEM) showed that the inlet temperature of 200 °C was obtained microcapsules with smooth surfaces. The Fourier transforms infrared spectroscopy (FTIR) analysis results indicating the absence of new compounds is formed.Conclusion: This research indicates that the spray drying conditions affecting the encapsulation efficiency and morphological characteristics of the red ginger oleoresin microcapsules.

Near-field dynamics of high-speed spray dryer coannular two fluid nozzle: Effects of operational conditions and formulations

2018 ◽  
Vol 333 ◽  
pp. 439-448 ◽  
Author(s):  
Sadegh Poozesh ◽  
Stephen W. Grib ◽  
Michael W. Renfro ◽  
Patrick J. Marsac
Keyword(s):  
High Speed ◽  
Near Field ◽  
Spray Dryer ◽  
Operational Conditions ◽  
Two Fluid

Effect of drying parameters on the physical, morphological and thermal properties of spray-dried inulin

2018 ◽  
Vol 38 (8) ◽  
pp. 775-783 ◽  
Author(s):  
Israr Ahmed ◽  
Muhammad Bilal Khan Niazi ◽  
Zaib Jahan ◽  
Salman Raza Naqvi
Keyword(s):  
Molecular Weight ◽  
Spray Drying ◽  
Solid Content ◽  
Inlet Temperature ◽  
Outlet Temperature ◽  
High Concentration ◽  
Scanning Calorimetry ◽  
Modulated Differential Scanning Calorimetry ◽  
Feed Temperature ◽  
Spray Dried

Abstract This study focuses on the thermal, morphological and physical properties of spray-dried chicory root inulin using a thermogravimetric analyzer, environmental scanning electron microscopy, X-ray diffractogram and modulated differential scanning calorimetry. Different spray-drying conditions were investigated by varying inlet temperature, outlet temperature and aspirator speed. The starting material was semicrystalline. A feed temperature of 95°C was employed, which produced a completely transparent solution for spray drying. At that particular temperature, the powder samples obtained were entirely amorphous and morphology resembled each other except for higher solid content. The low glass transition temperature (Tg) (106.83°C) was evident by treating low-molecular-weight samples, whereas high-molecular-weight samples exhibited high Tg (125.81°C). The semicrystalline samples due to the high concentration and milky dispersion exhibited high decomposition temperature. The feed temperature, molecular weight and concentration of the samples tend to have a significant effect on the properties of spray-dried inulin.

scholarly journals Optimization of drying parameters in the microencapsulation of volatile oil from Spiranthera odoratissima leaves

2021 ◽  
Vol 10 (4) ◽  
pp. e57510414322
Author(s):  
Sônia Júlia Oliveira de Souza ◽  
Leonardo Luiz Borges ◽  
Tatiana de Sousa Fiuza ◽  
Suzana Ferreira Alves ◽  
Luiz Carlos da Cunha ◽  
...  
Keyword(s):  
Volatile Oil ◽  
Morphological Properties ◽  
Inlet Temperature ◽  
Drying Process ◽  
Volatile Oils ◽  
Liver Disorders ◽  
Operational Conditions ◽  
Technological Potential ◽  
Physico Chemical ◽  
Spray Dried

Spiranthera odoratissima A. St.-Hil. (Rutaceae), "manacá", is popularly used for head, muscle aches, rheumatism and, stomach, uterine, renal and liver disorders. The aims of this study were to investigate the physico-chemical and morphological properties of microencapsulated powder of volatile oil from S. odoratissima leaves, optimize the drying process and verify the influence of drying parameters on microencapsulation by spray-drying. The volatile oils from leaves were extracting by hydrodistillation in a Clevenger type apparatus and analyzed by GC/MS. The emulsions were prepared and spray-dried. Box-Behnken experimental model was used for optimize the effects of drying parameters on the encapsulation responses. The β-caryophyllene content in the microcapsules was determined by HPLC. The results suggest that the best operational conditions for the atomization drying of S. odoratissima volatile oil were inlet temperature of 158°C, feed flow of 0.25L/h and drying nozzle diameter of 0.7mm. These results reveal the technological potential of the microcapsules obtained from S. odoratissima volatile oils.

