scholarly journals Effect of a hydroethanol 70% extract from trunk bark of Terminalia superba Engl. and diels (combretaceae) on some serum biochemical parameters in rats

2017 ◽  
Vol 6 (6) ◽  
pp. 1242
Author(s):  
Goze N. Bernard ◽  
N’Dri N. Mathieu ◽  
Yapo A. Paul
Keyword(s):  
Biochemical Parameters ◽  
Direct Bilirubin ◽  
Female Rats ◽  
Control Group ◽  
High Dose ◽  
Distilled Water ◽  
Serum Biochemical Parameters ◽  
Group A ◽  
Serum Biochemical ◽  
Terminalia Superba

Background: In the framework of the valorization of traditional medicine, the biotolerance study of a hydroethanol 70% extract from trunk bark of Terminalia superba (HE 70%) Engl. and Diels (Combretaceae), a medicinal plant used for the treatment of gastric ulcer in Côte d'Ivoire was carried out by oral administration repeated for 28 days to three rat groups at doses 250, 500 and 750 mg/kg per body weight (b.w.).Methods: Fifty rats were randomly divided in four groups of ten animals including three test groups and one control group. Each group included five male and five female rats. An additional satellite group of ten rats in group treated at high dose (750mg/kg b.w.) was included in order to observe reversibility, persistence or late appearance of toxic effects at least 14 days after stopping the treatment. Three doses were prepared (250; 500 and 750mg/kg b.w.) corresponding to extract concentrations (12.5; 25 and 37.5mg/ml) were given to groups B, C and D respectively. Group A, served as control group, received distilled water at 2ml/kg b.w. Groups B, C and D, received orally HE 70% extract at 250, 500 and 750mg/kg respectively. Serum AST, ALT, total and direct bilirubin, total, HDL, LDL-cholesterols, triglycerides, urea and creatinine were estimated using standard methods.Results: The blood withdrawal analysis done previously (day 0) and at the end of every week on dry tubes revealed that at all weeks and for all doses, this extract do not affect serum values of total and direct bilirubin, creatinine, total, HDL, LDL-cholesterols and triglycerides. Oppositely, this extract reduced significantly (P<0.05) ALT serum rate at the 14th and 28th day at 750mg/kg b.w. respectively. In addition, at the 28th day, AST rate decreased significantly (P<0.05) at 750mg/kg b.w. Glycemia showed a significant (P <0.05) reduction at the 28th day at doses 500 and 750 mg/kg b.w. In contrast, urea increased significantly (P<0.05) at the 28th day at 500mg/kg b.w.Conclusions: This study showed that the use of a hydroethanol 70% extract from trunk bark of T. superba would be hepatoprotective, nontoxic for kidneys, liver and hypoglycemic at the studied doses.

scholarly journals Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Zhenqiang You ◽  
Junying Sun ◽  
Feng Xie ◽  
Zhiqin Chen ◽  
Sheng Zhang ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Oxidative Dna Damage ◽  
Mammary Glands ◽  
Estradiol Benzoate ◽  
Female Rats ◽  
Control Group ◽  
High Dose ◽  
Protective Effects ◽  
Treatment Groups ◽  
Group A

Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts. In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen. Rats were randomly divided into 6 groups, including a control group, an FPE-alone group, a model group, and three FPE treatment groups (each receiving 30, 15, or 5 ml/kg FPEs). Severe mammary gland hyperplasia was induced upon estradiol benzoate and progestin administration. FPEs could improve the pathological features of the animal model and reduce estrogen levels in the serum. Analysis of oxidant indices revealed that FPEs could increase superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, decrease malondialdehyde (MDA) level in the mammary glands and serum of the animal models, and decrease the proportion of cells positive for the oxidative DNA damage marker 8-oxo-dG in the mammary glands. Additionally, estradiol benzoate and progestin altered the levels of serum biochemical compounds such as aspartate transaminase (AST), total bilirubin (TBIL), and alanine transaminase (ALT), as well as hepatic oxidant indices such as SOD, GSH-Px, MDA, and 8-oxo-2′-deoxyguanosine (8-oxo-dG). These indices reverted to normal levels upon oral administration of a high dose of FPEs. Taken together, our results indicate that FPEs can protect the mammary glands and other visceral organs from oxidative damage.

