Features of the clinical course of a new coronavirus infection in students who were under observation in the observatory

2021 ◽  
Vol 24 (4) ◽  
pp. 5-12
Author(s):  
Olga Yu. Kuznetsova ◽  
Anna V. Lubimova ◽  
Karina V. Ovakimyan ◽  
Olga S. Zamyatina ◽  
Nikita V. Donetskov
Keyword(s):  
Prospective Study ◽  
Close Contact ◽  
Severe Disease ◽  
Western State ◽  
The North ◽  
Significant Difference ◽  
Coronavirus Infection ◽  
A Prospective Study ◽  
Medical University ◽  
North Western

The emerging epidemic of a new coronavirus infection (COVID-19), received the status of an emergency of international importance and attracted the attention of not only health professionals, but also the population around the world. Although the risk of severe health consequences from COVID-19 for young people without comorbidities is relatively low, an increase in the incidence of infection in this age group may lead to an increase in the proportion of people with severe disease, as well as the spread of infection among older age groups who are in close contact with them and are at high risk of mortality from COVID-19. The aim of the study was to evaluate the clinical features of the new coronavirus infection among students of the North-Western State Medical University named after I.I. Mechnikov, placed in the observatory. Materials and methods. The study was conducted on the basis of the observatory of the North-Western State Medical University named after I.I. Mechnikov. All persons transferred to the observatory in the period from 21.04.2020 to 31.08.2020, epidemiological and clinical-anamnestic data were recorded. In a prospective study, all participants were asked to complete a Health Questionnaire (EQ-5D) over the phone 3 months after their stay at the observatory. Results. 113 people participated in the study: 45.1% of men (n = 51) and 54.9% of women (n = 62). The average age of the respondents was 22.4 2.5 years. When conducting a multivariate analysis, it was found that gender, age, belonging to an ethno-linguistic group, and chronic diseases are not reliable factors associated with the development of COVID-19 participants. According to the results of a prospective study, a statistically significant difference between the responses of respondents who had and did not have COVID-19 was obtained with a positive answer to the question about the presence of pain and discomfort (p 0.05).

School on HIV infection for future doctors of various specialties Vera HIV med school: importance and value for a young doctor

2021 ◽  
Vol 24 (4) ◽  
pp. 39-44
Author(s):  
Irina R. Abitova
Keyword(s):  
Family Medicine ◽  
Hiv Infection ◽  
Health Sector ◽  
People Living With Hiv ◽  
Young Doctor ◽  
Western State ◽  
The North ◽  
Living With Hiv ◽  
Medical University ◽  
North Western

The article presents a brief overview of the materials received by the author in September 2020 at the School HIV infection for future doctors of various specialties (Moscow), in which she participated as a resident of the Department of Family Medicine of the North-Western State Medical University named I.I. Mechnikov. The goal of the School is to raise the awareness of young doctors on the topic of HIV infection and reduce the level of discrimination against people living with HIV in the health sector.

Opinion of students of medical university on methods of contraception and prevention of unwanted pregnancy

2021 ◽  
Vol 24 (4) ◽  
pp. 19-24
Author(s):  
Anatoliy К. Lebedev ◽  
Elizaveta A. Redka ◽  
Anastasia M. Bugay ◽  
Elizaveta O. Lunenkova ◽  
Maria N. Sokolova
Keyword(s):  
Informed Consent ◽  
Young Women ◽  
Unwanted Pregnancy ◽  
Scientific Research ◽  
State University ◽  
Contraceptive Methods ◽  
Western State ◽  
The North ◽  
Medical University ◽  
North Western

The article analyzes an opinion of 6th grade of young women, the 6th grade medicine students, on the topic of using contraceptive methods for preventing unwanted pregnancy. In the North-Western State University named after I.I. Mechnikov an anonymous poll was conducted by filling specially prepared questionnaires, that included 29 questions and informed consent for using the results of the survey in scientific research. The study included an opinion of 300 6th grade students with the age 22 to 33 years. The results of the survey about the most frequently used contraception methods by 6th grade students was provided as well as the purpose of using certain modern types of contraception, the awareness of students about the chosen methods of contraception.