scholarly journals A Design of Experiment Approach to Optimize Spray-Dried Powders Containing Pseudomonas aeruginosaPodoviridae and Myoviridae Bacteriophages

Viruses ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1926
Author(s):  
Emilie Tabare ◽  
Tea Glonti ◽  
Christel Cochez ◽  
Cyrille Ngassam ◽  
Jean-Paul Pirnay ◽  
...  
Keyword(s):  
Spray Drying ◽  
Flow Rate ◽  
Gas Flow ◽  
Negative Impact ◽  
Positive Impact ◽  
Inlet Temperature ◽  
Spray Dryer ◽  
Gas Flow Rate ◽  
Residual Moisture ◽  
Spray Dried

In the present study, we evaluated the effect of spray-drying formulations and operating parameters of a laboratory-scale spray-dryer on the characteristics of spray-dried powders containing two Pseudomonas aeruginosa bacteriophages exhibiting different morphotypes: a podovirus (LUZ19) and a myovirus (14-1). We optimized the production process for bacteriophage-loaded powders, with an emphasis on long-term storage under ICH (international conference on harmonization) conditions. D-trehalose-/L-isoleucine-containing bacteriophage mixtures were spray-dried from aqueous solutions using a Büchi Mini Spray-dryer B-290 (Flawil, Switzerland). A response surface methodology was used for the optimization of the spray-drying process, with the following as-evaluated parameters: Inlet temperature, spray gas flow rate, and the D-trehalose/L-isoleucine ratio. The dried powders were characterized in terms of yield, residual moisture content, and bacteriophage lytic activity. L-isoleucine has demonstrated a positive impact on the activity of LUZ19, but a negative impact on 14-1. We observed a negligible impact of the inlet temperature and a positive correlation of the spray gas flow rate with bacteriophage activity. After optimization, we were able to obtain dry powder preparations of both bacteriophages, which were stable for a minimum of one year under different ICH storage conditions (up to and including 40 °C and 75% relative humidity).

Formulation Optimization and Characterization of Spray-Dried Medium Chain Triglycerides-Rich Oil

2021 ◽  
Vol 901 ◽  
pp. 73-78
Author(s):  
Worawut Kriangkrai ◽  
Pitchayut Sararuk ◽  
Thanawat Tothong ◽  
Nattakanwadee Khumpirapang ◽  
Sakchai Wittaya-Areekul
Keyword(s):  
Total Protein ◽  
Particle Morphology ◽  
Inlet Temperature ◽  
Outlet Temperature ◽  
Medium Chain Triglycerides ◽  
Medium Chain ◽  
Mixing Ratios ◽  
Oil Concentration ◽  
Key Variables ◽  
Spray Dried

Medium chain triglycerides (MCT) are important substrates of the energy metabolism and anabolic processes in mammals. In this study, MCT-rich oil was encapsulated in the mixing ratios of maltodextrin and protein by spray drying to produce spray-dried MCT-rich oil (SMCT). Spray-dried conditions were an inlet temperature of 200 °C, an outlet temperature of 90 °C, and a flow rate of 0.70 L/h. Box–Behnken experimental design and response surface methodology were applied for modeling the influence of formulation variables on powder recovery of SMCT. The key variables were concentration of maltodextrin (10-30% W/W), total protein (5–15% w/w), and MCT-rich oil (5–15% w/w). The microparticles were characterized in terms of particle morphology, yield, Carr's index, moisture content, flowability, hygroscopicity, and powder diffraction. The highest yield of SMCT was 41.19% obtained under the optimized conditions (maltodextrin concentration of 15% w/w, total protein concentration of 8% w/w, MCT-rich oil concentration of 15%). Experimentally obtained values were consistent with those predicted by the model, indicating the suitability of the employed model and the success of the model in optimizing the formulation.

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