scholarly journals The effect of camel milk curd masses on rats blood serum biochemical parameters: Preliminary study

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0256661
Author(s):  
Fatima Dikhanbayeva ◽  
Elmira Zhaxybayeva ◽  
Zhuldyz Smailova ◽  
Arman Issimov ◽  
Zhechko Dimitrov ◽  
...  
Keyword(s):  
Blood Serum ◽  
Total Protein ◽  
Biochemical Parameters ◽  
Camel Milk ◽  
Control Group ◽  
Serum Biochemical Parameters ◽  
Group V ◽  
Group I ◽  
Serum Biochemical ◽  
Group Ii

This study aimed to assess potential feeding effect of camel milk curd mass and its mixes to experimental rat’s blood serum biochemical parameters, enzymatic activity and the peptide toxicity. Fifty healthy male Sprague-Dawley rats were divided into five groups (n = 10 each). Each group was fed with camel milk pure curd mass and its mixes for 16 days. At the end of the experiment, rats were sacrificed to collect the samples from the blood serum. Blood serum biochemical parameters total protein, cholesterol, glucose, albumin, triglycerides; the enzymatic activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase were determined on the A25 automatic analyser, and peptide toxicity analysed by the reference method. The statistical data have shown no significant differences in body weight gain in all groups. Total protein decreased in group II, IV, and V; however, it increased in group III compared to the control group. Cholesterol grew up in group II and it slightly increased in group V, dropped in groups III and IV compared to group I result. Glucose increased in groups II, III, IV compared to group I; still, group V results show a slight decrease. Albumin decreased in group IV, yet in group V it increased than the group I result. Simultaneously, groups II and III results were changed with less percentage. Triglyceride grew up in groups II, V, and it dropped significantly in groups III, IV compared to the control group. De Ritis ratio of enzymes in groups II, III, and IV fluctuated between 1.31 and 0.98 IU/L; however, group V demonstrated significant data versus group I. Diets peptide toxicity in all groups was lower than control group data. The experimental results indicated that curd mass from camel milk could be used as a pure or with additives and it did not discover the observed side effects.

scholarly journals Effects of feeding varying levels of fufu sieviate meal based diets with Panicum maximum basal on the blood characteristics of West African dwarf goats

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Peter-Damian Chukwunomso Jiwuba ◽  
Ekeno Michael Assam ◽  
Eka Christian Inyang
Keyword(s):  
Biochemical Parameters ◽  
West African ◽  
Control Group ◽  
Panicum Maximum ◽  
Serum Biochemical Parameters ◽  
West African Dwarf ◽  
West African Dwarf Goats ◽  
Serum Biochemical ◽  
Biochemical Indices ◽  
Dwarf Goats

The effects of fufu sieviate meal based diets at 0%, 20%, 40% and 60% levels using Panicum maximum as the basal on the haematological and serum biochemical parameters of West African dwarf (WAD) goats were studied for 87 days. Thirty six blood samples were collected from the WAD goats and their haematological and serum biochemical indices were determined using Beckman Coulter Ac-T10 Laboratory Haematology Blood Analyzer and Bayer DCA 2000+ HbA1c analyzer, respectively using a completely randomized design. Packed cell volume (PCV) was better (p<0.05) at T1 than the other treatments. Red Blood Cell (RBC) and mean corpuscular haemoglobin (MCH) were numerically improved at T2, T3 and T4 than in the control group while lymphocyte increased significantly (P<0.05) with increasing levels of the test ingredient. Results on serum biochemical indices showed that serum urea, creatinine, glucose and ALP differed significantly (P<0.05) and tended to be higher in the treatment (T2, T3 and T4)groups than the control group. The study therefore revealed that inclusion of fufu sieviate in the diets of West African Dwarf goats had no deleterious effects on the haematological and serum biochemical parameters of WAD goats and could be included up to 60% in goat diets.