scholarly journals Tumor Tissue MIR92a and Plasma MIRs21 and 29a as Predictive Biomarkers Associated with Clinicopathological Features and Surgical Resection in a Prospective Study on Colorectal Cancer Patients

2020 ◽  
Vol 9 (8) ◽  
pp. 2509
Author(s):  
Masahiro Fukada ◽  
Nobuhisa Matsuhashi ◽  
Takao Takahashi ◽  
Nobuhiko Sugito ◽  
Kazuki Heishima ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prospective Study ◽  
Surgical Resection ◽  
Tumor Tissue ◽  
Lymphatic Invasion ◽  
Clinicopathological Features ◽  
Stage Iii ◽  
Sample Type ◽  
Significant Difference ◽  
A Prospective Study

Cancer-related microRNAs (miRNAs) are emerging as non-invasive biomarkers for colorectal cancer (CRC). This study aimed to analyze the correlation between the levels of tissue and plasma miRNAs and clinicopathological characteristics and surgical resection. This study was a prospective study of CRC patients who underwent surgery. Forty-four sample pairs of tissue and plasma were analyzed. The miRNA levels were evaluated by RT-qPCR. The level of tumor tissue MIR92a showed a significant difference in CRC with lymph node metastasis, stage ≥ III, and high lymphatic invasion. In preoperative plasma, there were significant differences in CRC with stage ≥ III (MIR29a) and perineural invasion (MIR21). In multivariate analysis of lymphatic invasion, the levels of both preoperative plasma MIR29a and tumor tissue MIR92a showed significant differences. Furthermore, in cases with higher plasma miRNA level, the levels of plasma MIRs21 and 29a were significantly decreased after the operation. In this study, there were significant differences in miRNAs levels with respect to the sample type, clinicopathological features, and surgical resection. The levels of tumor tissue MIR92a and preoperative plasma MIR29a may have the potential as a biomarker for prognosis. The plasma MIRs21 and 29a level has the potential to be a predictive biomarker for treatment efficacy.

scholarly journals A Prospective Study for the Mitigation of the Climate Change Effects: The Case of the North Aegean Region of Greece

2020 ◽  
Vol 12 (24) ◽  
pp. 10420
Author(s):  
Ioannis Chatziioannou ◽  
Efthimios Bakogiannis ◽  
Charalampos Kyriakidis ◽  
Luis Alvarez-Icaza
Keyword(s):  
Climate Change ◽  
Prospective Study ◽  
Adaptation To Climate Change ◽  
Water Shortages ◽  
Sea Levels ◽  
Aegean Region ◽  
Climate Change Effects ◽  
The North ◽  
North Aegean ◽  
A Prospective Study

One of the biggest challenges of our time is climate change. Every day, at different places of the world, the planet sends alarming messages about the enormous transformations it is experiencing due to human-based activities. The latter are responsible for changing weather patterns that threaten food production, energy production and energy consumption, the desertification of land, the displacement of people and animals because of food and water shortages due to the reductions in rainfall, natural disasters and rising sea levels. The effects of climate change affect us all, and if drastic measures are not considered in a timely manner, it will be more difficult and costly to adapt to the aforementioned effects in the future. Considering this context, the aim of this work is to implement a prospective study/structural analysis to the identified sectors of a regional plan of adaptation to climate change so as to promote the resilience of the region against the negative phenomena generated by the climate crisis. This was achieved in two steps: first, we identified the relationships between the strategic sectors of the plan and organized them in order of importance. Second, we assessed the effectiveness of several public policies oriented towards a city’s resilience according to their impact upon the strategic sectors of the plan and the co-benefits generated by their implementation for society. The results highlight that the most essential sectors for the mitigation of climate change are flood risk management, built environment, forest ecosystem management, human health, tourism and rise in sea level. As a consequence, the most important measures for the resilience of the North Aegean Region against climate change are the ones related to the preparation of strategic master plans for flood protection projects.

