scholarly journals Efficacy and safety of panchgavya GHRIT along with flunarizine in prophylaxis for migraine patients: a comparitive study

Author(s):  
Mohit Trivedi ◽  
Vishal Dixit ◽  
Syed Esam Mahmood ◽  
Sunil Kumar Mishra ◽  
S. S. Keshari

Background: Propranolol and flunarizine have proven to be useful tools in migraine prophylaxis. This trial aims the comparison of the efficacy of flunarizine, flunarizine and placebo and flunarizine and panchgavya ghrit in migraine prophylaxis.Methods: The present study was a prospective, randomized, open-label, blinded-endpoint trial. Patients with chronic migraine were randomized (1:1:1) to flunarizine and flunarizine and placebo and flunarizine and panchgavya ghrit in three treatment groups. The study was carried out in outdoor patients in the department of Psychiatry, T.S. Mishra Medical College and Hospital, Lucknow and K.G.M.U, Ayush Department, Lucknow after clearance from Institutional Ethical Committee. Data was analysed using SPSS software.Results: The prevalence of migraine was found to be higher in the age group greater than 30 years and females. Overall there was more reduction in CGI scores in flunarizine with panchgavya ghrit and the other two groups equally at the end of 4, 6 8 and 10 weeks. Decrease in MIDAS score was observed after the therapy. Clinical Global Impression rating scale employed revealed that to start with subjects scored 7 which stands for pathology interfering in many life functions which reduced drastically in Group C as compared to Group B and Group A in descending order. Pain scales namely VAS (visual analogue scale), NPRS (Numeric Pain Rating Scale), VRS (verbal rating scale) when employed denoted there was decreased migraine frequency, decreased perception of pain, less intake of abortive medication consumed by subjects implying there were reduction in number of migraine days and there was decrease in the abortive medications taken for the same. Group C scored better on pain scales followed by Group B and Group A. Lower proportion of individuals in group C had Behavioural Toxicity and Neurological Side effects as compared to Group A and B.Conclusions: Panch gavya ghrit when administered along with flunarizine was more efficacious and safe when compared with other two groups. However large multicentric RCTs of long duration and involving more number of subjects are required to ascertain these facts.

2021 ◽  
Vol 15 (8) ◽  
pp. 2442-2444
Author(s):  
Nighat Nasrullah Khan ◽  
Saima Riaz ◽  
Rehan Ramzan Khan ◽  
Hira Mannan ◽  
Sobia Ghafoor ◽  
...  

Objective: To compare the effects of aerobics and core stability exercises for the management of primary dysmenorrhea. Methodology: The study design was quasi-experimental, conducted in Yahya gym, Lahore, from February 2019 to July 2019. The sampling technique employed was non-probability convenient sampling with a sample size of 42 females within 18-30 years who had primary dysmenorrhea. The subjects were assigned into two groups. Group A was treated with aerobic exercises, while Group B was treated with core stability exercises with eight weeks workout plan and the results of three menstrual cycles were recorded. Stretching maneuvers were added as a standard treatment to both groups. Data were collected after 12 weeks and recorded for three menstrual cycles. Numeric Pain Rating Scale (NPRS) was used to measure pain intensity. Data were analyzed using IBM SPSS v.25. Results: Mean age of group A vs. group B participants was 25.23 ±2.64 vs. 21.38±3.41 years respectively. Mean BMI score of group A participants was 21.38±2.14 while for group B participants mean BMI score was 21.65±1.99 Kg/m2. Conclusion: This study concludes that both aerobic exercises and core stability exercises are effective to reduce the intensity of pain in primary dysmenorrhea. However aerobic exercises showed relatively better results in term of mean difference of NPRS score across both groups. Keywords: Menstruation, Primary dysmenorrhea, Exercise, Pain.


2021 ◽  
Vol 14(63) (1) ◽  
pp. 209-216
Author(s):  
G.S. IACOB ◽  
◽  
D. VRABIE ◽  
V.I. STEGARIU ◽  
◽  
...  