Effect of Thermal Stress on Serum Biochemical and Haematological Parameters in Broiler Chicken

2017 ◽  
Vol 12 (3) ◽  
Author(s):  
A. K. Chaturvedani ◽  
Sudhir Kumar Jaiswal ◽  
Meesam Raza
Keyword(s):  
Thermal Stress ◽  
Treatment Group ◽  
Biochemical Parameters ◽  
Broiler Chicken ◽  
Room Temperature ◽  
Haematological Parameters ◽  
Control Group ◽  
Serum Biochemical Parameters ◽  
Serum Biochemical

The present study was conducted to assess the effects of thermal stress on the serum biochemical and haematological parameters in broiler chicken. Forty CARIBRO- Vishal broiler chicken were divided into two groups with twenty birds each. The control group was kept at room temperature and treatment group was exposed to thermal stress under 40±1 °C for 4 hours at 35 day of age. The exposure of thermal stress significantly increased (P less than 0.05) the value of serum biochemical parameters (glucose, cholesterol and triglyceride), heterophills, H/L ratios and basophills, however the value of total leukocyte, haemoglobin, haematocrit value, and monocytes decreased significantly (P less than 0.05).

​A Study on Alteration in Serum Biochemical Parameters in Colibacillosis Affected Diarrhoeic Cattle Calves

2021 ◽  
Author(s):  
T.C. Nayak ◽  
A.P. Singh ◽  
A. Chahar ◽  
Savita . ◽  
R. Yadav ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Control Group ◽  
Serum Biochemical Parameters ◽  
Serum Samples ◽  
Clinically Normal ◽  
Serum Biochemical ◽  
Result Analysis ◽  
G Ratio

Background: The objective of the present study was to evaluate the changes in serum biochemical parameters in colibacillosis affected diarrhoeic cattle calves below one month of age. Methods: The study was undertaken at Veterinary Clinical Complex, College of Veterinary and Animal Science, Rajasthan University of Veterinary and Animal Sciences, Bikaner, Rajasthan, India, during the period from September 2018 to March 2019. A total of 32 calves affected with colibacillosis confirmed on the basis of Multiplex PCR (for presence of K99, Stx1 and eaeA genes of E. coli) and eight clinically normal healthy calves (as control) were taken to investigate the serum biochemical profiles. Result: Analysis of serum samples of calves affected with colibacillosis revealed significant increase in the values of total protein, albumin, globulin, A/G ratio, blood urea nitogen, creatinine, potassium, total oxidant status andoxidative stress index while there is a significant decrease in the values of glucose, sodium, chloride, bicarbonate, IgG, IgM and total antioxidant status. There were no significant changes observed in the values of ALP, AST and ALT in affected calves as compared to healthy control group of calves.

scholarly journals Influence of Hempedu bumi (Andrographis paniculata) on serum biochemical parameters and liver morphology in broiler chickens

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Masnindah Malahubban ◽  
Zakry Fitri Ab Ab Aziz
Keyword(s):  
Biochemical Parameters ◽  
Broiler Chickens ◽  
Basal Diet ◽  
Normal Structure ◽  
Andrographis Paniculata ◽  
Control Group ◽  
Serum Biochemical Parameters ◽  
Treatment Groups ◽  
Liver Morphology ◽  
Serum Biochemical

Serum biochemical parameters data was evaluated in broilers fed diets supplemented with  hempedu bumi (Andrographis paniculata, AP) ground leaf. Birds (n = 160) were assigned in four treatment groups with five replication and each group contain eight birds. Broilers in the control group were fed the basal diet without additives, the group dietary treatments, Diet AP2 (Basal diet + 2g/kg Andrographis paniculata); Diet AP4 (Basal diet + 4g/kg Andrographis paniculata) and Diet AP8 (Basal diet + 8g/kg Andrographis paniculata). During day-21 and day-42, five birds from each treatment groups were randomly selected for serum biochemical analysis which involve pancreatic, renal, and hepatic functions (aspartate transaminase (AST), alkaline transaminase (ALT), alkaline phosphatase (ALP), glucose, cholesterol, triglycerides, total protein, albumin, urea, sodium, potassium, chlorine, and globulins). Liver morphology was determined after slaughtering two birds and collected the liver samples. Based on these results AP at 8g/kg diet lowered serum cholesterol, glucose and triglycerides. It also maintain the normal structure of liver indicating that no toxic effect from AP supplementation at a rate up to 8 g/kg, it also that AP lowered ALP and ALT in blood of chicken. In conclusion, supplementation of AP at 8g/kg in diet its beneficial effects on health and safe for broiler chicken production.