P–542 Relationship between the single nucleotides polymorphisms in Mitochondrial Nicotinamide Adenine Dinucleotide Hydride dehydrogenase (NADH) Subunit 4 gene (MT-ND4) and male infertility

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
F Dahadhah ◽  
M. Sale Jaweesh ◽  
M. Sali. A Zoubi ◽  
M Issa. Ab. Alarjah ◽  
M Ei Hammadeh ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Male Infertility ◽  
Prospective Study ◽  
Nicotinamide Adenine Dinucleotide ◽  
Mitochondrial Gene ◽  
Genetic Disorders ◽  
Nicotinamide Adenine ◽  
Significant Difference ◽  
Repair Mechanisms ◽  
A Prospective Study

Abstract Study question Is there any association between male infertility and the polymorphic variants of Mitochondrial Nicotinamide Adenine Dinucleotide Hydride dehydrogenase (NADH) Subunit 4 (MT-ND4)? Summary answer Our findings suggested that male infertility was correlated to rs2853495 and rs869096886 SNPs in MTND4. What is known already The rate of mutations in the mtDNA, the powerhouse of the cell, is high due to the lack of histones and DNA repair mechanisms. Therefore, mutations that occur in the mitochondrial genome, play a major role in some human genetic disorders. 15 - 30% of male infertility are related to genetic predisposition. Sperm containing defective mitochondria cannot effectively produce ATP and more likely to produce reactive oxygen species (ROS) and free radicals, thereby causing a defect in mtDNA, make trouble energy, and deteriorate motility and fertility. Study design, size, duration: A prospective study carried out between 2018 and 2019. 112 semen samples were collected in this study. Participants/materials, setting, methods The present study was carried out at the department of Obstetrics and Gynecology, University of Saarland, Germany. Samples were divided into 68 subfertile and 44 fertile men. Mitochondrial DNA was extracted using a QIAamp DNA Mini Kit, after that the mtDNA was amplified by using REPLI-g Mitochondrial DNA Kit. Polymerase chain reaction (PCR) was used to amplify MT-ND4 gene. Then, samples were purified and sequenced using the Sanger method in the Microsynth Seq lab, Germany. Main results and the role of chance The genotypes frequencies of the study population showed a statistically significant association between rs2853495 G>A (Gly320Gly) and male infertility (P = 0.0351). Similarly, the allele frequency test showed that rs2853495 G>A (Gly320Gly) and rs869096886 A>G (Leu164Leu) were significantly associated with male infertility (adjusted OR = 2.616, 95% CI = 1.374 - 4.983, P = 0.0028; adjusted OR = 2.237, 95% CI = 1.245 - 4.017, P = 0.0073, respectively). On the other hand, no statistically significant difference was observed between the asthenozoospermia, oligozoospermia, teratozoospermia, asthenoteratozoospermia, oligoasthenoteratozoospermia, oligoteratozoospermia subgroups of subfertile males and the fertile ones. Limitations, reasons for caution The size number of the study samples. Wider implications of the findings: A larger prospective study will be required to confirm these associations of mitochondrial gene polymorphisms rs2853495 and rs869096886 in MT-ND4 and male infertility and to clarify the definite effect of the mitochondrial genetic variations on male infertility. Trial registration number Not applicable

scholarly journals Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis: A Prospective Study

Medicina ◽  
2011 ◽  
Vol 47 (4) ◽  
pp. 28 ◽  
Author(s):  
Ahmed Fahim ◽  
Peter Dettmar ◽  
Alyn Morice ◽  
Simon Hart
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Gastroesophageal Reflux ◽  
Prospective Study ◽  
Antibody Detection ◽  
Extraesophageal Reflux ◽  
Reflux Symptoms ◽  
Significant Difference ◽  
H Pylori ◽  
A Prospective Study