Hamstring strains are usually a result of a high mechanical stress produced by a quick extensive contraction or a violent stretch of the muscle group. This study aimed the effectiveness of INDIBA therapy (Group B) compared with the use of TECAR therapy (Group A). The first stage of rehabilitation represented first two weeks which were mainly based on the application of radiofrequency therapies to the posterior level of the thigh, progressive exercises and cryotherapy. Numeric Pain Rating Scale, manual muscle testing and range of motion had been used to evaluate the subjects, a significant advantage being shown for group B in the pain assessment


Author(s):  
Priti A. Mehendale ◽  
Mayur T. Revadkar

Background: There is evidence regarding beneficial use of Transcutaneous Electrical Nerve Stimulation (TENS) on post Lower Segment Caesarean Section (LSCS) incision pain. However, efficacy of different types of TENS following C section pain has not yet been explored adequately.Methods: 96 women who had recently undergone LSCS were included for the study. The subjects were in the age group of 20 to 40 years (25.84±3.96); having pain intensity 4 or more on Numerical Pain Rating Scale (NPRS). They were divided into three groups by random allocation method; namely Group A: Acupuncture (Low/Motor) TENS, Group B: Conventional (High/Sensory) TENS and Group C: Control group. Group A and B received specific type of TENS twice a day for 15 minutes. Control group C did not receive any TENS intervention. All subjects received standard post-operative medications and physiotherapy. Pain intensity was recorded on NPRS pre and post intervention.Results: Both Acupuncture TENS and Conventional TENS significantly decreased post-operative pain intensity as compared to control group (p value <0.0001).Conclusions: Both, acupuncture and conventional TENS are equally effective in reducing post LSCS incision pain at a strong and non-painful intensity.


Author(s):  
Mohammed Ziauddin Sarkhil ◽  
Hemant Kumar Dutt ◽  
Rajaram S.

Background: Preemptive analgesia, involves the introduction of an analgesic regimen before the onset of noxious stimuli, with the goal of preventing sensitization of the nervous system to subsequent stimuli that could amplify pain.Methods: To determine the efficacy and safety of Lornoxicam when administered preemptively by using Wong-Baker FACES Pain Rating scale. The patients undergoing abdominal surgery were randomly categorized into group A and B of 25 each. Group A- Received Lornoxicam 8mg (1ml) one hour before surgery. Group B- Not received any analgesic before surgery. Primary measurement of the efficacy was done by using Wong-Baker Faces Pain Rating Scale at 2, 4, 8, 12 and 24 hour. All parameters were analyzed by using student t test.Results: Surgeries which were included in the study are hernia repair, open appendectomy, laparoscopic (appendectomy, cholecystectomy). Reduction in pain scores at 12th hourly and 24th hourly pain scores (<0.05) was significant. Tramadol usage decreased significantly with laparoscopic surgeries.Conclusions: In this study we could demonstrate that lornoxicam when used preemptively reduces the pain score slightly and reduces the requirement of post-operative analgesics significantly.


2020 ◽  
Vol 7 (4) ◽  
pp. 643
Author(s):  
Nirmal Arya ◽  
Anuradha Nischal ◽  
Anil Nischal ◽  
Manu Agarwal

Background: Depression is a mood disorder treated with various antidepressant such as SSRIs due to lesser toxicity and improved safety profile.Methods: This was an eight week randomised active controlled parallel group study. 54 patients were allocated in two group. Group A received vilazodone while group B received sertraline. Assessment done at baseline, 2, 4 and 8 weeks on the basis of clinical efficacy, sexual dysfunction, side effects and weight gain using Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), Arizona Sexual Experience Scale (ASEX) and UKU Side Effect Rating Scale.Results: HAM-D score of group A was 18.78±1.78 and 7.67±1.66 while in group B was 19.04±2.12 and 8.15±1.77 at baseline and 8 weeks respectively. HAM-A score of group A was 15.44±1.50 and 6.63±1.39 while in group B was 15.26±1.83 and 7.07±1.14 at baseline and 8 weeks. ASEX total score of group A was 15.63±1.28 and 14.63±1.33 while group B was 15.52±1.37 and 16.41±1.12 at baseline and 8 weeks. ASEX desire score of group A was 9.63±0.93 and 8.67±0.88 while of group B was 9.59±0.93 and 10.07±0.92 at baseline and 8 weeks. UKU side effect rating at 2 and 8 weeks of group A was 0.22±0.42, 1.04±0.76 while in group B was 0.37±0.49, 1.89±0.85.Conclusions: Vilazodone and Sertraline are equally efficacious in treatment of depression and associated anxiety. When side effect profile were compared Vilazodone is found superior to Sertraline


2021 ◽  
Vol 15 (1) ◽  
pp. 51-54
Author(s):  
Muhammad Sheraz Javed ◽  
◽  
Ghulam Mehboob Subhani ◽  
Muhammad Akmal ◽  
Muhammad Irfan Munir ◽  
...  