Evaluation of nanoselenium (Nano-Se) effect on hematological and serum biochemical parameters of rat in experimentally lead poisoning

2016 ◽  
Vol 36 (4) ◽  
pp. 421-427 ◽  
Author(s):  
A Jafari Dehkordi ◽  
AN Mohebbi ◽  
MR Aslani ◽  
SM Ghoreyshi
Keyword(s):  
Biochemical Parameters ◽  
Thiobarbituric Acid ◽  
Male Rats ◽  
Control Group ◽  
Tbars Level ◽  
Serum Biochemical Parameters ◽  
Selenium Compounds ◽  
Significant Difference ◽  
Serum Biochemical ◽  
Hematological And Biochemical Parameters

The present study was designed to evaluate the effect of nanoselenium (Nano-Se) on hematological and biochemical parameters of rats experimentally intoxicated with lead (Pb). Thirty male rats were randomly divided into six groups as follows: the control, selenite, Nano-Se, Pb group, Pb + selenite, and Pb + Nano-Se groups. After 35 days, blood was collected from rats and hematology and serum biochemical parameters of oxidative stress were measured. The thiobarbituric acid reactive substances (TBARS) level of Pb group was significantly higher than other groups. Also, TBARS level was significantly lower in the Pb + Nano-Se group than Pb + selenite group. The serum superoxide dismutase activities were significantly lower in Pb group than the control, Pb + selenite, and Pb + Nano-Se groups. The catalase activities in the Pb group showed no significant change when compared to other groups. In the Pb group, packed cell volume was lower than the control group. A significant difference was observed between the control group and the Pb, Pb + selenite, and Pb + Nano-Se groups. In the Pb group, the numbers of white blood cell (WBC) decreased in comparison with the control group. Also, there was significant increase in WBC counts in the Pb + Nano-Se and Pb + selenite groups in comparison with Pb group. The number of lymphocytes in the Pb group decreased in comparison with the control group. By comparing the means of the Pb + Nano-Se and Pb + selenite groups together, it was determined that there were significant differences in the lymphocytes and neutrophil counts. In conclusion, usage of selenium compounds particularly Nano-Se particles inhibits the adverse effects of Pb on antioxidant activity and immune system function in the Pb poisoning.

scholarly journals Assessment of serum biochemical parameters and pathological changes in broilers with chronic aflatoxicosis fed glucomannan-containing yeast product (Mycosorb) and sodium bentonite

2015 ◽  
Vol 59 (2) ◽  
pp. 205-211 ◽  
Author(s):  
Aidin Azizpour ◽  
Navid Moghadam
Keyword(s):  
Biochemical Parameters ◽  
Fatty Degeneration ◽  
Control Group ◽  
Serum Biochemical Parameters ◽  
Pathological Changes ◽  
Negative Effects ◽  
Pathological Effect ◽  
Sodium Bentonite ◽  
Serum Biochemical ◽  
Hepatic Lesions