Background and Objective. Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. There is evidence of the increased prevalence of gastroesophageal reflux disease in patients with IPF. The aim of this prospective study was to evaluate reflux in patients with IPF by analyzing the scores of the reflux cough questionnaire, measurement of pepsin in exhaled breath condensate (EBC) to detect extraesophageal reflux, and Helicobacter pylori serology to evaluate the prevalence of this stomach bacterium in patients with IPF. Material and Methods. The Hull airway reflux questionnaire (HARQ) was completed by 40 patients with IPF and 50 controls in order to evaluate reflux symptoms. EBC was collected from 23 patients (17 patients with IPF and 6 controls) for measurement of pepsin by the lateral flow technique. A prospective study of 57 subjects (34 patients with IPF and 23 controls) for H. pylori antibody detection by ELISA was performed. Results. Significantly higher HARQ scores (maximum score, 70) were recorded in patients with IPF compared with controls (19.6 [SD, 12.4] vs. 3 [SD, 2.9], P<0.001). There was no significant difference in EBC pepsin positivity between patients with IPF and controls (2 of the 17 patients vs. none of the 6 controls, P=0.38). There was no significant difference in H. pylori serology between patients with IPF and controls (17 of the 34 patients vs. 14 of the 23 controls, P=0.42). Conclusion. Patients with IPF had significantly increased scores of airway reflux symptoms. However, no objective evidence of extraesophageal reflux or H. pylori infection in patients with IPF was obtained in this study. The role of gastroesophageal and extraesophageal reflux in pathogenesis of IPF should be evaluated in a larger prospective study.

scholarly journals Screening of epileptic seizures in children and adolescents with hydrocephalus and ventriculoperitoneal shunt

2009 ◽  
Vol 15 (3) ◽  
pp. 106-109 ◽  
Author(s):  
Raimundo Francisco de Amorim Júnior ◽  
Suerda Emiliana Cavalcanti Dantas ◽  
Rodrigo de Holanda Mendonça ◽  
Abdiel de Lira Rolim ◽  
Maria Luiza de Carvalho Jales ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Data Analysis ◽  
Prospective Study ◽  
Children And Adolescents ◽  
Ventriculoperitoneal Shunt ◽  
Epileptic Seizures ◽  
Significant Difference ◽  
A Prospective Study ◽  
Larger Sample ◽  
Diagnosis Age

OBJECTIVES: To assess the occurrence of epileptic seizures (ES) in children and adolescents with hydrocephalus and their relationship with ventriculoperitoneal shunt (VPS) treatment. METHODS: Retrospective study of 45 patients from both genders, aged 0 to 18 years, with hydrocephalus and presenting with ES or not. The following variables were analyzed: gender, hydrocephalus etiology, age at diagnosis, age at initial VPS treatment, age at first ES and types of ES. RESULTS: Data analysis showed the following: 20 (44.4%) presented with ES, 13 (65%) of the girls and seven (35%) of the boys. There was a predominance of ES in the girls, but with no statistically significant difference. In total, 13 (65%) patients used VPS. Of the 13 patients with VPS and ES, it was observed that the onset of ES was after VPS in 10 (76.9%) individuals, whereas it occurred before VPS in two (15.4%). CONCLUSIONS: The results showed no association between VPS treatment and ES (ρ=0.832); however, most of the patients presented with their first ES episode after VPS, suggesting a possible relationship between this treatment and the occurrence of ES. A larger sample and a prospective study might answer this question.

scholarly journals A prospective study on outcome of function after proximal row carpectomy

2019 ◽  
Vol 6 (1) ◽  
pp. 44
Author(s):  
Chaitanya Gadi ◽  
S. M. Venugopal ◽  
Bhaskaranand Kumar ◽  
Karthik Gudaru
Keyword(s):  
Prospective Study ◽  
Grip Strength ◽  
Neuromuscular Disorders ◽  
Wrist Flexion ◽  
Proximal Row Carpectomy ◽  
Significant Difference ◽  
Post Traumatic ◽  
A Prospective Study ◽  
Traumatic Arthritis