Background: Kidney stones has got high prevalence worldwide especially in our part of world and per-cutaneous nephrolithotomy (PCNL) is gold standard operative modality for renal stone management. Pain control after PCNL is the most important task for treating surgeon as effective pain control causes smooth patient recovery in post-operative period. For analgesia, many drugs can be used, out of which tramadol and nalbuphine always been in comparison for effective analgesic activity. Objective: To compare efficacy of tramadol and nalbuphine as potent analgesic in patients after PCNL. Study Design: A prospective randomized study. Settings: Department of Urology and Kidney Transplantation, Allied Hospital/Faisalabad Medical University, Faisalabad and Department of Urology, DHQ Hospital/Faisalabad Medical University, Faisalabad Pakistan. Duration: From September 2016 to September 2020 (4 Years). Methodology: 286 patients undergoing PCNL for either gender and sides enrolled in study according to inclusion and exclusion criteria. Patients divided into Group A (Administered with tramadol) and Group B (administered with nalbuphine) and patients evaluated for pain up to 48 hours after surgery using 11-point numerical pain rating scale rating from0-10 where 0 is no pain, 1-3 mild pain, 4-6 moderate pain, 7-9 severe pain and 10 as worst pain and use of rescue analgesia observed in either groups. Data obtained and statistical evaluation done. Results: 286 patients enrolled from age 15-75 years with mean age of 40.2 years. Among 286 patients, 161 were male and 125 were female patients. Both groups A and B having 143 patients each. Analysis showed that tramadol has superiority over nalbuphine and need of analgesia is more in patient given nalbuphine (118 vs 31) as maintenance analgesic agent in post-operative period after PCNL. Conclusion: This study showed that tramadol has superiority over nalbuphine for analgesia after PCNL.


2021 ◽  
pp. 54-55
Author(s):  
Abhishek Raj ◽  
Awadhesh Kumar Jha ◽  
Debarshi Jana

Aim: To determine the efcacy of combination of vitamin B1, B6 and B12 in the management of diabetic peripheral neuropathy. Methods: Patients of diabetes mellitus with diabetic peripheral neuropathy were selected from Department of Medicine, Govt. Medical College and Hospital, Bettiah, W. Champaran, Bihar and study done at Pharmacology Department of GMC, Bettiah, W. Champaran, Bihar. The duration of study was six months from March 2019 to August 2019. Patients were prescribed Tab Neurobion (vitamin B1 100mg, vitamin B6 100mg, Vitamin B12 200mcg) twice a day for a period of 4 weeks (28 days). Follow up visit was scheduled on 28th day of the initial visit. Efcacy was judged by documenting improvement in pain of at least 2 points from the baseline as assessed by numeric pain rating scale. Mean age of the patients was observed Results: 46.7±8.6 years. Out of 310 cases, 177 patients (57.0%) were male and remaining 133 patients (43.0%) were female. Duration of diabetes as follows: 83 patients (26.8%) had duration of 0-10 year, 139 patients (44.8%) had 11-20 year, 77 patients (24.8%) had 21-30 year and 11 patients (3.6%) had >30 years of duration. Combination of vitamin B1, B6 and B12 in the management of diabetic peripheral neuropathy was found to be efcacious in 271 patients (87.4%). Treatment with combination of vitamin B1, B6 and B12 Conclusion: appeared to improve pain relief among patients with diabetic peripheral neuropathy.