AbstractThe purpose of this study was to evaluate the efficacy of yeast glucomannan (YG) and sodium bentonite (SB) in reducing the toxicity in broilers fed a diet naturally contaminated with aflatoxin. Three hundred 7-day-old Ross 308 strain broilers were chosen and randomly assigned to 10 dietary treatments. Serum biochemical parameters and pathological changes in the liver were investigated at 42 d of age. Chickens fed a diet containing 250 ppb of aflatoxin displayed a decrease in uric acid, cholesterol, and triglycerides, and an increase in serum activities of AST and ALT when compared to control group. There were considerable gross and histopathological hepatic lesions (P < 0.05) in the form of small to moderate hydropic and/or fatty degeneration, bile duct hyperplasia, periportal fibrosis, cells infiltration, and congestion, in chickens fed the 250 ppb aflatoxincontaining diet. The addition of YG and SB to the aflatoxin-containing diet partially reduced the negative effects of aflatoxin. The 0.1% YG supplementation to the aflatoxin-contaminated diet significantly prevented the pathological effect of aflatoxin on serum biochemical parameters and liver, and was found to be more effective than other treatments.

scholarly journals Effect of addition of exogenous enzymes in hypocaloric diet in broiler chicken on performance, biochemical parameters and meat characteristics

2015 ◽  
Vol 31 (4) ◽  
pp. 551-565 ◽  
Author(s):  
L. Allouche ◽  
T. Madani ◽  
Ait Hamouda ◽  
M.R. Boucherit ◽  
H. Taleb ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Broiler Chickens ◽  
Hypocaloric Diet ◽  
Control Group ◽  
Standard Diet ◽  
Serum Biochemical Parameters ◽  
Control Groups ◽  
Exogenous Enzymes ◽  
Serum Biochemical ◽  
And Control

In developing countries, broiler farmers often use imbalanced energy diets, hence our study aims to evaluate the combined effect of addition of commercial exogenous enzymes (CEE), in low energy level corn/soybean meal based-diet on performance, serum biochemical parameters, meat characteristics in male and female of broiler chickens. A total of 120 one day old Hubbard F15 broiler chickens were divided on 2 groups (60 animals/group) with 5 replicates/group. The control group received a standard diet, while CEE group received the same diet supplemented with enzymes (250 g/ton). Addition of enzymes reduced significantly feed (p<0.001) and water intakes (p<0.05); in meantime, feed conversion ratio tended to be lower (p=0.08). No changes were observed in pH, protein or moisture contents of meat in both sexes broiler between CEE and control groups. No perturbation was found in all serum biochemical parameters in both sexes between CEE and control groups, except total protein and albumin levels were significantly higher in male birds fed enzymes when compared to male birds of the control group (p<0.001; p<0.01) respectively. Addition of enzymes allowed a decrease of 950 g/bird in feed intake for the total rearing period, hence save 337 ?/1000 birds; thus, use of CEE in hypocaloric diet enhances broilers feed efficiency and procures an economic benefit to farmers.

scholarly journals Effects of a clinoptilolite supplement in pig diets on performance and serum parameters

2008 ◽  
Vol 52 (No. 6) ◽  
pp. 159-166 ◽  
Author(s):  
D. Prvulović ◽  
A. Jovanović-Galović ◽  
B. Stanić ◽  
M. Popović ◽  
G. Grubor-Lajšić
Keyword(s):  
Biochemical Parameters ◽  
Growth Parameters ◽  
Body Weight Gain ◽  
Vena Cava ◽  
Cholesterol Concentration ◽  
Control Group ◽  
Serum Biochemical Parameters ◽  
Serum Biochemical ◽  
First 90 Days

The effects of clinoptilolite in pig&sbqua;s diets were examined on sixty Landrace &times; Yorkshire crossbred pigs of both sexes divided into two groups: 1. control group, with basal diets; 2. treatment, with basal diets supplemented with 5 g clinoptilolite per 1 kg diet (Cp group). Feed and water were available <i>ad libitum</i>. Individual live weights were recorded on days 45, 90 and 135 of the experiment. Feed consumptions were recorded weekly. Blood was drawn from the anterior vena cava of each pig at day 135 for the determination of serum biochemical parameters. During the first 90 days of the experiment pigs from the Cp group had higher body weight gain (BWG) compared with the control group (+2.5% and +7.0%, respectively) but in the finishing phase of growing their growth parameters were significantly lower (&minus;4.8%). Blood serum biochemical parameters from all experimental pigs were generally within the normal range. Higher triglyceride concentration, lower total cholesterol concentration and increased activity of AST were recorded in the serum of the Cp group.

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