<p class="abstract"><strong>Background:</strong> Proximal row carpectomy (PRC) is a procedure with varied indications. The purpose of this study was to evaluate functional outcomes with PRC in wrist flexion deformities, neuromuscular disorders and also post-traumatic wrist arthritis.</p><p class="abstract"><strong>Methods:</strong> A prospective study was performed on all patients who underwent PRC between April 2015 and December 2017, in BIRRD (T) hospital, Tirupati, Andhra Pradesh with a minimum follow up of 6 months. Outcome was assessed in terms of range of motion (ROM), grip strength, quick disabilities of the arm, shoulder, and hand (QDASH) score and pain score. Data was analyzed using the Student t-test.<strong></strong></p><p class="abstract"><strong>Results:</strong> Thirty-two patients underwent PRC of which 12 are neuromuscular disorders, 10 are wrist flexion deformities, 10 are post-traumatic wrist arthritis. On the final follow-up, significant improvement in ROM was observed in wrist flexion deformities and neuromuscular disorders, whereas grip strength and QDASH scores showed a significant difference in post-traumatic wrist arthritis. Pain was studied only in post-traumatic wrist arthritis, all were very much pleased with pain reduction.</p><p class="abstract"><strong>Conclusions:</strong> PRC is fairly a reliable procedure for all the indications in our study. We consider that PRC is a promising procedure in correcting wrist flexion deformities. Though there has been significant improvement in all the parameters for all the cases, we consider this procedure is best suited for post-traumatic arthritis group.</p>

scholarly journals Steatocrit Value in New-Born Babies

2018 ◽  
Vol 35 (7-8) ◽  
pp. 190-3
Author(s):  
Johnwan Usman ◽  
Irfan Abdullah ◽  
Muhazar Muhazar ◽  
Atan Baas Sinuhaji ◽  
A. H. Sutanto
Keyword(s):  
Body Weight ◽  
Breast Milk ◽  
Prospective Study ◽  
The Body ◽  
Milk Formula ◽  
Preterm Newborn ◽  
Formula Milk ◽  
Diet Patterns ◽  
Significant Difference ◽  
A Prospective Study

A prospective study on steatocrit value in full-term or preterm newborn babies of~ 2 days of age in Dr. Pimgadi Hospital, Medan is reported. This study was conducted from December 7, 1992, to February 7, 1993; there were 72 newborn babies (37 males and 35 females). The body weight was> 2500 gin 60 babies and s. 2500 gin 12 babies. The median steatocrit value in babies with body weight of> 2500 g was 9%, and it was 32% in babies less than 2500 g of body weight. The proportion of babies with > 25% steatocrit value was larger in babies less than 2500 g than that in 2500 g by the diet patterns of breast milk, breast milk and milk formula, milk formula. The proportion of babies with < 25% steatocrit value was higher in babies with body weight of< 2500 g than that in babies > 2500 g for those who had either breast milk, breast milk and milk formula or milk formula. There was significant difference (p<0,05) in the steatocrit levels between babies with the body weight of > 2500 g and those who had body weight of ≤ 2500 g.

scholarly journals Prospective study of strongyloidosis in patients with hematologic malignancies

1997 ◽  
Vol 30 (5) ◽  
pp. 355-357 ◽  
Author(s):  
Carlos Graeff-Teixeira ◽  
Cristina S.M. Leite ◽  
Cristina L. Sperhacke ◽  
Katia Fassina ◽  
Simone M.G. Petry ◽  
...  
Keyword(s):  
Prospective Study ◽  
Hematological Malignancies ◽  
Severe Disease ◽  
Strongyloides Stercoralis ◽  
Hematologic Malignancies ◽  
Porto Alegre ◽  
Stool Samples ◽  
A Prospective Study ◽  
Disseminated Disease ◽  
Baermann Method

Immunocompromised individuals infected with Strongyloides stercoralis may develop severe hyperinfection or disseminated disease with high mortality. Patients with hematological malignancies are at risk because of immunodepression produced either by the disease or its treatment. A prospective study was undertaken at the Hospital de Clínicas de Porto Alegre, from July 1994 to July 1995. Seventy-two (HIV negative), had 3 stool samples collected at different days and had not received recent anti-helmintic therapy. Larvae, isolated in a modified Baermann method, were found in 6 patients, with a resultant prevalence of 8.3%. No complicated strongyloidosis was documented. The positive result for S. stercoralis larvae was significantly associated (p < 0.001) with eosinophilia. Knowledge of prevalence figures and incidence of severe disease is important to adequate guidelines for empirical treatment besides the rigorous search for strongyloidosis in patients with hematological malignancies.

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