2021 ◽  
Vol 11 (10) ◽  
pp. 46-59
Author(s):  
Priyanka Chauhan ◽  
Pooja Attrey ◽  
Anand Kumar Singh

Background: Mechanical neck pain (MNP) is the most common type of pain confined in the posterior aspect of neck, also known as nonspecific or simple neck pain affecting two thirds of the general population at some time in their lives. Prevalence: Neck pain is most common muscular skeletal condition affecting up to 70% of individual and 5% to 10% of adults having a disabling neck pain problem. Neck pain is more common in women than men. The prevalence of neck pain in the general population has been reported to be 15% for men and 23% for women. Objectives of the Study: To find out the effect of Post Isometric Relaxation (PIR) along with Deep Neck Flexor (DNF) exercises in reducing pain and disability and improving ROM in patient with sub-acute mechanical neck pain. To find out the effect of Deep Neck Flexor exercise alone in reducing pain and disability and improving ROM in patient with sub-acute mechanical neck pain. To compare whether Post Isometric Relaxation (PIR) along with Deep Neck Flexor exercises or Deep Neck Flexor exercises alone are effective in reducing pain and disability and improving ROM in patient with sub-acute mechanical neck pain Methods: Study included 30 patients with lateral epicondylitis between ages 30-50 years. The subjects were randomly divided into 2 groups: Group-A and Group-B. Group A (n = 15) was treated using Cyriax physiotherapy, group B (n = 15) was treated with movement with mobilization. Patients were treated for 3 times a week for 4 weeks. Outcome measures are NPRS (Numeric Pain Rating Scale) and DASH (The Disabilities of the Arm, Shoulder and Hand). Results: The results of the study indicate that there were highly statistically significant improvement in functional disability on NDI, cervical lateral flexion(Right & Left), rotation (Right & Left) ROM and reduction in pain on VAS in Group-A as compared to Group-B. There was no significant difference observed when the groups were compared for cervical flexion and extension ROM. Conclusion: From the result it is concluded that Post isometric relaxation with DNF exercise is effective in mechanical neck pain. Key words: Mechanical neck pain (MNP), Post Isometric Relaxation (PIR), Deep Neck Flexor (DNF) exercise.


2021 ◽  
pp. 55-56
Author(s):  
Manasi Bhutani ◽  
Tanvi Patole

Background: The number of people is now becoming extremely health conscious hence taking up activities like marathons, sprinting and other forms of exercises to full recreational and tness needs. With an increasing number of sprinters chances of developing shin splints become higher. Warm ups, stretching and kinesio taping are great preventive measures and treatment protocols. Methodology: Group A received dynamic stretching and group B received dynamic stretching and kinesio taping. Outcome measures were time taken in seconds and pain intensity using Numerical Pain Rating Scale (NRS). Conclusion: Dynamic stretching along with Kinesio taping resulted in greater improvement in the 30-meter running time as compared to just dynamic stretching.


Author(s):  
Sowmya Sowmya ◽  
Jibu George Varghese ◽  
Poornima Poornima ◽  
Vikram Adhitya P.S.

Plantar fascitis is one of the most common cause of heel and foot pain, calcaneal taping technique places the foot in improved biomechanical position by re-positioning the calcaneal alignment closure to neutral and increasing the medial longitudinal arch height, thus reduce stress and pain. Hence this study is proposed to determine the effect of calcaneal taping technique in plantar fascitis. Total of 30 subjects diagnosed with planter fascitis was selected according to the inclusion and exclusion criteria and informed consent were obtained from the subjects involved in the study. Subjects were consecutively allocated to 2 Groups of 15 subjects each by odd and even method. Subjects in Group A (Conventional) was treated with ultrasound along with plantar fascia stretching. Group B (Experimental) was treated with ultrasound along with plantar fascia stretching and calcaneal taping technique. Patients were measured for pain with Numerical Pain Rating scale (NPRS), and functional ability measure with foot and ankle ability measure (FAAM). From statistical analysis made with the quantitative data revealed statistically significant difference between Pretest and posttest values of Group A and Group B. it has been concluded that ultrasound therapy along with plantar fascia stretching and calcaneal taping technique (Group B-Experimental group) was found to be more effective than ultrasound therapy and plantar fascia stretching (Group A-conventional group) reduces pain in the heel and increasing functional ability of the foot.


Sign in / Sign up

Export Citation Format

Share Document